Aspirin-triggered lipoxin prevents antiphospholipid antibody effects on human trophoblast migration and endothelial cell interactions

Arthritis and Rheumatology

Volumn 67, Issue 2, 2015, Pages 488-497

  Alvarez, Angela M ^a,b   Mulla, Melissa J ^b   Chamley, Lawrence W ^c   Cadavid, Angela P ^a   Abrahams, Vikki M ^b  

^a UNIVERSIDAD DE ANTIOQUIA   (Colombia)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

15 EPI LIPOXIN A 4; ACETYLSALICYLIC ACID DERIVATIVE; ANGIOGENIC FACTOR; CARDIOLIPIN ANTIBODY; CYTOKINE; INTERLEUKIN 6; INTERLEUKIN 8; LIPOXIN; PHOSPHOLIPID ANTIBODY; TISSUE INHIBITOR OF METALLOPROTEINASE 2; UNCLASSIFIED DRUG; BETA2 GLYCOPROTEIN 1; LIPOXIN A; MONOCLONAL ANTIBODY; NONSTEROID ANTIINFLAMMATORY AGENT;

ADULT; ANTIPHOSPHOLIPID SYNDROME; ARTICLE; CELL FUNCTION; CELL INTERACTION; CELLULAR SECRETION; COCULTURE; CONTROLLED STUDY; EMBRYO; ENDOMETRIUM; ENDOTHELIUM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FILTERS AND MEMBRANES; FIRST TRIMESTER PREGNANCY; HUMAN; HUMAN CELL; IN VITRO STUDY; INTERFERON PRODUCTION; PRIORITY JOURNAL; TRANSCELLULAR CELL MIGRATION; TROPHOBLAST; ANGIOGENESIS; ANTAGONISTS AND INHIBITORS; CELL COMMUNICATION; CELL CULTURE; CELL LINE; CELL MOTION; CYTOLOGY; DRUG EFFECTS; IMMUNOLOGY; METABOLISM; PREGNANCY;

ADULT; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIBODIES, ANTIPHOSPHOLIPID; ANTIBODIES, MONOCLONAL; BETA 2-GLYCOPROTEIN I; CELL COMMUNICATION; CELL LINE; CELL MOVEMENT; CELLS, CULTURED; COCULTURE TECHNIQUES; ENDOMETRIUM; ENDOTHELIAL CELLS; FEMALE; HUMANS; INTERLEUKIN-6; LIPOXINS; NEOVASCULARIZATION, PHYSIOLOGIC; PREGNANCY; PREGNANCY TRIMESTER, FIRST; TROPHOBLASTS;

EID: 84922825148     PISSN: 23265191     EISSN: 23265205     Source Type: Journal    
DOI: 10.1002/art.38934     Document Type: Article

References (51)

1. De Jesus GR, Rodrigues G, de Jesus NR, Levy RA,. Pregnancy morbidity in antiphospholipid syndrome: what is the impact of treatment? Curr Rheumatol Rep 2014; 16: 403.
2. De Laat B, Mertens K, de Groot PG,. Mechanisms of disease: antiphospholipid antibodies-from clinical association to pathologic mechanism. Nat Clin Pract Rheumatol 2008; 4: 192-9.
3. Meroni PL, Raschi E, Grossi C, Pregnolato F, Trespidi L, Acaia B, et al. Obstetric and vascular APS: same autoantibodies but different diseases? Lupus 2012; 21: 708-10.
4. Sebire NJ, Fox H, Backos M, Rai R, Paterson C, Regan L,. Defective endovascular trophoblast invasion in primary antiphospholipid antibody syndrome-associated early pregnancy failure. Hum Reprod 2002; 17: 1067-71.
5. Girardi G, Redecha P, Salmon JE,. Heparin prevents antiphospholipid antibody-induced fetal loss by inhibiting complement activation. Nat Med 2004; 10: 1222-6.
6. Mulla MJ, Brosens JJ, Chamley LW, Giles I, Pericleous C, Rahman A, et al. Antiphospholipid antibodies induce a pro-inflammatory response in first trimester trophoblast via the TLR4/MyD88 pathway. Am J Reprod Immunol 2009; 62: 96-111.
7. Harris LK,. Trophoblast-vascular cell interactions in early pregnancy: how to remodel a vessel [review]. Placenta 2010; 31 Suppl: S93-8.
8. 2 glycoprotein 1 by the human placenta. Placenta 1997; 18: 403-10.
9. Carroll TY, Mulla MJ, Han CS, Brosens JJ, Chamley LW, Giles I, et al. Modulation of trophoblast angiogenic factor secretion by antiphospholipid antibodies is not reversed by heparin. Am J Reprod Immunol 2011; 66: 286-96.
10. Mulla MJ, Myrtolli K, Brosens JJ, Chamley LW, Kwak-Kim JY, Paidas MJ, et al. Antiphospholipid antibodies limit trophoblast migration by reducing IL-6 production and STAT3 activity. Am J Reprod Immunol 2010; 63: 339-48.
11. Cohn DM, Goddijn M, Middeldorp S, Korevaar JC, Dawood F, Farquharson RG,. Recurrent miscarriage and antiphospholipid antibodies: prognosis of subsequent pregnancy. J Thromb Haemost 2010; 8: 2208-13.
12. Stephenson MD, Ballem PJ, Tsang P, Purkiss S, Ensworth S, Houlihan E, et al. Treatment of antiphospholipid antibody syndrome (APS) in pregnancy: a randomized pilot trial comparing low molecular weight heparin to unfractionated heparin. J Obstet Gynaecol Can 2004; 26: 729-34.
13. Farquharson RG, Quenby S, Greaves M,. Antiphospholipid syndrome in pregnancy: a randomized, controlled trial of treatment [published erratum appears in Obstet Gynecol 2002;100:1361]. Obstet Gynecol 2002; 100: 408-13.
14. Inbar O, Blank M, Faden D, Tincani A, Lorber M, Shoenfeld Y,. Prevention of fetal loss in experimental antiphospholipid syndrome by low-molecular-weight heparin. Am J Obstet Gynecol 1993; 169: 423-6.
15. Laskin CA, Spitzer KA, Clark CA, Crowther MR, Ginsberg JS, Hawker GA, et al. Low molecular weight heparin and aspirin for recurrent pregnancy loss: results from the randomized, controlled HepASA Trial. J Rheumatol 2009; 36: 279-87.
16. Di Simone N, Caliandro D, Castellani R, Ferrazzani S, De Carolis S, Caruso A,. Low-molecular weight heparin restores in-vitro trophoblast invasiveness and differentiation in presence of immunoglobulin G fractions obtained from patients with antiphospholipid syndrome. Hum Reprod 1999; 14: 489-95.
17. Di Simone N, Ferrazzani S, Castellani R, De Carolis S, Mancuso S, Caruso A,. Heparin and low-dose aspirin restore placental human chorionic gonadotrophin secretion abolished by antiphospholipid antibody-containing sera. Hum Reprod 1997; 12: 2061-5.
18. Moncada S, Vane JR,. Unstable metabolites of arachidonic acid and their role in haemostasis and thrombosis. Br Med Bull 1978; 34: 129-35.
19. Romano M,. Lipoxin and aspirin-triggered lipoxins. Scientific WorldJournal 2010; 10: 1048-64.
20. Serhan CN, Chiang N, Van Dyke TE,. Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators. Nat Rev Immunol 2008; 8: 349-61.
21. 4 analogs attenuate induction of intestinal epithelial proinflammatory gene expression and reduce the severity of dextran sodium sulfate-induced colitis. J Immunol 2002; 168: 5260-7.
22. Ueda T, Fukunaga K, Seki H, Miyata J, Arita M, Miyasho T, et al. Combination therapy of 15-epi-lipoxin A4 with antibiotics protects mice from Escherichia coli-induced sepsis. Crit Care Med 2014; 42: e288-95.
23. Ohse T, Ota T, Kieran N, Godson C, Yamada K, Tanaka T, et al. Modulation of interferon-induced genes by lipoxin analogue in anti-glomerular basement membrane nephritis. J Am Soc Nephrol 2004; 15: 919-27.
24. Albert CR, Schlesinger WJ, Viall CA, Mulla MJ, Brosens JJ, Chamley LW, et al. Effect of hydroxychloroquine on antiphospholipid antibody-induced changes in first trimester trophoblast function. Am J Reprod Immunol 2014; 71: 154-64.
25. Graham CH, Hawley TS, Hawley RG, MacDougall JR, Kerbel RS, Khoo N, et al. Establishment and characterization of first trimester human trophoblast cells with extended lifespan. Exp Cell Res 1993; 206: 204-11.
26. Aldo PB, Krikun G, Visintin I, Lockwood C, Romero R, Mor G,. A novel three-dimensional in vitro system to study trophoblast-endothelium cell interactions. Am J Reprod Immunol 2007; 58: 98-110.
27. Chamley LW, Konarkowska B, Duncalf AM, Mitchell MD, Johnson PM,. Is interleukin-3 important in antiphospholipid antibody-mediated pregnancy failure? Fertil Steril 2001; 76: 700-6.
28. 2-glycoprotein I is the antigen for anti-cardiolipin autoantibodies. Clin Exp Immunol 1999; 115: 571-6.
29. Viall CA, Chen Q, Liu B, Hickey A, Snowise S, Salmon JE, et al. Antiphospholipid antibodies internalised by human syncytiotrophoblast cause aberrant cell death and the release of necrotic trophoblast debris. J Autoimmun 2013; 47: 45-57.
30. Wilson WA, Gharavi AE, Koike T, Lockshin MD, Branch DW, Piette JC, et al. International consensus statement on preliminary classification criteria for definite antiphospholipid syndrome: report of an international workshop. Arthritis Rheum 1999; 42: 1309-11.
31. Bertolaccini ML, Amengual O, Atsumi T, Binder WL, de Laat B, Forastiero R, et al. 'Non-criteria' aPL tests: report of a task force and preconference workshop at the 13th International Congress on Antiphospholipid Antibodies, Galveston, TX, USA, April 2010. Lupus 2011; 20: 191-205.
32. Kwak-Kim J, Agcaoili MS, Aleta L, Liao A, Ota K, Dambaeva S, et al. Management of women with recurrent pregnancy losses and antiphospholipid antibody syndrome. Am J Reprod Immunol 2013; 69: 596-607.
33. Lockshin MD, Kim M, Laskin CA, Guerra M, Branch DW, Merrill J, et al. Prediction of adverse pregnancy outcome by the presence of lupus anticoagulant, but not anticardiolipin antibody, in patients with antiphospholipid antibodies. Arthritis Rheum 2012; 64: 2311-8.
34. 4 inhibit peroxynitrite formation, NF-κB and AP-1 activation, and IL-8 gene expression in human leukocytes. Proc Natl Acad Sci U S A 2002; 99: 13266-71.
35. Wu SH, Liao PY, Dong L, Chen ZQ,. Signal pathway involved in inhibition by lipoxin A(4) of production of interleukins induced in endothelial cells by lipopolysaccharide. Inflamm Res 2008; 57: 430-7.
36. 4 attenuates LPS-induced pro-inflammatory responses by inhibiting activation of NF-κB and MAPKs in BV-2 microglial cells. J Neuroinflammation 2011; 8: 95.
37. 4 as anti-inflammatory and proresolution mediator in human parturition. FASEB J 2011; 25: 569-75.
38. 4 on lipopolysaccharide-induced endothelial hyperpermeability. ScientificWorldJournal 2011; 11: 1056-67.
39. Liu SJ, Li YS, Zhou XY, Cai L, Liu XL, Huang YJ, et al. Protective effects and its mechanism of lipoxins on human umbilical vein endothelial cells under hypoxia. Zhonghua Fu Chan Ke Za Zhi 2009; 44: 281-4. In Chinese.
40. Gil-Villa AM, Norling LV, Serhan CN, Cordero D, Rojas M, Cadavid A,. Aspirin triggered-lipoxin A4 reduces the adhesion of human polymorphonuclear neutrophils to endothelial cells initiated by preeclamptic plasma. Prostaglandins Leukot Essent Fatty Acids 2012; 87: 127-34.
41. 4, an endogenous anti-inflammatory mediator. Fertil Steril 2014; 102: 282-90.
42. 4 partially alleviates dexamethasone-induced fetal growth restriction in rats. Placenta 2013; 34: 941-8.
43. 4 and its analogue on low-dose endotoxin induced preeclampsia in rat and possible mechanisms. Reprod Toxicol 2012; 34: 677-85.
44. 2-glycoprotein I by antibodies from antiphospholipid syndrome patients. Thromb Haemost 2000; 84: 374-80.
45. 2-glycoprotein I only after a conformational change. Blood 2006; 107: 1916-24.
46. Salafia CM, Cowchock FS,. Placental pathology and antiphospholipid antibodies: a descriptive study. Am J Perinatol 1997; 14: 435-41.
47. 2 glycoprotein 1: a promising candidate biomarker for risk management in antiphospholipid syndrome. Autoimmun Rev 2012; 12: 313-7.
48. 2-glycoprotein I: the one and only? Lupus 2012; 21: 769-72.
49. Balasch J, Cervera R,. Reflections on the management of reproductive failure in the antiphospholipid syndrome: the clinician's perspective. Lupus 2002; 11: 467-77.
50. 4 attenuates mechanical allodynia in association with inhibiting spinal JAK2/STAT3 signaling in neuropathic pain in rats. Neuroscience 2014; 273: 65-78.
51. 4. J Pharmacol Exp Ther 2002; 300: 385-92.