Cytotoxic and chemosensitization effects of Scutellarin from traditional Chinese herb Scutellaria altissima L. in human prostate cancer cells

Oncology Reports

Volumn 38, Issue 3, 2017, Pages 1491-1499

  Gao, Chen ^a   Zhou, Yinglu ^a   Zhongling, Jiang ^a   Zhao, Yuan ^b   Dongjun, Zhang ^c   Xia, Cong ^a   Cao, Rongfeng ^a   Li, Huatao ^a   Tian, Wenru ^a  

^a QINGDAO AGRICULTURAL UNIVERSITY   (China)

^b Shu Lan Animal Husbandry Bureau   (China)

^c Feicheng Animal Husbandry and Veterinary Bureau   (China)

Author keywords

Apoptosis; Cell cycle arrest; Chemosensitizing effects; Prostate cancer; Scutellarin

Indexed keywords

CASPASE 3; CASPASE 9; CISPLATIN; CYCLIN B1; CYCLIN DEPENDENT KINASE 1; DNA; HISTONE H2AX; PROTEIN BAX; PROTEIN BCL 2; SCUTELLARIN; APIGENIN; CDK1 PROTEIN, HUMAN; CYTOTOXIN; GLUCURONIC ACID; HERBACEOUS AGENT;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL VIABILITY; CHEMOSENSITIZATION; CHINESE HERB; COMET ASSAY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA DAMAGE; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG POTENTIATION; DRUG STRUCTURE; ENZYME ACTIVATION; FLOW CYTOMETRY; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; MALE; MEMBRANE DEPOLARIZATION; MITOCHONDRIAL MEMBRANE POTENTIAL; MOLECULAR MECHANICS; MTT ASSAY; PRIORITY JOURNAL; PROSTATE CANCER; PROSTATE CANCER CELL LINE; PROTEIN EXPRESSION; SCUTELLARIA; SCUTELLARIA ALLTISSIMA; UPREGULATION; WESTERN BLOTTING; CELL CYCLE CHECKPOINT; CELL PROLIFERATION; CHEMISTRY; DRUG EFFECTS; DRUG RESISTANCE; GENE EXPRESSION REGULATION; GENETICS; PATHOLOGY; PROSTATE TUMOR; TUMOR CELL LINE;

APIGENIN; APOPTOSIS; CDC2 PROTEIN KINASE; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN B1; CYTOTOXINS; DRUG RESISTANCE, NEOPLASM; DRUGS, CHINESE HERBAL; FLOW CYTOMETRY; GENE EXPRESSION REGULATION, NEOPLASTIC; GLUCURONATES; HUMANS; MALE; PROSTATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS C-BCL-2; SCUTELLARIA;

EID: 85026368927     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2017.5850     Document Type: Article

References (35)

1. da Silva FC and Oliveira P: Tumor clone dynamics in lethal prostate cancer. Eur Urol 71: 142-143, 2017.
2. Jazayeri SB, Samadi DB: Prostate cancer in African Americans: Early oncological and functional outcomes after robotic prostatectomy. Int J Urol 24: 236-237, 2017.
3. Zhang W, Meng Y, Liu N, Wen XF and Yang T: Insights into chemoresistance of prostate cancer. Int J Biol Sci 11: 1160-1170, 2015.
4. Keller ET: Prostate cancer cells metastasize to the hematopoietic stem cell niche in bone. Asian J Androl 13: 622-623, 2011.
5. Catalani E, Proietti Serafini F, Zecchini S, Picchietti S, Fausto AM, Marcantoni E, Buonanno F, Ortenzi C, Perrotta C, Cervia D: Natural products from aquatic eukaryotic microorganisms for cancer therapy: Perspectives on anti-tumour properties of ciliate bioactive molecules. Pharmacol Res 113: 409-420, 2016.
6. Tatullo M, Simone GM, Tarullo F, Irlandese G, Vito D, Marrelli M, Santacroce L, Cocco T, Ballini A and Scacco S: Antioxidant and antitumor activity of a bioactive polyphenolic fraction isolated from the brewing process. Sci Rep 6: 36042, 2016.
7. Ahmadi A, Shadboorestan A, Nabavi SF, Setzer WN and Nabavi SM: The role of hesperidin in cell signal transduction pathway for the prevention or treatment of cancer. Curr Med Chem 22: 3462-3471, 2015.
8. Wang Y, Ma Y, Zheng Y, Song J, Yang X, Bi C, Zhang D and Zhang Q: In vitro and in vivo anticancer activity of a novel puerarin nanosuspension against colon cancer, with high efficacy and low toxicity. Int J Pharm 441: 728-735, 2013.
9. Chai L, Guo H, Li H, Wang S, Wang YL, Shi F, Hu LM, Liu Y and Adah D: Scutellarin and caffeic acid ester fraction, active components of Dengzhanxixin injection, upregulate neurotrophins synthesis and release in hypoxia/reoxygenation rat astrocytes. J Ethnopharmacol 150: 100-107, 2013.
10. Grzegorczyk-Karolak I, Gob K, Gburek J, Wysoki-ska H and Matkowski A: Inhibition of advanced glycation end-product formation and antioxidant activity by extracts and polyphenols from Scutellaria alpina L. and S. altissima L. Molecules 21: pii: E 739, 2016.
11. Bozov PI and Coll J: Neo-clerodane diterpenoids from Scutellaria altissima. Nat Prod Commun 10: 13-16, 2015.
12. Zhao Q, Chen XY and Martin C: Scutellaria baicalensis, the golden herb from the garden of Chinese medicinal plants. Sci Bull 61: 1391-1398, 2016.
13. Choi W, No RH, Kwon HS, Lee HY: Enhancement of skin antiinflammatory activities of Scutellaria baicalensis extract using a nanoencapsulation process. J Cosmet Laser Ther 16: 271-278, 2014.
14. Shang YZ, Qin BW, Cheng JJ and Miao H: Prevention of oxidative injury by flavonoids from stems and leaves of Scutellaria baicalensis Georgi in PC12 cells. Phytother Res 20: 53-57, 2006.
15. Mallick A, More P, Syed MM and Basu S: Nanoparticle-mediated mitochondrial damage induces apoptosis in cancer. ACS Appl Mater Interfaces 8: 13218-13231, 2016.
16. Li H, Huang D, Gao Z, Lv Y, Zhang L, Cui H and Zheng J: Scutellarin inhibits cell migration by regulating production of ?v?6 integrin and E-cadherin in human tongue cancer cells. Oncol Rep 24: 1153-1160, 2010.
17. Adam-Zahir S, Plowman PN, Bourton EC, Sharif F and Parris CN: Increased ?-H2AX and Rad51 DNA repair biomarker expression in human cell lines resistant to the chemotherapeutic agents nitrogen mustard and cisplatin. Chemotherapy 60: 310-320, 2014.
18. Madan RA, Pal SK, Sartor O and Dahut WL: Overcoming chemotherapy resistance in prostate cancer. Clin Cancer Res 17: 3892-3902, 2011.
19. Cao H, Mu Y, Li X, Wang Y, Chen S and Liu JP: A systematic review of randomized controlled trials on oral Chinese herbal medicine for prostate cancer. PLoS One 11: e0160253, 2016.
20. Mohammadi A, Mansoori B, Aghapour M, Baradaran PC, Shajari N, Davudian S, Salehi S and Baradaran B: The herbal medicine Utrica dioica inhibits proliferation of colorectal cancer cell line by inducing apoptosis and arrest at the G2/M phase. J Gastrointest Cancer 47: 187-195, 2016.
21. Yuan Y, Zha H, Rangarajan P, Ling EA and Wu C: Antiinflammatory effects of Edaravone and Scutellarin in activated microglia in experimentally induced ischemia injury in rats and in BV-2 microglia. BMC Neurosci 15: 125, 2014.
22. Niu C, Sheng Y, Yang R, Lu B, Bai Q, Ji L and Wang Z: Scutellarin protects against the liver injury induced by diosbulbin B in mice and its mechanism. J Ethnopharmacol 164: 301-308, 2015.
23. Wang Z, Yu J, Wu J, Qi F, Wang H, Wang Z and Xu Z: Scutellarin protects cardiomyocyte ischemia-reperfusion injury by reducing apoptosis and oxidative stress. Life Sci 157: 200-207, 2016.
24. Cai F, Li J, Liu Y, Zhang Z, Hettiarachchi DS and Li D: Effect of ximenynic acid on cell cycle arrest and apoptosis and COX-1 in HepG2 cells. Mol Med Rep 14: 5667-5676, 2016.
25. Gao Y, Wang X and He C: An isoflavonoid-enriched extract from Pueraria lobata (kudzu) root protects human umbilical vein endothelial cells against oxidative stress induced apoptosis. J Ethnopharmacol 193: 524-530, 2016.
26. Forster L, Cornwall S, Finlayson J and Ghassemifar R: Cell cycle, proliferation and apoptosis in erythroblasts cultured from patients with ?-thalassaemia major. Br J Haematol 175: 539-542, 2016.
27. Chang CC, Hung CM, Yang YR, Lee MJ and Hsu YC: Sulforaphane induced cell cycle arrest in the G2/M phase via the blockade of cyclin B1/CDC2 in human ovarian cancer cells. J Ovarian Res 6: 41, 2013.
28. Qi LW, Zhang Z, Zhang CF, Anderson S, Liu Q, Yuan CS and Wang CZ: Anti-colon cancer effects of 6-Shogaol through G2/M cell cycle arrest by p53/p21-cdc2/cdc25A crosstalk. Am J Chin Med 43: 743-756, 2015.
29. Lohberger B, Leithner A, Stuendl N, Kaltenegger H, Kullich W and Steinecker-Frohnwieser B: Diacerein retards cell growth of chondrosarcoma cells at the G2/M cell cycle checkpoint via cyclin B1/CDK1 and CDK2 downregulation. BMC Cancer 15: 891, 2015.
30. Millimouno FM, Dong J, Yang L, Li J and Li X: Targeting apoptosis pathways in cancer and perspectives with natural compounds from mother nature. Cancer Prev Res 7: 1081-1107, 2014.
31. Zhang A, He W, Shi H, Huang X and Ji G: Natural compound oblongifolin C inhibits autophagic flux, and induces apoptosis and mitochondrial dysfunction in human cholangiocarcinoma QBC939 cells. Mol Med Rep 14: 3179-3183, 2016.
32. Song XF, Tian H, Zhang P and Zhang ZX: Expression of Cyt-cmediated mitochondrial apoptosis-related proteins in rat renal proximal tubules during development. Nephron 135: 77-86, 2016.
33. Wang Q, Zhang L, Yuan X, Ou Y, Zhu X, Cheng Z, Zhang P, Wu X, Meng Y and Zhang L: The relationship between the Bcl-2/Bax proteins and the mitochondria-mediated apoptosis pathway in the differentiation of adipose-derived stromal cells into neurons. PLoS One 11: e0163327, 2016.
34. Hardie ME, Kava HW and Murray V: Cisplatin analogues with an increased interaction with DNA: Prospects for therapy. Curr Pharm Des 22: 6645-6664, 2016.
35. Kim SH, Ho JN, Jin H, Lee SC, Lee SE, Hong SK, Lee JW, Lee E S and Byun SS: Upregulated expression of BCL2, MCM7, and CCNE1 indicate cisplatin-resistance in the set of two human bladder cancer cell lines: T24 cisplatin sensitive and T24R2 cisplatin resistant bladder cancer cell lines. Investig Clin Urol 57: 63-72, 2016.