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Volumn 7, Issue 1, 2017, Pages

High-Coverage Whole-Exome Sequencing Identifies Candidate Genes for Suicide in Victims with Major Depressive Disorder

Author keywords

[No Author keywords available]

Indexed keywords

MICROSATELLITE DNA; VIRUS DNA;

EID: 85026847218     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/s41598-017-06522-3     Document Type: Article
Times cited : (49)

References (60)
  • 1
    • 84880611904 scopus 로고    scopus 로고
    • WHO. (Accessed: 17th January 2017)
    • WHO. Global burden of disease. (2014). Available at: http://www.who.int/topics/global-burden-of-disease/en/. (Accessed: 17th January 2017).
    • (2014) Global Burden of Disease
  • 2
    • 84855300158 scopus 로고    scopus 로고
    • Genome-wide epigenetic regulation by early-life trauma
    • Labonté, B. et al. Genome-wide epigenetic regulation by early-life trauma. Arch. Gen. Psychiatry 69, 722-31 (2012).
    • (2012) Arch. Gen. Psychiatry , vol.69 , pp. 722-731
    • Labonté, B.1
  • 4
    • 84875465140 scopus 로고    scopus 로고
    • The Epidemiology of Depression Across Cultures
    • Kessler, R. C. & Bromet, E. J. The Epidemiology of Depression Across Cultures. Annu. Rev. Public Health 34, 119-138 (2013).
    • (2013) Annu. Rev. Public Health , vol.34 , pp. 119-138
    • Kessler, R.C.1    Bromet, E.J.2
  • 7
    • 34548522702 scopus 로고    scopus 로고
    • Genetics of suicide: A systematic review of twin studies
    • Voracek, M. & Loibl, L. M. Genetics of suicide: A systematic review of twin studies. Wien. Klin. Wochenschr. 119, 463-475 (2007).
    • (2007) Wien. Klin. Wochenschr. , vol.119 , pp. 463-475
    • Voracek, M.1    Loibl, L.M.2
  • 8
    • 30544445602 scopus 로고    scopus 로고
    • Cytokines sing the blues: Inflammation and the pathogenesis of depression
    • Raison, C. L., Capuron, L. & Miller, A. H. Cytokines sing the blues: inflammation and the pathogenesis of depression. Trends Immunol. 27, 24-31 (2006).
    • (2006) Trends Immunol. , vol.27 , pp. 24-31
    • Raison, C.L.1    Capuron, L.2    Miller, A.H.3
  • 9
    • 84886493093 scopus 로고    scopus 로고
    • Biological basis of suicide and suicidal behavior
    • Pandey, G. N. Biological basis of suicide and suicidal behavior. Bipolar Disord. 15, 524-541 (2013).
    • (2013) Bipolar Disord. , vol.15 , pp. 524-541
    • Pandey, G.N.1
  • 10
    • 84914151062 scopus 로고    scopus 로고
    • Toward a Biosignature for Suicide
    • Oquendo, M. A. et al. Toward a Biosignature for Suicide. Am. J. Psychiatry 171, 1259-1277 (2014).
    • (2014) Am. J. Psychiatry , vol.171 , pp. 1259-1277
    • Oquendo, M.A.1
  • 11
    • 84922127573 scopus 로고    scopus 로고
    • An overview of the neurobiology of suicidal behaviors as one meta-system
    • Sokolowski, M., Wasserman, J. & Wasserman, D. An overview of the neurobiology of suicidal behaviors as one meta-system. Mol. Psychiatry 20, 56-71 (2015).
    • (2015) Mol. Psychiatry , vol.20 , pp. 56-71
    • Sokolowski, M.1    Wasserman, J.2    Wasserman, D.3
  • 13
    • 84922544557 scopus 로고    scopus 로고
    • Genetic studies of major depressive disorder: Why are there no genome-wide association study findings and what can we do about it?
    • Levinson, D. F. et al. Genetic studies of major depressive disorder: why are there no genome-wide association study findings and what can we do about it? Biol. Psychiatry 76, 510-2 (2014).
    • (2014) Biol. Psychiatry , vol.76 , pp. 510-512
    • Levinson, D.F.1
  • 14
    • 38349050315 scopus 로고    scopus 로고
    • The CRHR1 gene: A marker for suicidality in depressed males exposed to low stress
    • Wasserman, D., Sokolowski, M., Rozanov, V. & Wasserman, J. The CRHR1 gene: A marker for suicidality in depressed males exposed to low stress. Genes. Brain. Behav. 7, 14-9 (2008).
    • (2008) Genes. Brain. Behav. , vol.7 , pp. 14-19
    • Wasserman, D.1    Sokolowski, M.2    Rozanov, V.3    Wasserman, J.4
  • 15
    • 35748958398 scopus 로고    scopus 로고
    • Genetic variability at HPA axis in major depression and clinical response to antidepressant treatment
    • Papiol, S. et al. Genetic variability at HPA axis in major depression and clinical response to antidepressant treatment. J. Affect. Disord. 104, 83-90 (2007).
    • (2007) J. Affect. Disord. , vol.104 , pp. 83-90
    • Papiol, S.1
  • 16
    • 27744604437 scopus 로고    scopus 로고
    • Risk Factors for Suicide Completion in Major Depression: A Case-Control Study of Impulsive and Aggressive Behaviors in Men
    • Dumais, A. et al. Risk Factors for Suicide Completion in Major Depression: A Case-Control Study of Impulsive and Aggressive Behaviors in Men. Am. J. Psychiatry 162, 2116-2124 (2005).
    • (2005) Am. J. Psychiatry , vol.162 , pp. 2116-2124
    • Dumais, A.1
  • 17
    • 0141758243 scopus 로고    scopus 로고
    • Impaired repression at a 5-hydroxytryptamine 1A receptor gene polymorphism associated with major depression and suicide
    • Lemonde, S. et al. Impaired repression at a 5-hydroxytryptamine 1A receptor gene polymorphism associated with major depression and suicide. J. Neurosci. 23, 8788-99 (2003).
    • (2003) J. Neurosci. , vol.23 , pp. 8788-8799
    • Lemonde, S.1
  • 18
    • 0029895783 scopus 로고    scopus 로고
    • Allelic variation of human serotonin transporter gene expression
    • Heils, A. et al. Allelic variation of human serotonin transporter gene expression. J. Neurochem. 66, 2621-4 (1996).
    • (1996) J. Neurochem. , vol.66 , pp. 2621-2624
    • Heils, A.1
  • 19
    • 0030933979 scopus 로고    scopus 로고
    • A functional polymorphism in the promoter region of the dopamine D2 receptor gene is associated with schizophrenia
    • Arinami, T., Gao, M., Hamaguchi, H. & Toru, M. A functional polymorphism in the promoter region of the dopamine D2 receptor gene is associated with schizophrenia. Hum. Mol. Genet. 6, 577-82 (1997).
    • (1997) Hum. Mol. Genet. , vol.6 , pp. 577-582
    • Arinami, T.1    Gao, M.2    Hamaguchi, H.3    Toru, M.4
  • 20
    • 36749103154 scopus 로고    scopus 로고
    • Meta-Analyses suggest association between COMT, but not HTR1B, alleles, and suicidal behavior
    • Kia-Keating, B. M., Glatt, S. J. & Tsuang, M. T. Meta-Analyses suggest association between COMT, but not HTR1B, alleles, and suicidal behavior. Am. J. Med. Genet. B. Neuropsychiatr. Genet. 144B, 1048-53 (2007).
    • (2007) Am. J. Med. Genet. B. Neuropsychiatr. Genet. , vol.144 , pp. 1048-1053
    • Kia-Keating, B.M.1    Glatt, S.J.2    Tsuang, M.T.3
  • 21
    • 84893438633 scopus 로고    scopus 로고
    • The Genetics of Major Depression
    • Flint, J. & Kendler, K. S. The Genetics of Major Depression. Neuron 81, 484-503 (2014).
    • (2014) Neuron , vol.81 , pp. 484-503
    • Flint, J.1    Kendler, K.S.2
  • 22
    • 84879892380 scopus 로고    scopus 로고
    • A mega-Analysis of genome-wide association studies for major depressive disorder
    • Ripke, S. et al. A mega-Analysis of genome-wide association studies for major depressive disorder. Mol. Psychiatry 18, 497-511 (2013).
    • (2013) Mol. Psychiatry , vol.18 , pp. 497-511
    • Ripke, S.1
  • 23
    • 70349956433 scopus 로고    scopus 로고
    • Finding the missing heritability of complex diseases
    • Manolio, T. A. et al. Finding the missing heritability of complex diseases. Nature 461, 747-753 (2009).
    • (2009) Nature , vol.461 , pp. 747-753
    • Manolio, T.A.1
  • 24
    • 84855853297 scopus 로고    scopus 로고
    • Molecular genetic studies of complex phenotypes
    • Marian, A. J. Molecular genetic studies of complex phenotypes. Transl. Res. 159, 64-79 (2012).
    • (2012) Transl. Res. , vol.159 , pp. 64-79
    • Marian, A.J.1
  • 25
    • 33646706079 scopus 로고    scopus 로고
    • Newborn Hearing Screening-A Silent Revolution
    • Morton, C. C. & Nance, W. E. Newborn Hearing Screening-A Silent Revolution. N. Engl. J. Med. 354, 2151-2164 (2006).
    • (2006) N. Engl. J. Med. , vol.354 , pp. 2151-2164
    • Morton, C.C.1    Nance, W.E.2
  • 26
    • 78650315390 scopus 로고    scopus 로고
    • Investigation of Mendelian forms of obesity holds out the prospect of personalized medicine
    • Blakemore, A. I. F. & Froguel, P. Investigation of Mendelian forms of obesity holds out the prospect of personalized medicine. Ann. N. Y. Acad. Sci. 1214, 180-9 (2010).
    • (2010) Ann. N. Y. Acad. Sci. , vol.1214 , pp. 180-189
    • Blakemore, A.I.F.1    Froguel, P.2
  • 27
    • 84884890589 scopus 로고    scopus 로고
    • A nondegenerate code of deleterious variants in Mendelian loci contributes to complex disease risk
    • Blair, D. R. et al. A nondegenerate code of deleterious variants in Mendelian loci contributes to complex disease risk. Cell 155, 70-80 (2013).
    • (2013) Cell , vol.155 , pp. 70-80
    • Blair, D.R.1
  • 29
    • 84939897536 scopus 로고    scopus 로고
    • The use of regression methods for the investigation of trends in suicide rates in Hungary between 1963 and 2011
    • Laszlo, A. M., Hulman, A., Csicsman, J., Bari, F. & Nyari, T. A. The use of regression methods for the investigation of trends in suicide rates in Hungary between 1963 and 2011. Soc. Psychiatry Psychiatr. Epidemiol. 50, 249-56 (2015).
    • (2015) Soc. Psychiatry Psychiatr. Epidemiol. , vol.50 , pp. 249-256
    • Laszlo, A.M.1    Hulman, A.2    Csicsman, J.3    Bari, F.4    Nyari, T.A.5
  • 30
    • 84938379545 scopus 로고    scopus 로고
    • Sparse whole-genome sequencing identifies two loci for major depressive disorder
    • CONVERGE consortium et al. 2015Natur.523.588C 4522619
    • CONVERGE consortium. et al. Sparse whole-genome sequencing identifies two loci for major depressive disorder. Nature 523, 588-91 (2015).
    • (2015) Nature , vol.523 , pp. 588-591
  • 31
    • 0024425966 scopus 로고
    • Binding properties of the neural cell adhesion molecule to different components of the extracellular matrix
    • Probstmeier, R., Kühn, K. & Schachner, M. Binding properties of the neural cell adhesion molecule to different components of the extracellular matrix. J. Neurochem. 53, 1794-801 (1989).
    • (1989) J. Neurochem. , vol.53 , pp. 1794-1801
    • Probstmeier, R.1    Kühn, K.2    Schachner, M.3
  • 32
    • 0029743717 scopus 로고    scopus 로고
    • Linkage disequilibrium analysis of G-olf alpha (GNAL) in bipolar affective disorder
    • Tsiouris, S. J., Breschel, T. S., Xu, J., McInnis, M. G. & McMahon, F. J. Linkage disequilibrium analysis of G-olf alpha (GNAL) in bipolar affective disorder. Am. J. Med. Genet. 67, 491-4 (1996).
    • (1996) Am. J. Med. Genet. , vol.67 , pp. 491-494
    • Tsiouris, S.J.1    Breschel, T.S.2    Xu, J.3    McInnis, M.G.4    McMahon, F.J.5
  • 33
    • 0035112647 scopus 로고    scopus 로고
    • BACE1 is the major beta-secretase for generation of Abeta peptides by neurons
    • Cai, H. et al. BACE1 is the major beta-secretase for generation of Abeta peptides by neurons. Nat. Neurosci. 4, 233-234 (2001).
    • (2001) Nat. Neurosci. , vol.4 , pp. 233-234
    • Cai, H.1
  • 34
    • 0023722309 scopus 로고
    • The yeast cell cycle gene CDC34 encodes a ubiquitin-conjugating enzyme
    • Goebl, M. G. et al. The yeast cell cycle gene CDC34 encodes a ubiquitin-conjugating enzyme. Science 241, 1331-5 (1988).
    • (1988) Science , vol.241 , pp. 1331-1335
    • Goebl, M.G.1
  • 35
    • 84876296688 scopus 로고    scopus 로고
    • Of the Psychiatric Genomics Consortium. Identification of risk loci with shared effects on five major psychiatric disorders: A genome-wide analysis
    • Group, C.-D. of the Psychiatric Genomics Consortium. Identification of risk loci with shared effects on five major psychiatric disorders: A genome-wide analysis. Lancet (London, England) 381, 1371-9 (2013).
    • (2013) Lancet (London, England) , vol.381 , pp. 1371-1379
    • Group, C.-D.1
  • 36
    • 84860625277 scopus 로고    scopus 로고
    • Identification of a CACNA2D4 deletion in late onset bipolar disorder patients and implications for the involvement of voltage-dependent calcium channels in psychiatric disorders
    • Van Den Bossche, M. J. et al. Identification of a CACNA2D4 deletion in late onset bipolar disorder patients and implications for the involvement of voltage-dependent calcium channels in psychiatric disorders. Am. J. Med. Genet. Part B Neuropsychiatr. Genet. 159B, 465-475 (2012).
    • (2012) Am. J. Med. Genet. Part B Neuropsychiatr. Genet. , vol.159 , pp. 465-475
    • Van Den Bossche, M.J.1
  • 37
    • 84896731172 scopus 로고    scopus 로고
    • Inferring short tandem repeat variation from paired-end short reads
    • Cao, M. D. et al. Inferring short tandem repeat variation from paired-end short reads. Nucleic Acids Res. 42, e16-e16 (2014).
    • (2014) Nucleic Acids Res. , vol.42 , pp. e16-e16
    • Cao, M.D.1
  • 38
    • 55149102787 scopus 로고    scopus 로고
    • Loss of transforming growth factor-beta 2 leads to impairment of central synapse function
    • Heupel, K. et al. Loss of transforming growth factor-beta 2 leads to impairment of central synapse function. Neural Dev. 3, 25 (2008).
    • (2008) Neural Dev. , vol.3 , pp. 25
    • Heupel, K.1
  • 39
    • 24644433745 scopus 로고    scopus 로고
    • Th1, Th2, and Th3 cytokine alterations in major depression
    • Myint, A., Leonard, B., Steinbusch, H. & Kim, Y. Th1, Th2, and Th3 cytokine alterations in major depression. J. Affect. Disord. 88, 167-173 (2005).
    • (2005) J. Affect. Disord. , vol.88 , pp. 167-173
    • Myint, A.1    Leonard, B.2    Steinbusch, H.3    Kim, Y.4
  • 40
    • 38649087659 scopus 로고    scopus 로고
    • Pro-and anti-inflammatory cytokine balance in major depression: Effect of sertraline therapy
    • Sutcigil, L. et al. Pro-and anti-inflammatory cytokine balance in major depression: effect of sertraline therapy. Clin. Dev. Immunol. 2007, 76396 (2007).
    • (2007) Clin. Dev. Immunol. , vol.2007 , pp. 76396
    • Sutcigil, L.1
  • 41
    • 77952287503 scopus 로고    scopus 로고
    • Altered expression of CD4(+)CD25(+) regulatory T cells and its 5-HT(1a) receptor in patients with major depression disorder
    • Li, Y. et al. Altered expression of CD4(+)CD25(+) regulatory T cells and its 5-HT(1a) receptor in patients with major depression disorder. J. Affect. Disord. 124, 68-75 (2010).
    • (2010) J. Affect. Disord. , vol.124 , pp. 68-75
    • Li, Y.1
  • 42
    • 84899152924 scopus 로고    scopus 로고
    • Altered choroid plexus gene expression in major depressive disorder
    • Turner, C. A. et al. Altered choroid plexus gene expression in major depressive disorder. Front. Hum. Neurosci. 8, 238 (2014).
    • (2014) Front. Hum. Neurosci. , vol.8 , pp. 238
    • Turner, C.A.1
  • 43
    • 84961213096 scopus 로고    scopus 로고
    • A study of TNF-α, TGF-β, IL-10, IL-6, and IFN-γ gene polymorphisms in patients with depression
    • Mihailova, S. et al. A study of TNF-α, TGF-β, IL-10, IL-6, and IFN-γ gene polymorphisms in patients with depression. J. Neuroimmunol. 293, 123-8 (2016).
    • (2016) J. Neuroimmunol. , vol.293 , pp. 123-128
    • Mihailova, S.1
  • 44
    • 80052453711 scopus 로고    scopus 로고
    • Transforming growth factor-beta1 and major depressive disorder with and without attempted suicide: Preliminary study
    • Lee, H.-Y. & Kim, Y.-K. Transforming growth factor-beta1 and major depressive disorder with and without attempted suicide: preliminary study. Psychiatry Res. 178, 92-6 (2010).
    • (2010) Psychiatry Res. , vol.178 , pp. 92-96
    • Lee, H.-Y.1    Kim, Y.-K.2
  • 45
    • 84876109471 scopus 로고    scopus 로고
    • Suicidal ideation is associated with elevated inflammation in patients with major depressive disorder
    • O'Donovan, A. et al. Suicidal ideation is associated with elevated inflammation in patients with major depressive disorder. Depress. Anxiety 30, 307-314 (2013).
    • (2013) Depress. Anxiety , vol.30 , pp. 307-314
    • O'Donovan, A.1
  • 47
    • 0042344877 scopus 로고    scopus 로고
    • Herpesviruses in brains in Alzheimer's and Parkinson's diseases
    • Hemling, N. et al. Herpesviruses in brains in Alzheimer's and Parkinson's diseases. Ann. Neurol. 54, 267-271 (2003).
    • (2003) Ann. Neurol. , vol.54 , pp. 267-271
    • Hemling, N.1
  • 48
    • 36549052113 scopus 로고    scopus 로고
    • Investigation of HSV-1, HSV-2, CMV, HHV-6 and HHV-8 DNA by real-Time PCR in surgical resection materials of epilepsy patients with mesial temporal lobe sclerosis
    • Karatas, H. et al. Investigation of HSV-1, HSV-2, CMV, HHV-6 and HHV-8 DNA by real-Time PCR in surgical resection materials of epilepsy patients with mesial temporal lobe sclerosis. J. Neurol. Sci. 264, 151-6 (2008).
    • (2008) J. Neurol. Sci. , vol.264 , pp. 151-156
    • Karatas, H.1
  • 49
    • 84866076485 scopus 로고    scopus 로고
    • Human herpesvirus 6 and 7 in febrile status epilepticus: The FEBSTAT study
    • Epstein, L. G. et al. Human herpesvirus 6 and 7 in febrile status epilepticus: The FEBSTAT study. Epilepsia 53, 1481-8 (2012).
    • (2012) Epilepsia , vol.53 , pp. 1481-1488
    • Epstein, L.G.1
  • 50
    • 0037075207 scopus 로고    scopus 로고
    • Wishful thinking encodes a BMP type II receptor that regulates synaptic growth in Drosophila
    • Aberle, H. et al. Wishful thinking encodes a BMP type II receptor that regulates synaptic growth in Drosophila. Neuron 33, 545-58 (2002).
    • (2002) Neuron , vol.33 , pp. 545-558
    • Aberle, H.1
  • 51
    • 0037313644 scopus 로고    scopus 로고
    • Wnts and TGF beta in synaptogenesis: Old friends signalling at new places
    • Packard, M., Mathew, D. & Budnik, V. Wnts and TGF beta in synaptogenesis: old friends signalling at new places. Nat. Rev. Neurosci. 4, 113-20 (2003).
    • (2003) Nat. Rev. Neurosci. , vol.4 , pp. 113-120
    • Packard, M.1    Mathew, D.2    Budnik, V.3
  • 52
    • 76749115181 scopus 로고    scopus 로고
    • Transforming growth factor beta promotes neuronal cell fate of mouse cortical and hippocampal progenitors in vitro and in vivo: Identification of Nedd9 as an essential signaling component
    • Vogel, T., Ahrens, S., Büttner, N. & Krieglstein, K. Transforming growth factor beta promotes neuronal cell fate of mouse cortical and hippocampal progenitors in vitro and in vivo: identification of Nedd9 as an essential signaling component. Cereb. Cortex 20, 661-71 (2010).
    • (2010) Cereb. Cortex , vol.20 , pp. 661-671
    • Vogel, T.1    Ahrens, S.2    Büttner, N.3    Krieglstein, K.4
  • 53
    • 1242314197 scopus 로고    scopus 로고
    • Dysregulation in the suicide brain: MRNA expression of corticotropin-releasing hormone receptors and GABA(A) receptor subunits in frontal cortical brain region
    • Merali, Z. et al. Dysregulation in the suicide brain: mRNA expression of corticotropin-releasing hormone receptors and GABA(A) receptor subunits in frontal cortical brain region. J. Neurosci. 24, 1478-85 (2004).
    • (2004) J. Neurosci. , vol.24 , pp. 1478-1485
    • Merali, Z.1
  • 55
    • 84862506964 scopus 로고    scopus 로고
    • A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff: SNPs in the genome of Drosophila melanogaster strain w1118; Iso-2; iso-3
    • Cingolani, P. et al. A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff: SNPs in the genome of Drosophila melanogaster strain w1118; iso-2; iso-3. Fly (Austin). 6, 80-92 (2012).
    • (2012) Fly (Austin). , vol.6 , pp. 80-92
    • Cingolani, P.1
  • 56
    • 84982253941 scopus 로고    scopus 로고
    • Analysis of protein-coding genetic variation in 60,706 humans
    • Lek, M. et al. Analysis of protein-coding genetic variation in 60,706 humans. Nature 536, 285-91 (2016).
    • (2016) Nature , vol.536 , pp. 285-291
    • Lek, M.1
  • 57
    • 84861861291 scopus 로고    scopus 로고
    • LobSTR: A short tandem repeat profiler for personal genomes
    • Gymrek, M., Golan, D., Rosset, S. & Erlich, Y. lobSTR: A short tandem repeat profiler for personal genomes. Genome Res. 22, 1154-62 (2012).
    • (2012) Genome Res. , vol.22 , pp. 1154-1162
    • Gymrek, M.1    Golan, D.2    Rosset, S.3    Erlich, Y.4
  • 58
    • 84946735654 scopus 로고    scopus 로고
    • Gene Ontology Consortium: Going forward
    • Gene Ontology Consortium
    • Gene Ontology Consortium. Gene Ontology Consortium: going forward. Nucleic Acids Res. 43, D1049-56 (2015).
    • (2015) Nucleic Acids Res. , vol.43 , pp. D1049-D1056
  • 59
    • 84892511644 scopus 로고    scopus 로고
    • Large-scale gene function analysis with the PANTHER classification system
    • Mi, H., Muruganujan, A., Casagrande, J. T. & Thomas, P. D. Large-scale gene function analysis with the PANTHER classification system. Nat. Protoc. 8, 1551-1566 (2013).
    • (2013) Nat. Protoc. , vol.8 , pp. 1551-1566
    • Mi, H.1    Muruganujan, A.2    Casagrande, J.T.3    Thomas, P.D.4
  • 60
    • 0036226603 scopus 로고    scopus 로고
    • BLAT-The BLAST-like alignment tool
    • Kent, W. J. BLAT-The BLAST-like alignment tool. Genome Res. 12, 656-64 (2002).
    • (2002) Genome Res. , vol.12 , pp. 656-664
    • Kent, W.J.1


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