Type III secretion chaperone-dependent regulation: Activation of virulence genes by SicA and InvF in Salmonella typhimurium

EMBO Journal

Volumn 20, Issue 8, 2001, Pages 1850-1862

  Darwin, K Heran ^a   Miller, Virginia L ^b  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

AraC; Binding site; Chaperone; Regulation

Indexed keywords

BACTERIAL PROTEIN; CHAPERONE; VIRULENCE FACTOR;

ARTICLE; BACTERIAL VIRULENCE; CELL FUNCTION; CONTROLLED STUDY; DNA BINDING; EUKARYOTIC CELL; GENE ACTIVATION; GENE EXPRESSION; GENETIC TRANSCRIPTION; INTESTINE EPITHELIUM; NONHUMAN; OPERON; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN INTERACTION; PROTEIN STABILITY; SALMONELLA TYPHIMURIUM; TRANSCRIPTION REGULATION;

BACTERIAL PROTEINS; BASE SEQUENCE; CONSENSUS SEQUENCE; DNA-BINDING PROTEINS; FLAGELLIN; GENE EXPRESSION REGULATION, BACTERIAL; GENETIC COMPLEMENTATION TEST; MODELS, GENETIC; MOLECULAR CHAPERONES; POINT MUTATION; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; REGULON; RNA, BACTERIAL; SALMONELLA TYPHIMURIUM; SEQUENCE DELETION; TRANSCRIPTION FACTORS;

ANIMALIA; BACTERIA (MICROORGANISMS); EUKARYOTA; NEGIBACTERIA; SALMONELLA SP.; SALMONELLA TYPHIMURIUM; TYPHIMURIUM;

EID: 0035901560     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/20.8.1850     Document Type: Article

References (73)

1. A mRNA signal for the type III secretion of Yop proteins by Yersinia enterocolitica
2. Yersinia enterocolitica type III secretion: A mRNA signal that couples translation and secretion of YopQ
3. hilA is a novel ompR/toxR family member that activates the expression of Salmonella typhimurium invasion genes
4. Co-ordinate regulation of Salmonella typhimurium invasion genes by environmental and regulatory factors is mediated by control of hilA expression
5. Identification of SopE2, a Salmonella secreted protein which is highly homologous to SopE and involved in bacterial invasion of epithelial cells
6. Identification of a new iron regulated locus of Salmonella typhi
7. A PhoP-repressed gene promotes Salmonella typhimurium invasion of epithelial cells
8. Analysis of the V antigen lcrGVH-yopBD operon of Yersinia pseudotuberculosis: Evidence for a regulatory role of LcrH and LcrV
9. Promoter structure, promoter recognition and transcription activation in prokaryotes
10. The two-hybrid system: A method to identify and clone genes for proteins that interact with a protein of interest
11. Single-column purification of free recombinant proteins using a self-cleavable affinity tag derived from a protein splicing element
12. Requirement for exported proteins in secretion through the invasion-associated type III system of Salmonella typhimurium
13. The invasion-associated type III system of Salmonella typhimurium directs the translocation of the sip proteins into the host cell
14. InvF is required for expression of genes encoding proteins secreted by the SPI1 type III secretion apparatus in Salmonella typhimurium
15. Molecular basis of the interaction of Salmonella with the intestinal mucosa
16. The putative invasion protein chaperone SicA acts together with InvF to activate the expression of Salmonella typhimurium virulence genes
17. The psp locus of Yersinia enterocolitica is required for virulence and for growth in vitro when the Ysc type III secretion system is produced
18. SigE is a chaperone for the Salmonella typhimurium invasion effector SigD
19. Differential regulation of Salmonella typhimurium type III secreted proteins by pathogenicity island 1 (SPI-1)-encoded transcriptional activators InvF and HilA
20. Identification of a specific chaperone for SptP, a substrate of the centisome 63 type III secretion system of Salmonella typhimurium
21. The Salmonella typhimurium tyrosine phosphatase SptP is translocated into host cells and disrupts the actin cytoskeleton
22. A Salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion
23. Cloning and molecular characterization of genes whose products allow Salmonella typhimurium to penetrate tissue culture cells
24. Molecular and functional characterization of the Salmonella invasion gene invA: Homology of InvA to members of a new protein family
25. AraC/Xy1S family of transcriptional regulators
26. A secreted effector protein of Salmonella dublin is translocated into eucaryotic cells and mediates inflammation and fluid secretion in infected ileal mucosa
27. Cognate gene clusters govern invasion of host epithelial cells by Salmonella typhimurium and Shigella flexneri
28. A secreted Salmonella protein with homology to an avirulence determinant of plant pathogenic bacteria
29. S. typhimurium encodes an activator of rho GTPases that induces membrane ruffling and nuclear responses in host cells
30. A substrate of the centisome 63 type III protein secretion system of Salmonella typhimurium is encoded by a cryptic prophage
31. Transposon vectors containing non-antibiotic resistance selection markers for cloning and stable chromosomal insertion of foreign genes in Gram-negative bacteria
32. The Salmonella invasin SipB induces macrophage apoptosis by binding to caspase-1
33. Aromatic-dependent Salmonella typhimurium are non-virulent and effective as live vaccines
34. Identification of a novel Salmonella invasion locus homologous to Shigella ipgDE
35. Sequence requirements for coiled-coils: Analysis with λ repressor-GCN4 leucine zipper fusions
36. Type III protein secretion in bacterial pathogens of animals and plants
37. Identification and characterization of a Salmonella typhimurium oxygen-regulated gene required for bacterial internalization
38. Secreted effector proteins of Salmonella dublin act in concert to induce enteritis
39. The Salmonella typhimurium invasion genes invF and invG encode homologues of the AraC and PulD family of proteins
40. Identification of two targets of the type III protein secretion system encoded by the inv and spa loci of Salmonella typhimurium that have homology to the Shigella IpaD and IpaA proteins
41. Homologs of the Shigella IpaB and IpaC invasins are required for Salmonella typhimurium entry into cultured epithelial cells
42. A bacterial two-hybrid system based on a reconstituted signal transduction pathway
43. A secreted Salmonella protein induces a proinflammatory response in epithelial cells, which promotes neutrophil migration
44. Broad host range plasmids carrying the Escherichia coli lactose and galactose operons
45. The cis requirements for transcription activation by HilA, a virulence determinant encoded on SPI-1
46. Unravelling the mysteries of virulence gene regulation in Salmonella typhimurium
47. Molecular chaperone proteins
48. Transepithelial signaling to neutrophils by Salmonellae: A novel virulence mechanism for gastroenteritis
49. recA protein-catalyzed strand assimilation: Stimulation by Escherichia coli single-stranded DNA-binding protein
50. Extracellular association and cytoplasmic partitioning of the IpaB and IpaC invasins of S. flexneri
51. A conserved amino acid sequence directing intracellular type III secretion by Salmonella typhimurium
52. Salmonella typhimurium leucine-rich repeat proteins are targeted to the SPI1 and SPI2 type III secretion systems
53. A 40 kb chromosomal fragment encoding Salmonella typhimurium invasion genes is absent from the corresponding region of the Escherichia coli K-12 chromosome
54. Rns, a virulence regulator within the AraC family, requires binding sites upstream and downstream of its own promoter to function as an activator
55. Non-invasive Salmonella typhimurium mutants are avirulent because of an inability to enter and destroy M cells of ileal Peyer's patches
56. A HilA-independent pathway to Salmonella typhimurium invasion gene transcription
57. A novel DNA-binding motif in MarA: The first structure for an AraC family transcriptional activator
58. Salmonella typhimurium strains used in genetic analysis
59. Two AraC/Xy1S family members can independently counteract the effect of repressing sequences upstream of the hi1A promoter
60. The Salmonella type III secretion translocon protein SspC is inserted into epithelial cell plasma membrane upon infection
61. Structural basis for ligand-regulated oligomerization of AraC
62. pHG165: A pBR322 copy number derivative of pUC8 for cloning and expression
63. Identification of novel loci affecting entry of Salmonella enteritidis into eukaryotic cells
64. Use of T7 RNA polymerase to direct expression of cloned genes
65. Complex function for SicA, a Salmonella enterica serovar typhimurium type III secretion-associated chaperone
66. Construction of versatile low-copy-number vectors for cloning, sequencing and gene expression in Escherichia coli
67. Customized secretion chaperones in pathogenic bacteria
68. SopE, a secreted protein of Salmonella dublin, is translocated into the target eukaryotic cell via a sip-dependent mechanism and promotes bacterial entry