KMT2A and KMT2B Mediate Memory Function by Affecting Distinct Genomic Regions

Cell Reports

Volumn 20, Issue 3, 2017, Pages 538-548

  Kerimoglu, Cemil ^a   Sakib, M Sadman ^a   Jain, Gaurav ^a   Benito, Eva ^a   Burkhardt, Susanne ^a   Capece, Vincenzo ^a   Kaurani, Lalit ^a   Halder, Rashi ^a,c   Agís Balboa, Roberto Carlos ^a,d   Stilling, Roman ^a,e   Urbanke, Hendrik ^a   Kranz, Andrea ^b   Stewart, A Francis ^b   Fischer, Andre ^a  

^a UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^b DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^c UNIVERSITY OF LUXEMBOURG   (Luxembourg)

^d CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED DE SALUD MENTAL CIBERSAM   (Spain)

^e GERMAN PRIMATE CENTER   (Germany)

Author keywords

Alzheimer's disease; ChIP seq; gene expression; hippocampus; histone methylation; Kmt2a; Kmt2b; memory; Mll1; Mll2; RNA seq

Indexed keywords

HISTONE METHYLTRANSFERASE; PROTEIN KMT2A; PROTEIN KMT2B; UNCLASSIFIED DRUG; HISTONE LYSINE METHYLTRANSFERASE; MIXED LINEAGE LEUKEMIA PROTEIN; MLL PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR ASSESSMENT; BRAIN NERVE CELL; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; ELEVATED PLUS MAZE TEST; FEAR CONDITIONING TEST; FEMALE; FORCED SWIM TEST; GENE EXPRESSION; HIPPOCAMPUS; HISTONE METHYLATION; MALE; MEMORY; MEMORY DISORDER; MORRIS WATER MAZE TEST; MOUSE; NERVE CELL PLASTICITY; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; METHYLATION; NERVE CELL;

ANIMALS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HIPPOCAMPUS; HISTONE-LYSINE N-METHYLTRANSFERASE; MEMORY; METHYLATION; MICE; MYELOID-LYMPHOID LEUKEMIA PROTEIN; NEURONS;

EID: 85025075807     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2017.06.072     Document Type: Article

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