Hyperglycemia Increases Interstitial Cells of Cajal via MAPK1 and MAPK3 Signaling to ETV1 and KIT, Leading to Rapid Gastric Emptying

Gastroenterology

Volumn 153, Issue 2, 2017, Pages 521-535.e20

  Hayashi, Yujiro ^a,b   Toyomasu, Yoshitaka ^a,b   Saravanaperumal, Siva Arumugam ^a,b   Bardsley, Michael R ^a,b   Smestad, John A ^b   Lorincz, Andrea ^a,b   Eisenman, Seth T ^a   Cipriani, Gianluca ^a   Nelson Holte, Molly H ^b   Al Khazal, Fatimah J ^b   Syed, Sabriya A ^a,b   Gajdos, Gabriella B ^a,b   Choi, Kyoung Moo ^a   Stoltz, Gary J ^a,b   Miller, Katie E ^a,b   Kendrick, Michael L ^a   Rubin, Brian P ^c   Gibbons, Simon J ^a,b   Bharucha, Adil E ^a   Linden, David R ^a,b   Maher, Louis James ^b   Farrugia, Gianrico ^a   Ordog, Tamas ^a,b   more..

^a MAYO CLINIC   (United States)

^b MAYO GRADUATE SCHOOL   (United States)

^c TAUSSIG CANCER INSTITUTE   (United States)

Author keywords

ERK; Gastrointestinal Motility; Mesenchymal Cells; Signal Transduction

Indexed keywords

BROXURIDINE; CASPASE 3; CASPASE 7; CELL PROTEIN; CRE RECOMBINASE; CYCLINE; LEPTIN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE KIT; SDHC PROTEIN; SUCCINATE DEHYDROGENASE; TRANSCRIPTION FACTOR ER81; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; ETV1 PROTEIN, MOUSE; STEM CELL FACTOR RECEPTOR; TRANSCRIPTION FACTOR;

ADULT; AEROBIC METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BREATH ANALYSIS; CELL COUNT; CELL GROWTH; CELL LINEAGE; CELL PROLIFERATION; CELL VIABILITY; COMPLEX FORMATION; CONTROLLED STUDY; DUMPING SYNDROME; ELECTROPHYSIOLOGY; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME PHOSPHORYLATION; ENZYME SUBUNIT; FEMALE; FLOW CYTOMETRY; GLUCOSE METABOLISM; HUMAN; HUMAN TISSUE; HYPERGLYCEMIA; HYPERINSULINEMIA; IMMUNOHISTOCHEMISTRY; INTERSTITIAL CELL OF CAJAL; METHYL THIAZOLYL TETRAZOLIUM ASSAY; MOLECULAR PATHOLOGY; MOUSE; MOUSE STRAIN; MUSCLE ISOMETRIC CONTRACTION; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OXIDATIVE STRESS; PRIMARY CULTURE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SMOOTH MUSCLE CONTRACTILITY; SOLID; STOMACH EMPTYING; UPREGULATION; WESTERN BLOTTING; YOUNG ADULT; ANIMAL; CYTOLOGY; GENETICS; MAPK SIGNALING; PATHOPHYSIOLOGY; PHYSIOLOGY;

ANIMALS; DNA-BINDING PROTEINS; FEMALE; GASTRIC EMPTYING; HUMANS; HYPERGLYCEMIA; INTERSTITIAL CELLS OF CAJAL; MAP KINASE SIGNALING SYSTEM; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PROTO-ONCOGENE PROTEINS C-KIT; RECEPTORS, LEPTIN; TRANSCRIPTION FACTORS; UP-REGULATION;

EID: 85024927473     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2017.04.020     Document Type: Article

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