Is oral immunotherapy the cure for food allergies?

Current Opinion in Allergy and Clinical Immunology

Volumn 10, Issue 3, 2010, Pages 214-219

  Nowak Wȩgrzyn, Anna ^a   Fiocchi, Alessandro ^b  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MILAN   (Italy)

Author keywords

Food allergy; Milk immunotherapy; Oral desensitization; Oral immunotherapy; Oral tolerance; Peanut allergy; Peanut immunotherapy

Indexed keywords

FOOD ALLERGEN; IMMUNOGLOBULIN E ANTIBODY; IMMUNOGLOBULIN G4;

ABDOMINAL DISCOMFORT; CLINICAL RESEARCH; CLINICAL TRIAL; DESENSITIZATION; FOOD ALLERGY; FOOD INTAKE; HUMAN; IMMUNOLOGICAL TOLERANCE; IMMUNOTHERAPY; MILK ALLERGY; ORAL IMMUNOTHERAPY; ORAL PRURITUS; PEANUT ALLERGY; PRIORITY JOURNAL; RASH; REVIEW; RISK FACTOR;

ADMINISTRATION, ORAL; ALLERGENS; DESENSITIZATION, IMMUNOLOGIC; EPINEPHRINE; EXANTHEMA; FOOD HYPERSENSITIVITY; HUMANS; IMMUNE TOLERANCE; PRURITUS; RISK ASSESSMENT;

EID: 77951771280     PISSN: 15284050     EISSN: 14736322     Source Type: Journal    
DOI: 10.1097/ACI.0b013e3283399404     Document Type: Review

References (26)

1. Branum AM, Lukacs SL. Food allergy among children in the United States. Pediatrics 2009.
2. Sicherer SH, Sampson HA. Food allergy: recent advances inpathophysiology and treatment. Annu Rev Med 2009;60:261-277.
3. Gupta R, Sheikh A, Strachan DP, Anderson HR. Time trends in allergic disorders in the UK. Thorax 2007;62:91-96.
4. Skripak JM, Sampson HA. Towards acure for food allergy. Curr Opin Immunol 2008;20:690-696.
5. Leung DY, Sampson HA, Yunginger JW, et al. Effect of anti-IgE therapy in patients with peanut allergy. N Engl J Med 2003;348:986-993.
6. Srivastava KD, Kattan JD, Zou ZM, et al. The Chinese herbal medicine formula FAHF-2 completely blocks anaphylacticreactions inamurine modelof peanut allergy. J Allergy Clin Immunol 2005;115:171-178.
7. Srivastava KD, Qu C, Zhang T, et al. Food Allergy Herbal Formula-2 silences peanut-induced anaphylaxis for a prolonged posttreatment period via IFN-gamma-producing CD8+ T cells. J Allergy Clin Immunol 2009;123:443-451.
8. Li XM, Srivastava K, Grishin A, et al. Persistent protective effect of heat-killed Escherichia coli producing 'engineered, ' recombinant peanut proteins in a murine model of peanut allergy. J Allergy Clin Immunol 2003;112:159-167.
9. Straumann A, Conus S, Grzonka P, et al. Antiinterleukin-5 antibody treatment (mepolizumab) in active eosinophilic oesophagitis: a randomised, placebocontrolled, double-blind trial. Gut 2010;59:21-30.
10. Scurlock AM, Burks AW, Jones SM. Oral immunotherapy for food allergy. Curr • Allergy Asthma Rep 2009;9:186-193. Very interesting review discussing OIT.
11. Schofield AT. A case of egg poisoning. Lancet 1908;1:716.
12. Chehade M, Mayer L Oral tolerance and its relation to food hypersensitivities. J Allergy Clin Immunol 2005;115:3-12.
13. Strid J, Hourihane J, Kimber I, et al. Epicutaneous exposure to peanut protein prevents oral tolerance and enhances allergic sensitization. Clin Exp Allergy 2005;35:757-766.
14. Rolinck-Werninghaus C, Staden U, Mehl A, et al. Specific oral tolerance induction with food in children: transient or persistent effect on food allergy? Allergy 2005;60:1320-1322.
15. Patriarca C, Romano A, Venuti A, et al. Oral specific hyposensitization in the management of patients allergic to food. Allergol Immunopathol (Madr) 1984;12:275-281.
16. Patriarca G, Nucera E, Roncallo C, et al. Oral desensitizing treatment in food allergy: clinical and immunological results. Aliment Pharmacol Ther 2003;17:459-465.
17. Meglio P, Bartone E, Plantamura M, et al. A protocol for oral desensitization in children with IgE-mediated cow's milk allergy. Allergy 2004;59:980-987.
18. Buchanan AD, Green TD, Jones SM, et al. Egg oral immunotherapy in nonanaphylactic children with egg allergy. J Allergy Clin Immunol 2007;119:199-205.
19. Morisset M, Moneret-Vautrin DA, Guenard L, et al. Oral desensitization in children with milk and egg allergies obtains recovery in a significant proportion of cases: a randomized study in 60 children with cow's milk allergy and 90 children with egg allergy. Allerg Immunol (Paris) 2007;39:12-19.
20. Staden U, Rolinck-Werninghaus C, Brewe F, et al. Specific oral tolerance induction in food allergy in children: efficacy and clinical patterns of reaction. Allergy 2007;62:1261-1269.
21. Longo G, Barbi E, Berti I, et al. Specific oral tolerance induction in children with very severe cow's milk-induced reactions. J Allergy Clin Immunol 2008;121:343-347.
22. Jones SM, Pons L, Roberts JL, et al. Clinical efficacy and immune regula-•• tion with peanut oral immunotherapy. J Allergy Clin Immunol 2009;124:292-300. The largest open study of peanut OIT in children that discusses efficacy, safety and mechanism of OIT.
23. Jones SM, Pons L, Roberts JL, et al. Clinical efficacy and immune regulation •• with peanut oral immunotherapy. J Allergy Clin Immunol 2009;124:292-300; 300. The largest open study of peanut OIT in children that discusses efficacy, safety and mechanism of OIT.
24. Narisety SD, Skripak JM, Steele P, et al. Open-label maintenance after milk oral immunotherapy for IgE-mediated cow's milk allergy. J Allergy Clin Immunol 2009;124:610-612.
25. Varshney P, Steele PH, Vickery BP, et al. Adverse reactions during peanut oral immunotherapy home dosing. J Allergy Clin Immunol 2009.
26. Hofmann AM, Scurlock AM, Jones SM, et al. Safety of a peanut oral immunotherapy protocol in children with peanut allergy. J Allergy Clin Immunol 2009;124:286-291.