Dopamine D2 receptor occupancy levels of acute sulpiride challenges that produce working memory and learning impairments in healthy volunteers

Psychopharmacology

Volumn 196, Issue 1, 2008, Pages 157-165

  Mehta, Mitul A ^a,b   Montgomery, Andrew J ^a   Kitamura, Yuri ^a   Grasby, Paul M ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Dopamine; Learning; PET; Receptor occupancy; Sulpiride; Working memory

Indexed keywords

DOPAMINE 2 RECEPTOR; PLACEBO; PROLACTIN; RACLOPRIDE C 11; SULPIRIDE;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORPUS STRIATUM; DOUBLE BLIND PROCEDURE; DRUG DOSE COMPARISON; HUMAN; HUMAN EXPERIMENT; LEARNING DISORDER; MALE; MEMORY DISORDER; NEUROPSYCHOLOGICAL TEST; NORMAL HUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROLACTIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; RECEPTOR OCCUPANCY; SPATIAL MEMORY; TASK PERFORMANCE; VISUAL ANALOG SCALE; VOLUNTEER; WORKING MEMORY;

ADULT; AFFECT; ANTIPSYCHOTIC AGENTS; CARBON RADIOISOTOPES; CORPUS STRIATUM; DOPAMINE ANTAGONISTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; HUMANS; MALE; MEMORY, SHORT-TERM; MOTOR ACTIVITY; NEUROPSYCHOLOGICAL TESTS; ORIENTATION; PAIN MEASUREMENT; PATTERN RECOGNITION, VISUAL; POSITRON-EMISSION TOMOGRAPHY; PROBABILITY LEARNING; PROLACTIN; RACLOPRIDE; REACTION TIME; RECEPTORS, DOPAMINE D2; SERIAL LEARNING; SULPIRIDE;

EID: 38149086734     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00213-007-0947-0     Document Type: Article

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