Zika-Virus-Encoded NS2A Disrupts Mammalian Cortical Neurogenesis by Degrading Adherens Junction Proteins

Cell Stem Cell

Volumn 21, Issue 3, 2017, Pages 349-358.e6

  Yoon, Ki Jun ^a   Song, Guang ^a   Qian, Xuyu ^a   Pan, Jianbo ^a   Xu, Dan ^b,c   Rho, Hee Sool ^a   Kim, Nam Shik ^a   Habela, Christa ^a   Zheng, Lily ^a   Jacob, Fadi ^a   Zhang, Feiran ^d   Lee, Emily M ^e   Huang, Wei Kai ^a   Ringeling, Francisca Rojas ^a   Vissers, Caroline ^a   Li, Cui ^b   Yuan, Ling ^b   Kang, Koeun ^a   Kim, Sunghan ^a   Yeo, Junghoon ^a   Cheng, Yichen ^e   Liu, Sheng ^a   Wen, Zhexing ^d   Qin, Cheng Feng ^f   Wu, Qingfeng ^b   Christian, Kimberly M ^g   Tang, Hengli ^e   Jin, Peng ^d   Xu, Zhiheng ^b   Qian, Jiang ^a   Zhu, Heng ^a   Song, Hongjun ^a,g   Ming, Guo li ^a,g   more..

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b INSTITUTE OF GENETICS AND DEVELOPMENTAL BIOLOGY   (China)

^c FUZHOU UNIVERSITY   (China)

^d EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e FLORIDA STATE UNIVERSITY   (United States)

^f BEIJING INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY   (China)

^g UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

adherens junction; cortical neurogenesis; flavivirus; human organoid; human protein microarray; microcephaly; neural stem cell; neuronal migration; radial glial cell; Zika virus

Indexed keywords

NS2A PROTEIN; UNCLASSIFIED DRUG; VIRAL PROTEIN; MEMBRANE PROTEIN; PROTEIN BINDING;

ADHERENS JUNCTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; EMBRYO; FEMALE; HEK293 CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; INDUCED PLURIPOTENT STEM CELL; MACROGLIA; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NEURAL STEM CELL; NONHUMAN; PLURIPOTENT STEM CELL LINE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; ZIKA FEVER; ZIKA VIRUS; ANIMAL; EMBRYOLOGY; GLIA; MAMMAL; METABOLISM; PATHOLOGY; PROTEIN ANALYSIS;

ADHERENS JUNCTIONS; ANIMALS; CELL DIFFERENTIATION; CELL PROLIFERATION; CEREBRAL CORTEX; HEK293 CELLS; HUMANS; MAMMALS; MEMBRANE PROTEINS; MICE; NEUROGENESIS; NEUROGLIA; PROTEIN BINDING; PROTEIN INTERACTION MAPPING; PROTEOLYSIS; VIRAL NONSTRUCTURAL PROTEINS; ZIKA VIRUS; ZIKA VIRUS INFECTION;

EID: 85027494399     PISSN: 19345909     EISSN: 18759777     Source Type: Journal    
DOI: 10.1016/j.stem.2017.07.014     Document Type: Article

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