메뉴 건너뛰기




Volumn 196, Issue 2, 2017, Pages 139-149

How do dual long-acting bronchodilators prevent exacerbations of chronic obstructive pulmonary disease?

(15)  Beeh, Kai M a   Burgel, Pierre Regis b   Franssen, Frits M E c   Lopez Campos, Jose Luis d,e   Loukides, Stelios f   Hurst, John R g   Fležar, Matjaž h   Ulrik, Charlotte Suppli i   Marco, Fabiano Di j   Stolz, Daiana k   Valipour, Arschang l   Casserly, Brian m,n   Ställberg, Björn o   Kostikas, Konstantinos p   Wedzicha, Jadwiga A q  


Author keywords

Hyperinflation; Inflammation; Inhaled corticosteroid; Mucus

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BRONCHODILATING AGENT; CHOLINERGIC RECEPTOR BLOCKING AGENT; CORTICOSTEROID; MUSCARINIC RECEPTOR; MUSCARINIC RECEPTOR BLOCKING AGENT;

EID: 85025154852     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201609-1794CI     Document Type: Review
Times cited : (68)

References (118)
  • 1
    • 34548290964 scopus 로고    scopus 로고
    • COPD exacerbations: Defining their cause and prevention
    • Wedzicha JA, Seemungal TA. COPD exacerbations: Defining their cause and prevention. Lancet 2007;370:786-796.
    • (2007) Lancet , vol.370 , pp. 786-796
    • Wedzicha, J.A.1    Seemungal, T.A.2
  • 2
    • 0036794862 scopus 로고    scopus 로고
    • Relationship between exacerbation frequency and lung function decline in chronic obstructive pulmonary disease
    • Donaldson GC, Seemungal TA, Bhowmik A, Wedzicha JA. Relationship between exacerbation frequency and lung function decline in chronic obstructive pulmonary disease. Thorax 2002;57:847-852.
    • (2002) Thorax , vol.57 , pp. 847-852
    • Donaldson, G.C.1    Seemungal, T.A.2    Bhowmik, A.3    Wedzicha, J.A.4
  • 3
    • 77951803863 scopus 로고    scopus 로고
    • Increased risk of myocardial infarction and stroke following exacerbation of COPD
    • Donaldson GC, Hurst JR, Smith CJ, Hubbard RB, Wedzicha JA. Increased risk of myocardial infarction and stroke following exacerbation of COPD. Chest 2010;137:1091-1097.
    • (2010) Chest , vol.137 , pp. 1091-1097
    • Donaldson, G.C.1    Hurst, J.R.2    Smith, C.J.3    Hubbard, R.B.4    Wedzicha, J.A.5
  • 5
    • 73449129243 scopus 로고    scopus 로고
    • Impact of frequency of COPD exacerbations on pulmonary function, health status and clinical outcomes
    • Anzueto A, Leimer I, Kesten S. Impact of frequency of COPD exacerbations on pulmonary function, health status and clinical outcomes. Int J Chron Obstruct Pulmon Dis 2009;4:245-251.
    • (2009) Int J Chron Obstruct Pulmon Dis , vol.4 , pp. 245-251
    • Anzueto, A.1    Leimer, I.2    Kesten, S.3
  • 7
    • 70350445133 scopus 로고    scopus 로고
    • Activities of life: The COPD patient
    • Bourbeau J. Activities of life: The COPD patient. COPD 2009;6:192-200.
    • (2009) COPD , vol.6 , pp. 192-200
    • Bourbeau, J.1
  • 8
    • 84868209480 scopus 로고    scopus 로고
    • Long-term natural history of chronic obstructive pulmonary disease: Severe exacerbations and mortality
    • Suissa S, Dell'Aniello S, Ernst P. Long-term natural history of chronic obstructive pulmonary disease: Severe exacerbations and mortality. Thorax 2012;67:957-963.
    • (2012) Thorax , vol.67 , pp. 957-963
    • Suissa, S.1    Dell'Aniello, S.2    Ernst, P.3
  • 10
    • 32644488381 scopus 로고    scopus 로고
    • Global Initiative for Chronic Obstructive Lung Disease. [updated 2015; accessed 2016 Jun 20]
    • Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management, and prevention of chronic obstructive lung disease; 2016 [updated 2015; accessed 2016 Jun 20]. Available from: Http://goldcopd.org/global-strategy-diagnosis-management-preventioncopd-2016/
    • (2016) Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease
  • 12
    • 64749104557 scopus 로고    scopus 로고
    • Cough and sputum production are associated with frequent exacerbations and hospitalizations in COPD subjects
    • Initiatives Bronchopneumopathie Chronique Obstructive Scientific Committee
    • Burgel PR, Nesme-Meyer P, Chanez P, Caillaud D, Carré P, Perez T, Roche N; Initiatives Bronchopneumopathie Chronique Obstructive Scientific Committee. Cough and sputum production are associated with frequent exacerbations and hospitalizations in COPD subjects. Chest 2009;135:975-982.
    • (2009) Chest , vol.135 , pp. 975-982
    • Burgel, P.R.1    Nesme-Meyer, P.2    Chanez, P.3    Caillaud, D.4    Carré, P.5    Perez, T.6    Roche, N.7
  • 14
    • 77956689733 scopus 로고    scopus 로고
    • Susceptibility to exacerbation in chronic obstructive pulmonary disease
    • Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Investigators
    • Hurst JR, Vestbo J, Anzueto A, Locantore N, Müllerova H, Tal-Singer R, Miller B, Lomas DA, Agusti A, Macnee W, et al.; Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Investigators. Susceptibility to exacerbation in chronic obstructive pulmonary disease. N Engl J Med 2010;363:1128-1138.
    • (2010) N Engl J Med , vol.363 , pp. 1128-1138
    • Hurst, J.R.1    Vestbo, J.2    Anzueto, A.3    Locantore, N.4    Müllerova, H.5    Tal-Singer, R.6    Miller, B.7    Lomas, D.A.8    Agusti, A.9    Macnee, W.10
  • 15
    • 33645573320 scopus 로고    scopus 로고
    • COPD exacerbations. 3: Pathophysiology
    • O'Donnell DE, Parker CM. COPD exacerbations. 3: Pathophysiology. Thorax 2006;61:354-361.
    • (2006) Thorax , vol.61 , pp. 354-361
    • O'Donnell, D.E.1    Parker, C.M.2
  • 16
    • 0034018102 scopus 로고    scopus 로고
    • Relation of sputum inflammatory markers to symptoms and lung function changes in COPD exacerbations
    • Bhowmik A, Seemungal TA, Sapsford RJ, Wedzicha JA. Relation of sputum inflammatory markers to symptoms and lung function changes in COPD exacerbations. Thorax 2000;55:114-120.
    • (2000) Thorax , vol.55 , pp. 114-120
    • Bhowmik, A.1    Seemungal, T.A.2    Sapsford, R.J.3    Wedzicha, J.A.4
  • 17
    • 84862100999 scopus 로고    scopus 로고
    • Persistent systemic inflammation is associated with poor clinical outcomes in COPD: A novel phenotype
    • Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Investigators
    • Agustí A, Edwards LD, Rennard SI, MacNee W, Tal-Singer R, Miller BE, Vestbo J, Lomas DA, Calverley PM, Wouters E, et al.; Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Investigators. Persistent systemic inflammation is associated with poor clinical outcomes in COPD: A novel phenotype. PLoS One 2012;7:e37483.
    • (2012) PLoS One , vol.7 , pp. e37483
    • Agustí, A.1    Edwards, L.D.2    Rennard, S.I.3    MacNee, W.4    Tal-Singer, R.5    Miller, B.E.6    Vestbo, J.7    Lomas, D.A.8    Calverley, P.M.9    Wouters, E.10
  • 18
    • 0036727140 scopus 로고    scopus 로고
    • Relationship between bacterial colonisation and the frequency, character, and severity of COPD exacerbations
    • Patel IS, Seemungal TA, Wilks M, Lloyd-Owen SJ, Donaldson GC, Wedzicha JA. Relationship between bacterial colonisation and the frequency, character, and severity of COPD exacerbations. Thorax 2002;57:759-764.
    • (2002) Thorax , vol.57 , pp. 759-764
    • Patel, I.S.1    Seemungal, T.A.2    Wilks, M.3    Lloyd-Owen, S.J.4    Donaldson, G.C.5    Wedzicha, J.A.6
  • 20
    • 84897532747 scopus 로고    scopus 로고
    • Prevalence and burden of breathlessness in patients with chronic obstructive pulmonary disease managed in primary care
    • Müllerová H, Lu C, Li H, Tabberer M. Prevalence and burden of breathlessness in patients with chronic obstructive pulmonary disease managed in primary care. PLoS One 2014;9:e85540.
    • (2014) PLoS One , vol.9 , pp. e85540
    • Müllerová, H.1    Lu, C.2    Li, H.3    Tabberer, M.4
  • 21
    • 84941736297 scopus 로고    scopus 로고
    • Associations between gastrooesophageal reflux, its management and exacerbations of chronic obstructive pulmonary disease
    • Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Investigators
    • Benson VS, Müllerová H, Vestbo J, Wedzicha JA, Patel A, Hurst JR; Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Investigators. Associations between gastrooesophageal reflux, its management and exacerbations of chronic obstructive pulmonary disease. Respir Med 2015;109:1147-1154.
    • (2015) Respir Med , vol.109 , pp. 1147-1154
    • Benson, V.S.1    Müllerová, H.2    Vestbo, J.3    Wedzicha, J.A.4    Patel, A.5    Hurst, J.R.6
  • 25
    • 0037425745 scopus 로고    scopus 로고
    • Combined salmeterol and fluticasone in the treatment of chronic obstructive pulmonary disease: A randomised controlled trial
    • TRial of Inhaled STeroids ANd long-acting beta2 agonists study group
    • Calverley P, Pauwels R, Vestbo J, Jones P, Pride N, Gulsvik A, Anderson J, Maden C; TRial of Inhaled STeroids ANd long-acting beta2 agonists study group. Combined salmeterol and fluticasone in the treatment of chronic obstructive pulmonary disease: A randomised controlled trial. Lancet 2003;361:449-456.
    • (2003) Lancet , vol.361 , pp. 449-456
    • Calverley, P.1    Pauwels, R.2    Vestbo, J.3    Jones, P.4    Pride, N.5    Gulsvik, A.6    Anderson, J.7    Maden, C.8
  • 26
    • 84855169766 scopus 로고    scopus 로고
    • Correlating changes in lung function with patient outcomes in chronic obstructive pulmonary disease: A pooled analysis
    • Jones PW, Donohue JF, Nedelman J, Pascoe S, Pinault G, Lassen C. Correlating changes in lung function with patient outcomes in chronic obstructive pulmonary disease: A pooled analysis. Respir Res 2011;12:161.
    • (2011) Respir Res , vol.12 , pp. 161
    • Jones, P.W.1    Donohue, J.F.2    Nedelman, J.3    Pascoe, S.4    Pinault, G.5    Lassen, C.6
  • 27
    • 84957094801 scopus 로고    scopus 로고
    • The lung function profile of once-daily tiotropium and olodaterol via Respimat(®) is superior to that of twice-daily salmeterol and fluticasone propionate via Accuhaler(®) (ENERGITO(®) study)
    • Beeh KM, Derom E, Echave-Sustaeta J, Grönke L, Hamilton A, Zhai D, Bjermer L. The lung function profile of once-daily tiotropium and olodaterol via Respimat(®) is superior to that of twice-daily salmeterol and fluticasone propionate via Accuhaler(®) (ENERGITO(®) study). Int J Chron Obstruct Pulmon Dis 2016;11:193-205.
    • (2016) Int J Chron Obstruct Pulmon Dis , vol.11 , pp. 193-205
    • Beeh, K.M.1    Derom, E.2    Echave-Sustaeta, J.3    Grönke, L.4    Hamilton, A.5    Zhai, D.6    Bjermer, L.7
  • 28
    • 84946575010 scopus 로고    scopus 로고
    • FLIGHT1 and FLIGHT2: Efficacy and safety of QVA149 (indacaterol/glycopyrrolate) versus its monocomponents and placebo in patients with chronic obstructive pulmonary disease
    • Mahler DA, Kerwin E, Ayers T, FowlerTaylor A, Maitra S, Thach C, Lloyd M, Patalano F, Banerji D. FLIGHT1 and FLIGHT2: Efficacy and safety of QVA149 (indacaterol/glycopyrrolate) versus its monocomponents and placebo in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2015;192:1068-1079.
    • (2015) Am J Respir Crit Care Med , vol.192 , pp. 1068-1079
    • Mahler, D.A.1    Kerwin, E.2    Ayers, T.3    FowlerTaylor, A.4    Maitra, S.5    Thach, C.6    Lloyd, M.7    Patalano, F.8    Banerji, D.9
  • 29
    • 84877131237 scopus 로고    scopus 로고
    • Analysis of chronic obstructive pulmonary disease exacerbations with the dual bronchodilator QVA149 compared with glycopyrronium and tiotropium (SPARK): A randomised, double-blind, parallel-group study
    • Wedzicha JA, Decramer M, Ficker JH, Niewoehner DE, Sandström T, Taylor AF, D'Andrea P, Arrasate C, Chen H, Banerji D. Analysis of chronic obstructive pulmonary disease exacerbations with the dual bronchodilator QVA149 compared with glycopyrronium and tiotropium (SPARK): A randomised, double-blind, parallel-group study. Lancet Respir Med 2013;1:199-209.
    • (2013) Lancet Respir Med , vol.1 , pp. 199-209
    • Wedzicha, J.A.1    Decramer, M.2    Ficker, J.H.3    Niewoehner, D.E.4    Sandström, T.5    Taylor, A.F.6    D'Andrea, P.7    Arrasate, C.8    Chen, H.9    Banerji, D.10
  • 33
    • 84960076299 scopus 로고    scopus 로고
    • Magnitude of umeclidinium/vilanterol lung function effect depends on monotherapy responses: Results from two randomised controlled trials
    • Donohue JF, Singh D, Munzu C, Kilbride S, Church A. Magnitude of umeclidinium/vilanterol lung function effect depends on monotherapy responses: Results from two randomised controlled trials. Respir Med 2016;112:65-74.
    • (2016) Respir Med , vol.112 , pp. 65-74
    • Donohue, J.F.1    Singh, D.2    Munzu, C.3    Kilbride, S.4    Church, A.5
  • 34
    • 84973623311 scopus 로고    scopus 로고
    • Pharmacological characterisation of the interaction between glycopyrronium bromide and indacaterol fumarate in human isolated bronchi, small airways and bronchial epithelial cells
    • Cazzola M, Calzetta L, Puxeddu E, Ora J, Facciolo F, Rogliani P, Matera MG. Pharmacological characterisation of the interaction between glycopyrronium bromide and indacaterol fumarate in human isolated bronchi, small airways and bronchial epithelial cells. Respir Res 2016;17:70.
    • (2016) Respir Res , vol.17 , pp. 70
    • Cazzola, M.1    Calzetta, L.2    Puxeddu, E.3    Ora, J.4    Facciolo, F.5    Rogliani, P.6    Matera, M.G.7
  • 35
    • 84942906853 scopus 로고    scopus 로고
    • Pharmacology of novel treatments for COPD: Are fixed dose combination LABA/LAMA synergistic?
    • [accessed 2017 May 3]
    • Spina D. Pharmacology of novel treatments for COPD: Are fixed dose combination LABA/LAMA synergistic?. Eur Clin Respir J 2015 [accessed 2017 May 3];2. Available from: Http://dx.doi.org/10.3402/ecrj.v2.26634
    • (2015) Eur Clin Respir J , vol.2
    • Spina, D.1
  • 36
    • 84879463930 scopus 로고    scopus 로고
    • M(2)-b(2) interaction: A basis for combined bronchodilator treatment
    • López-Campos JL. M(2)-b(2) interaction: A basis for combined bronchodilator treatment. Arch Bronconeumol 2013;49:279-281.
    • (2013) Arch Bronconeumol , vol.49 , pp. 279-281
    • López-Campos, J.L.1
  • 38
    • 0027358977 scopus 로고
    • Exertional breathlessness in patients with chronic airflow limitation: The role of lung hyperinflation
    • O'Donnell DE, Webb KA. Exertional breathlessness in patients with chronic airflow limitation: The role of lung hyperinflation. Am Rev Respir Dis 1993;148:1351-1357.
    • (1993) Am Rev Respir Dis , vol.148 , pp. 1351-1357
    • O'Donnell, D.E.1    Webb, K.A.2
  • 39
    • 0034128577 scopus 로고    scopus 로고
    • Physiological and symptom determinants of exercise performance in patients with chronic airway obstruction
    • Foglio K, Carone M, Pagani M, Bianchi L, Jones PW, Ambrosino N. Physiological and symptom determinants of exercise performance in patients with chronic airway obstruction. Respir Med 2000;94:256-263.
    • (2000) Respir Med , vol.94 , pp. 256-263
    • Foglio, K.1    Carone, M.2    Pagani, M.3    Bianchi, L.4    Jones, P.W.5    Ambrosino, N.6
  • 41
    • 0031888040 scopus 로고    scopus 로고
    • Right and left ventricular dysfunction in patients with severe pulmonary disease
    • Vizza CD, Lynch JP, Ochoa LL, Richardson G, Trulock EP. Right and left ventricular dysfunction in patients with severe pulmonary disease. Chest 1998;113:576-583.
    • (1998) Chest , vol.113 , pp. 576-583
    • Vizza, C.D.1    Lynch, J.P.2    Ochoa, L.L.3    Richardson, G.4    Trulock, E.P.5
  • 43
    • 24644518890 scopus 로고    scopus 로고
    • Physiological changes during symptom recovery from moderate exacerbations of COPD
    • Parker CM, Voduc N, Aaron SD, Webb KA, O'Donnell DE. Physiological changes during symptom recovery from moderate exacerbations of COPD. Eur Respir J 2005;26:420-428.
    • (2005) Eur Respir J , vol.26 , pp. 420-428
    • Parker, C.M.1    Voduc, N.2    Aaron, S.D.3    Webb, K.A.4    O'Donnell, D.E.5
  • 44
    • 33645526100 scopus 로고    scopus 로고
    • Hyperinflation, dyspnea, and exercise intolerance in chronic obstructive pulmonary disease
    • O'Donnell DE. Hyperinflation, dyspnea, and exercise intolerance in chronic obstructive pulmonary disease. Proc Am Thorac Soc 2006;3:180-184.
    • (2006) Proc Am Thorac Soc , vol.3 , pp. 180-184
    • O'Donnell, D.E.1
  • 45
    • 85014474079 scopus 로고    scopus 로고
    • Lung hyperinflation in COPD: Applying physiology to clinical practice
    • O'Donnell DE, Webb KA, Neder JA. Lung hyperinflation in COPD: Applying physiology to clinical practice. COPD Res and Practice 2015;1:4.
    • (2015) COPD Res and Practice , vol.1 , pp. 4
    • O'Donnell, D.E.1    Webb, K.A.2    Neder, J.A.3
  • 47
    • 84896080720 scopus 로고    scopus 로고
    • Effect of QVA149 on lung volumes and exercise tolerance in COPD patients: The BRIGHT study
    • Beeh KM, Korn S, Beier J, Jadayel D, Henley M, D'Andrea P, Banerji D. Effect of QVA149 on lung volumes and exercise tolerance in COPD patients: The BRIGHT study. Respir Med 2014;108:584-592.
    • (2014) Respir Med , vol.108 , pp. 584-592
    • Beeh, K.M.1    Korn, S.2    Beier, J.3    Jadayel, D.4    Henley, M.5    D'Andrea, P.6    Banerji, D.7
  • 48
    • 33749338192 scopus 로고    scopus 로고
    • Sensory-mechanical relationships during high-intensity, constant-work-rate exercise in COPD
    • O'Donnell DE, Hamilton AL, Webb KA. Sensory-mechanical relationships during high-intensity, constant-work-rate exercise in COPD. J Appl Physiol (1985) 2006;101:1025-1035.
    • (2006) J Appl Physiol (1985) , vol.101 , pp. 1025-1035
    • O'Donnell, D.E.1    Hamilton, A.L.2    Webb, K.A.3
  • 49
    • 60249085056 scopus 로고    scopus 로고
    • Long-acting beta2-agonists (LABA) in chronic obstructive pulmonary disease: Efficacy and safety
    • Rossi A, Khirani S, Cazzola M. Long-acting beta2-agonists (LABA) in chronic obstructive pulmonary disease: Efficacy and safety. Int J Chron Obstruct Pulmon Dis 2008;3:521-529.
    • (2008) Int J Chron Obstruct Pulmon Dis , vol.3 , pp. 521-529
    • Rossi, A.1    Khirani, S.2    Cazzola, M.3
  • 51
    • 84894777849 scopus 로고    scopus 로고
    • Efficacy and safety of coadministration of once-daily indacaterol and glycopyrronium versus indacaterol alone in COPD patients: The GLOW6 study
    • Vincken W, Aumann J, Chen H, Henley M, McBryan D, Goyal P. Efficacy and safety of coadministration of once-daily indacaterol and glycopyrronium versus indacaterol alone in COPD patients: The GLOW6 study. Int J Chron Obstruct Pulmon Dis 2014;9:215-228.
    • (2014) Int J Chron Obstruct Pulmon Dis , vol.9 , pp. 215-228
    • Vincken, W.1    Aumann, J.2    Chen, H.3    Henley, M.4    McBryan, D.5    Goyal, P.6
  • 52
    • 84922734756 scopus 로고    scopus 로고
    • Comparison of airway dimensions with once daily tiotropium plus indacaterol versus twice daily Advair(®) in chronic obstructive pulmonary disease
    • HoshinoM, Ohtawa J, Akitsu K. Comparison of airway dimensions with once daily tiotropium plus indacaterol versus twice daily Advair(®) in chronic obstructive pulmonary disease. Pulm Pharmacol Ther 2015;30:128-133.
    • (2015) Pulm Pharmacol Ther , vol.30 , pp. 128-133
    • Hoshino, M.1    Ohtawa, J.2    Akitsu, K.3
  • 54
    • 84865284777 scopus 로고    scopus 로고
    • Concurrent use of indacaterol plus tiotropium in patients with COPD provides superior bronchodilation compared with tiotropium alone: A randomised, double-blind comparison
    • INTRUST-1 and INTRUST-2 study investigators
    • Mahler DA, D'Urzo A, Bateman ED, Ozkan SA, White T, Peckitt C, Lassen C, Kramer B; INTRUST-1 and INTRUST-2 study investigators. Concurrent use of indacaterol plus tiotropium in patients with COPD provides superior bronchodilation compared with tiotropium alone: A randomised, double-blind comparison. Thorax 2012;67:781-788.
    • (2012) Thorax , vol.67 , pp. 781-788
    • Mahler, D.A.1    D'Urzo, A.2    Bateman, E.D.3    Ozkan, S.A.4    White, T.5    Peckitt, C.6    Lassen, C.7    Kramer, B.8
  • 55
    • 84901941194 scopus 로고    scopus 로고
    • The lungs need to be deflated: Effects of glycopyrronium on lung hyperinflation in COPD patients
    • Sanguinetti CM. The lungs need to be deflated: Effects of glycopyrronium on lung hyperinflation in COPD patients. Multidiscip Respir Med 2014;9:19.
    • (2014) Multidiscip Respir Med , vol.9 , pp. 19
    • Sanguinetti, C.M.1
  • 56
    • 84983334759 scopus 로고    scopus 로고
    • Does the term "deflators" reflect more accurately the beneficial effects of long-acting bronchodilators in COPD?
    • Kostikas K, Siafakas NM. Does the term "deflators" reflect more accurately the beneficial effects of long-acting bronchodilators in COPD?. COPD 2016;13:537-539.
    • (2016) COPD , vol.13 , pp. 537-539
    • Kostikas, K.1    Siafakas, N.M.2
  • 57
    • 77953028976 scopus 로고    scopus 로고
    • The short, the long and the "ultra-long": Why duration of bronchodilator action matters in chronic obstructive pulmonary disease
    • Beeh KM, Beier J. The short, the long and the "ultra-long": why duration of bronchodilator action matters in chronic obstructive pulmonary disease. Adv Ther 2010;27:150-159.
    • (2010) Adv Ther , vol.27 , pp. 150-159
    • Beeh, K.M.1    Beier, J.2
  • 59
    • 0029947193 scopus 로고    scopus 로고
    • Association of chronic mucus hypersecretion with FEV1 decline and chronic obstructive pulmonary disease morbidity
    • Copenhagen City Heart Study Group
    • Vestbo J, Prescott E, Lange P; Copenhagen City Heart Study Group. Association of chronic mucus hypersecretion with FEV1 decline and chronic obstructive pulmonary disease morbidity. Am J Respir Crit Care Med 1996;153:1530-1535.
    • (1996) Am J Respir Crit Care Med , vol.153 , pp. 1530-1535
    • Vestbo, J.1    Prescott, E.2    Lange, P.3
  • 60
    • 0038556973 scopus 로고    scopus 로고
    • Determinants of prognosis of COPD in the elderly: Mucus hypersecretion, infections, cardiovascular comorbidity
    • Pistelli R, Lange P, Miller DL. Determinants of prognosis of COPD in the elderly: Mucus hypersecretion, infections, cardiovascular comorbidity. Eur Respir J Suppl 2003;40:10s-14s.
    • (2003) Eur Respir J Suppl , vol.40 , pp. 10s-14s
    • Pistelli, R.1    Lange, P.2    Miller, D.L.3
  • 61
    • 73249145508 scopus 로고    scopus 로고
    • Association of impaired mucociliary clearance with occurrence of exacerbations in COPD
    • Siddiqi A, Berim I, Nabi H, Berenson CS, Sethi S. Association of impaired mucociliary clearance with occurrence of exacerbations in COPD. Am J Respir Crit Care Med 2009;179:A5350.
    • (2009) Am J Respir Crit Care Med , vol.179 , pp. A5350
    • Siddiqi, A.1    Berim, I.2    Nabi, H.3    Berenson, C.S.4    Sethi, S.5
  • 64
    • 84903891832 scopus 로고    scopus 로고
    • Targeting mucus hypersecretion: New therapeutic opportunities for COPD?
    • Martin C, Frija-Masson J, Burgel PR. Targeting mucus hypersecretion: new therapeutic opportunities for COPD?. Drugs 2014;74: 1073-1089.
    • (2014) Drugs , vol.74 , pp. 1073-1089
    • Martin, C.1    Frija-Masson, J.2    Burgel, P.R.3
  • 68
    • 84862516080 scopus 로고    scopus 로고
    • Ciliary beating is depressed in nasal cilia from chronic obstructive pulmonary disease subjects
    • Yaghi A, Zaman A, Cox G, Dolovich MB. Ciliary beating is depressed in nasal cilia from chronic obstructive pulmonary disease subjects. Respir Med 2012;106:1139-1147.
    • (2012) Respir Med , vol.106 , pp. 1139-1147
    • Yaghi, A.1    Zaman, A.2    Cox, G.3    Dolovich, M.B.4
  • 73
    • 84869219097 scopus 로고    scopus 로고
    • Prediction of the clinical course of chronic obstructive pulmonary disease, using the new GOLD classification: A study of the general population
    • Lange P, Marott JL, Vestbo J, Olsen KR, Ingebrigtsen TS, Dahl M, Nordestgaard BG. Prediction of the clinical course of chronic obstructive pulmonary disease, using the new GOLD classification: A study of the general population. Am J Respir Crit Care Med 2012; 186:975-981.
    • (2012) Am J Respir Crit Care Med , vol.186 , pp. 975-981
    • Lange, P.1    Marott, J.L.2    Vestbo, J.3    Olsen, K.R.4    Ingebrigtsen, T.S.5    Dahl, M.6    Nordestgaard, B.G.7
  • 75
  • 76
    • 84937553877 scopus 로고    scopus 로고
    • Differential effect of modified Medical Research Council Dyspnea, COPD Assessment Test, and Clinical COPD Questionnaire for symptoms evaluation within the new GOLD staging and mortality in COPD
    • COPD History Assessment in Spain (CHAIN) Cohort
    • Casanova C, Marin JM, Martinez-Gonzalez C, de Lucas-Ramos P, Mir-Viladrich I, Cosio B, Peces-Barba G, Solanes-García I, Agüero R, Feu-Collado N, et al.; COPD History Assessment in Spain (CHAIN) Cohort. Differential effect of modified Medical Research Council Dyspnea, COPD Assessment Test, and Clinical COPD Questionnaire for symptoms evaluation within the new GOLD staging and mortality in COPD. Chest 2015;148:159-168.
    • (2015) Chest , vol.148 , pp. 159-168
    • Casanova, C.1    Marin, J.M.2    Martinez-Gonzalez, C.3    De Lucas-Ramos, P.4    Mir-Viladrich, I.5    Cosio, B.6    Peces-Barba, G.7    Solanes-García, I.8    Agüero, R.9    Feu-Collado, N.10
  • 79
    • 84958166671 scopus 로고    scopus 로고
    • Efficacy and safety of long-acting b-agonist/long-acting muscarinic antagonist combinations in COPD: A network meta-analysis
    • Oba Y, Sarva ST, Dias S. Efficacy and safety of long-acting b-agonist/long-acting muscarinic antagonist combinations in COPD: A network meta-analysis. Thorax 2016;71:15-25.
    • (2016) Thorax , vol.71 , pp. 15-25
    • Oba, Y.1    Sarva, S.T.2    Dias, S.3
  • 81
    • 84861809353 scopus 로고    scopus 로고
    • Prediction and course of symptoms and lung function around an exacerbation in chronic obstructive pulmonary disease
    • COSMIC (COPD and Seretide: A Multi-Center Intervention and Characterization) study group
    • van den Berge M, Hop WC, van der Molen T, van Noord JA, Creemers JP, Schreurs AJ, Wouters EF, Postma DS; COSMIC (COPD and Seretide: A Multi-Center Intervention and Characterization) study group. Prediction and course of symptoms and lung function around an exacerbation in chronic obstructive pulmonary disease. Respir Res 2012;13:44.
    • (2012) Respir Res , vol.13 , pp. 44
    • Van Den Berge, M.1    Hop, W.C.2    Van Der Molen, T.3    Van Noord, J.A.4    Creemers, J.P.5    Schreurs, A.J.6    Wouters, E.F.7    Postma, D.S.8
  • 82
    • 84868590895 scopus 로고    scopus 로고
    • Detrended fluctuation analysis of peak expiratory flow and exacerbation frequency in COPD
    • Donaldson GC, Seemungal TA, Hurst JR, Wedzicha JA. Detrended fluctuation analysis of peak expiratory flow and exacerbation frequency in COPD. Eur Respir J 2012;40:1123-1129.
    • (2012) Eur Respir J , vol.40 , pp. 1123-1129
    • Donaldson, G.C.1    Seemungal, T.A.2    Hurst, J.R.3    Wedzicha, J.A.4
  • 83
    • 84996443987 scopus 로고    scopus 로고
    • Relationship between change in trough FEV1 and COPD patient outcomes: Pooled analysis of 23 clinical trials in patients with COPD
    • Donohue JF, Jones P, Bartels C, Marvel J, D'Andrea P, Banerji D, Patalano F, Fogel R. Relationship between change in trough FEV1 and COPD patient outcomes: Pooled analysis of 23 clinical trials in patients with COPD. Eur Respir J 2015;46:PA1013.
    • (2015) Eur Respir J , vol.46 , pp. PA1013
    • Donohue, J.F.1    Jones, P.2    Bartels, C.3    Marvel, J.4    D'Andrea, P.5    Banerji, D.6    Patalano, F.7    Fogel, R.8
  • 84
    • 0034988166 scopus 로고    scopus 로고
    • Inspiratory capacity, dynamic hyperinflation, breathlessness, and exercise performance during the 6-minute-walk test in chronic obstructive pulmonary disease
    • Marin JM, Carrizo SJ, Gascon M, Sanchez A, Gallego B, Celli BR. Inspiratory capacity, dynamic hyperinflation, breathlessness, and exercise performance during the 6-minute-walk test in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2001; 163:1395-1399.
    • (2001) Am J Respir Crit Care Med , vol.163 , pp. 1395-1399
    • Marin, J.M.1    Carrizo, S.J.2    Gascon, M.3    Sanchez, A.4    Gallego, B.5    Celli, B.R.6
  • 86
    • 3543055330 scopus 로고    scopus 로고
    • Effect of salmeterol on the ventilatory response to exercise in chronic obstructive pulmonary disease
    • O'Donnell DE, Voduc N, Fitzpatrick M, Webb KA. Effect of salmeterol on the ventilatory response to exercise in chronic obstructive pulmonary disease. Eur Respir J 2004;24:86-94.
    • (2004) Eur Respir J , vol.24 , pp. 86-94
    • O'Donnell, D.E.1    Voduc, N.2    Fitzpatrick, M.3    Webb, K.A.4
  • 88
    • 26944440146 scopus 로고    scopus 로고
    • Distribution of receptor targets in the lung
    • Barnes PJ. Distribution of receptor targets in the lung. Proc Am Thorac Soc 2004;1:345-351.
    • (2004) Proc Am Thorac Soc , vol.1 , pp. 345-351
    • Barnes, P.J.1
  • 89
    • 84925845564 scopus 로고    scopus 로고
    • Molecular mechanisms underlying b-adrenergic receptor-mediated cross-talk between sympathetic neurons and immune cells
    • Lorton D, Bellinger DL. Molecular mechanisms underlying b-adrenergic receptor-mediated cross-talk between sympathetic neurons and immune cells. Int J Mol Sci 2015;16:5635-5665.
    • (2015) Int J Mol Sci , vol.16 , pp. 5635-5665
    • Lorton, D.1    Bellinger, D.L.2
  • 90
    • 0035834825 scopus 로고    scopus 로고
    • Beta(2)-adrenergic receptor overexpression increases alveolar fluid clearance and responsiveness to endogenous catecholamines in rats
    • Dumasius V, Sznajder JI, Azzam ZS, Boja J, Mutlu GM, Maron MB, Factor P. beta(2)-adrenergic receptor overexpression increases alveolar fluid clearance and responsiveness to endogenous catecholamines in rats. Circ Res 2001;89:907-914.
    • (2001) Circ Res , vol.89 , pp. 907-914
    • Dumasius, V.1    Sznajder, J.I.2    Azzam, Z.S.3    Boja, J.4    Mutlu, G.M.5    Maron, M.B.6    Factor, P.7
  • 91
    • 84923874379 scopus 로고    scopus 로고
    • Acetylcholine beyond bronchoconstriction: Roles in inflammation and remodeling
    • Kistemaker LE, Gosens R. Acetylcholine beyond bronchoconstriction: Roles in inflammation and remodeling. Trends Pharmacol Sci 2015; 36:164-171.
    • (2015) Trends Pharmacol Sci , vol.36 , pp. 164-171
    • Kistemaker, L.E.1    Gosens, R.2
  • 93
    • 33745168973 scopus 로고    scopus 로고
    • Muscarinic receptor subtypes in neuronal and non-neuronal cholinergic function
    • Eglen RM. Muscarinic receptor subtypes in neuronal and non-neuronal cholinergic function. Auton Autacoid Pharmacol 2006;26:219-233.
    • (2006) Auton Autacoid Pharmacol , vol.26 , pp. 219-233
    • Eglen, R.M.1
  • 96
    • 79951951764 scopus 로고    scopus 로고
    • Inhibition of granulocyte migration by tiotropium bromide
    • Vacca G, Randerath WJ, Gillissen A. Inhibition of granulocyte migration by tiotropium bromide. Respir Res 2011;12:24.
    • (2011) Respir Res , vol.12 , pp. 24
    • Vacca, G.1    Randerath, W.J.2    Gillissen, A.3
  • 102
    • 84933042970 scopus 로고    scopus 로고
    • The longacting b2-adrenoceptor agonist olodaterol attenuates pulmonary inflammation
    • Wex E, Kollak I, Duechs MJ, Naline E, Wollin L, Devillier P. The longacting b2-adrenoceptor agonist olodaterol attenuates pulmonary inflammation. Br J Pharmacol 2015;172:3537-3547.
    • (2015) Br J Pharmacol , vol.172 , pp. 3537-3547
    • Wex, E.1    Kollak, I.2    Duechs, M.J.3    Naline, E.4    Wollin, L.5    Devillier, P.6
  • 104
    • 0036080175 scopus 로고    scopus 로고
    • Cyclic stretch upregulates interleukin-8 and transforming growth factorbeta1 production through a protein kinase C-dependent pathway in alveolar epithelial cells
    • Yamamoto H, Teramoto H, Uetani K, Igawa K, Shimizu E. Cyclic stretch upregulates interleukin-8 and transforming growth factorbeta1 production through a protein kinase C-dependent pathway in alveolar epithelial cells. Respirology 2002;7:103-109.
    • (2002) Respirology , vol.7 , pp. 103-109
    • Yamamoto, H.1    Teramoto, H.2    Uetani, K.3    Igawa, K.4    Shimizu, E.5
  • 105
    • 70349096803 scopus 로고    scopus 로고
    • Chronic intermittent mechanical stress increases MUC5AC protein expression
    • Park JA, Tschumperlin DJ. Chronic intermittent mechanical stress increases MUC5AC protein expression. Am J Respir Cell Mol Biol 2009;41:459-466.
    • (2009) Am J Respir Cell Mol Biol , vol.41 , pp. 459-466
    • Park, J.A.1    Tschumperlin, D.J.2
  • 107
    • 70350219119 scopus 로고    scopus 로고
    • Effect of fluticasone with and without salmeterol on pulmonary outcomes in chronic obstructive pulmonary disease: A randomized trial
    • Groningen Leiden Universities Corticosteroids in Obstructive Lung Disease Study Group
    • Lapperre TS, Snoeck-Stroband JB, Gosman MM, Jansen DF, van Schadewijk A, Thiadens HA, Vonk JM, Boezen HM, Ten Hacken NH, Sont JK, et al.; Groningen Leiden Universities Corticosteroids in Obstructive Lung Disease Study Group. Effect of fluticasone with and without salmeterol on pulmonary outcomes in chronic obstructive pulmonary disease: A randomized trial. Ann Intern Med 2009;151: 517-527.
    • (2009) Ann Intern Med , vol.151 , pp. 517-527
    • Lapperre, T.S.1    Snoeck-Stroband, J.B.2    Gosman, M.M.3    Jansen, D.F.4    Van Schadewijk, A.5    Thiadens, H.A.6    Vonk, J.M.7    Boezen, H.M.8    Ten Hacken, N.H.9    Sont, J.K.10
  • 109
    • 37849011194 scopus 로고    scopus 로고
    • The prevention of chronic obstructive pulmonary disease exacerbations by salmeterol/fluticasone propionate or tiotropium bromide
    • INSPIRE Investigators
    • Wedzicha JA, Calverley PM, Seemungal TA, Hagan G, Ansari Z, Stockley RA; INSPIRE Investigators. The prevention of chronic obstructive pulmonary disease exacerbations by salmeterol/fluticasone propionate or tiotropium bromide. Am J Respir Crit Care Med 2008;177:19-26.
    • (2008) Am J Respir Crit Care Med , vol.177 , pp. 19-26
    • Wedzicha, J.A.1    Calverley, P.M.2    Seemungal, T.A.3    Hagan, G.4    Ansari, Z.5    Stockley, R.A.6
  • 110
    • 84930866341 scopus 로고    scopus 로고
    • Blood eosinophil counts, exacerbations, and response to the addition of inhaled fluticasone furoate to vilanterol in patients with chronic obstructive pulmonary disease: A secondary analysis of data from two parallel randomised controlled trials
    • Pascoe S, Locantore N, Dransfield MT, Barnes NC, Pavord ID. Blood eosinophil counts, exacerbations, and response to the addition of inhaled fluticasone furoate to vilanterol in patients with chronic obstructive pulmonary disease: A secondary analysis of data from two parallel randomised controlled trials. Lancet Respir Med 2015; 3:435-442.
    • (2015) Lancet Respir Med , vol.3 , pp. 435-442
    • Pascoe, S.1    Locantore, N.2    Dransfield, M.T.3    Barnes, N.C.4    Pavord, I.D.5
  • 112
    • 42149166529 scopus 로고    scopus 로고
    • Superiority of "triple" therapy with salmeterol/fluticasone propionate and tiotropium bromide versus individual components in moderate to severe COPD
    • Singh D, Brooks J, Hagan G, Cahn A, O'Connor BJ. Superiority of "triple" therapy with salmeterol/fluticasone propionate and tiotropium bromide versus individual components in moderate to severe COPD. Thorax 2008;63:592-598.
    • (2008) Thorax , vol.63 , pp. 592-598
    • Singh, D.1    Brooks, J.2    Hagan, G.3    Cahn, A.4    O'Connor, B.J.5
  • 113
    • 84946839918 scopus 로고    scopus 로고
    • Triple therapy with salmeterol/fluticasone propionate 50/250 plus tiotropium bromide improve lung function versus individual treatments in moderate-to-severe Japanese COPD patients: A randomized controlled trial - Evaluation of Airway sGaw after treatment with tripLE
    • Saito T, Takeda A, Hashimoto K, Kobayashi A, Hayamizu T, Hagan GW. Triple therapy with salmeterol/fluticasone propionate 50/250 plus tiotropium bromide improve lung function versus individual treatments in moderate-to-severe Japanese COPD patients: A randomized controlled trial - Evaluation of Airway sGaw after treatment with tripLE. Int J Chron Obstruct Pulmon Dis 2015;10: 2393-2404.
    • (2015) Int J Chron Obstruct Pulmon Dis , vol.10 , pp. 2393-2404
    • Saito, T.1    Takeda, A.2    Hashimoto, K.3    Kobayashi, A.4    Hayamizu, T.5    Hagan, G.W.6
  • 114
    • 34247561439 scopus 로고    scopus 로고
    • Tiotropium in combination with placebo, salmeterol, or fluticasone-salmeterol for treatment of chronic obstructive pulmonary disease: A randomized trial
    • Canadian Thoracic Society/Canadian Respiratory Clinical Research Consortium
    • Aaron SD, Vandemheen KL, Fergusson D, Maltais F, Bourbeau J, Goldstein R, Balter M, O'Donnell D, McIvor A, Sharma S, et al.; Canadian Thoracic Society/Canadian Respiratory Clinical Research Consortium. Tiotropium in combination with placebo, salmeterol, or fluticasone-salmeterol for treatment of chronic obstructive pulmonary disease: A randomized trial. Ann Intern Med 2007;146:545-555.
    • (2007) Ann Intern Med , vol.146 , pp. 545-555
    • Aaron, S.D.1    Vandemheen, K.L.2    Fergusson, D.3    Maltais, F.4    Bourbeau, J.5    Goldstein, R.6    Balter, M.7    O'Donnell, D.8    McIvor, A.9    Sharma, S.10
  • 115
    • 84989195861 scopus 로고    scopus 로고
    • Single inhaler triple therapy versus inhaled corticosteroid plus long-acting b2-agonist therapy for chronic obstructive pulmonary disease (TRILOGY): A double-blind, parallel group, randomised controlled trial
    • Singh D, Papi A, Corradi M, Pavlišová I, Montagna I, Francisco C, Cohuet G, Vezzoli S, Scuri M, Vestbo J. Single inhaler triple therapy versus inhaled corticosteroid plus long-acting b2-agonist therapy for chronic obstructive pulmonary disease (TRILOGY): A double-blind, parallel group, randomised controlled trial. Lancet 2016;388:963-973.
    • (2016) Lancet , vol.388 , pp. 963-973
    • Singh, D.1    Papi, A.2    Corradi, M.3    Pavlišová, I.4    Montagna, I.5    Francisco, C.6    Cohuet, G.7    Vezzoli, S.8    Scuri, M.9    Vestbo, J.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.