Functional expression of chemokine receptor CCR6 on human effector memory CD8+ T cells

European Journal of Immunology

Volumn 37, Issue 1, 2007, Pages 54-65

  Kondo, Takaaki ^a   Takata, Hiroshi ^a   Takiguchi, Masafumi ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

Author keywords

Cell differentiation; Chemokines; Cytotoxic T cells; Human; Memory

Indexed keywords

CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CCR6; CHEMOKINE RECEPTOR CCR7; GAMMA INTERFERON; GRANZYME A; GRANZYME B; INTERLEUKIN 12; INTERLEUKIN 2; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; PERFORIN; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; CD8+ T LYMPHOCYTE; CELLULAR DISTRIBUTION; CHEMOTAXIS; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOKINE PRODUCTION; EFFECTOR CELL; ENZYME SPECIFICITY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LYMPHOCYTE FUNCTION; LYMPHOCYTE MIGRATION; MEMORY T LYMPHOCYTE; MUCOSAL IMMUNITY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE SUBPOPULATION;

ADULT; CD8-POSITIVE T-LYMPHOCYTES; CELL MEMBRANE; CHEMOKINES, CC; CHEMOTAXIS, LEUKOCYTE; COLON; FLOW CYTOMETRY; HUMANS; IMMUNITY, MUCOSAL; IMMUNOLOGIC MEMORY; IMMUNOPHENOTYPING; INTESTINAL MUCOSA; MACROPHAGE INFLAMMATORY PROTEINS; RECEPTORS, CHEMOKINE; T-LYMPHOCYTE SUBSETS;

EID: 33846400765     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200636251     Document Type: Article

References (42)

1. Guidotti, L. G. and Chisari, F. V., To kill or to cure: options in host defense against viral infection. Curr. Opin. Immunol. 1996. 8: 478-483.
2. + T cells. Immunol. Today 1996. 17: 217-224.
3. Trapani, J. A., Sutton, V. R. and Smyth, M. J., CTL granule: evolution of vesicles essential for combating virus infections. Immunol. Today 1999. 20: 351-356.
4. + T cells from a memory to memory/effector phenotype. J. Immunol 2002. 168: 5538-5550.
5. + T cells. J. Exp. Med. 1997. 186: 1407-1418.
6. + T cell development. Immunol. Today 1999. 20: 177-180.
7. + T cells reflecting their function: inverse correlation between quantitative expression of CD27 and cytotoxic effector function. Eur. J. Immunol. 2004. 34: 999-1010.
8. Campbell, J. J., Hedrick, J., Zlotnik, A., Siani, M. A., Thompson, D. A. and Butcher, E. C., Chemokines and the arrest of lymphocytes rolling under flow conditions. Science 1998. 279: 381-384.
9. Zlotnik, A. and Yoshie, O., Chemokines: a new classification system and their role in immunity. Immunity 2000. 12: 121-127.
10. Sallusto, F., Lanzavecchia, A. and Mackay, C. R., Chemokines and chemokine receptors in T-cell priming and Th1/Th2-mediated responses. Immunol. Today 1998. 19: 568-574.
11. Sallusto, F., Lenig, D., Forster, R., Lipp, M. and Lanzavecchia, A., Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 1999. 401: 708-712.
12. Sallusto, F., Gejinat, J. and Lanzavacchia, A., Central memory and effector memory T cell subsets: Function, generation, and maintenance. Annu. Rev. Immunol. 2004. 22: 745-763.
13. + T cells. J. Immunol 2004. 173: 2231-2235.
14. + T cells during peripheral differentiation. Eur. J. Immunol. 2004. 34: 3370-3378.
15. Hieshima, K., Imai, T., Opdenakker, G., Van Damme, J., Kusuda, J., Tei, H., Sakaki, Y. et al., Molecular cloning of a novel human CC chemokine liver and activation-regulated chemokine (LARC) expressed in liver. Chemotactic activity for lymphocytes and gene localization on chromosome 2. J. Biol. Chem 1997. 272: 5846-5853.
16. Power, C. A., Church, D. J., Meyer, A., Alouani, S., Proudfoot, A. E., Clark-Lewis, I., Sozzani, S. et al., Cloning and characterization of a specific receptor for the novel CC chemokine MIP-3α from lung dendritic cells. J. Exp. Med 1997. 186: 825-835.
17. Baba, M., Imai, T., Nishimura, M., Kakizaki, M., Takagi, S., Hieshima, K., Nomiyama, H. et al., Identification of CCR6, the specific receptor for a novel lymphocyte-directed CC chemokine LARC. J. Biol. Chem. 1997. 272: 14893-14898.
18. Greaves, D. R., Wang, W., Dairaghi, D. J., Dieu, M. C., Saint-Vis, B., Franz-Bacon, K., Rossi, D. et al., CCR6, a CC chemokine receptor that interacts with macrophage inflammatory protein 3α and is highly expressed in human dendritic cells. J. Exp. Med. 1997. 186: 837-844.
19. Liao, F., Rabin, R. L., Smith, C. S., Sharma, G., Nutman, T. B. and Farber, J. M., CC-chemokine receptor 6 is expressed on diverse memory subsets of T cells and determines responsiveness to macrophage inflammatory protein 3α. J. Immunol. 1999. 162: 186-194.
20. Vanbervliet, B., Homey, B., Durand, I., Massacrier, C., Ait-Yahia, S., de Bouteiller, O., Vicari, A. et al., Sequential involvement of CCR2 and CCR6 ligands for immature dendritic cell recruitment: possible role at inflamed epithelial surfaces. Eur. J. Immunol. 2002. 32: 231-242.
21. Cook, D. N., Prosser, D. M., Forster, R., Zhang, J., Kuklin, N. A., Abbondanzo, S. J., Niu, X. D. et al., CCR6 mediates dendritic cell localization, lymphocyte homeostasis, and immune responses in mucosal tissue. Immunity 2000. 12: 495-503.
22. + dendritic cells. J. Immunol. 2003. 171: 2797-2803.
23. Berlin, C., Bargatze, R. F., Campbell, J. J., von Andrian, U. H., Szabo, M.C., Hasslen, S. R., Nelson, R. D. et al., α4 integrins mediate lymphocyte attachment and rolling under physiologic flow. Cell 1995. 80: 413-422.
24. + T cell memory: relationships between epitope specificity, cell phenotype, and immediate effector function. J. Immunol. 2001. 167: 2019-2029.
25. Kanegasaki, S., Nomura, Y., Nitta, N., Akiyama, S., Tamatani, T., Goshoh, Y., Yoshida, T. et al., A novel optical assay system for the quantitative measurement of chemotaxis. J. Immunol. Methods 2003. 282: 1-11.
26. + T cell response. J. Immunol. 2002. 168: 5455-5464.
27. + T cells differently expressing 3 cytolytic effector molecules. J. Immunol. 2006. 177: 4330-4340.
28. Mallard, E., Vernel-Pauillac, F., Velu, T., Lehmann, F., Abastado, J.-P., Salcedo, M. and Bercovici, N., IL-2 production by virus- and tumor-specific human CD8 T cells is determined by their fine specificity. J. Immunol. 2004. 172: 3963-3970.
29. Yang, D., Howard, O. M., Chen, Q. and Oppenheim, J. J., Cutting edge: Immature dendritic cells generated from monocytes in the presence of TGF-β 1 express functional C-C chemokine receptor 6. J. Immunol. 1999. 167: 6644-6653.
30. Dieu, M. C., Vanbervliet, B., Vicari, A., Bridon, J. M., Oldham, E., Ait-Yahia, S., Briere, F. et al., Selective recruitment of immature and mature dendritic cells by distinct chemokines expressed in different anatomic sites. J. Exp. Med. 1998. 188: 373-386.
31. Izadpanah, A., Dwinell, B., Eckmann, L., Varki, N. M. and Kagnoff, M. F., Regulated MIP-3α/CCL20 production by human intestinal epithelium: mechanism for modulating mucosal immunity. Am. J. Physiol. Gastrointest. Liver Physiol. 2001. 280: G710-G719.
32. Kwon, J. H., Keates, S., Bassani, L., Mayer, L. F. and Keates, A. C.,Colonic epithelial cells are a major site of macrophage inflammatory protein 3α (MIP-3α) production in normal colon and inflammatory bowel disease. Gut 2002. 51: 818-826.
33. Homey, B., Dieu-Nosjean, M. C., Wiesenborn, A., Massacrier, C., Pin, J.J., Oldham, E., Catron, D. et al., Up-regulation of macrophage inflammatory protein-3 alpha/CCL20 and CC chemokine receptor 6 in psoriasis. J. Immunol. 2000. 164: 6621-6632.
34. Schmuth, M., Neyer, S., Rainer, C., Grassegger, A., Fritsch, P., Romani, N. and Heufler, C., Expression of the C-C chemokine MIP-3 alpha/CCL20 in human epidermis with impaired permeability barrier function. Exp. Dermatol. 2002. 11: 135-142.
35. Wherry, E. J., Teichgraber, V., Becker, T. C., Masopust, D., Kaech, S. M., Antia, R., von Andrian, U. H. et al., Lineage relationship and protective immunity of memory CD8 T cell subsets. Nat. Immunol 2003. 4: 225-234.
36. Masopust, D., Vezys, V., Marzo, A. L. and Lefrancois, L., Preferential localization of effector memory cells in nonlymphoid tissue. Science 2001. 291: 2413-2417.
37. Campbell, J. J., Murphy, K. E., Kunkel, E. J., Brightling, C. E., Soler,D., Shen, Z., Boisvert, J. et al., CCR7 expression and memory T cell diversity in humans. J. Immunol 2001. 166: 877-884.
38. + T cells vary in differentiation phenotype in different persistent virus infections. Nat. Med. 2002. 8: 379-338.
39. Altman, J. D., Moss, P. A., Goulder, P. J., Barouch, D. H., McHeyzer-Williams, M. G., Bell, J. i., McMichael, A. J. et al., Phenotypic analysis of antigen-specific T lymphocytes. Science 1996. 274: 94-96.
40. Gavioli, R., Kurilla, M. G., de Campos-Lima, P. O., Wallace, L. E., Dolcetti, R., Murray, R. J., Rickinson, A. B. et al., Multiple HLA-A11-restricted cytotoxic T-lymphocyte epitopes of different immunogenicities in the Epstein-Barr virus-encoded nuclear antigen 4. J. Virol 1993. 67: 1572-1578.
41. + T cells. Blood 2003. 101: 1460-1468.
42. Wills, M. R., Carmichael, A. J., Mynard, K., Jin, X., Weekes, M. P., Plachter, B. and Sissons, J. G., The human cytotoxic T-lymphocyte (CTL) response to cytomegalovirus is dominated by structural protein pp65: frequency, specificity, and T-cell receptor usage of pp65-specific CTL. J. Virol. 1996. 70: 7569-7579.