Vascular disease-causing mutation R258C in ACTA2 disrupts actin dynamics and interaction with myosin

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 31, 2015, Pages E4168-E4177

  Lu, Hailong ^a   Fagnant, Patricia M ^a   Bookwalter, Carol S ^a   Joel, Peteranne ^a   Trybus, Kathleen M ^a  

^a UNIVERSITY OF VERMONT   (United States)

Author keywords

Actin; Myosin ii; Smooth muscle; Thoracic aortic aneurysms; Vascular disease

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; COFILIN; DEOXYRIBONUCLEASE; G ACTIN; GELSOLIN; MYOSIN; MYOSIN ADENOSINE TRIPHOSPHATASE; MYOSIN HEAVY CHAIN; PROFILIN; TROPOMYOSIN; ACTA2 PROTEIN, HUMAN; ACTIN; ACTIN DEPOLYMERIZING FACTOR; GREEN FLUORESCENT PROTEIN; MUTANT PROTEIN; PROTEIN BINDING;

ACTA2 GENE; ACTIN FILAMENT; ACTIN POLYMERIZATION; AORTA DISSECTION; ARTICLE; BACULOVIRIDAE; BINDING AFFINITY; CONTROLLED STUDY; DROSOPHILA; FLUORESCENCE MICROSCOPY; GENE; GENE MUTATION; HUMAN; HUMAN CELL; IN VITRO STUDY; NONHUMAN; PATHOGENESIS; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; QUANTITATIVE ANALYSIS; R258C GENE; THORACIC AORTA ANEURYSM; THORACIC AORTIC ANEURYSM AND DISSECTION; TOTAL INTERNAL REFLECTION FLUORESCENCE MICROSCOPY; VASCULAR SMOOTH MUSCLE; ANIMAL; BIOLOGICAL MODEL; CHEMICAL STRUCTURE; CHICKEN; GENETICS; METABOLISM; MOUSE; MUTATION; PATHOLOGY; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN STABILITY; SF9 CELL LINE; VASCULAR DISEASE;

ACTIN CYTOSKELETON; ACTIN DEPOLYMERIZING FACTORS; ACTINS; ACTOMYOSIN; ANIMALS; CHICKENS; DEOXYRIBONUCLEASES; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GELSOLIN; GREEN FLUORESCENT PROTEINS; MICE; MICROSCOPY, FLUORESCENCE; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MUSCLE, SMOOTH, VASCULAR; MUTANT PROTEINS; MUTATION; MYOSINS; POLYMERIZATION; PROFILINS; PROTEIN BINDING; PROTEIN STABILITY; SF9 CELLS; TROPOMYOSIN; VASCULAR DISEASES;

EID: 84938652684     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1507587112     Document Type: Article

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