Zika Virus NS4A and NS4B Proteins Deregulate Akt-mTOR Signaling in Human Fetal Neural Stem Cells to Inhibit Neurogenesis and Induce Autophagy

Cell Stem Cell

Volumn 19, Issue 5, 2016, Pages 663-671

  Liang, Qiming ^a,b   Luo, Zhifei ^a   Zeng, Jianxiong ^a   Chen, Weiqiang ^a   Foo, Suan Sin ^a   Lee, Shin Ae ^a   Ge, Jianning ^a   Wang, Su ^c,d   Goldman, Steven A ^c,d   Zlokovic, Berislav V ^a   Zhao, Zhen ^a   Jung, Jae U ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^d UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN; NONSTRUCTURAL PROTEIN 4A; NONSTRUCTURAL PROTEIN 4B; PROTEIN KINASE B; NS4A PROTEIN, FLAVIVIRUS; NS4B PROTEIN, FLAVIVIRUS; TARGET OF RAPAMYCIN KINASE; VIRAL PROTEIN;

ARTICLE; AUTOPHAGY; CONTROLLED STUDY; ENZYME INHIBITION; FEMALE; FETUS; GROWTH INHIBITION; HUMAN; HUMAN CELL; MOLECULAR PATHOLOGY; NERVOUS SYSTEM DEVELOPMENT; NEURAL STEM CELL; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; UPREGULATION; VIRUS PATHOGENESIS; VIRUS REPLICATION; ZIKA FEVER; ZIKA VIRUS; ANIMAL; HEK293 CELL LINE; HELA CELL LINE; METABOLISM; MOUSE; MULTICELLULAR SPHEROID; PATHOLOGY; PHYSIOLOGY;

ANIMALS; AUTOPHAGY; FETUS; HEK293 CELLS; HELA CELLS; HUMANS; MICE; NEURAL STEM CELLS; NEUROGENESIS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; SPHEROIDS, CELLULAR; TOR SERINE-THREONINE KINASES; VIRAL NONSTRUCTURAL PROTEINS; ZIKA VIRUS; ZIKA VIRUS INFECTION;

EID: 84981742269     PISSN: 19345909     EISSN: 18759777     Source Type: Journal    
DOI: 10.1016/j.stem.2016.07.019     Document Type: Article

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