Increased serum enzyme levels associated with Kupffer cell reduction with no signs of hepatic or skeletal muscle injury

American Journal of Pathology

Volumn 179, Issue 1, 2011, Pages 240-247

  Radi, Zaher A ^a   Koza Taylor, Petra H ^a   Bell, Rosonald R ^a   Obert, Leslie A ^a   Runnels, Herbert A ^a   Beebe, Jean S ^a   Lawton, Michael P ^a   Sadis, Seth ^b  

^a PFIZER INC   (United States)

^b Services Department   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTATE AMINOTRANSFERASE; CD14 ANTIGEN; CD16 ANTIGEN; CLODRONIC ACID; COLONY STIMULATING FACTOR 1; CREATINE KINASE; HUMAN MONOCLONAL ANTIBODY; LIPOSOME;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CELL LOSS; CONTROLLED STUDY; CREATINE KINASE BLOOD LEVEL; EXPERIMENTAL MONKEY; FEMALE; KUPFFER CELL; LEUKOPENIA; MACACA; MONOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; WILD TYPE;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD14; ASPARTATE AMINOTRANSFERASES; BONE DENSITY CONSERVATION AGENTS; CLODRONIC ACID; CREATINE KINASE; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; KUPFFER CELLS; LIVER; MACACA FASCICULARIS; MACROPHAGE COLONY-STIMULATING FACTOR; MALE; MICE; MICE, KNOCKOUT; MONOCYTES; MUSCLE, SKELETAL; OSTEOPETROSIS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, IGG;

EID: 80052447945     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2011.03.029     Document Type: Article

References (32)

1. M. Naito, G. Hasegawa, Y. Ebe, and T. Yamamoto Differentiation and function of Kupffer cells Med Electron Microsc 37 2004 16 28
2. N. Charlier, A.M. Neyrinck, N. Beghein, N.M. Delzenne, and B. Gallez Assessment of liver phagocytic activity using EPR spectrometry and imaging Magn Reson Imaging 27 2009 565 569
3. K.Y. Helmy, K.J. Katschke Jr, N.N. Gorgani, N.M. Kljavin, J.M. Elliott, L. Diehl, S.J. Scales, N. Ghilardi, and M. van Lookeren Campagne CRIg: a macrophage complement receptor required for phagocytosis of circulating pathogens Cell 124 2006 915 927
4. C.A. Toth, and P. Thomas Liver endocytosis and Kupffer cells Hepatology 16 1992 255 266
5. M. Granado, A.I. Martín, T. Priego, M.A. Villana, and A. López-Calderón Inactivation of Kupffer cells by gadolinium administration prevent lipopolysaccharide-induced decrease in liver insulin-like growth factor-I and IGF-binding protein-3 gene expression J Endocrinol 188 2006 503 511
6. D.J. Loegering Kupffer cell complement receptor clearance function and host defense Circ Shock 20 1986 321 333
7. B.W. Mahy, and K.E. Rowson Isoenzymic specificity of impaired clearance in mice infected with the riley virus Science 149 1965 756
8. M.J. Smit, H. Beekhuis, A.M. Duursma, J.M. Bouma, and M. Gruber Catabolism of circulating enzymes: plasma clearance, endocytosis, and breakdown of lactate dehydrogenase-1 in rabbits Clin Chem 34 1988 2475 2480
9. M.J. Smit, A.M. Duursma, J. Koudstaal, M.J. Hardonk, and J.M. Bouma Infection of mice with lactate dehydrogenase-elevating virus destroys the subpopulation of Kupffer cells involved in receptor-mediated endocytosis of lactate dehydrogenase and other enzymes Hepatology 12 1990 1192 1199
10. E.R. Stanley, L.J. Guilbert, R.J. Tushinski, and S.H. Bartelmez CSF-1: a mononuclear phagocyte lineage-specific hemopoietic growth factor J Cell Biochem 21 1983 151 159
11. M. Naito, S. Hayashi, H. Yoshida, S. Nishikawa, L.D. Shultz, and K. Takahashi Abnormal differentiation of tissue macrophage populations in "osteopetrosis" (op) mice defective in the production of macrophage colony-stimulating factor Am J Pathol 139 1991 657 667
12. H. Yoshida, S. Hayashi, T. Kunisada, M. Ogawa, S. Nishikawa, H. Okamura, T. Sudo, L.D. Shultz, and S. Nishikawa The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene Nature 345 1990 442 444
13. W. Wiktor-Jedrzejczak, A. Bartocci, A.W. Ferrante Jr, A. Ahmed-Ansari, K.W. Sell, J.W. Pollard, and E.R. Stanley Total absence of colony-stimulating factor 1 in the macrophage- deficient osteopetrotic (op/op) mouse Proc Natl Acad Sci U S A 87 1990 4828 4832
14. M.G. Cecchini, M.G. Dominguez, S. Mocci, A. Wetterwald, R. Felix, H. Fleisch, O. Chisholm, W. Hofstetter, J.W. Pollard, and E.R. Stanley Role of colony stimulating factor-1 in the establishment and regulation of tissue macrophages during postnatal development of the mouse Development 120 1994 1357 1372
15. T. Yamamoto, C. Kaizu, T. Kawasaki, G. Hasegawa, H. Umezu, R. Ohashi, J. Sakurada, S. Jiang, L. Shultz, and M. Naito Macrophage colony-stimulating factor is indispensable for repopulation and differentiation of Kupffer cells but not for splenic red pulp macrophages in osteopetrotic (op/op) mice after macrophage depletion Cell Tissue Res 332 2008 245 256
16. S. Wei, D. Lightwood, H. Ladyman, S. Cross, H. Neale, M. Griffiths, R. Adams, D. Marshall, A. Lawson, A.J. McKnight, and E.R. Stanley Modulation of CSF-1-regulated post-natal development with anti-CSF-1 antibody Immunobiology 210 2005 109 119
17. Sadis S, Mukherjee A, Olson S, Dokmanovich M, Maher R, Cai C-H, Le V, Crawford M, Fedechko R, Whitfield L, Hellio Le Graverand Gastineau M-P, Stock T, Runnels HA, Zeiher B: Safety, pharmacokinetics, and pharmacodynamics of PD-0360324, a human monoclonal antibody to monocyte/macrophage colony stimulating factor, in healthy volunteers. Presented at the Annual Scientific Meeting of the American College of Rheumatology, October 1721, 2009, Philadelphia, PA, Abstract 408
18. N. Van Rooijen, and A. Sanders Liposome mediated depletion of macrophages: mechanism of action, preparation of liposomes and applications J Immunol Meth 174 1994 83 93
19. S.N. Campion, C. Tatis-Rios, L.M. Augustine, M.J. Goedken, N. van Rooijen, N.J. Cherrington, and J.E. Manautou Effect of allyl alcohol on hepatic transporter expression: zonal patterns of expression and role of Kupffer cell function Toxicol Appl Pharmacol 236 2009 49 58
20. R.D. Goldin, I.D. Ratnayaka, C.S. Breach, I.N. Brown, and S.N. Wickramasinghe Role of macrophages in acetaminophen (paracetamol)-induced hepatotoxicity J Pathol 179 1996 432 435
21. E. Sturm, R. Havinga, J.F. Baller, H. Wolters, N. van Rooijen, J.A. Kamps, H.J. Verkade, S.J. Karpen, and F. Kuipers Kupffer cell depletion with liposomal clodronate prevents suppression of Ntcp expression in endotoxin-treated rats J Hepatol 42 2005 102 109
22. R.D. Goldin, I.D. Ratnayaka, I.N. Brown, and S.N. Wickramasinghe The effect of Kupffer cell elimination on ethanol-induced liver damage in mice Int J Exp Pathol 76 1995 353 359
23. T.A. Korolenko, M.S. Klishevich, M.S. Cherkanova, T.V. Alexeenko, S.Y. Zhanaeva, N.G. Savchenko, I.A. Goncharova, and E.E. Filjushina In vivo effect of selective macrophage suppression on the development of intrahepatic cholestasis in mice Bull Exp Biol Med 146 2008 396 400
24. M.K. Bijsterbosch, A.M. Duursma, M.J. Smit, O.J. Bos, J.M. Bouma, and M. Gruber Several dehydrogenases and kinases compete for endocytosis from plasma by rat tissues Biochem J 229 1985 409 417
25. M.J. Smit, A.M. Duursma, M. Joop, W. Bouma, and J.M. Gruber Receptor-mediated endocytosis of lactate dehydrogenase M, by liver macrophages: a mechanism for elimination of enzymes from plasma J Biol Chem 262 1987 13020 13026
26. C.A. Burtis, and E.R. Ashwood Tietz Textbook of Clinical Chemistry 1999 WB Saunders & Co Philadelphia, PA
27. N. Kaku Short-term and long-term changes in hepatic function in 60 patients with blunt liver injury J Trauma 27 1987 607 614
28. B.O. Fabriek, C.D. Dijkstra, and T.K. van den Berg The macrophage scavenger receptor CD163 Immunobiology 210 2005 153 160
29. A.S. De Jong, A.M. Duursma, J.M. Bourna, M. Gruber, A. Brouwer, and D.L. Knook Endocytosis of lactate dehydrogenase isoenzyme M4 in rats in vivo: experiments with enzyme labelled with O-(4-diazo-3,5-di[125I]iodobenzoyl)sucrose Biochem J 202 1982 655 660
30. C.D. Dijkstra, E.A. Döpp, T.K. van den Berg, and J.G. Damoiseaux Monoclonal antibodies against rat macrophages J Immunol Methods 174 1994 21 23
31. M.M. Polfliet, B.O. Fabriek, W.P. Danils, C.D. Dijkstra, and T.K. van den Berg The rat macrophage scavenger receptor CD163: expression, regulation and role in inflammatory mediator production Immunobiology 211 2006 419 425
32. Z.A. Radi, R.E. Guzman, and R.R. Bell Increased connective tissue extracellular matrix in the op/op model of osteopetrosis Pathobiology 76 2009 199 203