Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression

Cell

Volumn 170, Issue 6, 2017, Pages 1079-1095.e20

  Cimmino, Luisa ^a   Dolgalev, Igor ^a   Wang, Yubao ^a   Yoshimi, Akihide ^b   Martin, Gaëlle H ^a   Wang, Jingjing ^a   Ng, Victor ^a   Xia, Bo ^a   Witkowski, Matthew T ^a   Mitchell Flack, Marisa ^a   Grillo, Isabella ^a   Bakogianni, Sofia ^a   Ndiaye Lobry, Delphine ^a   Martín, Miguel Torres ^c   Guillamot, Maria ^a   Banh, Robert S ^a   Xu, Mingjiang ^c   Figueroa, Maria E ^c   Dickins, Ross A ^d   Abdel Wahab, Omar ^b   Park, Christopher Y ^a   Tsirigos, Aristotelis ^a   Neel, Benjamin G ^a   Aifantis, Iannis ^a   more..

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^d MONASH UNIVERSITY   (Australia)

Author keywords

DNA demethylation; DNA oxidation; HSCs; hydroxymethylcytosine; leukemia; PARP inhibitor; reversible RNAi; self renewal; TET2; vitamin C

Indexed keywords

ATAXIN 1; CD11B ANTIGEN; CD150 ANTIGEN; CD34 ANTIGEN; CD48 ANTIGEN; GREEN FLUORESCENT PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; STEM CELL FACTOR; ASCORBIC ACID; DNA BINDING PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; ONCOPROTEIN; TET2 PROTEIN, HUMAN; TET2 PROTEIN, MOUSE; VITAMIN;

ACUTE MYELOID LEUKEMIA; ACUTE MYELOID LEUKEMIA CELL LINE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ARTICLE; BONE MARROW CELL; CANCER GROWTH; CELL CYCLE PROGRESSION; CELL DEATH; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; CELL VIABILITY; COLONY FORMATION; CONTROLLED STUDY; CPG ISLAND; DNA DAMAGE; DNA METHYLATION; DOWN REGULATION; ENZYME INHIBITION; EXON; GENE; GENE EXPRESSION; GENE FUNCTION; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INTRON; LEUKEMOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEM CELL SELF-RENEWAL; TET2 GENE; UPREGULATION; ANIMAL; CANCER TRANSPLANTATION; GENE SILENCING; GENETIC TRANSCRIPTION; GENETICS; LEUKEMIA, MYELOID, ACUTE; METABOLISM; MYELODYSPLASTIC SYNDROMES; TUMOR CELL LINE; XENOGRAFT;

ANIMALS; ASCORBIC ACID; CELL DEATH; CELL LINE, TUMOR; DNA METHYLATION; DNA-BINDING PROTEINS; GENE KNOCKDOWN TECHNIQUES; HUMANS; LEUKEMIA, MYELOID, ACUTE; MICE; MYELODYSPLASTIC SYNDROMES; NEOPLASM TRANSPLANTATION; POLY (ADP-RIBOSE) POLYMERASE-1; PROTO-ONCOGENE PROTEINS; TRANSCRIPTION, GENETIC; TRANSPLANTATION, HETEROLOGOUS; VITAMINS;

EID: 85027458667     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2017.07.032     Document Type: Article

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