Modafinil improves performance in the multiple T-Maze and modifies GluR1, GluR2, D2 and NR1 receptor complex levels in the C57BL/6J mouse

Amino Acids

Volumn 43, Issue 6, 2012, Pages 2285-2292

  Sase, Sunetra ^a   Khan, Deeba ^a   Sialana, Fernando ^a   Höger, Harald ^a   Russo Schlaff, Nina ^a   Lubec, Gert ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Brain receptor; Dopaminergic; Glutamatergic; Modafinil; Nicotinergic; Spatial memory

Indexed keywords

AMPA RECEPTOR; BUNGAROTOXIN RECEPTOR; DOPAMINE 2 RECEPTOR; GLUTAMATE RECEPTOR 1; GLUTAMATE RECEPTOR 2; MODAFINIL; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOPAMINERGIC SYSTEM; DRUG ACTIVITY; HIPPOCAMPUS; IMMUNOBLOTTING; LATENT PERIOD; MALE; MAZE TEST; MEMORY; MOUSE; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SPATIAL MEMORY; TASK PERFORMANCE; TRAINING; ULTRACENTRIFUGATION;

EID: 85027927198     PISSN: 09394451     EISSN: 14382199     Source Type: Journal    
DOI: 10.1007/s00726-012-1306-y     Document Type: Article

References (48)

1. Agnati LF, Ferre S, Cortelli P, Fuxe K (1995) A brief appraisal on some aspects of the receptor-receptor interaction. Neurochem Int 27:139-146
2. Beracochea D, Celerier A, Borde N, Valleau M, Peres M, Pierard C (2002) Improvement of learning processes following chronic systemic administration of modafinil in mice. Pharmacol Biochem Behav 73:723-728 (Pubitemid 34876723)
3. Blackwell AD, Paterson NS, Barker RA, Robbins TW, Sahakian BJ (2008) The effects of modafinil on mood and cognition in Huntington's disease. Psychopharmacology 199:29-36
4. Borroto-Escuela DO, Romero-Fernandez W, Tarakanov AO, Marcellino D, Ciruela F, Agnati LF, Fuxe K (2010) Dopamine D2 and 5-hydroxytryptamine 5-HT (A) receptors assemble into functionally interacting heteromers. Biochem Biophys Res Commun 401:605-610
5. Borroto-Escuela DO, Van Craenenbroeck K, Romero-Fernandez W, Guidolin D, Woods AS, Rivera A, Haegeman G, Agnati LF, Tarakanov AO, Fuxe K (2011) Dopamine D2 and D4 receptor heteromerization and its allosteric receptor-receptor interactions. Biochem Biophys Res Commun 404:928-934
6. de Saint Hilaire Z, Orosco M, Rouch C, Blanc G, Nicolaidis S (2001) Variations in extracellular monoamines in the prefrontal cortex and medial hypothalamus after modafinil administration: A microdialysis study in rats. NeuroReport 12:3533-3537 (Pubitemid 33065493)
7. El-Ghundi M, O'Dowd BF, George SR (2007) Insights into the role of dopamine receptor systems in learning and memory. Rev Neurosci 18:37-66
8. Ellis KA, Mehta MA, Wesnes KA, Armstrong S, Nathan PJ (2005) Combined D1/D2 receptor stimulation under conditions of dopamine depletion impairs spatial working memory performance in humans. Psychopharmacology 181:771-780 (Pubitemid 41400763)
9. Ferrada C, Ferre S, Casado V, Cortes A, Justinova Z, Barnes C, Canela EI, Goldberg SR, Leurs R, Lluis C, Franco R (2008) Interactions between histamine H3 and dopamine D2 receptors and the implications for striatal function. Neuropharmacology 55:190-197
10. Ferraro L, Antonelli T, O'Connor WT, Tanganelli S, Rambert FA, Fuxe K (1998) The effects of modafinil on striatal, pallidal and nigral GABA and glutamate release in the conscious rat: evidence for a preferential inhibition of striato-pallidal GABA transmission. Neurosci Lett 253:135-138 (Pubitemid 28430641)
11. Ferraro L, Antonelli T, Tanganelli S, O'Connor WT, Perez de la Mora M, Mendez-Franco J, Rambert FA, Fuxe K (1999) The vigilance promoting drug modafinil increases extracellular glutamate levels in the medial preoptic area and the posterior hypothalamus of the conscious rat: prevention by local GABAA receptor blockade. Neuropsychopharmacology 20:346-356 (Pubitemid 29099765)
12. Fuxe K, Canals M, Torvinen M, Marcellino D, Terasmaa A, Genedani S, Leo G, Guidolin D, Diaz-Cabiale Z, Rivera A, Lundstrom L, Langel U, Narvaez J, Tanganelli S, Lluis C, Ferre S, Woods A, Franco R, Agnati LF (2007) Intramembrane receptor-receptor interactions: A novel principle in molecular medicine. J Neural Transm 114:49-75 (Pubitemid 46018675)
13. Ghafari M, Falsafi SK, Hoeger H, Lubec G (2011) Hippocampal levels of GluR1 and GluR2 complexes are modulated by training in the multiple T-Maze in C57BL/6J mice. Brain Struct Funct. doi:10.1007/s00429-00011-00335-00428 (in press)
14. Glickstein SB, Hof PR, Schmauss C (2002) Mice lacking dopamine D2 and D3 receptors have spatial working memory deficits. J Neurosci 22:5619-5629 (Pubitemid 35386483)
15. Heo S, Patil SS, Jung G, Hoger H, Lubec G (2010) A serotonin receptor 1A containing complex in hippocampus of PWD/PhJ mice is linked to training effects in the Barnes maze. Behav Brain Res 216:389-395
16. Jasinski DR (2000) An evaluation of the abuse potential of modafinil using methylphenidate as a reference. J Psychopharmacol 14:53-60 (Pubitemid 30156539)
17. Kahbazi M, Ghoreishi A, Rahiminejad F, Mohammadi MR, Kamalipour A, Akhondzadeh S (2009) A randomized, double-blind and placebo-controlled trial of modafinil in children and adolescents with attention deficit and hyperactivity disorder. Psychiatry Res 168:234-237
18. Kang SU, Fuchs K, Sieghart W, Pollak A, Csaszar E, Lubec G (2009) Gel-based mass spectrometric analysis of a strongly hydrophobic GABAA-receptor subunit containing four transmembrane domains. Nat Protoc 4:1093-1102
19. Korotkova TM, Klyuch BP, Ponomarenko AA, Lin JS, Haas HL, Sergeeva OA (2007) Modafinil inhibits rat midbrain dopaminergic neurons through D2-like receptors. Neuropharmacology 52:626-633 (Pubitemid 46137978)
20. Lin JS, Roussel B, Akaoka H, Fort P, Debilly G, Jouvet M (1992) Role of catecholamines in the modafinil and amphetamine induced wakefulness, a comparative pharmacological study in the cat. Brain Res 591:319-326
21. Madras BK, Xie Z, Lin Z, Jassen A, Panas H, Lynch L, Johnson R, Livni E, Spencer TJ, Bonab AA, Miller GM, Fischman AJ (2006) Modafinil occupies dopamine and norepinephrine transporters in vivo and modulates the transporters and trace amine activity in vitro. J Pharmacol Exp Ther 319:561-569
22. Marcellino D, Ferre S, Casado V, Cortes A, Le Foll B, Mazzola C, Drago F, Saur O, Stark H, Soriano A, Barnes C, Goldberg SR, Lluis C, Fuxe K, Franco R (2008) Identification of dopamine D1-D3 receptor heteromers. Indications for a role of synergistic D1-D3 receptor interactions in the striatum. J Biol Chem 283:26016-26025
23. Mehta MA, Riedel WJ (2006) Dopaminergic enhancement of cognitive function. Curr Pharm Des 12:2487-2500
24. Mehta MA, Montgomery AJ, Kitamura Y, Grasby PM (2008) Dopamine D2 receptor occupancy levels of acute sulpiridechallenges that produce working memory and learning impairments in healthy volunteers. Psychopharmacology 196:157-165
25. Mele A, Avena M, Roullet P, De Leonibus E, Mandillo S, Sargolini F, Coccurello R, Oliverio A (2004) Nucleus accumbens dopamine receptors in the consolidation of spatial memory. Behav Pharmacol 15:423-431 (Pubitemid 39238356)
26. Minzenberg MJ, Carter CS (2008) Modafinil: A review of neurochemical actions and effects on cognition. Neuropsychopharmacology 33:1477-1502 (Pubitemid 351684703)
27. Mitchell HA, Bogenpohl JW, Liles LC, Epstein MP, Bozyczko-Coyne D, Williams M, Weinshenker D (2008) Behavioral responses of dopamine beta-hydroxylase knockout mice to modafinil suggest a dual noradrenergic- dopaminergic mechanism of action. Pharmacol Biochem Behav 91:217-222
28. Muller U, Steffenhagen N, Regenthal R, Bublak P (2004) Effects of modafinil on working memory processes in humans. Psychopharmacology 177:161-169 (Pubitemid 40109926)
29. Paterson NE, Fedolak A, Olivier B, Hanania T, Ghavami A, Caldarone B (2010) Psychostimulant-like discriminative stimulus and locomotor sensitization properties of the wake-promoting agent modafinil in rodents. Pharmacol Biochem Behav 95:449-456
30. Patil SS, Sunyer B, Hoger H, Lubec G (2009) Evaluation of spatial memory of C57BL/6J and CD1 mice in the Barnes maze, the Multiple T-maze and in the Morris water maze. Behav Brain Res 198:58-68
31. Qu WM, Huang ZL, Xu XH, Matsumoto N, Urade Y (2008) Dopaminergic D1 and D2 receptors are essential for the arousal effect of modafinil. J Neurosci 28:8462-8469
32. Randall DC, Viswanath A, Bharania P, Elsabagh SM, Hartley DE, Shneerson JM, File SE (2005) Does modafinil enhance cognitive performance in young volunteers who are not sleep-deprived? J Clin Psychopharmacol 25:175-179 (Pubitemid 40395097)
33. Rasetti R, Mattay VS, Stankevich B, Skjei K, Blasi G, Sambataro F, Arrillaga-Romany IC, Goldberg TE, Callicott JH, Apud JA, Weinberger DR (2010) Modulatory effects of modafinil on neural circuits regulating emotion and cognition. Neuropsychopharmacology 35:2101-2109
34. Rinaldi A, Mandillo S, Oliverio A, Mele A (2007) D1 and D2 receptor antagonist injections in the prefrontal cortex selectively impair spatial learning in mice. Neuropsychopharmacology 32:309-319 (Pubitemid 46106938)
35. Sase A, Khan D, Hoger H, Lubec G (2011) Intraperitoneal injection of saline modulates hippocampal brain receptor complex levels but does not impair performance in the Morris Water Maze. Amino Acids. doi:10.1007/s00726-00011- 01130-00729 (in press)
36. Seeman P, Guan HC, Hirbec H (2009) Dopamine D2High receptors stimulated by phencyclidines, lysergic acid diethylamide, salvinorin A, and modafinil. Synapse 63:698-704
37. Shuman T, Wood SC, Anagnostaras SG (2009) Modafinil and memory: effects of modafinil on Morris water maze learning and Pavlovian fear conditioning. Behav Neurosci 123:257-266
38. Spence SA, Green RD, Wilkinson ID, Hunter MD (2005) Modafinil modulates anterior cingulate function in chronic schizophrenia. Br J Psychiatry 187:55-61 (Pubitemid 41002514)
39. Tsanov M, Lyons DG, Barlow S, Gonzalez Reyes RE, O'Mara SM (2010) The psychostimulant modafinil facilitates water maze performance and augments synaptic potentiation in dentate gyrus. Neuropharmacology 59:9-19
40. Turner DC, Robbins TW, Clark L, Aron AR, Dowson J, Sahakian BJ (2003) Cognitive enhancing effects of modafinil in healthy volunteers. Psychopharmacology 165:260-269 (Pubitemid 36197601)
41. Turner DC, Clark L, Pomarol-Clotet E, McKenna P, Robbins TW, Sahakian BJ (2004) Modafinil improves cognition and attentional set shifting in patients with chronic schizophrenia. Neuropsychopharmacology 29:1363-1373 (Pubitemid 38780659)
42. Volkow ND, Fowler JS, Logan J, Alexoff D, Zhu W, Telang F, Wang GJ, Jayne M, Hooker JM, Wong C, Hubbard B, Carter P, Warner D, King P, Shea C, Xu Y, Muench L, Apelskog-Torres K (2009) Effects of modafinil on dopamine and dopamine transporters in the male human brain: clinical implications. JAMA 301:1148-1154
43. Ward CP, Harsh JR, York KM, Stewart KL, McCoy JG (2004) Modafinil facilitates performance on a delayed nonmatching to position swim task in rats. Pharmacol Biochem Behav 78:735-741 (Pubitemid 39037733)
44. Welinder C, Ekblad L (2010) Coomassie staining as loading control in Western blot analysis. J Proteome Res 10:1416-1419
45. Wilkerson A, Levin ED (1999) Ventral hippocampal dopamine D1 and D2 systems and spatial working memory in rats. Neuroscience 89:743-749 (Pubitemid 29071000)
46. Winder-Rhodes SE, Chamberlain SR, Idris MI, Robbins TW, Sahakian BJ, Muller U (2010) Effects of modafinil and prazosin on cognitive and physiological functions in healthy volunteers. J Psychopharmacol 24:1649-1657
47. Young JW (2009) Dopamine D1 and D2 receptor family contributions to modafinil-induced wakefulness. J Neurosci 29:2663-2665
48. Young JW, Geyer MA (2010) Action of modafinil-increased motivation via the dopamine transporter inhibition and D1 receptors? Biol Psychiatry 67:784-787