Effects of modafinil and prazosin on cognitive and physiological functions in healthy volunteers

Journal of Psychopharmacology

Volumn 24, Issue 11, 2010, Pages 1649-1657

  Winder Rhodes, S E ^a,b   Chamberlain, S R ^a,b   Idris, M I ^a   Robbins, T W ^c,d   Sahakian, B J ^a,c   Muller U ^a,c  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d UK   (United Kingdom)

Author keywords

attention deficit hyperactivity disorder (ADHD); cognition; executive function; human; modafinil; noradrenaline; physiological effects; prazosin; prefrontal cortex; salivary amylase

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR; AMYLASE; MODAFINIL; PLACEBO; PRAZOSIN;

ACCURACY; ADULT; ARTICLE; BLOOD PRESSURE; CLINICAL TRIAL; COGNITION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG POTENTIATION; HEART RATE; HUMAN; HUMAN EXPERIMENT; LATENT PERIOD; MALE; NEUROCHEMISTRY; NORMAL HUMAN; PRIORITY JOURNAL; SALIVA LEVEL; TASK PERFORMANCE; VALIDATION PROCESS; WORKING MEMORY;

ADOLESCENT; ADRENERGIC ALPHA-1 RECEPTOR ANTAGONISTS; ADULT; BENZHYDRYL COMPOUNDS; CENTRAL NERVOUS SYSTEM STIMULANTS; COGNITION; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; HEART RATE; HUMANS; MALE; MEMORY; MEMORY, SHORT-TERM; PRAZOSIN; PSYCHOMOTOR PERFORMANCE; REACTION TIME; YOUNG ADULT;

EID: 77955709809     PISSN: 02698811     EISSN: 14617285     Source Type: Journal    
DOI: 10.1177/0269881109105899     Document Type: Article

References (47)

1. Banerjee, D., Vitiello, MV, Grunstein, RR (2004) Pharmacotherapy for excessive daytime sleepiness. Sleep Med Rev 8: 339-354.
2. Birnbaum, SG, Yuan, PX, Wang, M., Vijayraghavan, S., Bloom, AK, Davis, DJ, et al. (2004) Protein kinase C overactivity impairs prefrontal cortical regulation of working memory. Science 306: 882-884.
3. Brum, PC, Hurt, CM, Shcherbakova, OG, Kobilka, B., Angelotti, T. (2006) Differential targeting and function of alpha2A and alpha2C adrenergic receptor subtypes in cultured sympathetic neurons. Neuropharmacology 51: 397-413.
4. Bylund, DB (1985) Heterogeneity of alpha-2 adrenergic receptors. Pharmacol Biochem Behav 22: 835-843.
5. Bylund, DB (1992) Subtypes of alpha 1- and alpha 2-adrenergic receptors. Faseb J 6: 832-839.
6. Chamberlain, SR, Muller, U., Blackwell, AD, Robbins, TW, Sahakian, BJ (2006) Noradrenergic modulation of working memory and emotional memory in humans. Psychopharmacology (Berl) 188: 397-407.
7. Chamberlain, SR, Robbins, TW, Sahakian, BJ (2007) The neurobiology of attention-deficit/hyperactivity disorder. Biol Psychiatry 61: 1317-1319.
8. Chatterton Jr, RT, Vogelsong, KM, Lu, YC, Ellman, AB, Hudgens, GA (1996) Salivary alpha-amylase as a measure of endogenous adrenergic activity. Clin Physiol 16: 433-448.
9. de Saint Hilaire, Z., Orosco, M., Rouch, C., Blanc, G., Nicolaidis, S. (2001) Variations in extracellular monoamines in the prefrontal cortex and medial hypothalamus after modafinil administration: a microdialysis study in rats. Neuroreport 12: 3533-3537.
10. Dierks, MR, Jordan, JK, Sheehan, AH (2007) Prazosin treatment of nightmares related to posttraumatic stress disorder. Ann Pharmacother 41: 1013-1017.
11. Duteil, J., Rambert, FA, Pessonnier, J., Hermant, JF, Gombert, R., Assous, E. (1990) Central alpha 1-adrenergic stimulation in relation to the behaviour stimulating effect of modafinil; studies with experimental animals. Eur J Pharmacol 180: 49-58.
12. Eagle, DM, Bari, A., Robbins, TW (2008) The neuropsychopharmacology of action inhibition: cross-species translation of the stop-signal and go/no-go tasks. Psychopharmacology (Berl) 199: 439-456.
13. Heitmann, J., Cassel, W., Grote, L., Bickel, U., Hartlaub, U., Penzel, T., et al. (1999) Does short-term treatment with modafinil affect blood pressure in patients with obstructive sleep apnea ? Clin Pharmacol Ther 65: 328-335.
14. Hermant, JF, Rambert, FA, Duteil, J. (1991) Awakening properties of modafinil: effect on nocturnal activity in monkeys (Macaca mulatta) after acute and repeated administration. Psychopharmacology (Berl) 103: 28-32.
15. Hou, RH, Freeman, C., Langley, RW, Szabadi, E., Bradshaw, CM (2005) Does modafinil activate the locus coeruleus in man? Comparison of modafinil and clonidine on arousal and autonomic functions in human volunteers. Psychopharmacology (Berl) 181: 537-549.
16. Jaillon, P. (1980) Clinical pharmacokinetics of prazosin. Clin Pharmacokinet 5: 365-376.
17. Lin, JS, Roussel, B., Akaoka, H., Fort, P., Debilly, G., Jouvet, M. (1992) Role of catecholamines in the modafinil and amphetamine induced wakefulness, a comparative pharmacological study in the cat. Brain Res 591: 319-326.
18. Madras, BK, Xie, Z., Lin, Z., Jassen, A., Panas, H., Lynch, L., et al. (2006) Modafinil occupies dopamine and norepinephrine transporters in vivo and modulates the transporters and trace amine activity in vitro. J Pharmacol Exp Ther 319: 561-569.
19. Makris, AP, Rush, CR, Frederich, RC, Kelly, TH (2004) Wake-promoting agents with different mechanisms of action: comparison of effects of modafinil and amphetamine on food intake and cardiovascular activity. Appetite 42: 185-195.
20. McCormick, DA, Wang, Z., Huguenard, J. (1993) Neurotransmitter control of neocortical neuronal activity and excitability. Cereb Cortex 3: 387-398.
21. Miller, LJ (2008) Prazosin for the treatment of posttraumatic stress disorder sleep disturbances. Pharmacotherapy 28: 656-666.
22. Minzenberg, MJ, Carter, CS (2008) Modafinil: a review of neurochemical actions and effects on cognition. Neuropsychopharmacology 33: 1477-1502.
23. Minzenberg, MJ, Watrous, AJ, Yoon, JH, Ursu, S., Carter, CS (2008) Modafinil shifts human locus coeruleus to low-tonic, high-phasic activity during functional MRI. Science 322: 1700-1702.
24. Müller, U., Steffenhagen, N., Regenthal, R., Bublak, P. (2004) Effects of modafinil on working memory processes in humans. Psychopharmacology (Berl) 177: 161-169.
25. Müller, U., Werheid, K., Hammerstein, E., Jungmann, S., Becker, T. (2005) Prefrontal cognitive deficits in patients with schizophrenia treated with atypical or conventional antipsychotics. Eur Psychiatry 20: 70-73.
26. Nelson, HE (1982) National Adult Reading Test (NART). Test Manual, NFER-NELSON, Windsor.
27. Randall, DC, Fleck, NL, Shneerson, JM, File, SE (2004) The cognitive-enhancing properties of modafinil are limited in non-sleep-deprived middle-aged volunteers. Pharmacol Biochem Behav 77: 547-555.
28. Randall, DC, Shneerson, JM, File, SE (2005) Cognitive effects of modafinil in student volunteers may depend on IQ. Pharmacol Biochem Behav 82: 133-139.
29. Randall, DC, Shneerson, JM, Plaha, KK, File, SE (2003) Modafinil affects mood, but not cognitive function, in healthy young volunteers. Hum Psychopharmacol 18: 163-173.
30. Robertson J. r, P, Hellriegel, ET (2003) Clinical pharmacokinetic profile of modafinil. Clin Pharmacokinet 42: 123-137.
31. Rohleder, N., Nater, UM, Wolf, JM, Ehlert, U., Kirschbaum, C. (2004) Psychosocial stress-induced activation of salivary alpha-amylase: an indicator of sympathetic activity ? Ann N Y Acad Sci 1032: 258-263.
32. Rohleder, N., Wolf, JM, Maldonado, EF, Kirschbaum, C. (2006) The psychosocial stress-induced increase in salivary alpha-amylase is independent of saliva flow rate. Psychophysiology 43: 645-652.
33. Rugino, TA, Samsock, TC (2003) Modafinil in children with attention-deficit hyperactivity disorder. Pediatr Neurol 29: 136-142.
34. Sahakian, BJ, Owen, AM (1992) Computerized assessment in neuropsychiatry using CANTAB: discussion paper. J R Soc Med 85: 399-402.
35. Sawaki, L., Werhahn, KJ, Barco, R., Kopylev, L., Cohen, LG (2003) Effect of an alpha(1)-adrenergic blocker on plasticity elicited by motor training. Exp Brain Res 148: 504-508.
36. Steer, RA, Cavalieri, TA, Leonard, DM, Beck, AT (1999) Use of the Beck Depression Inventory for Primary Care to screen for major depression disorders. Gen Hosp Psychiatry 21: 106-111.
37. Stone, EA, Cotecchia, S., Lin, Y., Quartermain, D. (2002) Role of brain alpha 1B-adrenoceptors in modafinil-induced behavioral activity. Synapse 46: 269-270.
38. Taneja, I., Diedrich, A., Black, BK, Byrne, DW, Paranjape, SY, Robertson, D. (2005) Modafinil elicits sympathomedullary activation. Hypertension 45: 612-618.
39. Taylor, FB, Lowe, K., Thompson, C., McFall, MM, Peskind, ER, Kanter, ED, et al. (2006) Daytime prazosin reduces psychological distress to trauma specific cues in civilian trauma posttraumatic stress disorder. Biol Psychiatry 59: 577-581.
40. Taylor, FB, Martin, P., Thompson, C., Williams, J., Mellman, TA, Gross, C., et al. (2008) Prazosin effects on objective sleep measures and clinical symptoms in civilian trauma posttraumatic stress disorder: a placebo-controlled study. Biol Psychiatry 63: 629-632.
41. Taylor, FB, Russo, J. (2000) Efficacy of modafinil compared to dextroamphetamine for the treatment of attention deficit hyperactivity disorder in adults. J Child Adolesc Psychopharmacol 10: 311-320.
42. Turner, D. (2006) A review of the use of modafinil for attention-deficit hyperactivity disorder. Expert Rev Neurother 6: 455-468.
43. Turner, DC, Clark, L., Dowson, J., Robbins, TW, Sahakian, BJ (2004 a) Modafinil improves cognition and response inhibition in adult attention-deficit/hyperactivity disorder. Biol Psychiatry 55: 1031-1040.
44. Turner, DC, Clark, L., Pomarol-Clotet, E., McKenna, P., Robbins, TW, Sahakian, BJ (2004 b) Modafinil improves cognition and attentional set shifting in patients with chronic schizophrenia. Neuropsychopharmacology 29: 1363-1373.
45. Turner, DC, Robbins, TW, Clark, L., Aron, AR, Dowson, J., Sahakian, BJ (2003) Cognitive enhancing effects of modafinil in healthy volunteers. Psychopharmacology (Berl) 165: 260-269.
46. van Stegeren, A., Rohleder, N., Everaerd, W., Wolf, OT (2006) Salivary alpha-amylase as marker for adrenergic activity during stress: effect of betablockade. Psychoneuroendocrinology 31: 137-141.
47. Wechsler, D. (1981) Wechsler Adult Intelligence Scale - Revised. The Psychological Corporation, San Antonio.