메뉴 건너뛰기




Volumn 96, Issue 1, 2017, Pages 145-158

Natural killer-cell deficiency alters placental development in rats

Author keywords

Interleukin 15; Invasion; Natural killer cells; Placenta; Pregnancy; Spiral artery; Trophoblast; Vascular remodeling

Indexed keywords

INTERLEUKIN 15; ZINC FINGER NUCLEASE;

EID: 85022321836     PISSN: 00063363     EISSN: 15297268     Source Type: Journal    
DOI: 10.1095/biolreprod.116.142752     Document Type: Article
Times cited : (43)

References (66)
  • 1
    • 33746500163 scopus 로고    scopus 로고
    • The uterine spiral arteries in human pregnancy: facts and controversies
    • Pijnenborg R, Vercruysse L, Hanssens M. The uterine spiral arteries in human pregnancy: facts and controversies. Placenta 2006; 27:939-958.
    • (2006) Placenta , vol.27 , pp. 939-958
    • Pijnenborg, R.1    Vercruysse, L.2    Hanssens, M.3
  • 2
    • 84904155945 scopus 로고    scopus 로고
    • Adaptive mechanisms controlling uterine spiral artery remodeling during the establishment of pregnancy
    • Soares MJ, Chakraborty D, Kubota K, Renaud SJ, Rumi MA. Adaptive mechanisms controlling uterine spiral artery remodeling during the establishment of pregnancy. Int J Dev Biol 2014; 58:247-259.
    • (2014) Int J Dev Biol , vol.58 , pp. 247-259
    • Soares, M.J.1    Chakraborty, D.2    Kubota, K.3    Renaud, S.J.4    Rumi, M.A.5
  • 3
    • 0347287033 scopus 로고    scopus 로고
    • A comparison of placental development and endocrine functions between the human and mouse model
    • Malassine A, Frendo JL, Evain-Brion D. A comparison of placental development and endocrine functions between the human and mouse model. Hum Reprod Update 2003; 9:531-539.
    • (2003) Hum Reprod Update , vol.9 , pp. 531-539
    • Malassine, A.1    Frendo, J.L.2    Evain-Brion, D.3
  • 4
    • 0032773438 scopus 로고    scopus 로고
    • The role of trophoblast in the physiological change in decidual spiral arteries
    • Kam EP, Gardner L, Loke YW, King A. The role of trophoblast in the physiological change in decidual spiral arteries. Hum Reprod 1999; 14:2131-2138.
    • (1999) Hum Reprod , vol.14 , pp. 2131-2138
    • Kam, E.P.1    Gardner, L.2    Loke, Y.W.3    King, A.4
  • 5
    • 3543123782 scopus 로고    scopus 로고
    • Comparative aspects of trophoblast development and placentation
    • Carter AM, Enders AC. Comparative aspects of trophoblast development and placentation. Reprod Biol Endocrinol 2004; 2:46.
    • (2004) Reprod Biol Endocrinol , vol.2 , pp. 46
    • Carter, A.M.1    Enders, A.C.2
  • 6
    • 0037631256 scopus 로고    scopus 로고
    • Gestation stage-dependent intrauterine trophoblast cell invasion in the rat and mouse: novel endocrine phenotype and regulation
    • Ain R, Canham LN, Soares MJ. Gestation stage-dependent intrauterine trophoblast cell invasion in the rat and mouse: novel endocrine phenotype and regulation. Dev Biol 2003; 260:176-190.
    • (2003) Dev Biol , vol.260 , pp. 176-190
    • Ain, R.1    Canham, L.N.2    Soares, M.J.3
  • 7
    • 21444445693 scopus 로고    scopus 로고
    • Endovascular trophoblast invasion and associated structural changes in uterine spiral arteries of the pregnant rat
    • Caluwaerts S, Vercruysse L, Luyten C, Pijnenborg R. Endovascular trophoblast invasion and associated structural changes in uterine spiral arteries of the pregnant rat. Placenta 2005; 26:574-584.
    • (2005) Placenta , vol.26 , pp. 574-584
    • Caluwaerts, S.1    Vercruysse, L.2    Luyten, C.3    Pijnenborg, R.4
  • 8
    • 79952310759 scopus 로고    scopus 로고
    • The "Great Obstetrical Syndromes" are associated with disorders of deep placentation
    • Brosens I, Pijnenborg R, Vercruysse L, Romero R. The "Great Obstetrical Syndromes" are associated with disorders of deep placentation. Am J Obstet Gynecol 2011; 204:193-201.
    • (2011) Am J Obstet Gynecol , vol.204 , pp. 193-201
    • Brosens, I.1    Pijnenborg, R.2    Vercruysse, L.3    Romero, R.4
  • 9
    • 0026302406 scopus 로고
    • CD3- leukocytes present in the human uterus during early placentation: phenotypic and morphologic characterization of the CD56++ population
    • King A, Balendran N, Wooding P, Carter NP, Loke YW. CD3- leukocytes present in the human uterus during early placentation: phenotypic and morphologic characterization of the CD56++ population. Dev Immunol 1991; 1:169-190.
    • (1991) Dev Immunol , vol.1 , pp. 169-190
    • King, A.1    Balendran, N.2    Wooding, P.3    Carter, N.P.4    Loke, Y.W.5
  • 11
    • 84899752735 scopus 로고    scopus 로고
    • Uterine NK cells: active regulators at the maternalfetal interface
    • Moffett A, Colucci F. Uterine NK cells: active regulators at the maternalfetal interface. J Clin Invest 2014; 124:1872-1879.
    • (2014) J Clin Invest , vol.124 , pp. 1872-1879
    • Moffett, A.1    Colucci, F.2
  • 12
    • 84899863070 scopus 로고    scopus 로고
    • Uterine natural killer cells pace early development of mouse decidua basalis
    • Hofmann AP, Gerber SA, Croy BA. Uterine natural killer cells pace early development of mouse decidua basalis. Mol Hum Reprod 2014; 20: 66-76.
    • (2014) Mol Hum Reprod , vol.20 , pp. 66-76
    • Hofmann, A.P.1    Gerber, S.A.2    Croy, B.A.3
  • 13
    • 0037869170 scopus 로고    scopus 로고
    • The uterine NK cell population requires IL- 15 but these cells are not required for pregnancy nor the resolution of a Listeria monocytogenes infection
    • Barber EM, Pollard JW. The uterine NK cell population requires IL- 15 but these cells are not required for pregnancy nor the resolution of a Listeria monocytogenes infection. J Immunol 2003; 171:37-46.
    • (2003) J Immunol , vol.171 , pp. 37-46
    • Barber, E.M.1    Pollard, J.W.2
  • 14
    • 0041331722 scopus 로고    scopus 로고
    • Assessment of requirements for IL-15 and IFN regulatory factors in uterine NK cell differentiation and function during pregnancy
    • Ashkar AA, Black GP, Wei Q, He H, Liang L, Head JR, Croy BA. Assessment of requirements for IL-15 and IFN regulatory factors in uterine NK cell differentiation and function during pregnancy. J Immunol 2003; 171:2937-2944.
    • (2003) J Immunol , vol.171 , pp. 2937-2944
    • Ashkar, A.A.1    Black, G.P.2    Wei, Q.3    He, H.4    Liang, L.5    Head, J.R.6    Croy, B.A.7
  • 15
    • 84896863018 scopus 로고    scopus 로고
    • MHC-dependent inhibition of uterine NK cells impedes fetal growth and decidual vascular remodelling
    • Kieckbusch J, Gaynor LM, Moffett A, Colucci F. MHC-dependent inhibition of uterine NK cells impedes fetal growth and decidual vascular remodelling. Nat Commun 2014; 5:3359.
    • (2014) Nat Commun , vol.5 , pp. 3359
    • Kieckbusch, J.1    Gaynor, L.M.2    Moffett, A.3    Colucci, F.4
  • 16
    • 80053651010 scopus 로고    scopus 로고
    • Natural killer cells direct hemochorial placentation by regulating hypoxia-inducible factor dependent trophoblast lineage decisions
    • Chakraborty D, Rumi MA, Konno T, Soares MJ. Natural killer cells direct hemochorial placentation by regulating hypoxia-inducible factor dependent trophoblast lineage decisions. Proc Natl Acad Sci USA 2011; 108:16295-16300.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 16295-16300
    • Chakraborty, D.1    Rumi, M.A.2    Konno, T.3    Soares, M.J.4
  • 17
    • 65649117361 scopus 로고    scopus 로고
    • Evidence for immune cell involvement in decidual spiral arteriole remodeling in early human pregnancy
    • Smith SD, Dunk CE, Aplin JD, Harris LK, Jones RL. Evidence for immune cell involvement in decidual spiral arteriole remodeling in early human pregnancy. Am J Pathol 2009; 174:1959-1971.
    • (2009) Am J Pathol , vol.174 , pp. 1959-1971
    • Smith, S.D.1    Dunk, C.E.2    Aplin, J.D.3    Harris, L.K.4    Jones, R.L.5
  • 18
    • 0035169507 scopus 로고    scopus 로고
    • Interleukin 15: biology and relevance to human disease
    • Fehniger TA, Caligiuri MA. Interleukin 15: biology and relevance to human disease. Blood 2001; 97:14-32.
    • (2001) Blood , vol.97 , pp. 14-32
    • Fehniger, T.A.1    Caligiuri, M.A.2
  • 20
    • 18444395565 scopus 로고    scopus 로고
    • Simplex PCR assay for sex determination in mice
    • Clapcote SJ, Roder JC. Simplex PCR assay for sex determination in mice. Biotechniques 2005; 38:702, 704, 706.
    • (2005) Biotechniques , vol.38 , pp. 702-706
    • Clapcote, S.J.1    Roder, J.C.2
  • 24
    • 38549151690 scopus 로고    scopus 로고
    • Pregnancy and lactation modulate maternal splenic growth and development of the erythroid lineage in the rat and mouse
    • Bustamante JJ, Dai G, Soares MJ. Pregnancy and lactation modulate maternal splenic growth and development of the erythroid lineage in the rat and mouse. Reprod Fertil Dev 2008; 20:303-310.
    • (2008) Reprod Fertil Dev , vol.20 , pp. 303-310
    • Bustamante, J.J.1    Dai, G.2    Soares, M.J.3
  • 25
    • 0036365762 scopus 로고    scopus 로고
    • Comparative developmental anatomy of the murine and human definitive placentae
    • Georgiades P, Ferguson-Smith AC, Burton GJ. Comparative developmental anatomy of the murine and human definitive placentae. Placenta 2002; 23:3-19.
    • (2002) Placenta , vol.23 , pp. 3-19
    • Georgiades, P.1    Ferguson-Smith, A.C.2    Burton, G.J.3
  • 26
    • 0030265629 scopus 로고    scopus 로고
    • Distribution of IL-15 receptor alpha-chains on human peripheral blood mononuclear cells and effect of immunosuppressive drugs on receptor expression
    • Chae DW, Nosaka Y, Strom TB, Maslinski W. Distribution of IL-15 receptor alpha-chains on human peripheral blood mononuclear cells and effect of immunosuppressive drugs on receptor expression. J Immunol 1996; 157:2813-2819.
    • (1996) J Immunol , vol.157 , pp. 2813-2819
    • Chae, D.W.1    Nosaka, Y.2    Strom, T.B.3    Maslinski, W.4
  • 27
    • 0031051547 scopus 로고    scopus 로고
    • Abnormal development of intestinal intraepithelial lymphocytes and peripheral natural killer cells in mice lacking the IL-2 receptor beta chain
    • Suzuki H, Duncan GS, Takimoto H, Mak TW. Abnormal development of intestinal intraepithelial lymphocytes and peripheral natural killer cells in mice lacking the IL-2 receptor beta chain. J Exp Med 1997; 185: 499-505.
    • (1997) J Exp Med , vol.185 , pp. 499-505
    • Suzuki, H.1    Duncan, G.S.2    Takimoto, H.3    Mak, T.W.4
  • 29
    • 0030456932 scopus 로고    scopus 로고
    • The involvement of interleukin (IL)-15 in regulating the differentiation of granulated metrial gland cells in mouse pregnant uterus
    • Ye W, Zheng LM, Young JD, Liu CC. The involvement of interleukin (IL)-15 in regulating the differentiation of granulated metrial gland cells in mouse pregnant uterus. J Exp Med 1996; 184:2405-2410.
    • (1996) J Exp Med , vol.184 , pp. 2405-2410
    • Ye, W.1    Zheng, L.M.2    Young, J.D.3    Liu, C.C.4
  • 30
    • 84951310757 scopus 로고    scopus 로고
    • NK cells and cancer: you can teach innate cells new tricks
    • Morvan MG, Lanier LL. NK cells and cancer: you can teach innate cells new tricks. Nat Rev Cancer 2016; 16:7-19.
    • (2016) Nat Rev Cancer , vol.16 , pp. 7-19
    • Morvan, M.G.1    Lanier, L.L.2
  • 35
    • 0025088565 scopus 로고
    • Cell populations in the human early pregnancy decidua: natural killer activity and response to interleukin-2 of CD56-positive large granular lymphocytes
    • Ferry BL, Starkey PM, Sargent IL,Watt GM, Jackson M, Redman CW. Cell populations in the human early pregnancy decidua: natural killer activity and response to interleukin-2 of CD56-positive large granular lymphocytes. Immunology 1990; 70:446-452.
    • (1990) Immunology , vol.70 , pp. 446-452
    • Ferry, B.L.1    Starkey, P.M.2    Sargent, I.L.3    Watt, G.M.4    Jackson, M.5    Redman, C.W.6
  • 37
    • 0028111420 scopus 로고
    • A block in both early T lymphocyte and natural killer cell development in transgenic mice with high-copy numbers of the human CD3E gene
    • Wang B, Biron C, She J, Higgins K, Sunshine MJ, Lacy E, Lonberg N, Terhorst C. A block in both early T lymphocyte and natural killer cell development in transgenic mice with high-copy numbers of the human CD3E gene. Proc Natl Acad Sci USA 1994; 91:9402-9406.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 9402-9406
    • Wang, B.1    Biron, C.2    She, J.3    Higgins, K.4    Sunshine, M.J.5    Lacy, E.6    Lonberg, N.7    Terhorst, C.8
  • 39
    • 0034646255 scopus 로고    scopus 로고
    • In vivo natural killer cell activities revealed by natural killer cell-deficient mice
    • Kim S, Iizuka K, Aguila HL, Weissman IL, Yokoyama WM. In vivo natural killer cell activities revealed by natural killer cell-deficient mice. Proc Natl Acad Sci USA 2000; 97:2731-2736.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 2731-2736
    • Kim, S.1    Iizuka, K.2    Aguila, H.L.3    Weissman, I.L.4    Yokoyama, W.M.5
  • 42
    • 84858964582 scopus 로고    scopus 로고
    • Analysis of uterine gene expression in interleukin-15 knockout mice reveals uterine natural killer cells do not play a major role in decidualization and associated angiogenesis
    • Bany BM, Scott CA, Eckstrum KS. Analysis of uterine gene expression in interleukin-15 knockout mice reveals uterine natural killer cells do not play a major role in decidualization and associated angiogenesis. Reproduction 2012; 143:359-375.
    • (2012) Reproduction , vol.143 , pp. 359-375
    • Bany, B.M.1    Scott, C.A.2    Eckstrum, K.S.3
  • 45
    • 84888266400 scopus 로고    scopus 로고
    • Decidual natural killer cell interactions with trophoblasts are impaired in pregnancies at increased risk of preeclampsia
    • Wallace AE, Host AJ, Whitley GS, Cartwright JE. Decidual natural killer cell interactions with trophoblasts are impaired in pregnancies at increased risk of preeclampsia. Am J Pathol 2013; 183:1853-1861.
    • (2013) Am J Pathol , vol.183 , pp. 1853-1861
    • Wallace, A.E.1    Host, A.J.2    Whitley, G.S.3    Cartwright, J.E.4
  • 46
    • 84898979648 scopus 로고    scopus 로고
    • Increased angiogenic factor secretion by decidual natural killer cells from pregnancies with high uterine artery resistance alters trophoblast function
    • Wallace AE, Fraser R, Gurung S, Goulwara SS, Whitley GS, Johnstone AP, Cartwright JE. Increased angiogenic factor secretion by decidual natural killer cells from pregnancies with high uterine artery resistance alters trophoblast function. Hum Reprod 2014; 29:652-660.
    • (2014) Hum Reprod , vol.29 , pp. 652-660
    • Wallace, A.E.1    Fraser, R.2    Gurung, S.3    Goulwara, S.S.4    Whitley, G.S.5    Johnstone, A.P.6    Cartwright, J.E.7
  • 48
    • 9644273989 scopus 로고    scopus 로고
    • Natural killer cells, miscarriage, and infertility
    • Moffett A, Regan L, Braude P. Natural killer cells, miscarriage, and infertility. BMJ 2004; 329:1283-1285.
    • (2004) BMJ , vol.329 , pp. 1283-1285
    • Moffett, A.1    Regan, L.2    Braude, P.3
  • 50
    • 84904201041 scopus 로고    scopus 로고
    • Natural killer cells and regulatory T cells in early pregnancy loss
    • Sharma S. Natural killer cells and regulatory T cells in early pregnancy loss. Int J Dev Biol 2014; 58:219-229.
    • (2014) Int J Dev Biol , vol.58 , pp. 219-229
    • Sharma, S.1
  • 51
    • 61349187628 scopus 로고    scopus 로고
    • Evidence for participation of uterine natural killer cells in the mechanisms responsible for spontaneous preterm labor and delivery
    • Murphy SP, Hanna NN, Fast LD, Shaw SK, Berg G, Padbury JF, Romero R, Sharma S. Evidence for participation of uterine natural killer cells in the mechanisms responsible for spontaneous preterm labor and delivery. Am J Obstet Gynecol 2009; 200:308. e301-309.
    • (2009) Am J Obstet Gynecol , vol.200 , pp. e301-e309
    • Murphy, S.P.1    Hanna, N.N.2    Fast, L.D.3    Shaw, S.K.4    Berg, G.5    Padbury, J.F.6    Romero, R.7    Sharma, S.8
  • 53
    • 77951139244 scopus 로고    scopus 로고
    • Regulation of extravillous trophoblast invasion by uterine natural killer cells is dependent on gestational age
    • Lash GE, Otun HA, Innes BA, Percival K, Searle RF, Robson SC, Bulmer JN. Regulation of extravillous trophoblast invasion by uterine natural killer cells is dependent on gestational age. Hum Reprod 2010; 25:1137-1145.
    • (2010) Hum Reprod , vol.25 , pp. 1137-1145
    • Lash, G.E.1    Otun, H.A.2    Innes, B.A.3    Percival, K.4    Searle, R.F.5    Robson, S.C.6    Bulmer, J.N.7
  • 54
    • 76749151383 scopus 로고    scopus 로고
    • Decidual NK cell-derived conditioned medium enhances capillary tube and network organization in an extravillous cytotrophoblast cell line
    • Hu Y, Eastabrook G, Tan R,MacCalman CD, Dutz JP, von Dadelszen P. Decidual NK cell-derived conditioned medium enhances capillary tube and network organization in an extravillous cytotrophoblast cell line. Placenta 2010; 31:213-221.
    • (2010) Placenta , vol.31 , pp. 213-221
    • Hu, Y.1    Eastabrook, G.2    Tan, R.3    MacCalman, C.D.4    Dutz, J.P.5    von Dadelszen, P.6
  • 56
    • 33845438523 scopus 로고    scopus 로고
    • Decidual NK cells alter in vitro first trimester extravillous cytotrophoblast migration: a role for IFN-gamma
    • Hu Y, Dutz JP, MacCalman CD, Yong P, Tan R, von Dadelszen P. Decidual NK cells alter in vitro first trimester extravillous cytotrophoblast migration: a role for IFN-gamma. J Immunol 2006; 177: 8522-8530.
    • (2006) J Immunol , vol.177 , pp. 8522-8530
    • Hu, Y.1    Dutz, J.P.2    MacCalman, C.D.3    Yong, P.4    Tan, R.5    von Dadelszen, P.6
  • 57
    • 33845605792 scopus 로고    scopus 로고
    • Interferon-gamma inhibits extravillous trophoblast cell invasion by a mechanism that involves both changes in apoptosis and protease levels
    • Lash GE,Otun HA, Innes BA, Kirkley M,De Oliveira L, Searle RF, Robson SC, Bulmer JN. Interferon-gamma inhibits extravillous trophoblast cell invasion by a mechanism that involves both changes in apoptosis and protease levels. FASEB J 2006; 20:2512-2518.
    • (2006) FASEB J , vol.20 , pp. 2512-2518
    • Lash, G.E.1    Otun, H.A.2    Innes, B.A.3    Kirkley, M.4    De Oliveira, L.5    Searle, R.F.6    Robson, S.C.7    Bulmer, J.N.8
  • 58
    • 1442352210 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha inhibits trophoblast migration through elevation of plasminogen activator inhibitor-1 in first-trimester villous explant cultures
    • Bauer S, Pollheimer J, Hartmann J, Husslein P, Aplin JD, Knofler M. Tumor necrosis factor-alpha inhibits trophoblast migration through elevation of plasminogen activator inhibitor-1 in first-trimester villous explant cultures. J Clin Endocrinol Metab 2004; 89:812-822.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 812-822
    • Bauer, S.1    Pollheimer, J.2    Hartmann, J.3    Husslein, P.4    Aplin, J.D.5    Knofler, M.6
  • 59
    • 22544467451 scopus 로고    scopus 로고
    • Inhibition of trophoblast cell invasion by TGFB1, 2, and 3 is associated with a decrease in active proteases
    • Lash GE, Otun HA, Innes BA, Bulmer JN, Searle RF, Robson SC. Inhibition of trophoblast cell invasion by TGFB1, 2, and 3 is associated with a decrease in active proteases. Biol Reprod 2005; 73:374-381.
    • (2005) Biol Reprod , vol.73 , pp. 374-381
    • Lash, G.E.1    Otun, H.A.2    Innes, B.A.3    Bulmer, J.N.4    Searle, R.F.5    Robson, S.C.6
  • 60
    • 33947542235 scopus 로고    scopus 로고
    • Pregnancy in the brown Norway rat: a model for investigating the genetics of placentation
    • Konno T, Rempel LA, Arroyo JA, Soares MJ. Pregnancy in the brown Norway rat: a model for investigating the genetics of placentation. Biol Reprod 2007; 76:709-718.
    • (2007) Biol Reprod , vol.76 , pp. 709-718
    • Konno, T.1    Rempel, L.A.2    Arroyo, J.A.3    Soares, M.J.4
  • 61
    • 10644246068 scopus 로고    scopus 로고
    • Human uterine natural killer cells: a reappraisal
    • Bulmer JN, Lash GE. Human uterine natural killer cells: a reappraisal. Mol Immunol 2005; 42:511-521.
    • (2005) Mol Immunol , vol.42 , pp. 511-521
    • Bulmer, J.N.1    Lash, G.E.2
  • 62
    • 84907970683 scopus 로고    scopus 로고
    • Placenta accreta is associated with decreased decidual natural killer (dNK) cells population: a comparative pilot study
    • Laban M, Ibrahim EA, Elsafty MS, Hassanin AS. Placenta accreta is associated with decreased decidual natural killer (dNK) cells population: a comparative pilot study. Eur J Obstet Gynecol Reprod Biol 2014; 181:284-288.
    • (2014) Eur J Obstet Gynecol Reprod Biol , vol.181 , pp. 284-288
    • Laban, M.1    Ibrahim, E.A.2    Elsafty, M.S.3    Hassanin, A.S.4
  • 63
    • 46549084302 scopus 로고    scopus 로고
    • Pathophysiology of placenta creta: the role of decidua and extravillous trophoblast
    • Tantbirojn P, Crum CP, Parast MM. Pathophysiology of placenta creta: the role of decidua and extravillous trophoblast. Placenta 2008; 29: 639-645.
    • (2008) Placenta , vol.29 , pp. 639-645
    • Tantbirojn, P.1    Crum, C.P.2    Parast, M.M.3
  • 64
    • 84863325925 scopus 로고    scopus 로고
    • Placental adaptations to the maternal-fetal environment: implications for fetal growth and developmental programming
    • Sandovici I, Hoelle K, Angiolini E, Constancia M. Placental adaptations to the maternal-fetal environment: implications for fetal growth and developmental programming. Reprod Biomed Online 2012; 25:68-89.
    • (2012) Reprod Biomed Online , vol.25 , pp. 68-89
    • Sandovici, I.1    Hoelle, K.2    Angiolini, E.3    Constancia, M.4
  • 65
    • 39149135857 scopus 로고    scopus 로고
    • Maternal hypoxia activates endovascular trophoblast cell invasion
    • Rosario GX, Konno T, Soares MJ. Maternal hypoxia activates endovascular trophoblast cell invasion. Dev Biol 2008; 314:362-375.
    • (2008) Dev Biol , vol.314 , pp. 362-375
    • Rosario, G.X.1    Konno, T.2    Soares, M.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.