Platelet-derived growth factor receptor-α regulates proliferation of gastrointestinal stromal tumor cells with mutations in KIT by stabilizing ETV1

Gastroenterology

Volumn 149, Issue 2, 2015, Pages 420-432.e16

  Hayashi, Yujiro ^a,b   Bardsley, Michael R ^a,b   Toyomasu, Yoshitaka ^a,b   Milosavljevic, Srdjan ^a,b   Gajdos, Gabriella B ^a,b   Choi, Kyoung Moo ^a   Reid Lombardo, Kmarie ^b   Kendrick, Michael L ^b   Bingener Casey, Juliane ^b   Tang, Chih Min ^c   Sicklick, Jason K ^c   Gibbons, Simon J ^a   Farrugia, Gianrico ^a,b   Taguchi, Takahiro ^d   Gupta, Anu ^e   Rubin, Brian P ^e   Fletcher, Jonathan A ^f   Ramachandran, Abhijit ^g   Ordog, Tamas ^a,b  

^a MAYO GRADUATE SCHOOL   (United States)

^b MAYO CLINIC   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d KOCHI UNIVERSITY   (Japan)

^e TAUSSIG CANCER INSTITUTE   (United States)

^f BRIGHAM AND WOMEN S HOSPITAL   (United States)

^g AROG Pharmaceuticals LLC   (United States)

Author keywords

Cancer; Receptor Tyrosine Kinase; Signal Transduction; Stem Cells

Indexed keywords

CRENOLANIB; IMATINIB; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PROTEIN TYROSINE KINASE; TRANSCRIPTION FACTOR ER81; UNCLASSIFIED DRUG; V KIT HARDY ZUCKERMAN 4 FELINE SARCOMA VIRAL ONCOGENE HOMOLOG; BENZAMIDE DERIVATIVE; BENZIMIDAZOLE DERIVATIVE; DNA BINDING PROTEIN; ETV1 PROTEIN, MOUSE; NUCLEIC ACID PRECURSOR; PIPERAZINE DERIVATIVE; PIPERIDINE DERIVATIVE; PYRIMIDINE DERIVATIVE; STEM CELL FACTOR RECEPTOR; TRANSCRIPTION FACTOR; TUMOR MARKER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER PATIENT; CANCER RESISTANCE; CELL NUCLEUS; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; FLOW CYTOMETRY; GASTROINTESTINAL STROMAL TUMOR; GENE MUTATION; GENE SILENCING; HETEROLOGOUS EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IC50; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INTERSTITIAL CELL OF CAJAL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; RNA INTERFERENCE; SIGNAL NOISE RATIO; SIGNAL TRANSDUCTION; SURGICAL PATIENT; ANIMAL; BAGG ALBINO MOUSE; GENETICS; METABOLISM; MUTATION; PHOSPHORYLATION; PROCEDURES; TUMOR CELL LINE;

ANIMALS; BENZAMIDES; BENZIMIDAZOLES; BIOMARKERS, TUMOR; CELL LINE, TUMOR; CELL PROLIFERATION; DNA-BINDING PROTEINS; FLOW CYTOMETRY; GASTROINTESTINAL STROMAL TUMORS; GENE KNOCKDOWN TECHNIQUES; HUMANS; IMATINIB MESYLATE; IMMUNOHISTOCHEMISTRY; MICE; MICE, INBRED BALB C; MUTATION; NUCLEIC ACID PRECURSORS; PHOSPHORYLATION; PIPERAZINES; PIPERIDINES; PROTO-ONCOGENE PROTEINS C-KIT; PYRIMIDINES; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR ALPHA; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR BETA; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 84938057222     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2015.04.006     Document Type: Article

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