Estrogen receptor-α mediates the detrimental effects of neonatal diethylstilbestrol (DES) exposure in the murine reproductive tract

Toxicology

Volumn 205, Issue 1-2 SPEC. ISS., 2004, Pages 55-63

  Couse, John F ^a,b   Korach, Kenneth S ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

Endocrine disruption; Homeobox; Prostate; Uterus

Indexed keywords

DIETHYLSTILBESTROL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; ISOPROTEIN; WNT PROTEIN;

ATROPHY; CONFERENCE PAPER; DEVELOPMENTAL BIOLOGY; ENVIRONMENTAL EXPOSURE; GENE EXPRESSION; GENITAL SYSTEM; HISTOPATHOLOGY; KNOCKOUT MOUSE; LONG TERM EXPOSURE; METAPLASIA; NEWBORN; NEWBORN PERIOD; NONHUMAN; PRIORITY JOURNAL; PROSTATE EPITHELIUM; PROTEIN EXPRESSION; RECEPTOR INTRINSIC ACTIVITY; SEX DIFFERENCE; TERATOLOGY; TISSUE DIFFERENTIATION; TOXICITY TESTING; UTERINE CERVIX CYTOLOGY; UTERINE TUBE MUCOSA; VAGINA EPITHELIUM; WILD TYPE;

ANIMALS; ANIMALS, NEWBORN; DIETHYLSTILBESTROL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FEMALE; GENITALIA; MALE; MICE; MICE, KNOCKOUT;

ANIMALIA; MURINAE;

EID: 5444266190     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2004.06.046     Document Type: Conference Paper

References (56)

1. W.C. Beckman Jr., R.R. Newbold, C.T. Teng, and J.A. McLachlan Molecular feminization of mouse seminal vesicles by prenatal exposure to diethylstilbestrol: altered expression of messenger RNA J. Urol. 151 1994 1370 1378
2. G.V. Benson, H. Lim, B.C. Paria, I. Satokata, S.K. Dey, and R.L. Maas Mechanisms of reduced fertility in Hoxa-10 mutant mice: uterine homeosis and loss of maternal Hoxa-10 expression Development 122 1996 2687 2696
3. K. Block, A. Kardana, P. Igarashi, and H.S. Taylor In utero diethylstilbestrol (DES) exposure alters Hox gene expression in the developing mullerian system FASEB J. 14 2000 1101 1108
4. J.F. Couse, V.L. Davis, R.B. Hanson, W.N. Jefferson, J.A. McLachlan, B.C. Bullock, R.R. Newbold, and K.S. Korach Accelerated onset of uterine tumors in transgenic mice with aberrant expression of the estrogen receptor after neonatal exposure to diethylstilbestrol Mol. Carcinog. 19 1997 236 242
5. J.F. Couse, D. Dixon, M. Yates, A.B. Moore, L. Ma, R. Maas, and K.S. Korach Estrogen receptor-α knockout mice exhibit resistance to the developmental effects of neonatal diethylstilbestrol exposure on the female reproductive tract Dev. Biol. 238 2001 224 238
6. J.F. Couse, and K.S. Korach Estrogen receptor null mice: what have we learned and where will they lead us? Endocr. Rev. 20 1999 358 417
7. J.F. Couse, J. Lindzey, K. Grandien, J.A. Gustafsson, and K.S. Korach Tissue distribution and quantitative analysis of estrogen receptor-α (ERα) and estrogen receptor-β (ERβ) messenger ribonucleic acid in the wild-type and ERα-knockout mouse Endocrinology 138 1997 4613 4621
8. G.R. Cunha, P.S. Cooke, R. Bigsby, and J.R. Brody Ontogeny of sex steroid receptors in mammals M.G. Parker Nuclear Hormone Receptors: Molecular Mechanisms, Cellular Functions, Clinical Abnormalities 1991 Academic Press London 235 268
9. W.J. Dieckmann, M.E. Davis, L.M. Rynkiewicz, and R.E. Pottinger Does the administration of diethylstilbestrol during pregnancy have therapeutic value? Am. J. Obstet. Gynecol. 66 1953 1062 1081
10. N.R. Drinkwater, and J.J. Ginsler Genetic control of hepatocarcinogenesis in C57BL/6J and C3H/HeJ inbred mice Carcinogenesis 7 1986 1701 1707
11. L. Falck, and J.-G. Forsberg Immunohistochemical studies on the expression and estrogen dependency of EGF and its receptor and c-fos proto-oncogene in the uterus and vagina of normal and neonatally estrogen-treated mice Anat. Rec. 245 1996 459 471
12. M.F. Festing, L. Lin, T.R. Devereux, F. Gao, A. Yang, C.H. Anna, C.M. White, A.M. Malkinson, and M. You At least four loci and gender are associated with susceptibility to the chemical induction of lung adenomas in A/J × BALB/c mice Genomics 53 1998 129 136
13. R.L. Gendron, H. Paradis, H.M. Hsieh-Li, D.W. Lee, S.S. Potter, and E. Markoff Abnormal uterine stromal and glandular function associated with maternal reproductive defects in Hoxa-11 null mice Biol. Reprod. 56 1997 1097 1105
14. V. Giguere, A. Tremblay, and G.B. Tremblay Estrogen receptor β: re-evaluation of estrogen and antiestrogen signaling Steroids 63 1998 335 339
15. R.J. Golden, K.L. Noller, L. Titus-Ernstoff, R.H. Kaufman, R. Mittendorf, R. Stillman, and E.A. Reese Environmental endocrine modulators and human health: an assessment of the biological evidence Crit. Rev. Toxicol. 28 1998 109 227
16. T.L. Greco, T.M. Duello, and J. Gorski Estrogen receptors, estradiol, and diethylstilbestrol in early development: the mouse as a model for the study of estrogen receptors and estrogen sensitivity in embryonic development of male and female reproductive tracts Endocr. Rev. 14 1993 59 71
17. P. Greenwald, J.J. Barlow, P.C. Nasca, and W.S. Burnett Vaginal cancer after maternal treatment with synthetic estrogens N. Engl. J. Med. 285 1971 390 392
18. R.A. Hajek, T.V. Nguyen, D.A. Johnston, and L.A. Jones In vivo induction of increased DNA ploidy of mouse cervicovaginal epithelium by neonatal estrogen treatment Biol. Reprod. 49 1993 908 917
19. A.L. Herbst Behavior of estrogen-associated female genital tract cancer and its relation to neoplasia following intrauterine exposure to diethylstilbestrol (DES) Gynecol. Oncol. 76 2000 147 156
20. A.L. Herbst, H. Ulfelder, and D.C. Poskanzer Adenocarcinoma of the vagina. Association of maternal stilbestrol therapy with tumor appearance in young women N. Engl. J. Med. 284 1971 878 881
21. International Agency for the Research of Cancer, 1979. IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals To Humans: Sex Hormones (II), IARC, Lyon, France.
22. International Agency for the Research of Cancer, 1987. IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals To Humans: An Updating of IARC Monographs 1987. vols. 1-42, IARC, Lyon, France.
23. J. Kitajewski, and D. Sassoon The emergence of molecular gynecology: homeobox and Wnt genes in the female reproductive tract Bioessays 22 2000 902 910
24. K.S. Korach, K. Chae, L.A. Levy, W.L. Daux, and P.J. Sarver Diethylstilbestrol metabolites and analogs: sterochemical probes for the estrogen receptor binding site J. Biol. Chem. 264 1989 5642 5647
25. K.S. Korach, M. Metzler, and J.A. McLachlan Estrogenic activity in vivo and in vitro of some diethylstilbestrol metabolites and analogs Proc. Natl. Acad. Sci. USA 75 1978 468 471
26. K.-M. Lau, I. Leav, and S.-M. Ho Rat estrogen receptor-α and -β, and progesterone receptor mRNA expression in various prostatic lobes and microdissected normal and dysplastic epithelial tissues of the Noble rats Endocrinology 139 1998 424 427
27. S. Li, K.A. Washburn, R. Moore, T. Uno, C. Teng, R.R. Newbold, J.A. McLachlan, and M. Negishi Developmental exposure to diethylstilbestrol elicits demethylation of estrogen-responsive lactoferrin gene in mouse uterus Cancer Res. 57 1997 4356 4359
28. J.G. Liehr Is estradiol a genotoxic mutagenic carcinogen? Endocr. Rev. 21 2000 40 54
29. L. Ma, G.V. Benson, H.J. Lim, S.K. Dey, and R.L. Maas Abdominal B (AbdB) Hoxa genes: regulation in adult uterus by estrogen and progesterone and repression in mullerian duct by the synthetic estrogen diethylstilbestrol (DES) Dev. Biol. 197 1998 141 154
30. D.B. Maier, R.R. Newbold, and J.A. McLachlan Prenatal diethylstilbestrol exposure alters murine uterine responses to prepubertal estrogen stimulation Endocrinology 116 1985 1878 1886
31. M. Marselos, and L. Tomatis Diethylstilboestrol: I, pharmacology, toxicology and carcinogenicity in humans Eur. J. Cancer 1992 1182 1189
32. M. Marselos, and L. Tomatis Diethylstilboestrol: II, pharmacology, toxicology and carcinogenicity in experimental animals Eur. J. Cancer 1 1993 149 155
33. K.L. Medlock, W.S. Branham, and D.M. Sheehan Long-term effects of postnatal exposure to diethylstilbestrol on uterine estrogen receptor and growth J. Steroid Biochem. Mol. Biol. 42 1992 23 28
34. K.L. Medlock, D.M. Sheehan, C.J. Nelson, and W.S. Branham Effects of postnatal DES treatment on uterine growth, development, and estrogen receptor levels J Steroid Biochem. 29 1988 527 532
35. C. Miller, K. Degenhardt, and D.A. Sassoon Fetal exposure to DES results in de-regulation of Wnt7a during uterine morphogenesis [letter] Nat. Genet. 20 1998 228 230
36. C. Miller, A. Pavlova, and D.A. Sassoon Differential expression patterns of Wnt genes in the murine female reproductive tract during development and the estrous cycle Mech. Dev. 76 1998 91 99
37. W.R. Miller, and R.M. Sharpe Environmental oestrogens and human reproductive cancers Endocr. Rel. Cancer. 5 1998 69 96
38. R. Mittendorf Teratogen update: carcinogenesis and teratogenesis associated with exposure to diethylstibestrol (DES) in utero Teratology 51 1995 435 445
39. K.G. Nelson, Y. Sakai, B. Eitzman, T. Steed, and J. McLachlan Exposure to diethylstilbestrol during a critical developmental period of the mouse reproductive tract leads to persistent induction of two estrogen-regulated genes Cell Growth Differ. 5 1994 595 606
40. R.R. Newbold, B.C. Bullock, and J.A. McLachlan Progressive proliferative changes in the oviduct of mice following developmental exposure to diethylstilbestrol Teratog. Carcinog. Mutagen. 5 1985 473 480
41. R.R. Newbold, B.C. Bullock, and J.A. McLachlan Uterine adenocarcinoma in mice following developmental treatment with estrogens: a model for hormonal cacinogenesis Cancer Res. 50 1990 7677 7681
42. R.R. Newbold, R.B. Hanson, W.N. Jefferson, B.C. Bullock, J. Haseman, and J.A. McLachlan Increased tumors but uncompromised fertility in the female descendants of mice exposed developmentally to diethylstilbestrol Carcinogenesis 19 1998 1655 1663
43. B.A. Parr, and A.P. McMahon Sexually dimorphic development of the mammalian reproductive tract requires Wnt-7a Nature 395 1998 707 710
44. G.S. Prins Neonatal estrogen exposure induces lobe-specific alterations in adult rat prostate androgen receptor expression Endocrinology 130 1992 3703 3714
45. G.S. Prins, L. Birch, J.F. Couse, I. Choi, B. Katzenellenbogen, and K.S. Korach Estrogen imprinting of the developing prostate gland is mediated through stromal estrogen receptor alpha: studies with αERKO and βERKO mice Cancer Res. 61 2001 6089 6097
46. G.S. Prins, C. Woodham, M. Lepinske, and L. Birch Effects of neonatal estrogen exposure on prostatic secretory genes and their correlation with androgen receptor expression in the separate prostate lobes of the adult rat Endocrinology 132 1993 2387 2398
47. L.K. Salo, S.I. Makela, G.M. Stancel, and R.S. Santti Neonatal exposure to diethylstilbestrol permanently alters the basal and 17 beta-estradiol induced expression of c-fos proto-oncogene in mouse urethroprostatic complex Mol. Cell. Endocrinol. 126 1997 133 141
48. H.S. Taylor, G.B. Vanden Heuvel, and P. Igarashi A conserved Hox axis in the mouse and human female reproductive system: late establishment and persistent adult expression of the Hoxa cluster genes Biol. Reprod. 57 1997 1338 1345
49. G.B. Tremblay, T. Kunath, D. Bergeron, L. Lapointe, C. Champigny, J.A. Bader, J. Rossant, and V. Giguere Diethylstilbestrol regulates trophoblast stem cell differentiation as a ligand of orphan nuclear receptor ERR beta Genes Dev. 15 2001 833 838
50. T. Tsutsui, H. Maizumi, J.A. McLachlan, and J.C. Barrett Aneuploidy induction and cell transformation by diethylstilbestrol: a possible chromosomal mechanism in carcinogenesis Cancer Res. 43 1983 3814 3821
51. V.S. Turusov, L.S. Trukhanova, D. Parfenov Yu, and L. Tomatis Occurrence of tumours in the descendants of CBA male mice prenatally treated with diethylstilbestrol Int. J. Cancer 50 1992 131 135
52. B.E. Walker Tumors of female offspring of mice exposed prenatally to diethylstilbestrol J. Natl. Cancer Inst. 73 1984 133 140
53. Z. Weihua, S. Makela, L.C. Andersson, S. Salmi, S. Saji, J.I. Webster, E.V. Jensen, S. Nilsson, M. Warner, and J.A. Gustafsson A role for estrogen receptor beta in the regulation of growth of the ventral prostate Proc. Natl. Acad. Sci. USA 98 2001 6330 6335
54. W.R. Welch, Y.S. Fu, S.J. Robboy, and A.L. Herbst Nuclear DNA content of clear cell adenocarcinoma of the vagina and cervix and its relationship to prognosis Gynecol. Oncol. 15 1983 230 238
55. S. Yamashita, R.R. Newbold, J.A. McLachlan, and K.S. Korach Developmental pattern of estrogen receptor expression in female mouse genital tracts Endocrinology 125 1989 2888 2896
56. X. Zheng, and W.J. Hendry III Neonatal diethylstilbestrol treatment alters the estrogen-regulated expression of both cell proliferation and apoptosis-related proto-oncogenes (c-jun, c-fos, c-myc, bax, bcl-2, and bcl-x) in the hamster uterus Cell Growth Diff. 8 1997 425 434