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Volumn 9, Issue 7, 2017, Pages 1118-1128

Fabs-in-tandem immunoglobulin is a novel and versatile bispecific design for engaging multiple therapeutic targets

Author keywords

Antibody engineering; bispecific antibody; epidermal growth factor receptor; Fabs in tandem immunoglobulin; FIT Ig; hepatocyte growth factor receptor; non small cell lung carcinoma

Indexed keywords

BISPECIFIC ANTIBODY;

EID: 85026532813     PISSN: 19420862     EISSN: 19420870     Source Type: Journal    
DOI: 10.1080/19420862.2017.1345401     Document Type: Article
Times cited : (37)

References (44)
  • 1
    • 0012870750 scopus 로고    scopus 로고
    • Generation and characterization of a novel tetravalent bispecific antibody that binds to hepatitis B virus surface antigens
    • 11451417.PMID
    • Park SS, Ryu CJ, Kang YJ, Kashmiri SV, Hong HJ. Generation and characterization of a novel tetravalent bispecific antibody that binds to hepatitis B virus surface antigens. Mol Immunol 2000; 37:1123-30; PMID:11451417; https://doi.org/10.1016/S0161-5890(01)00027-X
    • (2000) Mol Immunol , vol.37 , pp. 1123-1130
    • Park, S.S.1    Ryu, C.J.2    Kang, Y.J.3    Kashmiri, S.V.4    Hong, H.J.5
  • 2
    • 84919904195 scopus 로고    scopus 로고
    • Combined inhibition of tumor necrosis factor alpha and interleukin-17 as a therapeutic opportunity in rheumatoid arthritis: Development and characterization of a novel bispecific antibody
    • 25303306.PMID
    • Fischer JA, Hueber AJ, Wilson S, Galm M, Baum W, Kitson C, Auer J, Lorenz SH, Moelleken J, Bader M, et al. Combined inhibition of tumor necrosis factor alpha and interleukin-17 as a therapeutic opportunity in rheumatoid arthritis: Development and characterization of a novel bispecific antibody. Arthritis Rheumatol 2015; 67:51-62; PMID:25303306; https://doi.org/10.1002/art.38896
    • (2015) Arthritis Rheumatol , vol.67 , pp. 51-62
    • Fischer, J.A.1    Hueber, A.J.2    Wilson, S.3    Galm, M.4    Baum, W.5    Kitson, C.6    Auer, J.7    Lorenz, S.H.8    Moelleken, J.9    Bader, M.10
  • 3
    • 84977497581 scopus 로고    scopus 로고
    • A novel bispecific antibody targeting EGFR and cMet is effective against EGFR inhibitor-resistant lung tumors
    • 27216193.PMID
    • Moores SL, Chiu ML, Bushey BS, Chevalier K, Luistro L, Dorn K, Brezski RJ, Haytko P, Kelly T, Wu SJ, et al. A novel bispecific antibody targeting EGFR and cMet is effective against EGFR inhibitor-resistant lung tumors. Cancer Res 2016; 76:3942-53; PMID:27216193; https://doi.org/10.1158/0008-5472.CAN-15-2833
    • (2016) Cancer Res , vol.76 , pp. 3942-3953
    • Moores, S.L.1    Chiu, M.L.2    Bushey, B.S.3    Chevalier, K.4    Luistro, L.5    Dorn, K.6    Brezski, R.J.7    Haytko, P.8    Kelly, T.9    Wu, S.J.10
  • 4
    • 67449156132 scopus 로고    scopus 로고
    • Bispecific T-cell engaging antibodies for cancer therapy
    • 19509221.PMID
    • Baeuerle PA, Reinhardt C. Bispecific T-cell engaging antibodies for cancer therapy. Cancer Res 2009; 69:4941-4; PMID:19509221; https://doi.org/10.1158/0008-5472.CAN-09-0547
    • (2009) Cancer Res , vol.69 , pp. 4941-4944
    • Baeuerle, P.A.1    Reinhardt, C.2
  • 5
    • 84870302675 scopus 로고    scopus 로고
    • A bispecific antibody to factors IXa and X restores factor VIII hemostatic activity in a hemophilia A model
    • 23023498.PMID
    • Kitazawa T, Igawa T, Sampei Z, Muto A, Kojima T, Soeda T, Yoshihashi K, Okuyama-Nishida Y, Saito H, Tsunoda H, et al. A bispecific antibody to factors IXa and X restores factor VIII hemostatic activity in a hemophilia A model. Nat Med 2012; 18:1570-4; PMID:23023498; https://doi.org/10.1038/nm.2942
    • (2012) Nat Med , vol.18 , pp. 1570-1574
    • Kitazawa, T.1    Igawa, T.2    Sampei, Z.3    Muto, A.4    Kojima, T.5    Soeda, T.6    Yoshihashi, K.7    Okuyama-Nishida, Y.8    Saito, H.9    Tsunoda, H.10
  • 7
    • 85019289859 scopus 로고    scopus 로고
    • Despite slow progress, bispecifics generate buzz
    • 27926715.PMID
    • Sheridan C. Despite slow progress, bispecifics generate buzz. Nat Biotechnol 2016; 34:1215-7; PMID:27926715; https://doi.org/10.1038/nbt1216-1215
    • (2016) Nat Biotechnol , vol.34 , pp. 1215-1217
    • Sheridan, C.1
  • 8
    • 85011347310 scopus 로고    scopus 로고
    • The making of bispecific antibodies
    • 28071970.PMID
    • Brinkmann U, Kontermann RE. The making of bispecific antibodies. MAbs 2017; 9:182-212; PMID:28071970; https://doi.org/10.1080/19420862.2016.1268307
    • (2017) MAbs , vol.9 , pp. 182-212
    • Brinkmann, U.1    Kontermann, R.E.2
  • 9
    • 84881460836 scopus 로고    scopus 로고
    • Bispecific antibodies with natural architecture produced by co-culture of bacteria expressing two distinct half-antibodies
    • 23831709.PMID
    • Spiess C, Merchant M, Huang A, Zheng Z, Yang NY, Peng J, Ellerman D, Shatz W, Reilly D, Yansura DG, et al. Bispecific antibodies with natural architecture produced by co-culture of bacteria expressing two distinct half-antibodies. Nat Biotechnol 2013; 31:753-8; PMID:23831709; https://doi.org/10.1038/nbt.2621
    • (2013) Nat Biotechnol , vol.31 , pp. 753-758
    • Spiess, C.1    Merchant, M.2    Huang, A.3    Zheng, Z.4    Yang, N.Y.5    Peng, J.6    Ellerman, D.7    Shatz, W.8    Reilly, D.9    Yansura, D.G.10
  • 12
    • 84926348347 scopus 로고    scopus 로고
    • Alternative molecular formats and therapeutic applications for bispecific antibodies
    • 25637431.PMID
    • Spiess C, Zhai Q, Carter PJ. Alternative molecular formats and therapeutic applications for bispecific antibodies. Mol Immunol 2015; 67:95-106; PMID:25637431; https://doi.org/10.1016/j.molimm.2015.01.003
    • (2015) Mol Immunol , vol.67 , pp. 95-106
    • Spiess, C.1    Zhai, Q.2    Carter, P.J.3
  • 15
    • 84895153556 scopus 로고    scopus 로고
    • Emerging cell and cytokine targets in rheumatoid arthritis
    • 24217582.PMID
    • Burmester GR, Feist E, Dörner T. Emerging cell and cytokine targets in rheumatoid arthritis. Nat Rev Rheumatol 2014; 10:77-88; PMID:24217582; https://doi.org/10.1038/nrrheum.2013.168
    • (2014) Nat Rev Rheumatol , vol.10 , pp. 77-88
    • Burmester, G.R.1    Feist, E.2    Dörner, T.3
  • 20
    • 18244371651 scopus 로고    scopus 로고
    • Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain
    • Pao W, Miller VA, Politi KA, Riely GJ, Somwar R, Zakowski MF, Kris MG, Varmus H. Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. PLoS Med 2005; 2:0225-35; PMID:15737014; https://dx.doi/10.1371/journal.pmed.0020073
    • (2005) PLoS Med , vol.2 , pp. 0225-235
    • Pao, W.1    Miller, V.A.2    Politi, K.A.3    Riely, G.J.4    Somwar, R.5    Zakowski, M.F.6    Kris, M.G.7    Varmus, H.8
  • 22
    • 84950989868 scopus 로고    scopus 로고
    • Bispecific antibodies and their applications
    • 26692321.PMID
    • Fan G, Wang Z, Hao M, Li J. Bispecific antibodies and their applications. J Hematol Oncol 2015; 8:130; PMID:26692321; https://doi.org/10.1186/s13045-015-0227-0
    • (2015) J Hematol Oncol , vol.8 , pp. 130
    • Fan, G.1    Wang, Z.2    Hao, M.3    Li, J.4
  • 23
    • 84954316938 scopus 로고    scopus 로고
    • A bispecific antibody targeting CD47 and CD20 selectively binds and eliminates dual antigen expressing lymphoma cells
    • 26083076.PMID
    • Piccione EC, Juarez S, Liu J, Tseng S, Ryan CE, Narayanan C, Wang L, Weiskopf K, Majeti R. A bispecific antibody targeting CD47 and CD20 selectively binds and eliminates dual antigen expressing lymphoma cells. MAbs 2015; 7:946-56; PMID:26083076; https://doi.org/10.1080/19420862.2015.1062192
    • (2015) MAbs , vol.7 , pp. 946-956
    • Piccione, E.C.1    Juarez, S.2    Liu, J.3    Tseng, S.4    Ryan, C.E.5    Narayanan, C.6    Wang, L.7    Weiskopf, K.8    Majeti, R.9
  • 24
    • 68449086890 scopus 로고    scopus 로고
    • Immunotherapy of lymphoma and leukemia with T-cell engaging BiTE antibody blinatumomab
    • 19455460.PMID
    • Nagorsen D, Bargou R, Ruttinger D, Kufer P, Baeuerle PA, Zugmaier G. Immunotherapy of lymphoma and leukemia with T-cell engaging BiTE antibody blinatumomab. Leuk Lymphoma 2009; 50:886-91; PMID:19455460; https://doi.org/10.1080/10428190902943077
    • (2009) Leuk Lymphoma , vol.50 , pp. 886-891
    • Nagorsen, D.1    Bargou, R.2    Ruttinger, D.3    Kufer, P.4    Baeuerle, P.A.5    Zugmaier, G.6
  • 26
    • 84975270914 scopus 로고    scopus 로고
    • Bispecific Anti-HIV-1 antibodies with enhanced breadth and potency
    • 27315478.PMID
    • Bournazos S, Gazumyan A, Seaman MS, Nussenzweig MC, Ravetch J V. Bispecific Anti-HIV-1 antibodies with enhanced breadth and potency. Cell 2016; 165:1609-20; PMID:27315478; https://doi.org/10.1016/j.cell.2016.04.050
    • (2016) Cell , vol.165 , pp. 1609-1620
    • Bournazos, S.1    Gazumyan, A.2    Seaman, M.S.3    Nussenzweig, M.C.4    Ravetch, V.5
  • 27
    • 84945176688 scopus 로고    scopus 로고
    • Fab-based bispecific antibody formats with robust biophysical properties and biological activity
    • 25774965.PMID
    • Wu X, Sereno AJ, Huang F, Lewis SM, Lieu RL, Weldon C, Torres C, Fine C, Batt MA, Jonathan R, et al. Fab-based bispecific antibody formats with robust biophysical properties and biological activity. MAbs 2015; 862:470-82; PMID:25774965; https://doi.org/10.1080/19420862.2015.1022694
    • (2015) MAbs , vol.862 , pp. 470-482
    • Wu, X.1    Sereno, A.J.2    Huang, F.3    Lewis, S.M.4    Lieu, R.L.5    Weldon, C.6    Torres, C.7    Fine, C.8    Batt, M.A.9    Jonathan, R.10
  • 28
    • 84962622376 scopus 로고    scopus 로고
    • Design and validation of a novel generic platform for the production of tetravalent IgG1-like bispecific antibodies
    • 26921308.PMID
    • Golay J, Choblet S, Iwaszkiewicz J, Cérutti P, Ozil A, Loisel S, Pugnière M, Ubiali G, Zoete V, Michielin O, et al. Design and validation of a novel generic platform for the production of tetravalent IgG1-like bispecific antibodies. J Immunol 2016; 196:3199-211; PMID:26921308; https://doi.org/10.4049/jimmunol.1501592
    • (2016) J Immunol , vol.196 , pp. 3199-3211
    • Golay, J.1    Choblet, S.2    Iwaszkiewicz, J.3    Cérutti, P.4    Ozil, A.5    Loisel, S.6    Pugnière, M.7    Ubiali, G.8    Zoete, V.9    Michielin, O.10
  • 29
    • 4143137525 scopus 로고    scopus 로고
    • Effect of linker sequences between the antibody variable domains on the formation, stability and biological activity of a bispecific tandem diabody
    • 15126676.PMID
    • Le Gall F, Reusch U, Little M, Kipriyanov SM. Effect of linker sequences between the antibody variable domains on the formation, stability and biological activity of a bispecific tandem diabody. Protein Eng Des Sel 2004; 17:357-66; PMID:15126676; https://doi.org/10.1093/protein/gzh039
    • (2004) Protein Eng Des Sel , vol.17 , pp. 357-366
    • Le Gall, F.1    Reusch, U.2    Little, M.3    Kipriyanov, S.M.4
  • 30
    • 84982295378 scopus 로고    scopus 로고
    • Fab-dsFv: A bispecific antibody format with extended serum half-life through albumin binding
    • 27532598.PMID
    • Davé E, Adams R, Zaccheo O, Carrington B, Compson JE, Dugdale S, Airey M, Malcolm S, Hailu H, Wild G, et al. Fab-dsFv: A bispecific antibody format with extended serum half-life through albumin binding. MAbs 2016; 8:1319-35; PMID:27532598; https://doi.org/10.1080/19420862.2016.1210747
    • (2016) MAbs , vol.8 , pp. 1319-1335
    • Davé, E.1    Adams, R.2    Zaccheo, O.3    Carrington, B.4    Compson, J.E.5    Dugdale, S.6    Airey, M.7    Malcolm, S.8    Hailu, H.9    Wild, G.10
  • 32
    • 77951520735 scopus 로고    scopus 로고
    • Molecular construction and optimization of anti-human IL-1α/β dual variable domain immunoglobulin (DVD-Ig) molecules
    • 20068402.PMID
    • Wu C, Ying H, Bose S, Miller R, Medina L, Santora L, Ghayur T. Molecular construction and optimization of anti-human IL-1α/β dual variable domain immunoglobulin (DVD-Ig) molecules. MAbs 2009; 1:339-47; PMID:20068402; https://doi.org/10.4161/mabs.1.4.8755
    • (2009) MAbs , vol.1 , pp. 339-347
    • Wu, C.1    Ying, H.2    Bose, S.3    Miller, R.4    Medina, L.5    Santora, L.6    Ghayur, T.7
  • 33
    • 84876270534 scopus 로고    scopus 로고
    • Crystal structure of an Anti-Ang2 crossfab demonstrates complete structural and functional integrity of the variable domain
    • 23613981.PMID
    • Fenn S, Schiller CB, Griese JJ, Duerr H, Imhof-Jung S, Gassner C, Moelleken J, Regula JT, Schaefer W, Thomas M, et al. Crystal structure of an Anti-Ang2 crossfab demonstrates complete structural and functional integrity of the variable domain. PLoS One 2013; 8:1-7; PMID:23613981; https://doi.org/10.1371/journal.pone.0061953
    • (2013) PLoS One , vol.8 , pp. 1-7
    • Fenn, S.1    Schiller, C.B.2    Griese, J.J.3    Duerr, H.4    Imhof-Jung, S.5    Gassner, C.6    Moelleken, J.7    Regula, J.T.8    Schaefer, W.9    Thomas, M.10
  • 34
    • 84890551686 scopus 로고    scopus 로고
    • A novel bispecific EGFR/Met antibody blocks tumor-promoting phenotypic effects induced by resistance to EGFR inhibition and has potent antitumor activity
    • 23812422.PMID
    • Castoldi R, Ecker V, Wiehle L, Majety M, Busl-Schuller R, Asmussen M, Nopora A, Jucknischke U, Osl F, Kobold S, et al. A novel bispecific EGFR/Met antibody blocks tumor-promoting phenotypic effects induced by resistance to EGFR inhibition and has potent antitumor activity. Oncogene 2013; 32:5593-601; PMID:23812422; https://doi.org/10.1038/onc.2013.245
    • (2013) Oncogene , vol.32 , pp. 5593-5601
    • Castoldi, R.1    Ecker, V.2    Wiehle, L.3    Majety, M.4    Busl-Schuller, R.5    Asmussen, M.6    Nopora, A.7    Jucknischke, U.8    Osl, F.9    Kobold, S.10
  • 36
    • 80053517167 scopus 로고    scopus 로고
    • Antibodies to cell surface proteins redirect intracellular trafficking pathways
    • 21819978.PMID
    • St. Pierre CA, Leonard D, Corvera S, Kurt-Jones EA, Finberg RW. Antibodies to cell surface proteins redirect intracellular trafficking pathways. Exp Mol Pathol 2011; 91:723-32; PMID:21819978; https://doi.org/10.1016/j.yexmp.2011.05.011
    • (2011) Exp Mol Pathol , vol.91 , pp. 723-732
    • St. Pierre, C.A.1    Leonard, D.2    Corvera, S.3    Kurt-Jones, E.A.4    Finberg, R.W.5
  • 37
    • 84881058016 scopus 로고    scopus 로고
    • Multivalent immune complexes divert FcRn to lysosomes by exclusion from recycling sorting tubules
    • 23741050.PMID
    • Weflen AW, Baier N, Tang Q-J, Van den Hof M, Blumberg RS, Lencer WI, Massol RH. Multivalent immune complexes divert FcRn to lysosomes by exclusion from recycling sorting tubules. Mol Biol Cell 2013; 24:2398-405; PMID:23741050; https://doi.org/10.1091/mbc.E13-04-0174
    • (2013) Mol Biol Cell , vol.24 , pp. 2398-2405
    • Weflen, A.W.1    Baier, N.2    Tang, Q.-J.3    Van den Hof, M.4    Blumberg, R.S.5    Lencer, W.I.6    Massol, R.H.7
  • 38
    • 27344439995 scopus 로고    scopus 로고
    • Control of epidermal growth factor receptor endocytosis by receptor dimerization, rather than receptor kinase activation
    • 16113650.PMID
    • Wang Q, Villeneuve G, Wang Z. Control of epidermal growth factor receptor endocytosis by receptor dimerization, rather than receptor kinase activation. EMBO Rep 2005; 6:942-8; PMID:16113650; https://doi.org/10.1038/sj.embor.7400491
    • (2005) EMBO Rep , vol.6 , pp. 942-948
    • Wang, Q.1    Villeneuve, G.2    Wang, Z.3
  • 39
    • 84979224082 scopus 로고    scopus 로고
    • The use of CrossMAb technology for the generation of bi- and multispecific antibodies
    • 27285945.PMID
    • Klein C, Schaefer W, Regula JT. The use of CrossMAb technology for the generation of bi- and multispecific antibodies. MAbs 2016; 8:1010-20; PMID:27285945; https://doi.org/10.1080/19420862.2016.1197457
    • (2016) MAbs , vol.8 , pp. 1010-1020
    • Klein, C.1    Schaefer, W.2    Regula, J.T.3
  • 40
    • 84964316543 scopus 로고    scopus 로고
    • Editorial overview: Special section: New concepts in antibody therapeutics: What's in store for antibody therapy?
    • 27083411.PMID
    • Schuurman J, Parren PWHI. Editorial overview: Special section: New concepts in antibody therapeutics: What's in store for antibody therapy? Curr Opin Immunol 2016; 40:vii-xiii; PMID:27083411; https://doi.org/10.1016/j.coi.2016.04.001
    • (2016) Curr Opin Immunol , vol.40 , pp. vii-xiii
    • Schuurman, J.1    Parren, P.W.H.I.2
  • 41
    • 84924425633 scopus 로고    scopus 로고
    • Amgen's bispecific antibody puffs across finish line
    • 25748895.PMID
    • Sheridan C. Amgen's bispecific antibody puffs across finish line. Nat Biotechnol 2015; 33:219-21; PMID:25748895; https://doi.org/10.1038/nbt0315-219
    • (2015) Nat Biotechnol , vol.33 , pp. 219-221
    • Sheridan, C.1
  • 43
    • 0025342326 scopus 로고
    • Cytokine-related syndrome following injection of anti-CD3 monoclonal antibody: Further evidence for transient in vivo T cell activation
    • 2138557.PMID
    • Ferran C, Sheehan K, Dy M, Schreiber R, Merite S, Landais P, Noel LH, Grau G, Bluestone J, Bach JF, et al. Cytokine-related syndrome following injection of anti-CD3 monoclonal antibody: Further evidence for transient in vivo T cell activation. Eur J Immunol 1990; 20:509-15; PMID:2138557; https://doi.org/10.1002/eji.1830200308
    • (1990) Eur J Immunol , vol.20 , pp. 509-515
    • Ferran, C.1    Sheehan, K.2    Dy, M.3    Schreiber, R.4    Merite, S.5    Landais, P.6    Noel, L.H.7    Grau, G.8    Bluestone, J.9    Bach, J.F.10


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