Hormonal changes associated with physical activity and exercise training

Exercise and Human Reproduction: Induced Fertility Disorders and Possible Therapies

Volumn , Issue , 2016, Pages 125-143

  Hackney, Anthony C ^a,b   Kraemer, William J ^c   Hoope, David R ^c  

^a The University of North Carolina at Chapel Hill   (United States)

^b University of North Carolina at Chapel Hill   (United States)

^c UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 85025177916     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-1-4939-3402-7_8     Document Type: Chapter

References (104)

1. Henneman E. Relation between size of neurons and their susceptibility to discharge. Science. 1957;126:1345-7.
2. Vilensky JA, Gilman S. Renaming the "Henneman size principle". Science. 1998;280:2031.
3. Milner-Brown HS, Stein RB, Yemm R. The orderly recruitment of human motor units during voluntary isometric contractions. J Physiol. 1973;230:359-70.
4. Campos GE, Luecke TJ, Wendeln HK, Toma K, Hagerman FC, Murray TF, Ragg KE, Ratamess NA, Kraemer WJ, Staron RS. Muscular adaptations in response to three different resistance-training regimens: specificity of repetition maximum training zones. Eur J Appl Physiol. 2002;88:50-60.
5. Schuenke MD, Herman J, Staron RS. Preponderance of evidence proves "big" weights optimize hypertrophic and strength adaptations. Eur J Appl Physiol. 2013;113:269-71.
6. Schakman O, Kalista S, Barbe C, Loumaye A, Thissen JP. Glucocorticoid-induced skeletal muscle atrophy. Int J Biochem Cell Biol. 2013; 45(10):2163-72.
7. Powers SK, Jackson MJ. Exercise-induced oxidative stress: cellular mechanisms and impact on muscle force production. Physiol Rev. 2008;88:1243-76.
8. Hudson MB, Hosick PA, McCaulley GO, Schrieber L, Wrieden J, McAnulty SR, Triplett NT, McBride JM, Quindry JC. The effect of resistance exercise on humoral markers of oxidative stress. Med Sci Sports Exerc. 2008;40:542-8.
9. McArdle A, Pattwell D, Vasilaki A, Griffiths RD, Jackson MJ. Contractile activity-induced oxidative stress: cellular origin and adaptive responses. Am J Physiol Cell Physiol. 2001;280:C621-7.
10. Vasilaki A, Jackson MJ, McArdle A. Attenuated HSP70 response in skeletal muscle of aged rats following contractile activity. Muscle Nerve. 2002;25:902-5.
11. Balon TW, Nadler JL. Nitric oxide release is present from incubated skeletal muscle preparations. J Appl Physiol. 1994;77:2519-21.
12. Sen CK, Packer L, Hanninen O. Handbook of oxidants and antioxidants in exercise. New York: Elsevier; 2000.
13. Pothen JJ, Poynter ME, Bates JH. The inflammatory twitch as a general strategy for controlling the host response. J Immunol. 2013;190:3510-6.
14. Spiering BA, Kraemer WJ, Anderson JM, Armstrong LE, Nindl BC, Volek JS, Maresh CM. Resistance exercise biology: manipulation of resistance exercise programme variables determines the responses of cellular and molecular signalling pathways. Sports Med. 2008;38:527-40.
15. Kraemer WJ, Noble BJ, Clark MJ, Culver BW. Physiologic responses to heavy-resistance exercise with very short rest periods. Int J Sports Med. 1987;8:247-52.
16. French DN, Kraemer WJ, Volek JS, Spiering BA, Judelson DA, Hoffman JR, Maresh CM. Anticipatory responses of catecholamines on muscle force production. J Appl Physiol. 2007;102:94-102.
17. Szivak TK, Hooper DR, Dunn-Lewis C, Comstock BA, Kupchak BR, Apicella JM, Saenz C, Maresh CM, Denegar CR, Kraemer WJ. Adrenal cortical responses to high-intensity, short rest, resistance exercise in men and women. J Strength Cond Res. 2013;27:748-60.
18. Auclair D, Garrel DR, Chaouki Zerouala A, Ferland LH. Activation of the ubiquitin pathway in rat skeletal muscle by catabolic doses of glucocorticoids. Am J Physiol. 1997;272:C1007-16.
19. Seene T. Turnover of skeletal muscle contractile proteins in glucocorticoid myopathy. J Steroid Biochem Mol Biol. 1994;50:1-4.
20. Seene T, Alev K. Effect of glucocorticoids on the turnover rate of actin and myosin heavy and light chains on different types of skeletal muscle fibres. J Steroid Biochem. 1985;22:767-71.
21. Dekhuijzen PN, Gayan-Ramirez G, Bisschop A, De Bock V, Dom R, Decramer M. Corticosteroid treatment and nutritional deprivation cause a different pattern of atrophy in rat diaphragm. J Appl Physiol. 1995;78:629-37.
22. Spiering BA, Kraemer WJ, Anderson JM, Armstrong LE, Nindl BC, Volek JS, Judelson DA, Joseph M, Vingren JL, Hatfield DL, Fragala MS, Ho JY, Maresh CM. Effects of elevated circulating hormones on resistance exercise-induced Akt signaling. Med Sci Sports Exerc. 2008;40:1039-48.
23. Ratamess NA, Kraemer WJ, Volek JS, Maresh CM, Vanheest JL, Sharman MJ, Rubin MR, French DN, Vescovi JD, Silvestre R, Hatfield DL, Fleck SJ, Deschenes MR. Androgen receptor content following heavy resistance exercise in men. J Steroid Biochem Mol Biol. 2005;93:35-42.
24. Villanueva MG, Lane CJ, Schroeder ET. Influence of rest interval length on acute testosterone and cortisol responses to volume-load-equated total body hypertrophic and strength protocols. J Strength Cond Res. 2012;26:2755-64.
25. Kraemer WJ, Fleck SJ, Dziados JE, Harman EA, Marchitelli LJ, Gordon SE, Mello R, Frykman PN, Koziris LP, Triplett NT. Changes in hormonal concentrations after different heavy-resistance exercise protocols in women. J Appl Physiol. 1993;75:594-604.
26. Kraemer WJ, Marchitelli L, Gordon SE, Harman E, Dziados JE, Mello R, Frykman P, McCurry D, Fleck SJ. Hormonal and growth factor responses to heavy resistance exercise protocols. J Appl Physiol. 1990;69:1442-50.
27. Nunes JA, Crewther BT, Ugrinowitsch C, Tricoli V, Viveiros L, de Rose D Jr, Aoki MS. Salivary hormone and immune responses to three resistance exercise schemes in elite female athletes. J Strength Cond Res. 2011;25:2322-7.
28. Leite RD, Prestes J, Rosa C, De Salles BF, Maior A, Miranda H, Simao R. Acute effect of resistance training volume on hormonal responses in trained men. J Sports Med Phys Fitness. 2011;51:322-8.
29. Kraemer WJ, Gordon SE, Fleck SJ, Marchitelli LJ, Mello R, Dziados JE, Friedl K, Harman E, Maresh C, Fry AC. Endogenous anabolic hormonal and growth factor responses to heavy resistance exercise in males and females. Int J Sports Med. 1991;12:228-35.
30. Vingren JL, Kraemer WJ, Hatfield DL, Volek JS, Ratamess NA, Anderson JM, Hakkinen K, Ahtiainen J, Fragala MS, Thomas GA, Ho JY, Maresh CM. Effect of resistance exercise on muscle steroid receptor protein content in strength-trained men and women. Steroids. 2009;74:1033-9.
31. Mazon J, Gastaldi A, Di Sacco T, Cozza I, Dutra S, Souza H. Effects of training periodization on cardiac autonomic modulation and endogenous stress markers in volleyball players. Scand J Med Sci Sports. 2013;23:114-20.
32. Enea C, Boisseau N, Fargeas-Gluck MA, Diaz V, Dugue B. Circulating androgens in women: exerciseinduced changes. Sports Med. 2011;41:1-15.
33. Hoffman JR, Kraemer WJ, Bhasin S, Storer T, Ratamess NA, Haff GG, Willoughby DS, Rogol AD. Position stand on androgen and human growth hormone use. J Strength Cond Res. 2009;23:S1-59.
34. Mauras N, Hayes V, Welch S, Rini A, Helgeson K, Dokler M, Veldhuis JD, Urban RJ. Testosterone deficiency in young men: marked alterations in whole body protein kinetics, strength, and adiposity. J Clin Endocrinol Metab. 1998;83:1886-92.
35. Demling RH, Orgill DP. The anticatabolic and wound healing effects of the testosterone analog oxandrolone after severe burn injury. J Crit Care. 2000;15:12-7.
36. Dubois V, Laurent M, Boonen S, Vanderschueren D, Claessens F. Androgens and skeletal muscle: cellular and molecular action mechanisms underlying the anabolic actions. Cell Mol Life Sci. 2012;69:1651-67.
37. Mayer M, Rosen F. Interaction of glucocorticoids and androgens with skeletal muscle. Metabolism. 1977;26:937-62.
38. Nindl BC, Kraemer WJ, Gotshalk LA, Marx JO, Volek JS, Bush FA, Hakkinen K, Newton RU, Fleck SJ. Testosterone responses after resistance exercise in women: influence of regional fat distribution. Int J Sport Nutr Exerc Metab. 2001;11:451-65.
39. Spiering BA, Kraemer WJ, Vingren JL, Ratamess NA, Anderson JM, Armstrong LE, Nindl BC, Volek JS, Hakkinen K, Maresh CM. Elevated endogenous testosterone concentrations potentiate muscle androgen receptor responses to resistance exercise. J Steroid Biochem Mol Biol. 2009;114:195-9.
40. Vingren JL, Kraemer WJ, Ratamess NA, Anderson JM, Volek JS, Maresh CM. Testosterone physiology in resistance exercise and training: the up-stream regulatory elements. Sports Med. 2010;40:1037-53.
41. Kraemer WJ, Spiering BA, Volek JS, Ratamess NA, Sharman MJ, Rubin MR, French DN, Silvestre R, Hatfield DL, Van Heest JL, Vingren JL, Judelson DA, Deschenes MR, Maresh CM. Androgenic responses to resistance exercise: effects of feeding and L-carnitine. Med Sci Sports Exerc. 2006;38:1288-96.
42. Kvorning T, Andersen M, Brixen K, Madsen K. Suppression of endogenous testosterone production attenuates the response to strength training: a randomized, placebo-controlled, and blinded intervention study. Am J Physiol Endocrinol Metab. 2006;291:E1325-32.
43. Kvorning T, Andersen M, Brixen K, Schjerling P, Suetta C, Madsen K. Suppression of testosterone does not blunt mRNA expression of myoD, myogenin, IGF, myostatin or androgen receptor post strength training in humans. J Physiol. 2007;578:579-93.
44. Hwang AC, Liu LK, Lee WJ, Lin MH, Peng LN, Won CW, Chen LK. Association of androgen with skeletal muscle mass and muscle function among men and women age 50 years and older in Taiwan: results from I-Lan longitudinal aging study. Rejuvenation Res. 2013;16(6):453-9.
45. Baumann G. Growth hormone heterogeneity: genes, isohormones, variants, and binding proteins. Endocr Rev. 1991;12:424-49.
46. Kraemer WJ, Dunn-Lewis C, Comstock BA, Thomas GA, Clark JE, Nindl BC. Growth hormone, exercise, and athletic performance: a continued evolution of complexity. Curr Sports Med Rep. 2010;9:242-52.
47. Kraemer WJ, Nindl BC, Marx JO, Gotshalk LA, Bush JA, Welsch JR, Volek JS, Spiering BA, Maresh CM, Mastro AM, Hymer WC. Chronic resistance training in women potentiates growth hormone in vivo bioactivity: characterization of molecular mass variants. Am J Physiol Endocrinol Metab. 2006;291:E1177-87.
48. Rubin MR, Kraemer WJ, Maresh CM, Volek JS, Ratamess NA, Vanheest JL, Silvestre R, French DN, Sharman MJ, Judelson DA, Gomez AL, Vescovi JD, Hymer WC. High-affinity growth hormone binding protein and acute heavy resistance exercise. Med Sci Sports Exerc. 2005;37:395-403.
49. Gordon SE, Kraemer WJ, Vos NH, Lynch JM, Knuttgen HG. Effect of acid-base balance on the growth hormone response to acute high-intensity cycle exercise. J Appl Physiol. 1994;76:821-9.
50. Hymer WC, Kraemer WJ, Nindl BC, Marx JO, Benson DE, Welsch JR, Mazzetti SA, Volek JS, Deaver DR. Characteristics of circulating growth hormone in women after acute heavy resistance exercise. Am J Physiol Endocrinol Metab. 2001;281:E878-87.
51. Kraemer WJ, Nindl BC, Volek JS, Marx JO, Gotshalk LA, Bush JA, Welsch JR, Vingren JL, Spiering BA, Fragala MS, Hatfield DL, Ho JY, Maresh CM, Mastro AM, Hymer WC. Influence of oral contraceptive use on growth hormone in vivo bioactivity following resistance exercise: responses of molecular mass variants. Growth Horm IGF Res. 2008;18:238-44.
52. Sotiropoulos A, Ohanna M, Kedzia C, Menon RK, Kopchick JJ, Kelly PA, Pende M. Growth hormone promotes skeletal muscle cell fusion independent of insulin-like growth factor 1 up-regulation. Proc Natl Acad Sci U S A. 2006;103:7315-20.
53. Perrini S, Laviola L, Carreira MC, Cignarelli A, Natalicchio A, Giorgino F. The GH/IGF1 axis and signaling pathways in the muscle and bone: mechanisms underlying age-related skeletal muscle wasting and osteoporosis. J Endocrinol. 2010;205:201-10.
54. Nindl BC, Pierce JR. Insulin-like growth factor I as a biomarker of health, fitness, and training status. Med Sci Sports Exerc. 2010;42:39-49.
55. Frasca F, Pandini G, Scalia P, Sciacca L, Mineo R, Costantino A, Goldfine ID, Belfiore A, Vigneri R. Insulin receptor isoform A, a newly recognized, high-affinity insulin-like growth factor II receptor in fetal and cancer cells. Mol Cell Biol. 1999;19:3278-88.
56. Nindl BC, Alemany JA, Tuckow AP, Kellogg MD, Sharp MA, Patton JF. Effects of exercise mode and duration on 24-h IGF-I system recovery responses. Med Sci Sports Exerc. 2009;41:1261-70.
57. Nindl BC, Castellani JW, Young AJ, Patton JF, Khosravi MJ, Diamandi A, Montain SJ. Differential responses of IGF-I molecular complexes to military operational field training. J Appl Physiol. 2003;95:1083-9.
58. Nindl BC, Kraemer WJ, Marx JO, Arciero PJ, Dohi K, Kellogg MD, Loomis GA. Overnight responses of the circulating IGF-I system after acute, heavy-resistance exercise. J Appl Physiol. 2001;90:1319-26.
59. Coolican SA, Samuel DS, Ewton DZ, McWade FJ, Florini JR. The mitogenic and myogenic actions of insulin-like growth factors utilize distinct signaling pathways. J Biol Chem. 1997;272:6653-62.
60. Fuentes EN, Bjornsson BT, Valdes JA, Einarsdottir IE, Lorca B, Alvarez M, Molina A. IGF-I/PI3K/Akt and IGF-I/MAPK/ERK pathways in vivo in skeletal muscle are regulated by nutrition and contribute to somatic growth in the fine flounder. Am J Physiol Regul Integr Comp Physiol. 2011;300:R1532-42.
61. Singleton JR, Feldman EL. Insulin-like growth factor-I in muscle metabolism and myotherapies. Neurobiol Dis. 2001;8:541-54.
62. Matheny RW Jr, Nindl BC, Adamo ML. Minireview: Mechano-growth factor: a putative product of IGF-I gene expression involved in tissue repair and regeneration. Endocrinology. 2010;151:865-75.
63. Esposito S, Deventer K, Van Eenoo P. Characterization and identification of a C-terminal amidated mechano growth factor (MGF) analogue in black market products. Rapid Commun Mass Spectrom. 2012;26:686-92.
64. Borer KT. Exercise endocrinology. Champaign: Human Kinetics Publishing; 2003. p. 77-96.
65. Viru A. Hormonal ensemble in exercise-Hormones in muscular activity, Vol. 1. Boca Raton: CRC Press; 1985. p. 34-96.
66. Viru A, Viru M. Biochemical monitoring of sport training. Champaign: Human Kinetics Publishing; 2001.
67. Bunt JC. Hormonal alterations due to exercise. Sports Med. 1986;3:331-45.
68. Galbo H. Hormonal and metabolic adaptation to exercise. Stuttgart: Georg Thieme Verlag; 1983.
69. Hackney AC, Viru A. Research methodology: issues with endocrinological measurements in exercise science and sport medicine. J Athletic Training. 2008;43(6):631-9.
70. Hackney AC. Exercise as a stressor to the neuroendocrine system. Medicina. 2006;42(10):788-97.
71. Chrousos GP, Gold PW. The concept of stress systems disorders: overview of physical and behavioral homeostasis. JAMA. 1992;267:1244-52.
72. Tsigo C, Chrousos GP. Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress. J Psychosomatic Res. 2002;53:865-71.
73. Farrell PA, Garthwaite TL, Gustafson AB. Plasma adrenocorticotropin and cortisol responses to submaximal and exhaustive exercise. J Appl Physiol. 1983;55(5):1441-4.
74. Goldstein DS. Catecholamines and stress. Endocrine Reg. 2003;37:69-80.
75. Davies CTM, Few JD. Effects of exercise on adrenocortical function. J Appl Physiol. 1973;5:887-91.
76. Widmaier EP. Metabolic feedback in mammalian endocrine systems. Hormone Metab Res. 1992;24:147-53.
77. Röcker L, Kirsch KA, Heyduck B, Altenkirch HU. Influence of prolonged physical exercise on plasma volume, plasma proteins, electrolytes, and fluid-regulating hormones. Int J Sports Med. 1989;10(4):270-4.
78. Mastorakos G, Pavlatou M, Diamanti-Kandaraki E, Chrousos GP. Exercise and the stress system. Hormones (Athens). 2005;4(2):73-89.
79. Park E, Chan O, Li Q, Kiraly M, Matthews SG, Vranic M, Riddell MC. Changes in basal hypothalamic-pituitary-adrenal activity during exercise are centrally mediated. Am J Physiol. 2005;289:R1360-71.
80. Hackney AC. Testosterone, the hypothalamo-pituitary-testicular axis and endurance exercise training: a review. Biology of Sport. 1996;13(2):85-98.
81. Fahrner CL, Hackney AC. Effects of exercise on the binding affinity of sex-hormone binding globulin for testosterone. Int J Sports Med. 1998;19(1):12-5.
82. Petersen AMW, Pedersen BK. The anti-inflammatory effect of exercise. J Appl Physiol. 2005;98:1154-62.
83. Febbraio MA, Pedersen BK. Contraction-induced myokine production and release: Is skeletal muscle an endocrine organ? Exerc Sport Sci Rev. 2005;33(3):114-9.
84. Nieman DC. Exercise effects on systemic immunity. Immunol Cell Biol. 2000;78:496-501.
85. Cody RJ. The sympathetic nervous system and the renin-angiotensin-aldosterone system in cardiovascular disease. Am J Cardiol. 1997;80(9B):9J-14J.
86. Convertino VA. Blood volume response to physical activity and inactivity. Am J Med Sci. 2007;334(1):72-9.
87. Daly W, Seegers CA, Rubin DA, Dobridge JD, Hackney AC. Relationship between stress hormones and testosterone with prolonged endurance exercise. Eur J Appl Physiol. 2005;93:375-80.
88. Ignacak A, Kasztelnik M, Sliwa T, Korbut RA, Rajda K, Guzik TJ. Prolactin-not only lactotrophin: A "new" view of the "old" hormone. J Physiol Pharmacol. 2012;63(5):435-43.
89. Dill DB, Costill DL. Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration. J Appl Physiol. 1974;2:247-8.
90. Sawka MN, Cheuvront SN, Kenefick RW. High skin temperature and hypohydration impair aerobic performance. Exp Physiol. 2012;97(3):327-32.
91. Walsh NP, Whitham M. Exercising in environmental extremes: a greater threat to immune function? Sports Med. 2006;36(11):941-76.
92. Hackney AC, Viru A. Twenty-four cortisol response to multiple daily exercise sessions of moderate and high intensity. Clin Physiol. 1999;19:178-82.
93. Hackney AC, Hodgdon JA, Hesslink R, Trygg K. Thyroid hormone responses to military winter activities in the Arctic Region. Arctic Med Res. 1995;54:82-90.
94. McMurray RG, Hackney AC. The endocrine system and exercise. In: Garrett W, editor. Exercise & sports science. New York: Lippincott Williams & Wilkins; 2000. p. 135-62.
95. Goodman HM. Endocrinology concepts for medical students. Adv Physiol Educ. 2001;25(1-4):213-24.
96. Redman LM, Loucks AB. Menstrual disorders in athletes. Sports Med. 2005;35(9):747-55
97. Hackney AC. Endurance exercise training and reproductive dysfunction in men: alterations in the hypo-thalamic-pituitary-testicular axis. Curr Pharm Des. 2001;7:261-73.
98. Hackney AC. Stress and the neuroendocrine system: the role of exercise as a stressor and modifier of stress. Expert Rev Endocrinol Metab. 2006;1(6):783-92.
99. Hackney AC, Szczepanowska E, Viru A. Basal testicular testosterone production in endurance-trained men is suppressed. Eur J Appl Physiol. 2003;89(2):198-201.
100. Hackney AC. The male reproductive system and endurance exercise. Med Sci Sports Exerc. 1996;28(2):180-9.
101. Hackney AC, Sharp RL, Runyan WS, Ness RJ. Relationship of resting prolactin and testosterone changes in males during intensive training. Br J Sports Med. 1989;23(3):194.
102. Hackney AC, Sinning WE, Bruot BC. Hypothalamic-pituitary-testicular axis function in endurance trained males. Int J Sports Med. 1990;11:298-303.
103. Maggi M, Buvat J, Corona G, Guay A, Torres LO. Hormonal causes of male sexual dysfunctions and their management (hyperprolactinemia, thyroid disorders, GH disorders, and DHEA). J Sex Med. 2013;10(3):661-77.
104. Simon JA. Low sexual desire-is it all in her head? Pathophysiology, diagnosis, and treatment of hypoactive sexual desire disorder. Postgrad Med. 2010;122(6):128-36.