Neuronal Kmt2a/Mll1 histone methyltransferase is essential for prefrontal synaptic plasticity and working memory

Journal of Neuroscience

Volumn 35, Issue 13, 2015, Pages 5097-5108

  Jakovcevski, Mira ^a,e   Ruan, Hongyu ^b   Shen, Erica Y ^a   Dincer, Aslihan ^a   Javidfar, Behnam ^a   Ma, Q ^a   Peter, Cyril J ^a   Cheung, Iris ^c   Mitchell, Amanda C ^b   Jiang, Yan ^a   Lin, Cong L ^a   Pothula, Venu ^a   Francis Stewart, A ^f   Ernst, Patricia ^d   Yao, Wei Dong ^b   Akbarian, Schahram ^a,c  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^d DARTMOUTH MEDICAL SCHOOL   (United States)

^e MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

^f DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

ChiP seq; Histone H3 lysine 4 methylation; Neuroepigenetics; Neuronal nuclei sorting; Short term plasticity; Working memory

Indexed keywords

HISTONE METHYLTRANSFERASE; MIXED LINEAGE LEUKEMIA 1; MIXED LINEAGE LEUKEMIA PROTEIN; TRANSCRIPTOME; UNCLASSIFIED DRUG; ACTIVITY REGULATED CYTOSKELETAL-ASSOCIATED PROTEIN; CYTOSKELETON PROTEIN; HISTONE LYSINE METHYLTRANSFERASE; HOMEODOMAIN PROTEIN; MLL PROTEIN, MOUSE; MRG1 PROTEIN, MOUSE; NERVE PROTEIN;

ADENO ASSOCIATED VIRUS 8; ANIMAL CELL; ANIMAL TISSUE; ANXIETY; ANXIETY ASSESSMENT; ARTICLE; BEHAVIOR ASSESSMENT; CELL SELECTION; CHROMATIN IMMUNOPRECIPITATION; COGNITIVE DEFECT; CONTROLLED STUDY; DOWN REGULATION; ELECTROPHYSIOLOGY; GENE EXPRESSION; GENOMICS; HISTONE METHYLATION; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MOTOR PERFORMANCE; MOUSE; MUTAGENESIS; NERVE CELL PLASTICITY; NONHUMAN; POLYMERASE CHAIN REACTION; PREFRONTAL CORTEX; PRIORITY JOURNAL; RADIAL ARM MAZE TEST; RNA ANALYSIS; SEQUENCE ANALYSIS; SPATIAL MEMORY; WORKING MEMORY; ANIMAL; ANIMAL BEHAVIOR; DRUG EFFECTS; FOREBRAIN; GENE SILENCING; GENETICS; MALE; METABOLISM; METHYLATION; MUTATION; PHYSIOLOGY; PYRAMIDAL NERVE CELL; SHORT TERM MEMORY; TRANSGENIC MOUSE;

ANIMALS; BEHAVIOR, ANIMAL; CYTOSKELETAL PROTEINS; GENE EXPRESSION; GENE KNOCKDOWN TECHNIQUES; HISTONE-LYSINE N-METHYLTRANSFERASE; HOMEODOMAIN PROTEINS; MALE; MEMORY, SHORT-TERM; METHYLATION; MICE; MICE, TRANSGENIC; MUTATION; MYELOID-LYMPHOID LEUKEMIA PROTEIN; NERVE TISSUE PROTEINS; NEURONAL PLASTICITY; PREFRONTAL CORTEX; PROSENCEPHALON; PYRAMIDAL CELLS;

EID: 84929346689     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3004-14.2015     Document Type: Article

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