Reviving antibiotics: Efflux pump inhibitors that interact with AcrA, a membrane fusion protein of the AcrAB-TolC multidrug efflux pump

ACS Infectious Diseases

Volumn 3, Issue 1, 2017, Pages 89-98

  Abdali, Narges ^a   Parks, Jerry M ^b,c   Haynes, Keith M ^d   Chaney, Julie L ^a   Green, Adam T ^b   Wolloscheck, David ^a   Walker, John K ^d   Rybenkov, Valentin V ^a   Baudry, Jerome ^b,c   Smith, Jeremy C ^b,c   Zgurskaya, Helen I ^a  

^a UNIVERSITY OF OKLAHOMA   (United States)

^b OAK RIDGE NATIONAL LABORATORY   (United States)

^c UNIVERSITY OF TENNESSEE   (United States)

^d SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Antibiotic resistance; Efflux pump inhibitors; Gram negative bacteria; Hyperporinated outer membrane

Indexed keywords

ACRA PROTEIN; BACTERIAL PROTEIN; BACTOBOLIN; ERYTHROMYCIN; FLUORESCENT DYE; MEMBRANE FUSION PROTEIN; MITOMYCIN; MULTIDRUG EFFLUX PUMP INHIBITOR; NOVOBIOCIN; NSC 207895; NSC 227186; NSC 260594; NSC 305798; NSC 33353; NSC 354844; NSC 50651; NSC 60339; PORFIROMYCIN; PROTEIN INHIBITOR; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; CARRIER PROTEIN;

ANTIBACTERIAL ACTIVITY; ARTICLE; CONFORMATIONAL TRANSITION; DRUG POTENTIATION; DRUG PROTEIN BINDING; ESCHERICHIA COLI; GRAM NEGATIVE BACTERIUM; IN VIVO STUDY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; CHEMISTRY; DRUG DESIGN; DRUG DEVELOPMENT; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOLECULAR MODEL; PROTEIN CONFORMATION;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; DRUG DESIGN; DRUG DISCOVERY; GENE EXPRESSION REGULATION, BACTERIAL; GRAM-NEGATIVE BACTERIA; MEMBRANE TRANSPORT PROTEINS; MODELS, MOLECULAR; PROTEIN CONFORMATION;

EID: 85026398409     PISSN: None     EISSN: 23738227     Source Type: Journal    
DOI: 10.1021/acsinfecdis.6b00167     Document Type: Article

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