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Volumn 131, Issue 15, 2017, Pages 1905-1917

Metabolic disturbances of non-alcoholic fatty liver resemble the alterations typical for type 2 diabetes

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CHOLESTEROL; GAMMA GLUTAMYLTRANSFERASE; GLUCOSE; HIGH DENSITY LIPOPROTEIN; INSULIN; LOW DENSITY LIPOPROTEIN; TRIACYLGLYCEROL;

EID: 85023640817     PISSN: 01435221     EISSN: 14708736     Source Type: Journal    
DOI: 10.1042/CS20170261     Document Type: Article
Times cited : (39)

References (50)
  • 1
    • 77952558012 scopus 로고    scopus 로고
    • The natural history of non-alcoholic fatty liver disease
    • Caldwell, S. and Argo, C. (2010) The natural history of non-alcoholic fatty liver disease. Dig. Dis. 28, 162-168
    • (2010) Dig. Dis , vol.28 , pp. 162-168
    • Caldwell, S.1    Argo, C.2
  • 3
    • 84905381294 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease and type 2 diabetes mellitus: the liver disease of our age?
    • Firneisz, G. (2014) Non-alcoholic fatty liver disease and type 2 diabetes mellitus: the liver disease of our age? World J. Gastroenterol. 20, 9072-9089
    • (2014) World J. Gastroenterol , vol.20 , pp. 9072-9089
    • Firneisz, G.1
  • 4
    • 33845490856 scopus 로고    scopus 로고
    • Review: The role of insulin resistance in nonalcoholic fatty liver disease
    • Utzschneider, K.M. and Kahn, S.E. (2006) Review: The role of insulin resistance in nonalcoholic fatty liver disease. J. Clin. Endocrinol. Metab. 91, 4753-4761
    • (2006) J. Clin. Endocrinol. Metab , vol.91 , pp. 4753-4761
    • Utzschneider, K.M.1    Kahn, S.E.2
  • 5
    • 77952563455 scopus 로고    scopus 로고
    • Liver fat in the pathogenesis of insulin resistance and type 2 diabetes
    • Yki-Jarvinen, H. (2010) Liver fat in the pathogenesis of insulin resistance and type 2 diabetes. Dig. Dis. 28, 203-209
    • (2010) Dig. Dis , vol.28 , pp. 203-209
    • Yki-Jarvinen, H.1
  • 6
    • 84859393575 scopus 로고    scopus 로고
    • Prevalence of prediabetes and diabetes and metabolic profile of patients with nonalcoholic fatty liver disease (NAFLD)
    • Ortiz-Lopez, C., Lomonaco, R., Orsak, B., Finch, J., Chang, Z., Kochunov, V.G. et al. (2012) Prevalence of prediabetes and diabetes and metabolic profile of patients with nonalcoholic fatty liver disease (NAFLD). Diabetes Care 35, 873-878
    • (2012) Diabetes Care , vol.35 , pp. 873-878
    • Ortiz-Lopez, C.1    Lomonaco, R.2    Orsak, B.3    Finch, J.4    Chang, Z.5    Kochunov, V.G.6
  • 7
    • 71849084817 scopus 로고    scopus 로고
    • The association between normal alanine aminotransferase levels and the metabolic syndrome: 2005 Korean National Health and Nutrition Examination Survey
    • Suh, S.Y., Choi, S.E., Ahn, H.Y., Yang, H.M., Kim, Y.I. and Sung, N.J. (2009) The association between normal alanine aminotransferase levels and the metabolic syndrome: 2005 Korean National Health and Nutrition Examination Survey. Metabolism 58, 1731-1736
    • (2009) Metabolism , vol.58 , pp. 1731-1736
    • Suh, S.Y.1    Choi, S.E.2    Ahn, H.Y.3    Yang, H.M.4    Kim, Y.I.5    Sung, N.J.6
  • 8
    • 15744377647 scopus 로고    scopus 로고
    • Contribution of metabolic factors to alanine aminotransferase activity in persons with other causes of liver disease
    • Ioannou, G.N., Weiss, N.S., Boyko, E.J., Kahn, S.E. and Lee, S.P. (2005) Contribution of metabolic factors to alanine aminotransferase activity in persons with other causes of liver disease. Gastroenterology 128, 627-635
    • (2005) Gastroenterology , vol.128 , pp. 627-635
    • Ioannou, G.N.1    Weiss, N.S.2    Boyko, E.J.3    Kahn, S.E.4    Lee, S.P.5
  • 9
    • 42949178538 scopus 로고    scopus 로고
    • Liver, muscle, and adipose tissue insulin action is directly related to intrahepatic triglyceride content in obese subjects
    • Korenblat, K.M., Fabbrini, E., Mohammed, B.S. and Klein, S. (2008) Liver, muscle, and adipose tissue insulin action is directly related to intrahepatic triglyceride content in obese subjects. Gastroenterology 134, 1369-1375
    • (2008) Gastroenterology , vol.134 , pp. 1369-1375
    • Korenblat, K.M.1    Fabbrini, E.2    Mohammed, B.S.3    Klein, S.4
  • 10
    • 38949192017 scopus 로고    scopus 로고
    • Increased fat accumulation in liver may link insulin resistance with subcutaneous abdominal adipocyte enlargement, visceral adiposity, and hypoadiponectinemia in obese individuals
    • Koska, J., Stefan, N., Permana, P.A., Weyer, C., Sonoda, M., Bogardus, C. et al. (2008) Increased fat accumulation in liver may link insulin resistance with subcutaneous abdominal adipocyte enlargement, visceral adiposity, and hypoadiponectinemia in obese individuals. Am. J. Clin. Nutr. 87, 295-302
    • (2008) Am. J. Clin. Nutr , vol.87 , pp. 295-302
    • Koska, J.1    Stefan, N.2    Permana, P.A.3    Weyer, C.4    Sonoda, M.5    Bogardus, C.6
  • 11
    • 37149001609 scopus 로고    scopus 로고
    • Increased intrahepatic triglyceride is associated with peripheral insulin resistance: in vivo MR imaging and spectroscopy studies
    • Hwang, J.H., Stein, D.T., Barzilai, N., Cui, M.H., Tonelli, J., Kishore, P. et al. (2007) Increased intrahepatic triglyceride is associated with peripheral insulin resistance: in vivo MR imaging and spectroscopy studies. Am. J. Physiol. Endocrinol. Metab. 293, E1663-1669
    • (2007) Am. J. Physiol. Endocrinol. Metab , vol.293 , pp. E1663-E1669
    • Hwang, J.H.1    Stein, D.T.2    Barzilai, N.3    Cui, M.H.4    Tonelli, J.5    Kishore, P.6
  • 12
    • 34547514221 scopus 로고    scopus 로고
    • Relationship between hepatic/visceral fat and hepatic insulin resistance in nondiabetic and type 2 diabetic subjects
    • Gastaldelli, A., Cusi, K., Pettiti, M., Hardies, J., Miyazaki, Y., Berria, R. et al. (2007) Relationship between hepatic/visceral fat and hepatic insulin resistance in nondiabetic and type 2 diabetic subjects. Gastroenterology 133, 496-506
    • (2007) Gastroenterology , vol.133 , pp. 496-506
    • Gastaldelli, A.1    Cusi, K.2    Pettiti, M.3    Hardies, J.4    Miyazaki, Y.5    Berria, R.6
  • 13
    • 33745107554 scopus 로고    scopus 로고
    • Mechanisms of Disease: hepatic steatosis in type 2 diabetes-pathogenesis and clinical relevance
    • Roden, M. (2006) Mechanisms of Disease: hepatic steatosis in type 2 diabetes-pathogenesis and clinical relevance. Nature clinical practice. Endocrinol. Metab. 2, 335-348
    • (2006) Nature clinical practice. Endocrinol. Metab , vol.2 , pp. 335-348
    • Roden, M.1
  • 14
    • 84898645515 scopus 로고    scopus 로고
    • Ectopic fat accumulation and distant organ-specific insulin resistance in Japanese people with nonalcoholic fatty liver disease
    • Kato, K., Takamura, T., Takeshita, Y., Ryu, Y., Misu, H., Ota, T. et al. (2014) Ectopic fat accumulation and distant organ-specific insulin resistance in Japanese people with nonalcoholic fatty liver disease. PLoS ONE 9, e92170
    • (2014) PLoS ONE , vol.9
    • Kato, K.1    Takamura, T.2    Takeshita, Y.3    Ryu, Y.4    Misu, H.5    Ota, T.6
  • 16
    • 49449097960 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease is associated with hepatic and skeletal muscle insulin resistance in overweight adolescents
    • Deivanayagam, S., Mohammed, B.S., Vitola, B.E., Naguib, G.H., Keshen, T.H., Kirk, E.P. et al. (2008) Nonalcoholic fatty liver disease is associated with hepatic and skeletal muscle insulin resistance in overweight adolescents. Am. J. Clin. Nutr. 88, 257-262
    • (2008) Am. J. Clin. Nutr , vol.88 , pp. 257-262
    • Deivanayagam, S.1    Mohammed, B.S.2    Vitola, B.E.3    Naguib, G.H.4    Keshen, T.H.5    Kirk, E.P.6
  • 17
    • 84859942552 scopus 로고    scopus 로고
    • Effect of adipose tissue insulin resistance on metabolic parameters and liver histology in obese patients with nonalcoholic fatty liver disease
    • Lomonaco, R., Ortiz-Lopez, C., Orsak, B., Webb, A., Hardies, J., Darland, C. et al. (2012) Effect of adipose tissue insulin resistance on metabolic parameters and liver histology in obese patients with nonalcoholic fatty liver disease. Hepatology 55, 1389-1397
    • (2012) Hepatology , vol.55 , pp. 1389-1397
    • Lomonaco, R.1    Ortiz-Lopez, C.2    Orsak, B.3    Webb, A.4    Hardies, J.5    Darland, C.6
  • 18
    • 58049093391 scopus 로고    scopus 로고
    • Reduced basal ATP synthetic flux of skeletal muscle in patients with previous acromegaly
    • Szendroedi, J., Zwettler, E., Schmid, A.I., Chmelik, M., Pacini, G., Kacerovsky, G. et al. (2008) Reduced basal ATP synthetic flux of skeletal muscle in patients with previous acromegaly. PLoS ONE 3, e3958
    • (2008) PLoS ONE , vol.3
    • Szendroedi, J.1    Zwettler, E.2    Schmid, A.I.3    Chmelik, M.4    Pacini, G.5    Kacerovsky, G.6
  • 19
    • 58149346025 scopus 로고    scopus 로고
    • Lower intrinsic ADP-stimulated mitochondrial respiration underlies in vivo mitochondrial dysfunction in muscle of male type 2 diabetic patients
    • Phielix, E., Schrauwen-Hinderling, V.B., Mensink, M., Lenaers, E., Meex, R., Hoeks, J. et al. (2008) Lower intrinsic ADP-stimulated mitochondrial respiration underlies in vivo mitochondrial dysfunction in muscle of male type 2 diabetic patients. Diabetes 57, 2943-2949
    • (2008) Diabetes , vol.57 , pp. 2943-2949
    • Phielix, E.1    Schrauwen-Hinderling, V.B.2    Mensink, M.3    Lenaers, E.4    Meex, R.5    Hoeks, J.6
  • 20
    • 85028266326 scopus 로고    scopus 로고
    • Triglyceride glucose index as a surrogate measure of insulin sensitivity in obese adolescents with normoglycemia, prediabetes, and type 2 diabetes mellitus: comparison with the hyperinsulinemic-euglycemic clamp
    • Mohd Nor, N.S., Lee, S., Bacha, F., Tfayli, H. and Arslanian, S. (2016) Triglyceride glucose index as a surrogate measure of insulin sensitivity in obese adolescents with normoglycemia, prediabetes, and type 2 diabetes mellitus: comparison with the hyperinsulinemic-euglycemic clamp. Pediatr. Diab. 17, 458-465
    • (2016) Pediatr. Diab , vol.17 , pp. 458-465
    • Mohd Nor, N.S.1    Lee, S.2    Bacha, F.3    Tfayli, H.4    Arslanian, S.5
  • 23
    • 84919609004 scopus 로고    scopus 로고
    • Proton magnetic resonance spectroscopy reveals increased hepatic lipid content after a single high-fat meal with no additional modulation by added protein
    • Lindeboom, L., Nabuurs, C.I., Hesselink, M.K., Wildberger, J.E., Schrauwen, P. and Schrauwen-Hinderling, V.B. (2015) Proton magnetic resonance spectroscopy reveals increased hepatic lipid content after a single high-fat meal with no additional modulation by added protein. Am. J. Clin. Nutr. 101, 65-71
    • (2015) Am. J. Clin. Nutr , vol.101 , pp. 65-71
    • Lindeboom, L.1    Nabuurs, C.I.2    Hesselink, M.K.3    Wildberger, J.E.4    Schrauwen, P.5    Schrauwen-Hinderling, V.B.6
  • 24
    • 58149359688 scopus 로고    scopus 로고
    • Quantification of liver fat content: comparison of triple-echo chemical shift gradient-echo imaging and in vivo proton MR spectroscopy
    • Guiu, B., Petit, J.M., Loffroy, R., Ben Salem, D., Aho, S., Masson, D. et al. (2009) Quantification of liver fat content: comparison of triple-echo chemical shift gradient-echo imaging and in vivo proton MR spectroscopy. Radiology 250, 95-102
    • (2009) Radiology , vol.250 , pp. 95-102
    • Guiu, B.1    Petit, J.M.2    Loffroy, R.3    Ben Salem, D.4    Aho, S.5    Masson, D.6
  • 25
    • 12144259379 scopus 로고    scopus 로고
    • Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population
    • Szczepaniak, L.S., Nurenberg, P., Leonard, D., Browning, J.D., Reingold, J.S., Grundy, S. et al. (2005) Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population. Am. J. Physiol. Endocrinol. Metab. 288, E462-E468
    • (2005) Am. J. Physiol. Endocrinol. Metab , vol.288 , pp. E462-E468
    • Szczepaniak, L.S.1    Nurenberg, P.2    Leonard, D.3    Browning, J.D.4    Reingold, J.S.5    Grundy, S.6
  • 26
    • 0018520840 scopus 로고
    • Glucose clamp technique: a method for quantifying insulin secretion and resistance
    • DeFronzo, R.A., Tobin, J.D. and Andres, R. (1979) Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am. J. Physiol. 237, E214-E223
    • (1979) Am. J. Physiol , vol.237 , pp. E214-E223
    • DeFronzo, R.A.1    Tobin, J.D.2    Andres, R.3
  • 27
    • 84962030356 scopus 로고    scopus 로고
    • Evidence for a direct effect of the NAD+ precursor acipimox on muscle mitochondrial function in humans
    • van de Weijer, T., Phielix, E., Bilet, L., Williams, E.G., Ropelle, E.R., Bierwagen, A. et al. (2015) Evidence for a direct effect of the NAD+ precursor acipimox on muscle mitochondrial function in humans. Diabetes 64, 1193-1201
    • (2015) Diabetes , vol.64 , pp. 1193-1201
    • van de Weijer, T.1    Phielix, E.2    Bilet, L.3    Williams, E.G.4    Ropelle, E.R.5    Bierwagen, A.6
  • 28
    • 0023245416 scopus 로고
    • Estimation of endogenous glucose production during hyperinsulinemic-euglycemic glucose clamps Comparison of unlabeled and labeled exogenous glucose infusates
    • Finegood, D.T., Bergman, R.N. and Vranic, M. (1987) Estimation of endogenous glucose production during hyperinsulinemic-euglycemic glucose clamps. Comparison of unlabeled and labeled exogenous glucose infusates. Diabetes 36, 914-924
    • (1987) Diabetes , vol.36 , pp. 914-924
    • Finegood, D.T.1    Bergman, R.N.2    Vranic, M.3
  • 29
    • 0035012319 scopus 로고    scopus 로고
    • The quantification of gluconeogenesis in healthy men by (2)H2O and [2-(13)C]glycerol yields different results: rates of gluconeogenesis in healthy men measured with (2)H2O are higher than those measured with [2-(13)C]glycerol
    • Ackermans, M.T., Pereira Arias, A.M., Bisschop, P.H., Endert, E., Sauerwein, H.P. and Romijn, J.A. (2001) The quantification of gluconeogenesis in healthy men by (2)H2O and [2-(13)C]glycerol yields different results: rates of gluconeogenesis in healthy men measured with (2)H2O are higher than those measured with [2-(13)C]glycerol. J. Clin. Endocrinol. Metab. 86, 2220-2226
    • (2001) J. Clin. Endocrinol. Metab , vol.86 , pp. 2220-2226
    • Ackermans, M.T.1    Pereira Arias, A.M.2    Bisschop, P.H.3    Endert, E.4    Sauerwein, H.P.5    Romijn, J.A.6
  • 30
    • 0000648085 scopus 로고
    • Influences of glucose loading and of injected insulin on hepatic glucose output
    • Steele, R. (1959) Influences of glucose loading and of injected insulin on hepatic glucose output. Ann. N.Y. Acad. Sci. 82, 420-430
    • (1959) Ann. N.Y. Acad. Sci , vol.82 , pp. 420-430
    • Steele, R.1
  • 31
    • 0026128307 scopus 로고
    • Table of nonprotein respiratory quotient: an update
    • Peronnet, F. and Massicotte, D. (1991) Table of nonprotein respiratory quotient: an update. Can. J. Sport Sci. 16, 23-29
    • (1991) Can. J. Sport Sci , vol.16 , pp. 23-29
    • Peronnet, F.1    Massicotte, D.2
  • 32
    • 0015348189 scopus 로고
    • Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge
    • Friedewald, W.T., Levy, R.I. and Fredrickson, D.S. (1972) Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin. Chem. 18, 499-502
    • (1972) Clin. Chem , vol.18 , pp. 499-502
    • Friedewald, W.T.1    Levy, R.I.2    Fredrickson, D.S.3
  • 34
    • 84951855878 scopus 로고    scopus 로고
    • Peripheral insulin resistance predicts liver damage in nondiabetic subjects with nonalcoholic fatty liver disease
    • Rosso, C., Mezzabotta, L., Gaggini, M., Salomone, F., Gambino, R., Marengo, A. et al. (2016) Peripheral insulin resistance predicts liver damage in nondiabetic subjects with nonalcoholic fatty liver disease. Hepatology 63, 107-116
    • (2016) Hepatology , vol.63 , pp. 107-116
    • Rosso, C.1    Mezzabotta, L.2    Gaggini, M.3    Salomone, F.4    Gambino, R.5    Marengo, A.6
  • 35
    • 84920998988 scopus 로고    scopus 로고
    • The role of liver fat and insulin resistance as determinants of plasma aminotransferase elevation in nonalcoholic fatty liver disease
    • Maximos, M., Bril, F., Portillo Sanchez, P., Lomonaco, R., Orsak, B., Biernacki, D. et al. (2015) The role of liver fat and insulin resistance as determinants of plasma aminotransferase elevation in nonalcoholic fatty liver disease. Hepatology 61, 153-160
    • (2015) Hepatology , vol.61 , pp. 153-160
    • Maximos, M.1    Bril, F.2    Portillo Sanchez, P.3    Lomonaco, R.4    Orsak, B.5    Biernacki, D.6
  • 36
    • 85011406124 scopus 로고    scopus 로고
    • Prevalence and determinants of non-alcoholic fatty liver disease in lifelines: a large Dutch population cohort
    • van den Berg, E.H., Amini, M., Schreuder, T.C., Dullaart, R.P., Faber, K.N., Alizadeh, B.Z. et al. (2017) Prevalence and determinants of non-alcoholic fatty liver disease in lifelines: a large Dutch population cohort. PLoS ONE 12, e0171502
    • (2017) PLoS ONE , vol.12
    • van den Berg, E.H.1    Amini, M.2    Schreuder, T.C.3    Dullaart, R.P.4    Faber, K.N.5    Alizadeh, B.Z.6
  • 37
    • 84904908862 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease
    • Sattar, N., Forrest, E. and Preiss, D. (2014) Non-alcoholic fatty liver disease. BMJ 349, g4596
    • (2014) BMJ , vol.349
    • Sattar, N.1    Forrest, E.2    Preiss, D.3
  • 38
    • 0000881165 scopus 로고
    • The clinical significance of alterations in transaminase activities of serum and other body fluids
    • Wroblewski, F. (1958) The clinical significance of alterations in transaminase activities of serum and other body fluids. Adv. Clin. Chem. 1, 313-351
    • (1958) Adv. Clin. Chem , vol.1 , pp. 313-351
    • Wroblewski, F.1
  • 39
    • 10644220306 scopus 로고    scopus 로고
    • Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity
    • Browning, J.D., Szczepaniak, L.S., Dobbins, R., Nuremberg, P., Horton, J.D., Cohen, J.C. et al. (2004) Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Hepatology 40, 1387-1395
    • (2004) Hepatology , vol.40 , pp. 1387-1395
    • Browning, J.D.1    Szczepaniak, L.S.2    Dobbins, R.3    Nuremberg, P.4    Horton, J.D.5    Cohen, J.C.6
  • 40
    • 84930791899 scopus 로고    scopus 로고
    • High prevalence of nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus and normal plasma aminotransferase levels
    • Portillo-Sanchez, P., Bril, F., Maximos, M., Lomonaco, R., Biernacki, D., Orsak, B. et al. (2015) High prevalence of nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus and normal plasma aminotransferase levels. J. Clin. Endocrinol. Metab. 100, 2231-2238
    • (2015) J. Clin. Endocrinol. Metab , vol.100 , pp. 2231-2238
    • Portillo-Sanchez, P.1    Bril, F.2    Maximos, M.3    Lomonaco, R.4    Biernacki, D.5    Orsak, B.6
  • 41
    • 84928994487 scopus 로고    scopus 로고
    • Importance of imaging and recent developments in diagnosis of nonalcoholic fatty liver disease
    • Koplay, M., Sivri, M., Erdogan, H. and Nayman, A. (2015) Importance of imaging and recent developments in diagnosis of nonalcoholic fatty liver disease. World J. Hepatol. 7, 769-776
    • (2015) World J. Hepatol , vol.7 , pp. 769-776
    • Koplay, M.1    Sivri, M.2    Erdogan, H.3    Nayman, A.4
  • 42
    • 50249101135 scopus 로고    scopus 로고
    • Effects of metformin on peripheral insulin sensitivity and intracellular lipid contents in muscle and liver of overweight Japanese subjects
    • Tamura, Y., Watada, H., Sato, F., Kumashiro, N., Sakurai, Y., Hirose, T. et al. (2008) Effects of metformin on peripheral insulin sensitivity and intracellular lipid contents in muscle and liver of overweight Japanese subjects. Diabetes Obes. Metab. 10, 733-738
    • (2008) Diabetes Obes. Metab , vol.10 , pp. 733-738
    • Tamura, Y.1    Watada, H.2    Sato, F.3    Kumashiro, N.4    Sakurai, Y.5    Hirose, T.6
  • 43
    • 0036312905 scopus 로고    scopus 로고
    • Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men
    • Seppala-Lindroos, A., Vehkavaara, S., Hakkinen, A.M., Goto, T., Westerbacka, J., Sovijarvi, A. et al. (2002) Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men. J. Clin. Endocrinol. Metab. 87, 3023-3028
    • (2002) J. Clin. Endocrinol. Metab , vol.87 , pp. 3023-3028
    • Seppala-Lindroos, A.1    Vehkavaara, S.2    Hakkinen, A.M.3    Goto, T.4    Westerbacka, J.5    Sovijarvi, A.6
  • 44
    • 20944450486 scopus 로고    scopus 로고
    • Insulin resistance in non-diabetic patients with non-alcoholic fatty liver disease: sites and mechanisms
    • Bugianesi, E., Gastaldelli, A., Vanni, E., Gambino, R., Cassader, M., Baldi, S. et al. (2005) Insulin resistance in non-diabetic patients with non-alcoholic fatty liver disease: sites and mechanisms. Diabetologia 48, 634-642
    • (2005) Diabetologia , vol.48 , pp. 634-642
    • Bugianesi, E.1    Gastaldelli, A.2    Vanni, E.3    Gambino, R.4    Cassader, M.5    Baldi, S.6
  • 45
    • 70350064027 scopus 로고    scopus 로고
    • Importance of changes in adipose tissue insulin resistance to histological response during thiazolidinedione treatment of patients with nonalcoholic steatohepatitis
    • Gastaldelli, A., Harrison, S.A., Belfort-Aguilar, R., Hardies, L.J., Balas, B., Schenker, S. et al. (2009) Importance of changes in adipose tissue insulin resistance to histological response during thiazolidinedione treatment of patients with nonalcoholic steatohepatitis. Hepatology 50, 1087-1093
    • (2009) Hepatology , vol.50 , pp. 1087-1093
    • Gastaldelli, A.1    Harrison, S.A.2    Belfort-Aguilar, R.3    Hardies, L.J.4    Balas, B.5    Schenker, S.6
  • 46
    • 85019562792 scopus 로고    scopus 로고
    • Role of adipose tissue insulin resistance in the natural history of type 2 diabetes: results from the San Antonio Metabolism Study
    • Gastaldelli, A., Gaggini, M. and DeFronzo, R.A. (2017) Role of adipose tissue insulin resistance in the natural history of type 2 diabetes: results from the San Antonio Metabolism Study. Diabetes 66, 815-822
    • (2017) Diabetes , vol.66 , pp. 815-822
    • Gastaldelli, A.1    Gaggini, M.2    DeFronzo, R.A.3
  • 47
    • 84877854022 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease (NAFLD) and its connection with insulin resistance, dyslipidemia, atherosclerosis and coronary heart disease
    • Gaggini, M., Morelli, M., Buzzigoli, E., DeFronzo, R.A., Bugianesi, E. and Gastaldelli, A. (2013) Non-alcoholic fatty liver disease (NAFLD) and its connection with insulin resistance, dyslipidemia, atherosclerosis and coronary heart disease. Nutrients 5, 1544-1560
    • (2013) Nutrients , vol.5 , pp. 1544-1560
    • Gaggini, M.1    Morelli, M.2    Buzzigoli, E.3    DeFronzo, R.A.4    Bugianesi, E.5    Gastaldelli, A.6
  • 48
    • 46049089412 scopus 로고    scopus 로고
    • Increased liver fat, impaired insulin clearance, and hepatic and adipose tissue insulin resistance in type 2 diabetes
    • Kotronen, A., Juurinen, L., Tiikkainen, M., Vehkavaara, S. and Yki-Jarvinen, H. (2008) Increased liver fat, impaired insulin clearance, and hepatic and adipose tissue insulin resistance in type 2 diabetes. Gastroenterology 135, 122-130
    • (2008) Gastroenterology , vol.135 , pp. 122-130
    • Kotronen, A.1    Juurinen, L.2    Tiikkainen, M.3    Vehkavaara, S.4    Yki-Jarvinen, H.5
  • 49
    • 0034076660 scopus 로고    scopus 로고
    • Fuel selection in human skeletal muscle in insulin resistance: a reexamination
    • Kelley, D.E. and Mandarino, L.J. (2000) Fuel selection in human skeletal muscle in insulin resistance: a reexamination. Diabetes 49, 677-683
    • (2000) Diabetes , vol.49 , pp. 677-683
    • Kelley, D.E.1    Mandarino, L.J.2
  • 50
    • 85013833413 scopus 로고    scopus 로고
    • Metabolic and histological implications of intrahepatic triglyceride content in nonalcoholic fatty liver disease
    • Bril, F., Barb, D., Portillo-Sanchez, P., Biernacki, D., Lomonaco, R., Suman, A. et al. (2017) Metabolic and histological implications of intrahepatic triglyceride content in nonalcoholic fatty liver disease. Hepatology 65, 1132-1144
    • (2017) Hepatology , vol.65 , pp. 1132-1144
    • Bril, F.1    Barb, D.2    Portillo-Sanchez, P.3    Biernacki, D.4    Lomonaco, R.5    Suman, A.6


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