Vascular disease-causing mutation, smooth muscle α-actin R258C, dominantly suppresses functions of α-actin in human patient fibroblasts

Proceedings of the National Academy of Sciences of the United States of America

Volumn 114, Issue 28, 2017, Pages E5569-E5578

  Liu, Zhenan ^a   Chang, Audrey N ^a   Grinnell, Frederick ^b   Trybus, Kathleen M ^c   Milewicz, Dianna M ^d   Stull, James T ^a   Kamm, Kristine E ^a   Korn, Edward D ^e  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c UNIVERSITY OF VERMONT   (United States)

^d UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^e NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

ACTA2 mutation; Cell migration; Human fibroblasts; Thoracic aortic aneurysms; Vascular disease

Indexed keywords

ADENOVIRUS VECTOR; ALPHA ACTIN; ALPHA SMOOTH MUSCLE ACTIN; MUTANT PROTEIN; MYOCARDIAL RELATED TRANSCRIPTION FACTOR A; PHALLOIDIN; TELOMERASE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; VINCULIN; ACTA2 PROTEIN, HUMAN; ACTIN; TERT PROTEIN, HUMAN;

ACTA2 GENE; ADVENTITIA; AORTIC SMOOTH MUSCLE CELL; ARTICLE; CELL MIGRATION; CELL PROLIFERATION; CHILD; CONTROLLED STUDY; CYTOSKELETON; FEMALE; FOCAL ADHESION; GENE; GENE MUTATION; HETEROZYGOSITY; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; MYOFIBROBLAST; PERIPHERAL OCCLUSIVE ARTERY DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; SCHOOL CHILD; SKIN FIBROBLAST; STRESS FIBER; THORACIC AORTA ANEURYSM; TRANSCRIPTION REGULATION; VASCULAR DISEASE; WESTERN BLOTTING; WILD TYPE; ADULT; AORTA; BIOPSY; CELL MOTION; CYTOLOGY; DISEASE EXACERBATION; DISSECTING ANEURYSM; ENZYME ACTIVE SITE; FIBROBLAST; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; MISSENSE MUTATION; SKIN; SMOOTH MUSCLE; SMOOTH MUSCLE CELL;

ACTINS; ADULT; ANEURYSM, DISSECTING; AORTA; AORTIC ANEURYSM, THORACIC; BIOPSY; CATALYTIC DOMAIN; CELL MOVEMENT; CELL PROLIFERATION; CHILD; CYTOSKELETON; DISEASE PROGRESSION; FEMALE; FIBROBLASTS; HUMANS; MALE; MUSCLE, SMOOTH; MUTATION, MISSENSE; MYOCYTES, SMOOTH MUSCLE; MYOFIBROBLASTS; SKIN; TELOMERASE; TRANSCRIPTION, GENETIC;

EID: 85023202287     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1703506114     Document Type: Article

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