Involvement of activin signaling in abnormalities of mouse vagina exposed neonatally to diethylstilbestrol

Cell and Tissue Research

Volumn 344, Issue 3, 2011, Pages 527-538

  Nakajima, Tadaaki ^a   Iguchi, Taisen ^b   Sato, Tomomi ^a  

^a YOKOHAMA CITY UNIVERSITY   (Japan)

^b GRADUATE UNIVERSITY FOR ADVANCED STUDIES   (Japan)

Author keywords

Activin; Cervicovaginal adenosis; Diethylstilbestrol; Mouse; Uterus; Vagina

Indexed keywords

ACTIVIN A; ACTIVIN A RECEPTOR TYPE 1B; ACTIVIN A RECEPTOR TYPE 2B; CYTOKINE RECEPTOR; DIETHYLSTILBESTROL; MESSENGER RNA; SMAD2 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; EPITHELIUM CELL; EXPOSURE; FEMALE; IN VITRO STUDY; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STROMA; TISSUE DISTRIBUTION; VAGINA ADENOSIS; VAGINA EPITHELIUM;

MUS;

EID: 85027921142     PISSN: 0302766X     EISSN: 14320878     Source Type: Journal    
DOI: 10.1007/s00441-011-1161-2     Document Type: Article

References (40)

1. Ball EM, Risbridger GP (2001) Activins as regulators of branching morphogenesis. Dev Biol 238:1-12 (Pubitemid 32939282)
2. Bigsby RM, Cooke PS, Cunha GR (1986) A simple efficient method for separating murine uterine epithelial and mesenchymal cells. Am J Physiol 251: E630-E636
3. Brown CW, Houston-Hawkins DE, Woodruff TK, Matzuk MM (2000) Insertion of Inhbb into the Inhba locus rescues the Inhba-null phenotype and reveals new activin functions. Nat Genet 25:453-457 (Pubitemid 32983442)
4. Chabicovsky M, Herkner K, Rossmanith W (2003) Overexpression of activin β(C) or activin β(E) in the mouse liver inhibits regenerative deoxyribonucleic acid synthesis of hepatic cells. Endocrinology 144:3497-3504 (Pubitemid 36904428)
5. Chang H, Lau AL, Matzuk MM (2001) Studying TGF-β superfamily signaling by knockouts and knockins. Mol Cell Endocrinol 180:39-46 (Pubitemid 32645627)
6. Chang H, Brown CW, Matzuk MM (2002) Genetic analysis of the mammalian transforming growth factor-β superfamily. Endocr Rev 23:787-823 (Pubitemid 35454589)
7. Cook RW, Thompson TB, Jardetzky TS, Woodruff TK (2004) Molecular biology of inhibin action. Semin Reprod Med 22:269-276 (Pubitemid 39122131)
8. Couse JF, Korach KS (2004) Estrogen receptor-α mediates the detrimental effects of neonatal diethylstilbestrol (DES) exposure in the murine reproductive tract. Toxicology 205:55-63 (Pubitemid 39359151)
9. Forsberg JG (1979) Developmental mechanism of estrogen-induced irreversible changes in the mouse cervicovaginal epithelium. Natl Cancer Inst Monogr 51:41-56
10. Giusti RM, Iwamoto K, Hatch EE (1995) Diethylstilbestrol revisited: a review of the long-term health effects. Ann Intern Med 122:778-788
11. Herbst AL, Ulfelder H, Poskanzer DC (1971) Adenocarcinoma of the vagina. Association of maternal stilbestrol therapy with tumor appearance in young women. N Engl J Med 284:878-881
12. Iguchi T (1992) Cellular effects of early exposure to sex hormones and abnormalities of female reproduction. Int Rev Cytol 139:1-57
13. Iguchi T, Sato T (2000) Endocrine disruption and developmental abnormalities of female reproduction. Am Zool 40:402-411
14. Iguchi T, Takasugi N (1987) Postnatal development of uterine abnormalities in mice exposed to DES in utero. Biol Neonate 52:97-103
15. Iguchi T, Takase M, Takasugi N (1986) Development of vaginal adenosis-like lesions and uterine epithelial stratification in mice exposed perinatally to diethylstilbestrol. Proc Soc Exp Biol Med 181:59-65 (Pubitemid 16139493)
16. Jones RL, Stoikos C, Findlay JK, Salamonsen LA (2006) TGF-β superfamily expression and actions in the endometrium and placenta. Reproduction 132:217-232 (Pubitemid 44269704)
17. Kim H, Nakajima T, Hayashi S, Chambon P, Watanabe H, Iguchi T, Sato T (2009) Effects of diethylstilbestrol on programmed oocyte death and induction of polyovular follicles in neonatal mouse ovaries. Biol Reprod 81:1002-1009
18. Kipp JL, Kilen SM, Bristol-Gould S, Woodruff TK, Mayo KE (2007) Neonatal exposure to estrogens suppresses activin expression and signaling in the mouse ovary. Endocrinology 148:1968-1976 (Pubitemid 46997073)
19. Knight PG, Glister C (2001) Potential local regulatory functions of inhibins, activins and follistatin in the ovary. Reproduction 121:503-512 (Pubitemid 32327912)
20. Kurita T, Mills AA, Cunha GR (2004) Roles of p63 in the diethylstilbestrol-induced cervicovaginal adenosis. Development 131:1639-1649 (Pubitemid 38559290)
21. Miyagawa S, Buchanan DL, Sato T, Ohta Y, Nishina Y, Iguchi T (2002) Characterization of diethylstilbestrol-induced hypospadias in female mice. Anat Rec 266:43-50 (Pubitemid 34027834)
22. Miyagawa S, Katsu Y, Watanabe H, Iguchi T (2004a) Estrogen-independent activation of erbBs signaling and estrogen receptor alpha in the mouse vagina exposed neonatally to diethylstilbestrol. Oncogene 23:340-349 (Pubitemid 38174987)
23. Miyagawa S, Suzuki A, Katsu Y, Kobayashi M, Goto M, Handa H, Watanabe H, Iguchi T (2004b) Persistent gene expression in mouse vagina exposed neonatally to diethylstilbestrol. J Mol Endocrinol 32:663-677 (Pubitemid 38877680)
24. Mori T, Iguchi T (1988) Long-term effects of perinatal treatment with sex steroids and related substances on reproductive organs of female mice. In: Mori T, Nagasawa H (eds) Toxicity of hormones in perinatal life. CRC Press, Boca Raton, pp 63-79
25. Murata K, Ota S, Niki T, Goto A, Li CP, Ruriko UM, Ishikawa S, Aburatani H, Kuriyama T, Fukayama M (2007) p63 - Key molecule in the early phase of epithelial abnormality in idiopathic pulmonary fibrosis. Exp Mol Pathol 83:367-376 (Pubitemid 350087016)
26. Niimi S, Hyuga M, Kazama H, Inagawa M, Seki T, Ariga T, Kobayashi T, Hayakawa T (2002a) Activins A, AB, and B inhibit hepatocyte growth factor synthesis by MRC-5 human lung fibroblasts. Biol Pharm Bull 25:1405-1408
27. Niimi S, Horikawa M, Seki T, Ariga T, Kobayashi T, Hayakawa T (2002b) Effect of activins AB and B on DNA synthesis stimulated by epidermal growth factor in primary cultured rat hepatocytes. Biol Pharm Bull 25:437-440 (Pubitemid 40036732)
28. Ozawa S, Iguchi T, Sawada K, Ohta Y, Takasugi N, Bern HA (1991) Postnatal vaginal nodules induced by prenatal diethylstilbestrol treatment correlate with later development of ovary-independent vaginal and uterine changes in mice. Cancer Lett 58:167-175
29. Pangas SA, Woodruff TK (2000) Activin signal transduction pathways. Trends Endocrinol Metab 11:309-314
30. Perttu MC, Martikainen PM, Huhtala HS, Bläuer M, Tammela TL, Tuohimaa PJ, Syvälä H (2006) Altered levels of Smad2 and Smad4 are associated with human prostate carcinogenesis. Prostate Cancer Prostatic Dis 9:185-189 (Pubitemid 43970969)
31. Risbridger GP, Schmitt JF, Robertson DM (2001) Activins and inhibins in endocrine and other tumors. Endocr Rev 22:836-858 (Pubitemid 34214298)
32. Robboy SJ, Szyfelbein WM, Goellner JR, Kaufman RH, Taft PD, Richard RM, Gaffey TA, Prat J, Virata R, Hatab PA, McGorray SP, Noller KL, Townsend D, Labarthe D, Barnes AB (1981) Dysplasia and cytologic findings in 4,589 young women enrolled in diethylstilbestrol-adenosis (DESAD) project. Am J Obstet Gynecol 140:579-586
33. Simon DP, Vadakkadath Meethal S, Wilson AC, Gallego MJ, Weinecke SL, Bruce E, Lyons PF, Haasl RJ, Bowen RL, Atwood CS (2009) Activin receptor signaling regulates prostatic epithelial cell adhesion and viability. Neoplasia 11:365-376
34. Suzuki A, Sugihara A, Uchida K, Sato T, Ohta Y, Katsu Y, Watanabe H, Iguchi T (2002) Developmental effects of perinatal exposure to bisphenol-A and diethylstilbestrol on reproductive organs in female mice. Reprod Toxicol 16:107-116 (Pubitemid 34457182)
35. Suzuki A, Watanabe H, Mizutani T, Sato T, Ohta Y, Iguchi T (2006) Global gene expression in mouse vaginae exposed to diethylstilbestrol at different ages. Exp Biol Med 231:632-640
36. Suzuki A, Urushitani H, Sato T, Kobayashi T, Watanabe H, Ohta Y, Iguchi T (2007) Gene expression change in the Müllerian duct of the mouse fetus exposed to diethylstilbestrol in utero. Exp Biol Med 232:503-514 (Pubitemid 46524472)
37. Thompson TB, Cook RW, Chapman SC, Jardetzky TS, Woodruff TK (2004) Beta A versus beta B: is it merely a matter of expression? Mol Cell Endocrinol 225:9-17
38. Truong AB, Khavari PA (2007) Control of keratinocyte proliferation and differentiation by p63. Cell Cycle 6:295-299
39. Waltermann A, Kartasheva NN, Dobbelstein M (2003) Differential regulation of p63 and p73 expression. Oncogene 22:5686-5693 (Pubitemid 37102705)
40. Yang J, Wahdan-Alaswad R, Danielpour D (2009) Critical role of Smad2 in tumor suppression and transforming growth factor-beta-induced apoptosis of prostate epithelial cells. Cancer Res 69:2185-2190