How to measure adipose tissue insulin sensitivity

Journal of Clinical Endocrinology and Metabolism

Volumn 102, Issue 4, 2017, Pages 1193-1199

  Søndergaard, Esben ^a,b,c   De Ycaza, Ana Elena Espinosa ^a,d   Morgan Bathke, Maria ^a,e   Jensen, Michael D ^a  

^a MAYO CLINIC   (United States)

^b AARHUS UNIVERSITY HOSPITAL   (Denmark)

^c DANISH DIABETES ACADEMY   (Denmark)

^d UNIVERSIDAD DE PANAMÁ   (Panama)

^e VITERBO UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; INSULIN; PALMITIC ACID; PALMITIC ACID DERIVATIVE;

ADIPOSE TISSUE; ADIPOSE TISSUE INSULIN RESISTANCE INDEX; ADULT; AGE; ARTICLE; CLINICAL ARTICLE; CONCENTRATION (PARAMETERS); CORRELATIONAL STUDY; FEMALE; FITNESS; HUMAN; HYPERINSULINEMIC EUGLYCEMIC CLAMP TECHNIQUE; IC50; INSULIN SENSITIVITY; INTERMETHOD COMPARISON; LIPOLYSIS; MALE; MEASUREMENT; MULTISTEP PANCREATIC CLAMP; NON INSULIN DEPENDENT DIABETES MELLITUS; OXYGEN CONSUMPTION; PREDICTION; PREDICTIVE VALUE; PREDICTOR VARIABLE; REPRODUCIBILITY; TREND STUDY; BLOOD; CHEMISTRY; COMPARATIVE STUDY; DIET RESTRICTION; GLUCOSE CLAMP TECHNIQUE; INSULIN RESISTANCE; METABOLISM; MIDDLE AGED; PROCEDURES; YOUNG ADULT;

ADIPOSE TISSUE; ADULT; FASTING; FATTY ACIDS, NONESTERIFIED; FEMALE; GLUCOSE CLAMP TECHNIQUE; HUMANS; INSULIN; INSULIN RESISTANCE; MALE; MIDDLE AGED; PALMITATES; YOUNG ADULT;

EID: 85017291713     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2017-00047     Document Type: Article

References (26)

1. Groop LC, Bonadonna RC, DelPrato S, Ratheiser K, Zyck K, Ferrannini E, DeFronzo RA. Glucose and free fatty acid metabolism in non-insulin-dependent diabetes mellitus. Evidence for multiple sites of insulin resistance. J Clin Invest. 1989;84(1):205-213.
2. Ferrannini E, Barrett EJ, Bevilacqua S, DeFronzo RA. Effect of fatty acids on glucose production and utilization in man. J Clin Invest. 1983;72(5):1737-1747.
3. Shulman GI. Ectopic fat in insulin resistance, dyslipidemia, and cardiometabolic disease. N Engl J Med. 2014;371(12):1131-1141.
4. Søndergaard E, Jensen MD. Quantification of adipose tissue insulin sensitivity. J Investig Med. 2016;64(5):989-991.
5. Groop LC, Saloranta C, Shank M, Bonadonna RC, Ferrannini E, DeFronzo RA. The role of free fatty acid metabolism in the pathogenesis of insulin resistance in obesity and noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab. 1991;72(1):96-107.
6. Jensen MD, Caruso M, Heiling V, Miles JM. Insulin regulation of lipolysis in nondiabetic andIDDMsubjects. Diabetes. 1989;38(12): 1595-1601.
7. Gastaldelli A, Harrison SA, Belfort-Aguilar R, Hardies LJ, Balas B, Schenker S, Cusi K. Importance of changes in adipose tissue insulin resistance to histological response during thiazolidinedione treatment of patients with nonalcoholic steatohepatitis. Hepatology. 2009;50(4):1087-1093.
8. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28(7):412-419.
9. Bell LN, Wang J, Muralidharan S, Chalasani S, Fullenkamp AM, Wilson LA, Sanyal AJ, Kowdley KV, Neuschwander-Tetri BA, Brunt EM, McCullough AJ, Bass NM, Diehl AM, Unalp-Arida A, Chalasani N; Nonalcoholic Steatohepatitis Clinical Research Network. Relationship between adipose tissue insulin resistance and liver histology in nonalcoholic steatohepatitis: a pioglitazone versus vitamin E versus placebo for the treatment of nondiabetic patients with nonalcoholic steatohepatitis trial follow-up study. Hepatology. 2012;56(4):1311-1318.
10. Jensen MD, Nielsen S. Insulin dose response analysis of free fatty acid kinetics. Metabolism. 2007;56(1):68-76.
11. Jensen MD, Kanaley JA, Reed JE, Sheedy PF. Measurement of abdominal and visceral fat with computed tomography and dualenergy x-ray absorptiometry. Am J Clin Nutr. 1995;61(2):274-278.
12. Harrison MH, Brown GA, Cochrane LA. Maximal oxygen uptake: its measurement, application, and limitations. Aviat Space Environ Med. 1980;51(10):1123-1127.
13. Persson XM, Blachnio-Zabielska AU, Jensen MD. Rapid measurement of plasma free fatty acid concentration and isotopic enrichment using LC/MS. J Lipid Res. 2010;51(9):2761-2765.
14. Gastaldelli A, Cusi K, Pettiti M, Hardies J, Miyazaki Y, Berria R, Buzzigoli E, Sironi AM, Cersosimo E, Ferrannini E, Defronzo RA. Relationship between hepatic/visceral fat and hepatic insulin resistance in nondiabetic and type 2 diabetic subjects. Gastroenterology. 2007;133(2):496-506.
15. Itoh Y, Kawamata Y, Harada M, Kobayashi M, Fujii R, Fukusumi S, Ogi K, Hosoya M, Tanaka Y, Uejima H, Tanaka H, Maruyama M, Satoh R, Okubo S, Kizawa H, Komatsu H, Matsumura F, Noguchi Y, Shinohara T, Hinuma S, Fujisawa Y, Fujino M. Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40. Nature. 2003;422(6928):173-176.
16. Dobbins RL, Chester MW, Stevenson BE, Daniels MB, Stein DT, McGarry JD. A fatty acid-dependent step is critically important for both glucose-and non-glucose-stimulated insulin secretion. J Clin Invest. 1998;101(11):2370-2376.
17. Abdul-Ghani MA, Molina-Carrion M, Jani R, Jenkinson C, Defronzo RA. Adipocytes in subjects with impaired fasting glucose and impaired glucose tolerance are resistant to the anti-lipolytic effect of insulin. Acta Diabetol. 2008;45(3):147-150.
18. Hershkop K, Besor O, Santoro N, Pierpont B, Caprio S, Weiss R. Adipose insulin resistance in obese adolescents across the spectrumof glucose tolerance. JClin Endocrinol Metab 2016;101(6)2423-2431.
19. Nielsen S, Guo Z, Albu JB, Klein S,O'Brien PC, Jensen MD. Energy expenditure, sex, and endogenous fuel availability in humans. J Clin Invest. 2003;111(7):981-988.
20. Raben MS. Growth hormone. 1. Physiologic aspects.NEngl JMed. 1962;266:31-35.
21. Finkelstein JW, Roffwarg HP, Boyar RM, Kream J, Hellman L. Age-related change in the twenty-four-hour spontaneous secretion of growth hormone. J Clin Endocrinol Metab. 1972;35(5):665-670.
22. Lönnqvist F, Nyberg B, Wahrenberg H, Arner P. Catecholamineinduced lipolysis in adipose tissue of the elderly. J Clin Invest. 1990; 85(5):1614-1621.
23. De Glisezinski I, Crampes F, Harant I, Berlan M, Hejnova J, Langin D, Rivière D, Stich V. Endurance training changes in lipolytic responsiveness of obese adipose tissue.AmJ Physiol. 1998;275(6 Pt 1): E951-E956.
24. Godfrey RJ, Madgwick Z, Whyte GP. The exercise-induced growth hormone response in athletes. Sports Med. 2003;33(8):599-613.
25. Koppo K, Larrouy D, Marques MA, Berlan M, Bajzova M, Polak J, Van de Voorde J, Bülow J, Lafontan M, Crampes F, Langin D, Stich V, de Glisezinski I. Lipid mobilization in subcutaneous adipose tissue during exercise in lean and obese humans. Roles of insulin and natriuretic peptides. Am J Physiol Endocrinol Metab. 2010; 299(2):E258-E265.
26. Miles JM, Jensen MD. Does glucagon regulate adipose tissue lipolysis? J Clin Endocrinol Metab 1993;77(1):5A-5B.