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Volumn 69, Issue 9, 2017, Pages 1710-1721

Emerging Treatment Models in Rheumatology: Antiphospholipid Syndrome and Pregnancy: Pathogenesis to Translation

Author keywords

[No Author keywords available]

Indexed keywords

ANTICOAGULANT AGENT; ANTIINFLAMMATORY AGENT; AUTACOID; COMPLEMENT; INTERFERON; MICRORNA; MICRORNA 146A 3P; PHOSPHOLIPID ANTIBODY; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; URIC ACID;

EID: 85024858233     PISSN: 23265191     EISSN: 23265205     Source Type: Journal    
DOI: 10.1002/art.40136     Document Type: Review
Times cited : (78)

References (87)
  • 1
    • 33344458573 scopus 로고    scopus 로고
    • International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS)
    • Miyakis S, Lockshin MD, Atsumi T, Branch DW, Brey RL, Cervera R, et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost 2006;4:295–306.
    • (2006) J Thromb Haemost , vol.4 , pp. 295-306
    • Miyakis, S.1    Lockshin, M.D.2    Atsumi, T.3    Branch, D.W.4    Brey, R.L.5    Cervera, R.6
  • 2
    • 84863197776 scopus 로고    scopus 로고
    • Prediction of adverse pregnancy outcome by the presence of lupus anticoagulant, but not anticardiolipin antibody, in patients with antiphospholipid antibodies
    • Lockshin MD, Kim M, Laskin CA, Guerra M, Branch DW, Merrill J, et al. Prediction of adverse pregnancy outcome by the presence of lupus anticoagulant, but not anticardiolipin antibody, in patients with antiphospholipid antibodies. Arthritis Rheum 2012;64:2311–8.
    • (2012) Arthritis Rheum , vol.64 , pp. 2311-2318
    • Lockshin, M.D.1    Kim, M.2    Laskin, C.A.3    Guerra, M.4    Branch, D.W.5    Merrill, J.6
  • 3
    • 85015780849 scopus 로고    scopus 로고
    • Antiphospholipid antibody profile based obstetric outcomes of primary antiphospholipid syndrome: the PREGNANTS study
    • E-pub ahead of print
    • Saccone G, Berghella V, Maruotti GM, Ghi T, Rizzo G, Simonazzi G, et al. Antiphospholipid antibody profile based obstetric outcomes of primary antiphospholipid syndrome: the PREGNANTS study. Am J Obstet Gynecol 2017. E-pub ahead of print.
    • (2017) Am J Obstet Gynecol
    • Saccone, G.1    Berghella, V.2    Maruotti, G.M.3    Ghi, T.4    Rizzo, G.5    Simonazzi, G.6
  • 5
    • 0036228886 scopus 로고    scopus 로고
    • Antiphospholipid syndrome: clinical and immunologic manifestations and patterns of disease expression in a cohort of 1,000 patients
    • Cervera R, Piette JC, Font J, Khamashta MA, Shoenfeld Y, Camps MT, et al. Antiphospholipid syndrome: clinical and immunologic manifestations and patterns of disease expression in a cohort of 1,000 patients. Arthritis Rheum 2002;46:1019–27.
    • (2002) Arthritis Rheum , vol.46 , pp. 1019-1027
    • Cervera, R.1    Piette, J.C.2    Font, J.3    Khamashta, M.A.4    Shoenfeld, Y.5    Camps, M.T.6
  • 6
    • 84902193546 scopus 로고    scopus 로고
    • 14th International Congress on Antiphospholipid Antibodies Task Force report on obstetric antiphospholipid syndrome
    • De Jesus GR, Agmon-Levin N, Andrade CA, Andreoli L, Chighizola CB, Porter TF, et al. 14th International Congress on Antiphospholipid Antibodies Task Force report on obstetric antiphospholipid syndrome. Autoimmun Rev 2014;13:795–813.
    • (2014) Autoimmun Rev , vol.13 , pp. 795-813
    • De Jesus, G.R.1    Agmon-Levin, N.2    Andrade, C.A.3    Andreoli, L.4    Chighizola, C.B.5    Porter, T.F.6
  • 7
    • 84921048179 scopus 로고    scopus 로고
    • Prevalence of antiphospholipid antibodies and risk of subsequent adverse obstetric outcomes in women with prior pregnancy loss
    • Bowman ZS, Wunsche V, Porter TF, Silver RM, Branch DW. Prevalence of antiphospholipid antibodies and risk of subsequent adverse obstetric outcomes in women with prior pregnancy loss. J Reprod Immunol 2015;107:59–63.
    • (2015) J Reprod Immunol , vol.107 , pp. 59-63
    • Bowman, Z.S.1    Wunsche, V.2    Porter, T.F.3    Silver, R.M.4    Branch, D.W.5
  • 9
    • 70349880351 scopus 로고    scopus 로고
    • Mechanisms of antiphospholipid antibody-associated pregnancy complications
    • Abrahams VM. Mechanisms of antiphospholipid antibody-associated pregnancy complications. Thromb Res 2009;124:521–5.
    • (2009) Thromb Res , vol.124 , pp. 521-525
    • Abrahams, V.M.1
  • 10
    • 84925202181 scopus 로고    scopus 로고
    • Histopathology in the placentae of women with antiphospholipid antibodies: a systematic review of the literature
    • Viall CA, Chamley LW. Histopathology in the placentae of women with antiphospholipid antibodies: a systematic review of the literature. Autoimmun Rev 2015;14:446–71.
    • (2015) Autoimmun Rev , vol.14 , pp. 446-471
    • Viall, C.A.1    Chamley, L.W.2
  • 11
    • 33746500163 scopus 로고    scopus 로고
    • The uterine spiral arteries in human pregnancy: facts and controversies
    • Pijnenborg R, Vercruysse L, Hanssens M. The uterine spiral arteries in human pregnancy: facts and controversies. Placenta 2006;27:939–58.
    • (2006) Placenta , vol.27 , pp. 939-958
    • Pijnenborg, R.1    Vercruysse, L.2    Hanssens, M.3
  • 12
    • 0014029050 scopus 로고
    • Trophoblast in human utero-placental arteries
    • Hamilton WJ, Boyd JD. Trophoblast in human utero-placental arteries. Nature 1966;212:906–8.
    • (1966) Nature , vol.212 , pp. 906-908
    • Hamilton, W.J.1    Boyd, J.D.2
  • 13
    • 67349192531 scopus 로고    scopus 로고
    • Rheological and physiological consequences of conversion of the maternal spiral arteries for uteroplacental blood flow during human pregnancy
    • Burton GJ, Woods AW, Jauniaux E, Kingdom JC. Rheological and physiological consequences of conversion of the maternal spiral arteries for uteroplacental blood flow during human pregnancy. Placenta 2009;30:473–82.
    • (2009) Placenta , vol.30 , pp. 473-482
    • Burton, G.J.1    Woods, A.W.2    Jauniaux, E.3    Kingdom, J.C.4
  • 14
    • 60249089098 scopus 로고    scopus 로고
    • The two stage model of preeclampsia: variations on the theme
    • Roberts JM, Hubel CA. The two stage model of preeclampsia: variations on the theme. Placenta 2009;30 Suppl A:S32–7.
    • (2009) Placenta , vol.30 , pp. S32-S37
    • Roberts, J.M.1    Hubel, C.A.2
  • 15
    • 0037373006 scopus 로고    scopus 로고
    • Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia
    • Maynard SE, Min JY, Merchan J, Lim KH, Li J, Mondal S, et al. Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J Clin Invest 2003;111:649–58.
    • (2003) J Clin Invest , vol.111 , pp. 649-658
    • Maynard, S.E.1    Min, J.Y.2    Merchan, J.3    Lim, K.H.4    Li, J.5    Mondal, S.6
  • 16
    • 79959507759 scopus 로고    scopus 로고
    • Preeclampsia, a disease of the maternal endothelium: the role of antiangiogenic factors and implications for later cardiovascular disease
    • Powe CE, Levine RJ, Karumanchi SA. Preeclampsia, a disease of the maternal endothelium: the role of antiangiogenic factors and implications for later cardiovascular disease. Circulation 2011;123:2856–69.
    • (2011) Circulation , vol.123 , pp. 2856-2869
    • Powe, C.E.1    Levine, R.J.2    Karumanchi, S.A.3
  • 19
    • 33748421660 scopus 로고    scopus 로고
    • Soluble endoglin and other circulating antiangiogenic factors in preeclampsia
    • Levine RJ, Lam C, Qian C, Yu KF, Maynard SE, Sachs BP, et al. Soluble endoglin and other circulating antiangiogenic factors in preeclampsia. N Engl J Med 2006;355:992–1005.
    • (2006) N Engl J Med , vol.355 , pp. 992-1005
    • Levine, R.J.1    Lam, C.2    Qian, C.3    Yu, K.F.4    Maynard, S.E.5    Sachs, B.P.6
  • 20
    • 77955417702 scopus 로고    scopus 로고
    • Prospective study of placental angiogenic factors and maternal vascular function before and after preeclampsia and gestational hypertension
    • Noori M, Donald AE, Angelakopoulou A, Hingorani AD, Williams DJ. Prospective study of placental angiogenic factors and maternal vascular function before and after preeclampsia and gestational hypertension. Circulation 2010;122:478–87.
    • (2010) Circulation , vol.122 , pp. 478-487
    • Noori, M.1    Donald, A.E.2    Angelakopoulou, A.3    Hingorani, A.D.4    Williams, D.J.5
  • 21
    • 0036114404 scopus 로고    scopus 로고
    • Vascular endothelial growth factor ligands and receptors that regulate human cytotrophoblast survival are dysregulated in severe preeclampsia and hemolysis, elevated liver enzymes, and low platelets syndrome
    • Zhou Y, McMaster M, Woo K, Janatpour M, Perry J, Karpanen T, et al. Vascular endothelial growth factor ligands and receptors that regulate human cytotrophoblast survival are dysregulated in severe preeclampsia and hemolysis, elevated liver enzymes, and low platelets syndrome. Am J Pathol 2002;160:1405–23.
    • (2002) Am J Pathol , vol.160 , pp. 1405-1423
    • Zhou, Y.1    McMaster, M.2    Woo, K.3    Janatpour, M.4    Perry, J.5    Karpanen, T.6
  • 22
    • 0030610220 scopus 로고    scopus 로고
    • Synthesis of β2 glycoprotein 1 by the human placenta
    • Chamley LW, Allen JL, Johnson PM. Synthesis of β2 glycoprotein 1 by the human placenta. Placenta 1997;18:403–10.
    • (1997) Placenta , vol.18 , pp. 403-410
    • Chamley, L.W.1    Allen, J.L.2    Johnson, P.M.3
  • 23
    • 84888206002 scopus 로고    scopus 로고
    • Antiphospholipid antibodies internalised by human syncytiotrophoblast cause aberrant cell death and the release of necrotic trophoblast debris
    • Viall CA, Chen Q, Liu B, Hickey A, Snowise S, Salmon JE, et al. Antiphospholipid antibodies internalised by human syncytiotrophoblast cause aberrant cell death and the release of necrotic trophoblast debris. J Autoimmun 2013;47:45–57.
    • (2013) J Autoimmun , vol.47 , pp. 45-57
    • Viall, C.A.1    Chen, Q.2    Liu, B.3    Hickey, A.4    Snowise, S.5    Salmon, J.E.6
  • 24
    • 84978946940 scopus 로고    scopus 로고
    • Human extravillous trophoblasts bind but do not internalize antiphospholipid antibodies
    • Viall CA, Chen Q, Stone PR, Chamley LW. Human extravillous trophoblasts bind but do not internalize antiphospholipid antibodies. Placenta 2016;42:9–16.
    • (2016) Placenta , vol.42 , pp. 9-16
    • Viall, C.A.1    Chen, Q.2    Stone, P.R.3    Chamley, L.W.4
  • 25
    • 67650651969 scopus 로고    scopus 로고
    • Antiphospholipid antibodies induce a pro-inflammatory response in first trimester trophoblast via the TLR4/MyD88 pathway
    • Mulla MJ, Brosens JJ, Chamley LW, Giles I, Pericleous C, Rahman A, et al. Antiphospholipid antibodies induce a pro-inflammatory response in first trimester trophoblast via the TLR4/MyD88 pathway. Am J Reprod Immunol 2009;62:96–111.
    • (2009) Am J Reprod Immunol , vol.62 , pp. 96-111
    • Mulla, M.J.1    Brosens, J.J.2    Chamley, L.W.3    Giles, I.4    Pericleous, C.5    Rahman, A.6
  • 27
    • 80052564643 scopus 로고    scopus 로고
    • Modulation of trophoblast angiogenic factor secretion by antiphospholipid antibodies is not reversed by heparin
    • Carroll TY, Mulla MJ, Han CS, Brosens JJ, Chamley LW, Giles I, et al. Modulation of trophoblast angiogenic factor secretion by antiphospholipid antibodies is not reversed by heparin. Am J Reprod Immunol 2011;66:286–96.
    • (2011) Am J Reprod Immunol , vol.66 , pp. 286-296
    • Carroll, T.Y.1    Mulla, M.J.2    Han, C.S.3    Brosens, J.J.4    Chamley, L.W.5    Giles, I.6
  • 28
    • 84922825148 scopus 로고    scopus 로고
    • Aspirin-triggered lipoxin prevents antiphospholipid antibody effects on human trophoblast migration and endothelial cell interactions
    • Alvarez AM, Mulla MJ, Chamley LW, Cadavid AP, Abrahams VM. Aspirin-triggered lipoxin prevents antiphospholipid antibody effects on human trophoblast migration and endothelial cell interactions. Arthritis Rheumatol 2015;67:488–97.
    • (2015) Arthritis Rheumatol , vol.67 , pp. 488-497
    • Alvarez, A.M.1    Mulla, M.J.2    Chamley, L.W.3    Cadavid, A.P.4    Abrahams, V.M.5
  • 29
    • 84878810794 scopus 로고    scopus 로고
    • A role for uric acid and the Nalp3 inflammasome in antiphospholipid antibody-induced IL-1β production by human first trimester trophoblast
    • Mulla MJ, Salmon JE, Chamley LW, Brosens JJ, Boeras CM, Kavathas PB, et al. A role for uric acid and the Nalp3 inflammasome in antiphospholipid antibody-induced IL-1β production by human first trimester trophoblast. PLoS One 2013;8:e65237.
    • (2013) PLoS One , vol.8
    • Mulla, M.J.1    Salmon, J.E.2    Chamley, L.W.3    Brosens, J.J.4    Boeras, C.M.5    Kavathas, P.B.6
  • 30
    • 84978632067 scopus 로고    scopus 로고
    • Antiphospholipid antibody-induced miR-146a-3p drives trophoblast interleukin-8 secretion through activation of Toll-like receptor 8
    • Gysler SM, Mulla MJ, Guerra M, Brosens JJ, Salmon JE, Chamley LW, et al. Antiphospholipid antibody-induced miR-146a-3p drives trophoblast interleukin-8 secretion through activation of Toll-like receptor 8. Mol Hum Reprod 2016 Jul;22:465–74.
    • (2016) Mol Hum Reprod , vol.22 , pp. 465-474
    • Gysler, S.M.1    Mulla, M.J.2    Guerra, M.3    Brosens, J.J.4    Salmon, J.E.5    Chamley, L.W.6
  • 31
    • 84963800435 scopus 로고    scopus 로고
    • ApoE receptor 2 mediation of trophoblast dysfunction and pregnancy complications induced by antiphospholipid antibodies in mice
    • Ulrich V, Gelber SE, Vukelic M, Sacharidou A, Herz J, Urbanus RT, et al. ApoE receptor 2 mediation of trophoblast dysfunction and pregnancy complications induced by antiphospholipid antibodies in mice. Arthritis Rheumatol 2016;68:730–9.
    • (2016) Arthritis Rheumatol , vol.68 , pp. 730-739
    • Ulrich, V.1    Gelber, S.E.2    Vukelic, M.3    Sacharidou, A.4    Herz, J.5    Urbanus, R.T.6
  • 32
    • 0038335391 scopus 로고    scopus 로고
    • Hypoxia favours necrotic versus apoptotic shedding of placental syncytiotrophoblast into the maternal circulation
    • Huppertz B, Kingdom J, Caniggia I, Desoye G, Black S, Korr H, et al. Hypoxia favours necrotic versus apoptotic shedding of placental syncytiotrophoblast into the maternal circulation. Placenta 2003;24:181–90.
    • (2003) Placenta , vol.24 , pp. 181-190
    • Huppertz, B.1    Kingdom, J.2    Caniggia, I.3    Desoye, G.4    Black, S.5    Korr, H.6
  • 33
    • 84996917456 scopus 로고    scopus 로고
    • Increased levels of HMGB1 in trophoblastic debris may contribute to preeclampsia
    • Shao J, Zhao M, Tong M, Wei J, Wise MR, Stone P, et al. Increased levels of HMGB1 in trophoblastic debris may contribute to preeclampsia. Reproduction 2016;152:775–84.
    • (2016) Reproduction , vol.152 , pp. 775-784
    • Shao, J.1    Zhao, M.2    Tong, M.3    Wei, J.4    Wise, M.R.5    Stone, P.6
  • 34
    • 84979912173 scopus 로고    scopus 로고
    • Trophoblastic debris modifies endothelial cell transcriptome in vitro: a mechanism by which fetal cells might control maternal responses to pregnancy
    • Wei J, Lau SY, Blenkiron C, Chen Q, James JL, Kleffmann T, et al. Trophoblastic debris modifies endothelial cell transcriptome in vitro: a mechanism by which fetal cells might control maternal responses to pregnancy. Sci Rep 2016;6:30632.
    • (2016) Sci Rep , vol.6 , pp. 30632
    • Wei, J.1    Lau, S.Y.2    Blenkiron, C.3    Chen, Q.4    James, J.L.5    Kleffmann, T.6
  • 35
    • 84902107289 scopus 로고    scopus 로고
    • Hydroxychloroquine restores trophoblast fusion affected by antiphospholipid antibodies
    • Marchetti T, Ruffatti A, Wuillemin C, de Moerloose P, Cohen M. Hydroxychloroquine restores trophoblast fusion affected by antiphospholipid antibodies. J Thromb Haemost 2014;12:910–20.
    • (2014) J Thromb Haemost , vol.12 , pp. 910-920
    • Marchetti, T.1    Ruffatti, A.2    Wuillemin, C.3    de Moerloose, P.4    Cohen, M.5
  • 36
    • 34249871684 scopus 로고    scopus 로고
    • Placental ABCA1 expression is reduced in primary antiphospholipid syndrome compared to pre-eclampsia and controls
    • Albrecht C, Soumian S, Tetlow N, Patel P, Sullivan MH, Lakasing L, et al. Placental ABCA1 expression is reduced in primary antiphospholipid syndrome compared to pre-eclampsia and controls. Placenta 2007;28:701–8.
    • (2007) Placenta , vol.28 , pp. 701-708
    • Albrecht, C.1    Soumian, S.2    Tetlow, N.3    Patel, P.4    Sullivan, M.H.5    Lakasing, L.6
  • 37
    • 0037148520 scopus 로고    scopus 로고
    • Complement C3 activation is required for antiphospholipid antibody-induced fetal loss
    • Holers VM, Girardi G, Mo L, Guthridge JM, Molina H, Pierangeli SS, et al. Complement C3 activation is required for antiphospholipid antibody-induced fetal loss. J Exp Med 2002;195:211–20.
    • (2002) J Exp Med , vol.195 , pp. 211-220
    • Holers, V.M.1    Girardi, G.2    Mo, L.3    Guthridge, J.M.4    Molina, H.5    Pierangeli, S.S.6
  • 38
    • 0346969977 scopus 로고    scopus 로고
    • Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome
    • Girardi G, Berman J, Redecha P, Spruce L, Thurman JM, Kraus D, et al. Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome. J Clin Invest 2003;112:1644–54.
    • (2003) J Clin Invest , vol.112 , pp. 1644-1654
    • Girardi, G.1    Berman, J.2    Redecha, P.3    Spruce, L.4    Thurman, J.M.5    Kraus, D.6
  • 39
    • 10844288801 scopus 로고    scopus 로고
    • TNF-α is a critical effector and a target for therapy in antiphospholipid antibody-induced pregnancy loss
    • Berman J, Girardi G, Salmon JE. TNF-α is a critical effector and a target for therapy in antiphospholipid antibody-induced pregnancy loss. J Immunol 2005;174:485–90.
    • (2005) J Immunol , vol.174 , pp. 485-490
    • Berman, J.1    Girardi, G.2    Salmon, J.E.3
  • 40
    • 33748450585 scopus 로고    scopus 로고
    • Complement activation induces dysregulation of angiogenic factors and causes fetal rejection and growth restriction
    • Girardi G, Yarilin D, Thurman JM, Holers VM, Salmon JE. Complement activation induces dysregulation of angiogenic factors and causes fetal rejection and growth restriction. J Exp Med 2006;203:2165–75.
    • (2006) J Exp Med , vol.203 , pp. 2165-2175
    • Girardi, G.1    Yarilin, D.2    Thurman, J.M.3    Holers, V.M.4    Salmon, J.E.5
  • 41
    • 84937717879 scopus 로고    scopus 로고
    • Prevention of defective placentation and pregnancy loss by blocking innate immune pathways in a syngeneic model of placental insufficiency
    • Gelber SE, Brent E, Redecha P, Perino G, Tomlinson S, Davisson RL, et al. Prevention of defective placentation and pregnancy loss by blocking innate immune pathways in a syngeneic model of placental insufficiency. J Immunol 2015;195:1129–38.
    • (2015) J Immunol , vol.195 , pp. 1129-1138
    • Gelber, S.E.1    Brent, E.2    Redecha, P.3    Perino, G.4    Tomlinson, S.5    Davisson, R.L.6
  • 42
    • 84946099830 scopus 로고    scopus 로고
    • Release of neutrophil extracellular traps by neutrophils stimulated with antiphospholipid antibodies: a newly identified mechanism of thrombosis in the antiphospholipid syndrome
    • Yalavarthi S, Gould TJ, Rao AN, Mazza LF, Morris AE, Nunez-Alvarez C, et al. Release of neutrophil extracellular traps by neutrophils stimulated with antiphospholipid antibodies: a newly identified mechanism of thrombosis in the antiphospholipid syndrome. Arthritis Rheumatol 2015;67:2990–3003.
    • (2015) Arthritis Rheumatol , vol.67 , pp. 2990-3003
    • Yalavarthi, S.1    Gould, T.J.2    Rao, A.N.3    Mazza, L.F.4    Morris, A.E.5    Nunez-Alvarez, C.6
  • 43
    • 85007218050 scopus 로고    scopus 로고
    • Placental histology and neutrophil extracellular traps in lupus and pre-eclampsia pregnancies
    • Marder W, Knight JS, Kaplan MJ, Somers EC, Zhang X, O'Dell AA, et al. Placental histology and neutrophil extracellular traps in lupus and pre-eclampsia pregnancies. Lupus Sci Med 2016;3:e000134.
    • (2016) Lupus Sci Med , vol.3
    • Marder, W.1    Knight, J.S.2    Kaplan, M.J.3    Somers, E.C.4    Zhang, X.5    O'Dell, A.A.6
  • 44
    • 9144243607 scopus 로고    scopus 로고
    • Heparin prevents antiphospholipid antibody-induced fetal loss by inhibiting complement activation
    • Girardi G, Redecha P, Salmon JE. Heparin prevents antiphospholipid antibody-induced fetal loss by inhibiting complement activation. Nat Med 2004;10:1222–6.
    • (2004) Nat Med , vol.10 , pp. 1222-1226
    • Girardi, G.1    Redecha, P.2    Salmon, J.E.3
  • 45
    • 33846930928 scopus 로고    scopus 로고
    • Excessive complement activation is associated with placental injury in patients with antiphospholipid antibodies
    • Shamonki JM, Salmon JE, Hyjek E, Baergen RN. Excessive complement activation is associated with placental injury in patients with antiphospholipid antibodies. Am J Obstet Gynecol 2007;196:167e1–5.
    • (2007) Am J Obstet Gynecol , vol.196 , pp. 167e1-167e5
    • Shamonki, J.M.1    Salmon, J.E.2    Hyjek, E.3    Baergen, R.N.4
  • 46
    • 79960450137 scopus 로고    scopus 로고
    • Classical complement activation as a footprint for murine and human antiphospholipid antibody-induced fetal loss
    • Cohen D, Buurma A, Goemaere NN, Girardi G, le Cessie S, Scherjon S, et al. Classical complement activation as a footprint for murine and human antiphospholipid antibody-induced fetal loss. J Pathol 2011;225:502–11.
    • (2011) J Pathol , vol.225 , pp. 502-511
    • Cohen, D.1    Buurma, A.2    Goemaere, N.N.3    Girardi, G.4    le Cessie, S.5    Scherjon, S.6
  • 47
    • 79953691827 scopus 로고    scopus 로고
    • Mutations in complement regulatory proteins predispose to preeclampsia: a genetic analysis of the PROMISSE cohort
    • Salmon JE, Heuser C, Triebwasser M, Liszewski MK, Kavanagh D, Roumenina L, et al. Mutations in complement regulatory proteins predispose to preeclampsia: a genetic analysis of the PROMISSE cohort. PLoS Med 2011;8:e1001013.
    • (2011) PLoS Med , vol.8
    • Salmon, J.E.1    Heuser, C.2    Triebwasser, M.3    Liszewski, M.K.4    Kavanagh, D.5    Roumenina, L.6
  • 48
    • 67449159236 scopus 로고    scopus 로고
    • Complement activation in patients with primary antiphospholipid syndrome
    • Oku K, Atsumi T, Bohgaki M, Amengual O, Kataoka H, Horita T, et al. Complement activation in patients with primary antiphospholipid syndrome. Ann Rheum Dis 2009;68:1030–5.
    • (2009) Ann Rheum Dis , vol.68 , pp. 1030-1035
    • Oku, K.1    Atsumi, T.2    Bohgaki, M.3    Amengual, O.4    Kataoka, H.5    Horita, T.6
  • 49
    • 84857751661 scopus 로고    scopus 로고
    • Complement activation in patients with isolated antiphospholipid antibodies or primary antiphospholipid syndrome
    • Breen KA, Seed P, Parmar K, Moore GW, Stuart-Smith SE, Hunt BJ. Complement activation in patients with isolated antiphospholipid antibodies or primary antiphospholipid syndrome. Thromb Haemost 2012;107:423–9.
    • (2012) Thromb Haemost , vol.107 , pp. 423-429
    • Breen, K.A.1    Seed, P.2    Parmar, K.3    Moore, G.W.4    Stuart-Smith, S.E.5    Hunt, B.J.6
  • 50
    • 0028174929 scopus 로고
    • Tumor necrosis factor-α is elevated in plasma and amniotic fluid of patients with severe preeclampsia
    • discussion 7–9
    • Kupferminc MJ, Peaceman AM, Wigton TR, Rehnberg KA, Socol ML. Tumor necrosis factor-α is elevated in plasma and amniotic fluid of patients with severe preeclampsia. Am J Obstet Gynecol 1994;170:1752–7; discussion 7–9.
    • (1994) Am J Obstet Gynecol , vol.170 , pp. 1752-1757
    • Kupferminc, M.J.1    Peaceman, A.M.2    Wigton, T.R.3    Rehnberg, K.A.4    Socol, M.L.5
  • 51
    • 77954726290 scopus 로고    scopus 로고
    • Maternal and umbilical serum levels of interleukin-6, interleukin-8, and tumor necrosis factor-α in normal pregnancies and in pregnancies complicated by preeclampsia
    • Tosun M, Celik H, Avci B, Yavuz E, Alper T, Malatyalioğlu E. Maternal and umbilical serum levels of interleukin-6, interleukin-8, and tumor necrosis factor-α in normal pregnancies and in pregnancies complicated by preeclampsia. J Matern Fetal Neonatal Med 2010;23:880–6.
    • (2010) J Matern Fetal Neonatal Med , vol.23 , pp. 880-886
    • Tosun, M.1    Celik, H.2    Avci, B.3    Yavuz, E.4    Alper, T.5    Malatyalioğlu, E.6
  • 52
    • 0031955360 scopus 로고    scopus 로고
    • Immunolocalization of tumour necrosis factor-α (TNF-α) in the placental bed of normotensive and hypertensive human pregnancies
    • Pijnenborg R, McLaughlin PJ, Vercruysse L, Hanssens M, Johnson PM, Keith JC Jr, et al. Immunolocalization of tumour necrosis factor-α (TNF-α) in the placental bed of normotensive and hypertensive human pregnancies. Placenta 1998;19:231–9.
    • (1998) Placenta , vol.19 , pp. 231-239
    • Pijnenborg, R.1    McLaughlin, P.J.2    Vercruysse, L.3    Hanssens, M.4    Johnson, P.M.5    Keith, J.C.6
  • 53
    • 33749118495 scopus 로고    scopus 로고
    • A novel C5a receptor-tissue factor cross-talk in neutrophils links innate immunity to coagulation pathways
    • Ritis K, Doumas M, Mastellos D, Micheli A, Giaglis S, Magotti P, et al. A novel C5a receptor-tissue factor cross-talk in neutrophils links innate immunity to coagulation pathways. J Immunol 2006;177:4794–802.
    • (2006) J Immunol , vol.177 , pp. 4794-4802
    • Ritis, K.1    Doumas, M.2    Mastellos, D.3    Micheli, A.4    Giaglis, S.5    Magotti, P.6
  • 54
    • 35548948085 scopus 로고    scopus 로고
    • Interferon-α promotes abnormal vasculogenesis in lupus: a potential pathway for premature atherosclerosis
    • Denny MF, Thacker S, Mehta H, Somers EC, Dodick T, Barrat FJ, et al. Interferon-α promotes abnormal vasculogenesis in lupus: a potential pathway for premature atherosclerosis. Blood 2007;110:2907–15.
    • (2007) Blood , vol.110 , pp. 2907-2915
    • Denny, M.F.1    Thacker, S.2    Mehta, H.3    Somers, E.C.4    Dodick, T.5    Barrat, F.J.6
  • 55
    • 36049038869 scopus 로고    scopus 로고
    • Type I interferon as a novel risk factor for endothelial progenitor cell depletion and endothelial dysfunction in systemic lupus erythematosus
    • Lee PY, Li Y, Richards HB, Chan FS, Zhuang H, Narain S, et al. Type I interferon as a novel risk factor for endothelial progenitor cell depletion and endothelial dysfunction in systemic lupus erythematosus. Arthritis Rheum 2007;56:3759–69.
    • (2007) Arthritis Rheum , vol.56 , pp. 3759-3769
    • Lee, P.Y.1    Li, Y.2    Richards, H.B.3    Chan, F.S.4    Zhuang, H.5    Narain, S.6
  • 56
    • 77349098305 scopus 로고    scopus 로고
    • Interferon-α: a therapeutic target in systemic lupus erythematosus
    • Crow MK. Interferon-α: a therapeutic target in systemic lupus erythematosus. Rheum Dis Clin North Am 2010;36:173–86, x.
    • (2010) Rheum Dis Clin North Am , vol.36 , pp. 173-86, x
    • Crow, M.K.1
  • 57
    • 84925727366 scopus 로고    scopus 로고
    • Interferon-α and angiogenic dysregulation in pregnant lupus patients who develop preeclampsia
    • Andrade D, Kim M, Blanco LP, Karumanchi SA, Koo GC, Redecha P, et al. Interferon-α and angiogenic dysregulation in pregnant lupus patients who develop preeclampsia. Arthritis Rheumatol 2015;67:977–87.
    • (2015) Arthritis Rheumatol , vol.67 , pp. 977-987
    • Andrade, D.1    Kim, M.2    Blanco, L.P.3    Karumanchi, S.A.4    Koo, G.C.5    Redecha, P.6
  • 58
    • 47949126782 scopus 로고    scopus 로고
    • A national study of the complications of lupus in pregnancy
    • Clowse ME, Jamison M, Myers E, James AH. A national study of the complications of lupus in pregnancy. Am J Obstet Gynecol 2008;199:127.e1–6.
    • (2008) Am J Obstet Gynecol , vol.199 , pp. 127.e1-6
    • Clowse, M.E.1    Jamison, M.2    Myers, E.3    James, A.H.4
  • 59
    • 78149308775 scopus 로고    scopus 로고
    • A systematic review and meta-analysis of pregnancy outcomes in patients with systemic lupus erythematosus and lupus nephritis
    • Smyth A, Oliveira GH, Lahr BD, Bailey KR, Norby SM, Garovic VD. A systematic review and meta-analysis of pregnancy outcomes in patients with systemic lupus erythematosus and lupus nephritis. Clin J Am Soc Nephrol 2010;5:2060–8.
    • (2010) Clin J Am Soc Nephrol , vol.5 , pp. 2060-2068
    • Smyth, A.1    Oliveira, G.H.2    Lahr, B.D.3    Bailey, K.R.4    Norby, S.M.5    Garovic, V.D.6
  • 60
    • 84875424639 scopus 로고    scopus 로고
    • Maternal plasma concentrations of angiogenic/antiangiogenic factors in the third trimester of pregnancy to identify the patient at risk for stillbirth at or near term and severe late preeclampsia
    • Chaiworapongsa T, Romero R, Korzeniewski SJ, Kusanovic JP, Soto E, Lam J, et al. Maternal plasma concentrations of angiogenic/antiangiogenic factors in the third trimester of pregnancy to identify the patient at risk for stillbirth at or near term and severe late preeclampsia. Am J Obstet Gynecol 2013;208:287.e1–15.
    • (2013) Am J Obstet Gynecol , vol.208 , pp. 287.e1-15
    • Chaiworapongsa, T.1    Romero, R.2    Korzeniewski, S.J.3    Kusanovic, J.P.4    Soto, E.5    Lam, J.6
  • 61
    • 84955508652 scopus 로고    scopus 로고
    • Angiogenic factor imbalance early in pregnancy predicts adverse outcomes in patients with lupus and antiphospholipid antibodies: results of the PROMISSE study
    • Kim MY, Buyon JP, Guerra MM, Rana S, Zhang D, Laskin CA, et al. Angiogenic factor imbalance early in pregnancy predicts adverse outcomes in patients with lupus and antiphospholipid antibodies: results of the PROMISSE study. Am J Obstet Gynecol 2016;214:108.e1–14.
    • (2016) Am J Obstet Gynecol , vol.214 , pp. 108.e1-14
    • Kim, M.Y.1    Buyon, J.P.2    Guerra, M.M.3    Rana, S.4    Zhang, D.5    Laskin, C.A.6
  • 62
    • 77953922052 scopus 로고    scopus 로고
    • Dysregulated complement activation as a common pathway of injury in preeclampsia and other pregnancy complications
    • Lynch AM, Salmon JE. Dysregulated complement activation as a common pathway of injury in preeclampsia and other pregnancy complications. Placenta 2010;31:561–7.
    • (2010) Placenta , vol.31 , pp. 561-567
    • Lynch, A.M.1    Salmon, J.E.2
  • 65
    • 80054948464 scopus 로고    scopus 로고
    • Aspirin and heparin effect on basal and antiphospholipid antibody modulation of trophoblast function
    • Han CS, Mulla MJ, Brosens JJ, Chamley LW, Paidas MJ, Lockwood CJ, et al. Aspirin and heparin effect on basal and antiphospholipid antibody modulation of trophoblast function. Obstet Gynecol 2011;118:1021–8.
    • (2011) Obstet Gynecol , vol.118 , pp. 1021-1028
    • Han, C.S.1    Mulla, M.J.2    Brosens, J.J.3    Chamley, L.W.4    Paidas, M.J.5    Lockwood, C.J.6
  • 66
    • 84896720948 scopus 로고    scopus 로고
    • Pregnancy morbidity in antiphospholipid syndrome: what is the impact of treatment?
    • De Jesus GR, Rodrigues G, de Jesus NR, Levy RA. Pregnancy morbidity in antiphospholipid syndrome: what is the impact of treatment? Curr Rheumatol Rep 2014;16:403.
    • (2014) Curr Rheumatol Rep , vol.16 , pp. 403
    • De Jesus, G.R.1    Rodrigues, G.2    de Jesus, N.R.3    Levy, R.A.4
  • 67
    • 84968773485 scopus 로고    scopus 로고
    • The role of anti-phospholipid antibodies in autoimmune reproductive failure
    • Pantham P, Abrahams VM, Chamley LW. The role of anti-phospholipid antibodies in autoimmune reproductive failure. Reproduction 2016;151:R79–90.
    • (2016) Reproduction , vol.151 , pp. R79-90
    • Pantham, P.1    Abrahams, V.M.2    Chamley, L.W.3
  • 68
    • 79955582750 scopus 로고    scopus 로고
    • Local retention versus systemic release of soluble VEGF receptor-1 are mediated by heparin-binding and regulated by heparanase
    • Sela S, Natanson-Yaron S, Zcharia E, Vlodavsky I, Yagel S, Keshet E. Local retention versus systemic release of soluble VEGF receptor-1 are mediated by heparin-binding and regulated by heparanase. Circ Res 2011;108:1063–70.
    • (2011) Circ Res , vol.108 , pp. 1063-1070
    • Sela, S.1    Natanson-Yaron, S.2    Zcharia, E.3    Vlodavsky, I.4    Yagel, S.5    Keshet, E.6
  • 69
    • 84992360792 scopus 로고    scopus 로고
    • Low-molecular-weight heparin and recurrent placenta-mediated pregnancy complications: a meta-analysis of individual patient data from randomised controlled trials
    • Rodger MA, Gris JC, de Vries JI, Martinelli I, Rey E, Schleussner E, et al, for the Low-Molecular-Weight Heparin for Placenta-Mediated Pregnancy Complications Study Group. Low-molecular-weight heparin and recurrent placenta-mediated pregnancy complications: a meta-analysis of individual patient data from randomised controlled trials. Lancet 2016;388:2629–41.
    • (2016) Lancet , vol.388 , pp. 2629-2641
    • Rodger, M.A.1    Gris, J.C.2    de Vries, J.I.3    Martinelli, I.4    Rey, E.5    Schleussner, E.6
  • 70
    • 84858745359 scopus 로고    scopus 로고
    • Anti-phospholipid induced murine fetal loss: novel protective effect of a peptide targeting the β2 glycoprotein I phospholipid-binding site: implications for human fetal loss
    • De la Torre YM, Pregnolato F, D'Amelio F, Grossi C, di Simone N, Pasqualini F, et al. Anti-phospholipid induced murine fetal loss: novel protective effect of a peptide targeting the β2 glycoprotein I phospholipid-binding site: implications for human fetal loss. J Autoimmun 2012;38:J209–15.
    • (2012) J Autoimmun , vol.38 , pp. J209-J215
    • De la Torre, Y.M.1    Pregnolato, F.2    D'Amelio, F.3    Grossi, C.4    di Simone, N.5    Pasqualini, F.6
  • 71
    • 77951215752 scopus 로고    scopus 로고
    • Domain I of β2-glycoprotein I: its role as an epitope and the potential to be developed as a specific target for the treatment of the antiphospholipid syndrome
    • Ioannou Y, Rahman A. Domain I of β2-glycoprotein I: its role as an epitope and the potential to be developed as a specific target for the treatment of the antiphospholipid syndrome. Lupus 2010;19:400–5.
    • (2010) Lupus , vol.19 , pp. 400-405
    • Ioannou, Y.1    Rahman, A.2
  • 72
    • 85024388342 scopus 로고    scopus 로고
    • Identification of a monoclonal antibody that attenuates antiphospholipid syndrome-related pregnancy complications and thrombosis
    • Mineo C, Lanier L, Jung E, Sengupta S, Ulrich V, Sacharidou A, et al. Identification of a monoclonal antibody that attenuates antiphospholipid syndrome-related pregnancy complications and thrombosis. PLoS One 2016;11:e0158757.
    • (2016) PLoS One , vol.11
    • Mineo, C.1    Lanier, L.2    Jung, E.3    Sengupta, S.4    Ulrich, V.5    Sacharidou, A.6
  • 73
    • 84901705578 scopus 로고    scopus 로고
    • A non-complement-fixing antibody to β2 glycoprotein I as a novel therapy for antiphospholipid syndrome
    • Agostinis C, Durigutto P, Sblattero D, Borghi MO, Grossi C, Guida F, et al. A non-complement-fixing antibody to β2 glycoprotein I as a novel therapy for antiphospholipid syndrome. Blood 2014;123:3478–87.
    • (2014) Blood , vol.123 , pp. 3478-3487
    • Agostinis, C.1    Durigutto, P.2    Sblattero, D.3    Borghi, M.O.4    Grossi, C.5    Guida, F.6
  • 75
    • 84863625124 scopus 로고    scopus 로고
    • Maternal use of hydroxychloroquine is associated with a reduced risk of recurrent anti-SSA/Ro-antibody-associated cardiac manifestations of neonatal lupus
    • Izmirly PM, Costedoat-Chalumeau N, Pisoni CN, Khamashta MA, Kim MY, Saxena A, et al. Maternal use of hydroxychloroquine is associated with a reduced risk of recurrent anti-SSA/Ro-antibody-associated cardiac manifestations of neonatal lupus. Circulation 2012;126:76–82.
    • (2012) Circulation , vol.126 , pp. 76-82
    • Izmirly, P.M.1    Costedoat-Chalumeau, N.2    Pisoni, C.N.3    Khamashta, M.A.4    Kim, M.Y.5    Saxena, A.6
  • 76
    • 84892438423 scopus 로고    scopus 로고
    • Effect of hydroxychloroquine on antiphospholipid antibody-induced changes in first trimester trophoblast function
    • Albert CR, Schlesinger WJ, Viall CA, Mulla MJ, Brosens JJ, Chamley LW, et al. Effect of hydroxychloroquine on antiphospholipid antibody-induced changes in first trimester trophoblast function. Am J Reprod Immunol 2014;71:154–64.
    • (2014) Am J Reprod Immunol , vol.71 , pp. 154-164
    • Albert, C.R.1    Schlesinger, W.J.2    Viall, C.A.3    Mulla, M.J.4    Brosens, J.J.5    Chamley, L.W.6
  • 77
    • 77950435764 scopus 로고    scopus 로고
    • Hydroxychloroquine protects the annexin A5 anticoagulant shield from disruption by antiphospholipid antibodies: evidence for a novel effect for an old antimalarial drug
    • Rand JH, Wu XX, Quinn AS, Ashton AW, Chen PP, Hathcock JJ, et al. Hydroxychloroquine protects the annexin A5 anticoagulant shield from disruption by antiphospholipid antibodies: evidence for a novel effect for an old antimalarial drug. Blood 2010;115:2292–9.
    • (2010) Blood , vol.115 , pp. 2292-2299
    • Rand, J.H.1    Wu, X.X.2    Quinn, A.S.3    Ashton, A.W.4    Chen, P.P.5    Hathcock, J.J.6
  • 78
    • 65649140025 scopus 로고    scopus 로고
    • Uric acid is a danger signal activating NALP3 inflammasome in lung injury inflammation and fibrosis
    • Gasse P, Riteau N, Charron S, Girre S, Fick L, Petrilli V, et al. Uric acid is a danger signal activating NALP3 inflammasome in lung injury inflammation and fibrosis. Am J Respir Crit Care Med 2009;179:903–13.
    • (2009) Am J Respir Crit Care Med , vol.179 , pp. 903-913
    • Gasse, P.1    Riteau, N.2    Charron, S.3    Girre, S.4    Fick, L.5    Petrilli, V.6
  • 79
    • 84874331687 scopus 로고    scopus 로고
    • Oxidative stress produced by xanthine oxidase induces apoptosis in human extravillous trophoblast cells
    • Murata M, Fukushima K, Takao T, Seki H, Takeda S, Wake N. Oxidative stress produced by xanthine oxidase induces apoptosis in human extravillous trophoblast cells. J Reprod Dev 2013;59:7–13.
    • (2013) J Reprod Dev , vol.59 , pp. 7-13
    • Murata, M.1    Fukushima, K.2    Takao, T.3    Seki, H.4    Takeda, S.5    Wake, N.6
  • 80
    • 67649587151 scopus 로고    scopus 로고
    • Maternal allopurinol during fetal hypoxia lowers cord blood levels of the brain injury marker S-100B
    • Torrance HL, Benders MJ, Derks JB, Rademaker CM, Bos AF, van den Berg P, et al. Maternal allopurinol during fetal hypoxia lowers cord blood levels of the brain injury marker S-100B. Pediatrics 2009;124:350–7.
    • (2009) Pediatrics , vol.124 , pp. 350-357
    • Torrance, H.L.1    Benders, M.J.2    Derks, J.B.3    Rademaker, C.M.4    Bos, A.F.5    van den Berg, P.6
  • 81
    • 84938983161 scopus 로고    scopus 로고
    • Interleukin-1 receptor blockade in perinatal brain injury
    • Rosenzweig JM, Lei J, Burd I. Interleukin-1 receptor blockade in perinatal brain injury. Front Pediatr 2014;2:108.
    • (2014) Front Pediatr , vol.2 , pp. 108
    • Rosenzweig, J.M.1    Lei, J.2    Burd, I.3
  • 82
    • 84866355658 scopus 로고    scopus 로고
    • Pravastatin does not prevent antiphospholipid antibody-mediated changes in human first trimester trophoblast function
    • Odiari EA, Mulla MJ, Sfakianaki AK, Paidas MJ, Stanwood NL, Gariepy A, et al. Pravastatin does not prevent antiphospholipid antibody-mediated changes in human first trimester trophoblast function. Hum Reprod 2012;27:2933–40.
    • (2012) Hum Reprod , vol.27 , pp. 2933-2940
    • Odiari, E.A.1    Mulla, M.J.2    Sfakianaki, A.K.3    Paidas, M.J.4    Stanwood, N.L.5    Gariepy, A.6
  • 83
    • 84899916939 scopus 로고    scopus 로고
    • A prospective open-label pilot study of fluvastatin on proinflammatory and prothrombotic biomarkers in antiphospholipid antibody positive patients
    • Erkan D, Willis R, Murthy VL, Basra G, Vega J, Ruiz-Limon P, et al. A prospective open-label pilot study of fluvastatin on proinflammatory and prothrombotic biomarkers in antiphospholipid antibody positive patients. Ann Rheum Dis 2014;73:1176–80.
    • (2014) Ann Rheum Dis , vol.73 , pp. 1176-1180
    • Erkan, D.1    Willis, R.2    Murthy, V.L.3    Basra, G.4    Vega, J.5    Ruiz-Limon, P.6
  • 84
    • 84987837104 scopus 로고    scopus 로고
    • Pravastatin improves pregnancy outcomes in obstetric antiphospholipid syndrome refractory to antithrombotic therapy
    • Lefkou E, Mamopoulos A, Dagklis T, Vosnakis C, Rousso D, Girardi G. Pravastatin improves pregnancy outcomes in obstetric antiphospholipid syndrome refractory to antithrombotic therapy. J Clin Invest 2016;126:2933–40.
    • (2016) J Clin Invest , vol.126 , pp. 2933-2940
    • Lefkou, E.1    Mamopoulos, A.2    Dagklis, T.3    Vosnakis, C.4    Rousso, D.5    Girardi, G.6
  • 86
    • 84965056655 scopus 로고    scopus 로고
    • Complement inhibition by hydroxychloroquine prevents placental and fetal brain abnormalities in antiphospholipid syndrome
    • Bertolaccini ML, Contento G, Lennen R, Sanna G, Blower PJ, Ma MT, et al. Complement inhibition by hydroxychloroquine prevents placental and fetal brain abnormalities in antiphospholipid syndrome. J Autoimmun 2016;75:30–8.
    • (2016) J Autoimmun , vol.75 , pp. 30-38
    • Bertolaccini, M.L.1    Contento, G.2    Lennen, R.3    Sanna, G.4    Blower, P.J.5    Ma, M.T.6
  • 87
    • 84923303586 scopus 로고    scopus 로고
    • Proceedings from the American College of Rheumatology Reproductive Health Summit: the management of fertility, pregnancy, and lactation in women with autoimmune and systemic inflammatory diseases
    • Kavanaugh A, Cush JJ, Ahmed MS, Bermas BL, Chakravarty E, Chambers C, et al. Proceedings from the American College of Rheumatology Reproductive Health Summit: the management of fertility, pregnancy, and lactation in women with autoimmune and systemic inflammatory diseases. Arthritis Care Res (Hoboken) 2015;67:313–25.
    • (2015) Arthritis Care Res (Hoboken) , vol.67 , pp. 313-325
    • Kavanaugh, A.1    Cush, J.J.2    Ahmed, M.S.3    Bermas, B.L.4    Chakravarty, E.5    Chambers, C.6


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