Results from a phase IIA parallel group study of JNJ-40346527, an oral CSF-1R inhibitor, in patients with active rheumatoid arthritis despite disease-modifying antirheumatic drug therapy

Journal of Rheumatology

Volumn 42, Issue 10, 2015, Pages 1752-1760

  Genovese, Mark C ^a   Hsia, Elizabeth ^b   Belkowski, Stanley M ^b   Chien, Caly ^b   Masterson, Tara ^b   Thurmond, Robin L ^b   Manthey, Carl L ^b   Yan, Xiaoyu ^b   Ge, Tingting ^b   Franks, Carol ^b   Greenspan, Andrew ^c  

^a STANFORD UNIVERSITY   (United States)

^b Janssen Research and Development LLC   (United States)

^c Janssen Scientific Affairs LLC   (United States)

Author keywords

Colony stimulating factor 1; Efficacy; Rheumatoid arthritis; Safety

Indexed keywords

4 CYANO N [2 (4,4 DIMETHYLCYCLOHEX 1 EN 1 YL) 6 (2,2,6,6 TETRAMETHYLTETRAHYDRO 2H PYRAN 4 YL)PYRIDIN 3 YL] 1H IMIDAZOLE 2 CARBOXAMIDE; ANTIINFLAMMATORY AGENT; C REACTIVE PROTEIN; COLONY STIMULATING FACTOR 1; DISEASE MODIFYING ANTIRHEUMATIC DRUG; HYDROXYCHLOROQUINE; LACTATE DEHYDROGENASE; METHOTREXATE; PLACEBO; SALAZOSULFAPYRIDINE; UNCLASSIFIED DRUG; ANTIRHEUMATIC AGENT; NEW DRUG;

ADULT; AGED; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DAS28; DENDRITIC CELL; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG DISPOSITION; DRUG EFFICACY; DRUG METABOLISM; DRUG SAFETY; DRUG WITHDRAWAL; DYSPNEA; ERYTHROCYTE SEDIMENTATION RATE; FEMALE; FEMUR FRACTURE; GASTROESOPHAGEAL REFLUX; HEALTH ASSESSMENT QUESTIONNAIRE; HUMAN; LACTATE DEHYDROGENASE BLOOD LEVEL; LIMIT OF QUANTITATION; MAJOR CLINICAL STUDY; MALE; MAXIMUM PLASMA CONCENTRATION; MONOCYTE; MUSCLE WEAKNESS; MYOSITIS; OSTEOCLAST; PATHOGENESIS; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RANDOMIZED CONTROLLED TRIAL; RHEUMATOID ARTHRITIS; SYNOVIUM; THROMBOPHLEBITIS; TIME TO MAXIMUM PLASMA CONCENTRATION; UPPER ABDOMINAL PAIN; URETER STONE; URINARY TRACT INFECTION; ANTAGONISTS AND INHIBITORS; ARTHRITIS, RHEUMATOID; CLINICAL TRIAL; COMBINATION DRUG THERAPY; DOSE RESPONSE; DRUG ADMINISTRATION; FOLLOW UP; MIDDLE AGED; ORAL DRUG ADMINISTRATION; PATIENT SAFETY; RISK ASSESSMENT; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

ADMINISTRATION, ORAL; ADULT; ANTIRHEUMATIC AGENTS; ARTHRITIS, RHEUMATOID; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; DRUG THERAPY, COMBINATION; DRUGS, INVESTIGATIONAL; FEMALE; FOLLOW-UP STUDIES; HUMANS; MACROPHAGE COLONY-STIMULATING FACTOR; MALE; MIDDLE AGED; PATIENT SAFETY; RISK ASSESSMENT; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

EID: 84943302777     PISSN: 0315162X     EISSN: 14992752     Source Type: Journal    
DOI: 10.3899/jrheum.141580     Document Type: Article

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