메뉴 건너뛰기




Volumn 6, Issue 8, 2017, Pages 1596-1604

Decoupling Resource-Coupled Gene Expression in Living Cells

Author keywords

biological robustness; negative feedback; protein sequestration; regulatory architecture; resource competition

Indexed keywords

ESCHERICHIA COLI PROTEIN;

EID: 85027580695     PISSN: None     EISSN: 21615063     Source Type: Journal    
DOI: 10.1021/acssynbio.7b00119     Document Type: Article
Times cited : (51)

References (61)
  • 3
    • 82655179954 scopus 로고    scopus 로고
    • How Molecular Competition Influences Fluxes in Gene Expression Networks
    • De Vos, D., Bruggeman, F. J., Westerhoff, H. V., and Bakker, B. M. (2011) How Molecular Competition Influences Fluxes in Gene Expression Networks PLoS One 6 (12) e28494 10.1371/journal.pone.0028494
    • (2011) PLoS One , vol.6 , Issue.12 , pp. e28494
    • De Vos, D.1    Bruggeman, F.J.2    Westerhoff, H.V.3    Bakker, B.M.4
  • 4
    • 84861204284 scopus 로고    scopus 로고
    • Cost-Benefit Tradeoffs in Engineered lac Operons
    • Eames, M. and Kortemme, T. (2012) Cost-Benefit Tradeoffs in Engineered lac Operons Science 336, 911-915 10.1126/science.1219083
    • (2012) Science , vol.336 , pp. 911-915
    • Eames, M.1    Kortemme, T.2
  • 5
    • 45149128433 scopus 로고    scopus 로고
    • The cost of expression of Escherichia coli lac operon proteins is in the process, not in the products
    • Stoebel, D. M., Dean, A. M., and Dykhuizen, D. E. (2008) The cost of expression of Escherichia coli lac operon proteins is in the process, not in the products Genetics 178, 1653-1660 10.1534/genetics.107.085399
    • (2008) Genetics , vol.178 , pp. 1653-1660
    • Stoebel, D.M.1    Dean, A.M.2    Dykhuizen, D.E.3
  • 6
    • 84960804379 scopus 로고    scopus 로고
    • Towards Engineering Biological Systems in a Broader Context
    • Venturelli, O. S., Egbert, R. G., and Arkin, A. P. (2016) Towards Engineering Biological Systems in a Broader Context J. Mol. Biol. 428, 928-944 10.1016/j.jmb.2015.10.025
    • (2016) J. Mol. Biol. , vol.428 , pp. 928-944
    • Venturelli, O.S.1    Egbert, R.G.2    Arkin, A.P.3
  • 7
    • 77957860815 scopus 로고    scopus 로고
    • Evolutionary Systems Biology of Amino Acid Biosynthetic Cost in Yeast
    • Barton, M. D., Delneri, D., Oliver, S. G., Rattray, M., and Bergman, C. M. (2010) Evolutionary Systems Biology of Amino Acid Biosynthetic Cost in Yeast PLoS One 5 (8) e11935 10.1371/journal.pone.0011935
    • (2010) PLoS One , vol.5 , Issue.8 , pp. e11935
    • Barton, M.D.1    Delneri, D.2    Oliver, S.G.3    Rattray, M.4    Bergman, C.M.5
  • 8
    • 47649125318 scopus 로고    scopus 로고
    • Tuning gene expression to changing environments: From rapid responses to evolutionary adaptation
    • Lopez-Maury, L., Marguerat, S., and Bahler, J. (2008) Tuning gene expression to changing environments: from rapid responses to evolutionary adaptation Nat. Rev. Genet. 9, 583-593 10.1038/nrg2398
    • (2008) Nat. Rev. Genet. , vol.9 , pp. 583-593
    • Lopez-Maury, L.1    Marguerat, S.2    Bahler, J.3
  • 9
    • 0034666279 scopus 로고    scopus 로고
    • Competition among seven Escherichia coli sigma subunits: Relative binding affinities to the core RNA polymerase
    • Maeda, H., Fujita, N., and Ishihama, A. (2000) Competition among seven Escherichia coli sigma subunits: relative binding affinities to the core RNA polymerase Nucleic Acids Res. 28, 3497-3503 10.1093/nar/28.18.3497
    • (2000) Nucleic Acids Res. , vol.28 , pp. 3497-3503
    • Maeda, H.1    Fujita, N.2    Ishihama, A.3
  • 10
    • 59049099861 scopus 로고    scopus 로고
    • Genetic redundancy: New tricks for old genes
    • Kafri, R., Springer, M., and Pilpel, Y. (2009) Genetic redundancy: new tricks for old genes Cell 136, 389-392 10.1016/j.cell.2009.01.027
    • (2009) Cell , vol.136 , pp. 389-392
    • Kafri, R.1    Springer, M.2    Pilpel, Y.3
  • 11
    • 0345107239 scopus 로고    scopus 로고
    • Selection in the evolution of gene duplications
    • Kondrashov, F. A., Rogozin, I. B., Wolf, Y. I., and Koonin, E. V. (2002) Selection in the evolution of gene duplications Genome Biol. 3 (2) RESEARCH0008 10.1186/gb-2002-3-2-research0008
    • (2002) Genome Biol. , vol.3 , Issue.2
    • Kondrashov, F.A.1    Rogozin, I.B.2    Wolf, Y.I.3    Koonin, E.V.4
  • 12
    • 84863322344 scopus 로고    scopus 로고
    • Contextualizing context for synthetic biology - Identifying causes of failure of synthetic biological systems
    • Cardinale, S. and Arkin, A. P. (2012) Contextualizing context for synthetic biology-identifying causes of failure of synthetic biological systems Biotechnol. J. 7, 856-866 10.1002/biot.201200085
    • (2012) Biotechnol. J. , vol.7 , pp. 856-866
    • Cardinale, S.1    Arkin, A.P.2
  • 13
    • 72249097352 scopus 로고    scopus 로고
    • Growth Rate-Dependent Global Effects on Gene Expression in Bacteria
    • Klumpp, S., Zhang, Z. G., and Hwa, T. (2009) Growth Rate-Dependent Global Effects on Gene Expression in Bacteria Cell 139, 1366-1375 10.1016/j.cell.2009.12.001
    • (2009) Cell , vol.139 , pp. 1366-1375
    • Klumpp, S.1    Zhang, Z.G.2    Hwa, T.3
  • 14
    • 0028907619 scopus 로고
    • Gratuitous Overexpression of Genes in Escherichia-Coli Leads to Growth-Inhibition and Ribosome Destruction
    • Dong, H. J., Nilsson, L., and Kurland, C. G. (1995) Gratuitous Overexpression of Genes in Escherichia-Coli Leads to Growth-Inhibition and Ribosome Destruction J. Bacteriol. 177, 1497-1504 10.1128/jb.177.6.1497-1504.1995
    • (1995) J. Bacteriol. , vol.177 , pp. 1497-1504
    • Dong, H.J.1    Nilsson, L.2    Kurland, C.G.3
  • 15
    • 84928927536 scopus 로고    scopus 로고
    • Quantifying cellular capacity identifies gene expression designs with reduced burden
    • Ceroni, F., Algar, R., Stan, G. B., and Ellis, T. (2015) Quantifying cellular capacity identifies gene expression designs with reduced burden Nat. Methods 12, 415-418 10.1038/nmeth.3339
    • (2015) Nat. Methods , vol.12 , pp. 415-418
    • Ceroni, F.1    Algar, R.2    Stan, G.B.3    Ellis, T.4
  • 16
    • 85010187554 scopus 로고    scopus 로고
    • A Two-Layer Gene Circuit for Decoupling Cell Growth from Metabolite Production
    • Lo, T.-M., Chng, Si H., Teo, Wei, S., Cho, H.-S., and Chang, M. W. (2016) A Two-Layer Gene Circuit for Decoupling Cell Growth from Metabolite Production Cell systems 3, 133-143 10.1016/j.cels.2016.07.012
    • (2016) Cell Systems , vol.3 , pp. 133-143
    • Lo, T.-M.1    Chng, S.H.2    Teo3    Wei, S.4    Cho, H.-S.5    Chang, M.W.6
  • 17
    • 70350324632 scopus 로고    scopus 로고
    • Emergent bistability by a growth-modulating positive feedback circuit
    • Tan, C., Marguet, P., and You, L. (2009) Emergent bistability by a growth-modulating positive feedback circuit Nat. Chem. Biol. 5, 842-848 10.1038/nchembio.218
    • (2009) Nat. Chem. Biol. , vol.5 , pp. 842-848
    • Tan, C.1    Marguet, P.2    You, L.3
  • 18
    • 84898931419 scopus 로고    scopus 로고
    • Rapid and tunable post-translational coupling of genetic circuits
    • Prindle, A., Selimkhanov, J., Li, H., Razinkov, I., Tsimring, L. S., and Hasty, J. (2014) Rapid and tunable post-translational coupling of genetic circuits Nature 508, 387-391 10.1038/nature13238
    • (2014) Nature , vol.508 , pp. 387-391
    • Prindle, A.1    Selimkhanov, J.2    Li, H.3    Razinkov, I.4    Tsimring, L.S.5    Hasty, J.6
  • 19
    • 78449268845 scopus 로고    scopus 로고
    • Interdependence of cell growth and gene expression: Origins and consequences
    • Scott, M., Gunderson, C. W., Mateescu, E. M., Zhang, Z., and Hwa, T. (2010) Interdependence of cell growth and gene expression: origins and consequences Science 330, 1099-1102 10.1126/science.1192588
    • (2010) Science , vol.330 , pp. 1099-1102
    • Scott, M.1    Gunderson, C.W.2    Mateescu, E.M.3    Zhang, Z.4    Hwa, T.5
  • 20
    • 84952982656 scopus 로고    scopus 로고
    • The Cost of Protein Production
    • Kafri, M., Metzl-Raz, E., Jona, G., and Barkai, N. (2016) The Cost of Protein Production Cell Rep. 14, 22-31 10.1016/j.celrep.2015.12.015
    • (2016) Cell Rep. , vol.14 , pp. 22-31
    • Kafri, M.1    Metzl-Raz, E.2    Jona, G.3    Barkai, N.4
  • 21
    • 0027250549 scopus 로고
    • Synthesis of Proteins in Escherichia-Coli Is Limited by the Concentration of Free Ribosomes - Expression from Reporter Genes Does Not Always Reflect Functional Messenger-RNA Levels
    • Vind, J., Sorensen, M. A., Rasmussen, M. D., and Pedersen, S. (1993) Synthesis of Proteins in Escherichia-Coli Is Limited by the Concentration of Free Ribosomes-Expression from Reporter Genes Does Not Always Reflect Functional Messenger-Rna Levels J. Mol. Biol. 231, 678-688 10.1006/jmbi.1993.1319
    • (1993) J. Mol. Biol. , vol.231 , pp. 678-688
    • Vind, J.1    Sorensen, M.A.2    Rasmussen, M.D.3    Pedersen, S.4
  • 22
    • 66649105445 scopus 로고    scopus 로고
    • Synthesis of orthogonal transcription-translation networks
    • An, W. L. and Chin, J. W. (2009) Synthesis of orthogonal transcription-translation networks Proc. Natl. Acad. Sci. U. S. A. 106, 8477-8482 10.1073/pnas.0900267106
    • (2009) Proc. Natl. Acad. Sci. U. S. A. , vol.106 , pp. 8477-8482
    • An, W.L.1    Chin, J.W.2
  • 23
    • 84905376865 scopus 로고    scopus 로고
    • A 'resource allocator' for transcription based on a highly fragmented T7 RNA polymerase
    • Segall-Shapiro, T. H., Meyer, A. J., Ellington, A. D., Sontag, E. D., and Voigt, C. A. (2014) A 'resource allocator' for transcription based on a highly fragmented T7 RNA polymerase Mol. Syst. Biol. 10, 742 10.15252/msb.20145299
    • (2014) Mol. Syst. Biol. , vol.10 , pp. 742
    • Segall-Shapiro, T.H.1    Meyer, A.J.2    Ellington, A.D.3    Sontag, E.D.4    Voigt, C.A.5
  • 25
    • 84921609773 scopus 로고    scopus 로고
    • Modularity, context-dependence, and insulation in engineered biological circuits
    • Del Vecchio, D. (2015) Modularity, context-dependence, and insulation in engineered biological circuits Trends Biotechnol. 33, 111-119 10.1016/j.tibtech.2014.11.009
    • (2015) Trends Biotechnol. , vol.33 , pp. 111-119
    • Del Vecchio, D.1
  • 26
    • 84883495741 scopus 로고    scopus 로고
    • Biomolecular Resource Utilization in Elementary Cell-Free Gene Circuits
    • Siegal-Gaskins, D., Noireaux, V., and Murray, R. M. (2013) Biomolecular Resource Utilization in Elementary Cell-Free Gene Circuits ACC 1531-1536 10.1109/ACC.2013.6580053
    • (2013) ACC , pp. 1531-1536
    • Siegal-Gaskins, D.1    Noireaux, V.2    Murray, R.M.3
  • 27
    • 84855481443 scopus 로고    scopus 로고
    • Competition for Catalytic Resources Alters Biological Network Dynamics
    • Rondelez, Y. (2012) Competition for Catalytic Resources Alters Biological Network Dynamics Phys. Rev. Lett. 108 (1) 018102 10.1103/PhysRevLett.108.018102
    • (2012) Phys. Rev. Lett. , vol.108 , Issue.1 , pp. 018102
    • Rondelez, Y.1
  • 29
    • 84959319814 scopus 로고    scopus 로고
    • Dealing with the genetic load in bacterial synthetic biology circuits: Convergences with the Ohm's law
    • Carbonell-Ballestero, M., Garcia-Ramallo, E., Montanez, R., Rodriguez-Caso, C., and Macia, J. (2016) Dealing with the genetic load in bacterial synthetic biology circuits: convergences with the Ohm's law Nucleic Acids Res. 44, 496-507 10.1093/nar/gkv1280
    • (2016) Nucleic Acids Res. , vol.44 , pp. 496-507
    • Carbonell-Ballestero, M.1    Garcia-Ramallo, E.2    Montanez, R.3    Rodriguez-Caso, C.4    Macia, J.5
  • 30
    • 71849110893 scopus 로고    scopus 로고
    • Next-generation synthetic gene networks
    • Lu, T. K., Khalil, A. S., and Collins, J. J. (2009) Next-generation synthetic gene networks Nat. Biotechnol. 27, 1139-1150 10.1038/nbt.1591
    • (2009) Nat. Biotechnol. , vol.27 , pp. 1139-1150
    • Lu, T.K.1    Khalil, A.S.2    Collins, J.J.3
  • 31
    • 84868619337 scopus 로고    scopus 로고
    • Genetic programs constructed from layered logic gates in single cells
    • Moon, T. S., Lou, C. B., Tamsir, A., Stanton, B. C., and Voigt, C. A. (2012) Genetic programs constructed from layered logic gates in single cells Nature 491, 249-253 10.1038/nature11516
    • (2012) Nature , vol.491 , pp. 249-253
    • Moon, T.S.1    Lou, C.B.2    Tamsir, A.3    Stanton, B.C.4    Voigt, C.A.5
  • 32
    • 66249088017 scopus 로고    scopus 로고
    • The second wave of synthetic biology: From modules to systems
    • Purnick, P. E. M. and Weiss, R. (2009) The second wave of synthetic biology: from modules to systems Nat. Rev. Mol. Cell Biol. 10, 410-422 10.1038/nrm2698
    • (2009) Nat. Rev. Mol. Cell Biol. , vol.10 , pp. 410-422
    • Purnick, P.E.M.1    Weiss, R.2
  • 33
    • 84963832616 scopus 로고    scopus 로고
    • Robust, tunable genetic memory from protein sequestration combined with positive feedback
    • Shopera, T., Henson, W. R., Ng, A., Lee, Y. J., Ng, K., and Moon, T. S. (2015) Robust, tunable genetic memory from protein sequestration combined with positive feedback Nucleic Acids Res. 43, 9086-9094 10.1093/nar/gkv936
    • (2015) Nucleic Acids Res. , vol.43 , pp. 9086-9094
    • Shopera, T.1    Henson, W.R.2    Ng, A.3    Lee, Y.J.4    Ng, K.5    Moon, T.S.6
  • 34
    • 84979993746 scopus 로고    scopus 로고
    • Overloaded and stressed: Whole-cell considerations for bacterial synthetic biology
    • Borkowski, O., Ceroni, F., Stan, G.-B., and Ellis, T. (2016) Overloaded and stressed: whole-cell considerations for bacterial synthetic biology Curr. Opin. Microbiol. 33, 123-130 10.1016/j.mib.2016.07.009
    • (2016) Curr. Opin. Microbiol. , vol.33 , pp. 123-130
    • Borkowski, O.1    Ceroni, F.2    Stan, G.-B.3    Ellis, T.4
  • 35
    • 34249079154 scopus 로고    scopus 로고
    • Network motifs: Theory and experimental approaches
    • Alon, U. (2007) Network motifs: theory and experimental approaches Nat. Rev. Genet. 8, 450-461 10.1038/nrg2102
    • (2007) Nat. Rev. Genet. , vol.8 , pp. 450-461
    • Alon, U.1
  • 36
    • 0032077377 scopus 로고    scopus 로고
    • From specific gene regulation to genomic networks: A global analysis of transcriptional regulation in Escherichia coli
    • Thieffry, D., Huerta, A. M., Perez-Rueda, E., and Collado-Vides, J. (1998) From specific gene regulation to genomic networks: a global analysis of transcriptional regulation in Escherichia coli BioEssays 20, 433-440 10.1002/(SICI)1521-1878(199805)20:5<433::AID-BIES10>3.0.CO;2-2
    • (1998) BioEssays , vol.20 , pp. 433-440
    • Thieffry, D.1    Huerta, A.M.2    Perez-Rueda, E.3    Collado-Vides, J.4
  • 37
    • 0025948303 scopus 로고
    • Cloning and sequence analysis of a trans-regulatory locus required for exoenzyme S synthesis in Pseudomonas aeruginosa
    • Frank, D. W. and Iglewski, B. H. (1991) Cloning and sequence analysis of a trans-regulatory locus required for exoenzyme S synthesis in Pseudomonas aeruginosa J. Bacteriol. 173, 6460-6468 10.1128/jb.173.20.6460-6468.1991
    • (1991) J. Bacteriol. , vol.173 , pp. 6460-6468
    • Frank, D.W.1    Iglewski, B.H.2
  • 38
    • 0035901560 scopus 로고    scopus 로고
    • Type III secretion chaperone-dependent regulation: Activation of virulence genes by SicA and InvF in Salmonella typhimurium
    • Darwin, K. H. and Miller, V. L. (2001) Type III secretion chaperone-dependent regulation: activation of virulence genes by SicA and InvF in Salmonella typhimurium EMBO J. 20, 1850-1862 10.1093/emboj/20.8.1850
    • (2001) EMBO J. , vol.20 , pp. 1850-1862
    • Darwin, K.H.1    Miller, V.L.2
  • 39
    • 39649083113 scopus 로고    scopus 로고
    • Induction and relaxation dynamics of the regulatory network controlling the type III secretion system encoded within Salmonella pathogenicity island 1
    • Temme, K., Salis, H., Tullman-Ercek, D., Levskaya, A., Hong, S. H., and Voigt, C. A. (2008) Induction and relaxation dynamics of the regulatory network controlling the type III secretion system encoded within Salmonella pathogenicity island 1 J. Mol. Biol. 377, 47-61 10.1016/j.jmb.2007.12.044
    • (2008) J. Mol. Biol. , vol.377 , pp. 47-61
    • Temme, K.1    Salis, H.2    Tullman-Ercek, D.3    Levskaya, A.4    Hong, S.H.5    Voigt, C.A.6
  • 40
    • 67649861394 scopus 로고    scopus 로고
    • IpaB-IpgC interaction defines binding motif for type III secretion translocator
    • Lunelli, M., Lokareddy, R. K., Zychlinsky, A., and Kolbe, M. (2009) IpaB-IpgC interaction defines binding motif for type III secretion translocator Proc. Natl. Acad. Sci. U. S. A. 106, 9661-9666 10.1073/pnas.0812900106
    • (2009) Proc. Natl. Acad. Sci. U. S. A. , vol.106 , pp. 9661-9666
    • Lunelli, M.1    Lokareddy, R.K.2    Zychlinsky, A.3    Kolbe, M.4
  • 42
    • 84899550455 scopus 로고    scopus 로고
    • Quantifying Absolute Protein Synthesis Rates Reveals Principles Underlying Allocation of Cellular Resources
    • Li, G.-W., Burkhardt, D., Gross, C., and Weissman, J. S. (2014) Quantifying Absolute Protein Synthesis Rates Reveals Principles Underlying Allocation of Cellular Resources Cell 157, 624-635 10.1016/j.cell.2014.02.033
    • (2014) Cell , vol.157 , pp. 624-635
    • Li, G.-W.1    Burkhardt, D.2    Gross, C.3    Weissman, J.S.4
  • 43
    • 84940940971 scopus 로고    scopus 로고
    • Mitigation of resource competition in synthetic genetic circuits through feedback regulation
    • Los Angeles, CA
    • Hamadeh, A. and Del Vecchio, D. (2014) Mitigation of resource competition in synthetic genetic circuits through feedback regulation, in Proceedings of the 53rd Conference on Decision and Control, pp 3829-3834, Los Angeles, CA.
    • (2014) Proceedings of the 53rd Conference on Decision and Control , pp. 3829-3834
    • Hamadeh, A.1    Del Vecchio, D.2
  • 44
    • 79960165588 scopus 로고    scopus 로고
    • Negative auto-regulation increases the input dynamic-range of the arabinose system of Escherichia coli
    • Madar, D., Dekel, E., Bren, A., and Alon, U. (2011) Negative auto-regulation increases the input dynamic-range of the arabinose system of Escherichia coli BMC Syst. Biol. 5, 111 10.1186/1752-0509-5-111
    • (2011) BMC Syst. Biol. , vol.5 , pp. 111
    • Madar, D.1    Dekel, E.2    Bren, A.3    Alon, U.4
  • 45
    • 0036428761 scopus 로고    scopus 로고
    • Negative autoregulation speeds the response times of transcription networks
    • Rosenfeld, N., Elowitz, M. B., and Alon, U. (2002) Negative autoregulation speeds the response times of transcription networks J. Mol. Biol. 323, 785-793 10.1016/S0022-2836(02)00994-4
    • (2002) J. Mol. Biol. , vol.323 , pp. 785-793
    • Rosenfeld, N.1    Elowitz, M.B.2    Alon, U.3
  • 46
    • 62549083590 scopus 로고    scopus 로고
    • Negative autoregulation linearizes the dose-response and suppresses the heterogeneity of gene expression
    • Nevozhay, D., Adams, R. M., Murphy, K. F., Josic, K., and Balazsi, G. (2009) Negative autoregulation linearizes the dose-response and suppresses the heterogeneity of gene expression Proc. Natl. Acad. Sci. U. S. A. 106, 5123-5128 10.1073/pnas.0809901106
    • (2009) Proc. Natl. Acad. Sci. U. S. A. , vol.106 , pp. 5123-5128
    • Nevozhay, D.1    Adams, R.M.2    Murphy, K.F.3    Josic, K.4    Balazsi, G.5
  • 48
    • 0034212551 scopus 로고    scopus 로고
    • Engineering stability in gene networks by autoregulation
    • Becskei, A. and Serrano, L. (2000) Engineering stability in gene networks by autoregulation Nature 405, 590-593 10.1038/35014651
    • (2000) Nature , vol.405 , pp. 590-593
    • Becskei, A.1    Serrano, L.2
  • 49
    • 46849090495 scopus 로고    scopus 로고
    • Robust, tunable biological oscillations from interlinked positive and negative feedback loops
    • Tsai, T. Y. C., Choi, Y. S., Ma, W. Z., Pomerening, J. R., Tang, C., and Ferrell, J. E. (2008) Robust, tunable biological oscillations from interlinked positive and negative feedback loops Science 321, 126-129 10.1126/science.1156951
    • (2008) Science , vol.321 , pp. 126-129
    • Tsai, T.Y.C.1    Choi, Y.S.2    Ma, W.Z.3    Pomerening, J.R.4    Tang, C.5    Ferrell, J.E.6
  • 50
    • 0034688173 scopus 로고    scopus 로고
    • A synthetic oscillatory network of transcriptional regulators
    • Elowitz, M. B. and Leibler, S. (2000) A synthetic oscillatory network of transcriptional regulators Nature 403, 335-338 10.1038/35002125
    • (2000) Nature , vol.403 , pp. 335-338
    • Elowitz, M.B.1    Leibler, S.2
  • 51
    • 0036434715 scopus 로고    scopus 로고
    • ExsD is a negative regulator of the Pseudomonas aeruginosa type III secretion regulon
    • McCaw, M. L., Lykken, G. L., Singh, P. K., and Yahr, T. L. (2002) ExsD is a negative regulator of the Pseudomonas aeruginosa type III secretion regulon Mol. Microbiol. 46, 1123-1133 10.1046/j.1365-2958.2002.03228.x
    • (2002) Mol. Microbiol. , vol.46 , pp. 1123-1133
    • McCaw, M.L.1    Lykken, G.L.2    Singh, P.K.3    Yahr, T.L.4
  • 52
    • 33749362995 scopus 로고    scopus 로고
    • Characterization of ExsC and ExsD self-association and heterocomplex formation
    • Lykken, G. L., Chen, G., Brutinel, E. D., Chen, L., and Yahr, T. L. (2006) Characterization of ExsC and ExsD self-association and heterocomplex formation Journal of bacteriology 188, 6832-6840 10.1128/JB.00884-06
    • (2006) Journal of Bacteriology , vol.188 , pp. 6832-6840
    • Lykken, G.L.1    Chen, G.2    Brutinel, E.D.3    Chen, L.4    Yahr, T.L.5
  • 53
    • 34548825690 scopus 로고    scopus 로고
    • Towards a theory of biological robustness
    • Kitano, H. (2007) Towards a theory of biological robustness Mol. Syst. Biol. 3, 137 10.1038/msb4100179
    • (2007) Mol. Syst. Biol. , vol.3 , pp. 137
    • Kitano, H.1
  • 54
    • 0842285841 scopus 로고    scopus 로고
    • Summing up the noise in gene networks
    • Paulsson, J. (2004) Summing up the noise in gene networks Nature 427, 415-418 10.1038/nature02257
    • (2004) Nature , vol.427 , pp. 415-418
    • Paulsson, J.1
  • 55
    • 77957366856 scopus 로고    scopus 로고
    • A general mechanism for network-dosage compensation in gene circuits
    • Acar, M., Pando, B. F., Arnold, F. H., Elowitz, M. B., and van Oudenaarden, A. (2010) A general mechanism for network-dosage compensation in gene circuits Science 329, 1656-1660 10.1126/science.1190544
    • (2010) Science , vol.329 , pp. 1656-1660
    • Acar, M.1    Pando, B.F.2    Arnold, F.H.3    Elowitz, M.B.4    Van Oudenaarden, A.5
  • 56
    • 77749246295 scopus 로고    scopus 로고
    • Abduction and asylum in the lives of transcription factors
    • Burger, A., Walczak, A. M., and Wolynes, P. G. (2010) Abduction and asylum in the lives of transcription factors Proc. Natl. Acad. Sci. U. S. A. 107, 4016-4021 10.1073/pnas.0915138107
    • (2010) Proc. Natl. Acad. Sci. U. S. A. , vol.107 , pp. 4016-4021
    • Burger, A.1    Walczak, A.M.2    Wolynes, P.G.3
  • 57
    • 67149138163 scopus 로고    scopus 로고
    • Protein sequestration generates a flexible ultrasensitive response in a genetic network
    • Buchler, N. E. and Cross, F. R. (2009) Protein sequestration generates a flexible ultrasensitive response in a genetic network Mol. Syst. Biol. 5, 272 10.1038/msb.2009.30
    • (2009) Mol. Syst. Biol. , vol.5 , pp. 272
    • Buchler, N.E.1    Cross, F.R.2
  • 59
    • 84941299991 scopus 로고    scopus 로고
    • De novo design of heat-repressible RNA thermosensors in E-coli
    • Hoynes-O'Connor, A., Hinman, K., Kirchner, L., and Moon, T. S. (2015) De novo design of heat-repressible RNA thermosensors in E-coli Nucleic Acids Res. 43, 6166-6179 10.1093/nar/gkv499
    • (2015) Nucleic Acids Res. , vol.43 , pp. 6166-6179
    • Hoynes-O'Connor, A.1    Hinman, K.2    Kirchner, L.3    Moon, T.S.4
  • 60
    • 56649114274 scopus 로고    scopus 로고
    • A one pot, one step, precision cloning method with high throughput capability
    • Engler, C., Kandzia, R., and Marillonnet, S. (2008) A one pot, one step, precision cloning method with high throughput capability PLoS One 3, e3647 10.1371/journal.pone.0003647
    • (2008) PLoS One , vol.3 , pp. e3647
    • Engler, C.1    Kandzia, R.2    Marillonnet, S.3
  • 61
    • 0030861452 scopus 로고    scopus 로고
    • Independent and tight regulation of transcriptional units in Escherichia coli via the LacR/O, the TetR/O and AraC/I1-I2 regulatory elements
    • Lutz, R. and Bujard, H. (1997) Independent and tight regulation of transcriptional units in Escherichia coli via the LacR/O, the TetR/O and AraC/I1-I2 regulatory elements Nucleic acids research 25, 1203-1210 10.1093/nar/25.6.1203
    • (1997) Nucleic Acids Research , vol.25 , pp. 1203-1210
    • Lutz, R.1    Bujard, H.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.