Delineation of an immunosuppressive gradient in hepatocellular carcinoma using high-dimensional proteomic and transcriptomic analyses

Proceedings of the National Academy of Sciences of the United States of America

Volumn 114, Issue 29, 2017, Pages E5900-E5909

  Chew, Valerie ^a   Lai, Liyun ^a   Pan, Lu ^a   Lim, Chun Jye ^a   Li, Juntao ^a   Ong, Raymond ^a   Chua, Camillus ^a   Leong, Jing Yao ^a   Lim, Kiat Hon ^b,c   Toh, Han Chong ^c,d   Lee, Ser Yee ^b,c,d   Chan, Chung Yip ^b,c,d   Goh, Brian K P ^b,c,d   Chung, Alexander ^b,c,d   Chow, Pierce K H ^b,c,d   Albani, Salvatore ^a  

^a Singapore Health Services   (Singapore)

^b SINGAPORE GENERAL HOSPITAL   (Singapore)

^c DUKE NUS MEDICAL SCHOOL   (Singapore)

^d DIVISION OF MEDICAL ONCOLOGY   (Singapore)

Author keywords

CyTOF; Hepatocellular carcinoma; Regulatory T cells; Resident memory T cells; Tumor microenvironment

Indexed keywords

CD14 ANTIGEN; CD4 ANTIGEN; CD56 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; HEPATITIS A VIRUS CELLULAR RECEPTOR 2; INTERLEUKIN 10; LAG3 PROTEIN; PROTEIN; UNCLASSIFIED DRUG; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN; PDCD1 PROTEIN, HUMAN; PROGRAMMED DEATH 1 RECEPTOR; RECEPTOR TYPE TYROSINE PROTEIN PHOSPHATASE C;

ADAPTIVE IMMUNITY; ARTICLE; CANCER GROWTH; CANCER IMMUNOTHERAPY; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOCOMPETENCE; IMMUNOFLUORESCENCE; LIVER CELL CARCINOMA; MEMORY T LYMPHOCYTE; NATURAL KILLER CELL; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEOMICS; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; TRANSCRIPTOMICS; TUMOR ASSOCIATED LEUKOCYTE; TUMOR MICROENVIRONMENT; GENE EXPRESSION PROFILING; GENETICS; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; LEUKOCYTE; LIVER TUMOR; METABOLISM; MONONUCLEAR CELL; PATHOLOGY;

CARCINOMA, HEPATOCELLULAR; CD8-POSITIVE T-LYMPHOCYTES; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION PROFILING; HUMANS; IMMUNE TOLERANCE; LEUKOCYTE COMMON ANTIGENS; LEUKOCYTES; LEUKOCYTES, MONONUCLEAR; LIVER NEOPLASMS; PROGRAMMED CELL DEATH 1 RECEPTOR; PROTEOMICS; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY; TUMOR MICROENVIRONMENT;

EID: 85024374252     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1706559114     Document Type: Article

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