CMV-specific T-cell responses at older ages: Broad responses with a large central memory component may be key to long-term survival

Journal of Infectious Diseases

Volumn 215, Issue 8, 2017, Pages 1212-1220

  Bajwa, Martha ^a   Vita, Serena ^b   Vescovini, Rosanna ^c   Larsen, Martin ^d,e   Sansoni, Paolo ^c   Terrazzini, Nadia ^f   Caserta, Stefano ^a   Thomas, David ^a   Davies, Kevin A ^a   Smith, Helen ^a   Kern, Florian ^a  

^a BRIGHTON AND SUSSEX MEDICAL SCHOOL   (United Kingdom)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c UNIVERSITY OF PARMA   (Italy)

^d Assistance publique Hôpitaux de Paris   (France)

^e PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^f UNIVERSITY OF BRIGHTON   (United Kingdom)

Author keywords

Ageing; Central memory T cells; Cytomegalovirus; Response breadth; T cell memory inflation; T cells

Indexed keywords

CD107 ANTIGEN; CD27 ANTIGEN; CD40 LIGAND; CD45RA ANTIGEN; CELL ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 2; TUMOR NECROSIS FACTOR; UL123 PROTEIN; UL83 PROTEIN; UNCLASSIFIED DRUG; VIRAL PROTEIN; BIOLOGICAL MARKER;

ADULT; AGED; ARTICLE; CD4+ T LYMPHOCYTE; CELL EXPANSION; CELL SPECIFICITY; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOMEGALOVIRUS; FEMALE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; IMMUNOSENESCENCE; IN VITRO STUDY; MALE; MEMORY T LYMPHOCYTE; MIDDLE AGED; NONHUMAN; NORMAL HUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN TARGETING; SURVIVAL TIME; T LYMPHOCYTE ACTIVATION; VERY ELDERLY; VIRUS CELL INTERACTION; YOUNG ADULT; AGING; CD8+ T LYMPHOCYTE; COMPARATIVE STUDY; CYTOMEGALOVIRUS INFECTION; FLOW CYTOMETRY; GENETICS; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; METABOLISM;

ADULT; AGED; AGED, 80 AND OVER; AGING; BIOMARKERS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; FEMALE; FLOW CYTOMETRY; HEALTHY VOLUNTEERS; HUMANS; IMMUNOLOGIC MEMORY; INTERFERON-GAMMA; MALE; MIDDLE AGED; TUMOR NECROSIS FACTOR-ALPHA; YOUNG ADULT;

EID: 85023774635     PISSN: 00221899     EISSN: 15376613     Source Type: Journal    
DOI: 10.1093/infdis/jix080     Document Type: Article

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