Maternal inflammation induces immune activation of fetal microglia and leads to disrupted microglia immune responses, behavior, and learning performance in adulthood

Neurobiology of Disease

Volumn 106, Issue , 2017, Pages 291-300

  Schaafsma, Wandert ^a   Basterra, Laura Bozal ^a   Jacobs, Sabrina ^a   Brouwer, Nieske ^a   Meerlo, Peter ^b   Schaafsma, Anne ^c   Boddeke, Erik W G M ^a   Eggen, Bart J L ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b UNIVERSITY OF GRONINGEN   (Netherlands)

^c FRIESLANDCAMPINA   (Netherlands)

Author keywords

Behavior; Fetal neuroinflammation; Innate immunity; Maternal inflammation; Microglia

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; LIPOPOLYSACCHARIDE; TUMOR NECROSIS FACTOR;

ADULT; ADULTHOOD; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANXIETY; ARTICLE; BEHAVIOR DISORDER; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; ELEVATED PLUS MAZE TEST; EMBRYO DEVELOPMENT; FEMALE; FETUS; FETUS CELL; GESTATIONAL AGE; HIPPOCAMPUS; HOME-CAGE ACTIVITY TEST; IMMUNOPATHOLOGY; INFLAMMATION; INNATE IMMUNITY; LEARNING DISORDER; MATERNAL DISEASE; MICROGLIA; MOUSE; NONHUMAN; OPEN FIELD TEST; PRIORITY JOURNAL; T-MAZE TEST; ANIMAL; BLOOD; BRAIN; C57BL MOUSE; ESCHERICHIA COLI; EXPLORATORY BEHAVIOR; GROWTH, DEVELOPMENT AND AGING; IMMUNOLOGY; LEARNING; MALE; METABOLISM; MOTOR ACTIVITY; PATHOPHYSIOLOGY; PHYSIOLOGY; PREGNANCY; PREGNANCY COMPLICATION;

ANIMALS; ANXIETY; BRAIN; BRAIN-DERIVED NEUROTROPHIC FACTOR; ESCHERICHIA COLI; EXPLORATORY BEHAVIOR; FEMALE; INFLAMMATION; LEARNING; LIPOPOLYSACCHARIDES; MALE; MICE, INBRED C57BL; MICROGLIA; MOTOR ACTIVITY; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 85026192650     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2017.07.017     Document Type: Article

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