A novel immunodeficient mouse model - RAG2 x common cytokine receptor γ chain double mutants - Requiring exogenous cytokine administration for human hematopoietic stem cell engraftment

Journal of Interferon and Cytokine Research

Volumn 19, Issue 5, 1999, Pages 533-541

  Mazurier, Frederic ^a   Fontanellas, Antonio ^a   Salesse, Stephanie ^a   Taine, Laurence ^a   Landriau, Serge ^b   Moreau Gaudry, François ^a   Reiffers, Josy ^a   Peault, Bruno ^c   Santo, James P D I ^d   De Verneuil, Hubert ^a,e  

^a CNRS Bordeaux Segalen University   (France)

^b INSTITUT BERGONIÉ   (France)

^c CNRS   (France)

^d HÔPITAL NECKER ENFANTS MALADES   (France)

^e UNIVERSITÉ DE BORDEAUX   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; CYTOKINE RECEPTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DIFFERENTIATION; CELL FUNCTION; CELL POPULATION; CHIMERA; CONTROLLED STUDY; ENZYME ACTIVATION; GENE TRANSFER; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC SYSTEM; IMMUNE DEFICIENCY; MOUSE; NONHUMAN; PRIORITY JOURNAL; STEM CELL; STEM CELL TRANSPLANTATION; UMBILICAL CORD BLOOD;

ANIMALS; ANTIGENS, CD34; CYTOKINES; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; INTERLEUKIN-3; MICE; MICE, INBRED NOD; MICE, SCID; MUTATION; NUCLEAR PROTEINS; PEPTIDE FRAGMENTS; PHENOTYPE; RECEPTORS, CYTOKINE; SEVERE COMBINED IMMUNODEFICIENCY;

ANIMALIA; MURINAE;

EID: 0033008647     PISSN: 10799907     EISSN: None     Source Type: Journal    
DOI: 10.1089/107999099313983     Document Type: Article

References (33)

1. MULLIGAN, R.C. (1993). The basic science of gene therapy. Science 260, 926-932.
2. BORDIGNON, C., NOTARANGELO, L.D., NOBILI, N., FERRARI, G., CASORATI, G., PANINA, P., MAZZOLARI, E., MAGGIONI, D., ROSSI, C., SERVIDA, P., UGAZIO, A.C., and MAVILIO, F. (1995). Gene therapy in peripheral blood lymphocytes and bone marrow for ADA-immunodeficient patients. Science 270, 470-475.
3. KAY, M.A., LIU, D., and HOOGERBRUGGE, P.M. (1997). Gene therapy. Proc. Natl. Acad. Sci. USA 94, 12744-12746.
4. -) human hematopoietic cells: novel responses to Flt3-ligand and thrombopoietin. J. Exp. Med. 183, 2551-2558.
5. McCUNE, J.M., NAMIKAWA, R., KANESHIMA, H., SHULTZ, L.D., LIEBERMAN, M., and WEISSMAN, I.L. (1988). The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and function. Science 241, 1632-1639.
6. KOLLMANN, T.R., KIM, A., ZHUANG, X.J., HACHAMOVITCH, M., and GOLDSTEIN, H. (1994). Reconstitution of SCID mice with human lymphoid and myeloid cells after transplantation with human fetal bone marrow without the requirement for exogenous human cytokines. Proc. Natl. Acad. Sci. USA 91, 8032-8036.
7. VORMOOR, J., LAPIDOT, T., PFLUMIO, F., RISDON, G., PATTERSON, B., BROXMEYER, H.E., and DICK, J.E. (1994). Immature human cord blood progenitors engraft and proliferate to high levels in severe combined immunodeficient mice. Blood 83, 2489-2497.
8. GOAN, S.R., FICHTNER, I., JUST, U., KARAWAJEW, L., SHULTZE, W., KRAUSE, K.P., von HARSDORF, S., von SCHILLING, C., and HERRMANN, F. (1996). The severe combined immunodeficient-human peripheral blood stem cell (SCID-huPBSC) mouse: a xenotransplant model for huPBSC-initiated hematopoiesis. Blood 86, 89-100.
9. HUMEAU, L., CHABANNON, C., FIRPO, M.T., MANNONI, P., BAGNIS, C., RONCAROLO, M.G., and NAMIKAWA, R. (1997). Successful reconstitution of human hematopoiesis in the SCID-hu mouse by genetically modified, highly enriched progenitors isolated from fetal liver. Blood 90, 3496-3506.
10. RAMIREZ, M., ROTTMAN, G.A., SHULTZ, L.D., and CIVIN, C.I. (1998). Mature human hematopoietic cells in donor bone marrow complicate interpretation of stem/progenitor cell assays in xenogeneic hematopoietic chimeras. Exp. Hematol. 26, 332-344.
11. PFLUMIO, F., IZAC, B., KATZ, A., SHULTZ, L.D., VAINCHENKER, W., and COULOMBEL, L. (1996). Phenotype and function of human hematopoietic cells engrafting immune-deficient CB17-severe combined immunodeficiency mice and nonobese diabetic-severe combined immunodeficiency mice after transplantation of human cord blood mononuclear cells. Blood 88, 3731-3740.
12. LAROCHELLE, A., VORMOOR, J., HANENBERG, H., WANG, J.C.Y., BHATIA, M., LAPIDOT, T., MORITZ, T., MURDOCH, B., XIAO, X.L., KATO, I., WILLIAMS, D.A., and DICK, I.E. (1996). Identification of primitive human hematopoietic cells capable of repopulating NOD/SCID mouse bone marrow: implications for gene therapy. Nature Med. 2, 1329-1337.
13. BOCK, T.A., ORLIC, D., DUNBAR, C.E., BROXMEYER, H.E., and BODINE, D.M. (1995). Improved engraftment of human hematopoietic cells in severe combined immunodeficient (SCID) mice carrying human cytokine transgenes. J. Exp. Med. 182, 2037-2043.
14. LAROCHELLE, A., VORMOOR, J., LAPIDOT, T., SHER, G., FURUKAWA, T., LI, Q., SHULTZ, L.D., OLIVIERI, N.F., STAMATOYANNOPOULOS, G., and DICK, I.E. (1995). Engraftment of immune-deficient mice with primitive hematopoietic cells from β-thalassemia and sickle cell anemia patients: implications for evaluating human gene therapy protocols. Hum. Mol. Genet. 4, 163-172.
15. GREINER, D.L., SHULTZ, L.D., YATES, J., APPEL, M.C., PERDRIZET, G., HESSELTON, R.A.M., SCHWEITZER, I., BEAMER, W.G., SHULTZ, K.L., PELSUE, S.C., LEIF, J.H., and RAJAN, T.V. (1995). Improved engraftment of human spleen cells in NOD/LtSz-scid/scid mice as compared with CB-17-scid/scid mice. Am. J. Pathol. 146, 888-902.
16. + enriched cells from umbilical cord blood in NOD/LtSz-scid/scid mice. Blood 90, 85-96.
17. CONNEALLY, E., CASHMAN, J., PETZER, A., and EAVES, C. (1997). Expansion in vitro of transplantable human cord blood stem cells demonstrated using a quantitative assay of their lymphomyeloid repopulating activity in nonobese diabetic-scid/scid mice. Proc. Natl. Acad. Sci. USA 94, 9836-9841.
18. WANG, J.C.Y., DOEDENS, M., and DICK, J.E. (1997). Primitive human hematopoietic cells are enriched in cord blood compared with adult bone marrow or mobilized peripheral blood as measured by the quantitative in vivo SCID-repopulating cell assay. Blood 89, 3919-3924.
19. BOSMA, G.C., CUSTER, R.P., and BOSMA, M.J. (1983). A severe combined immunodeficient mutation in the mouse. Nature 301, 527-530.
20. BOSMA, G.G., FRIED, M., CUSTER, R.P., CARROL, A., GIBSON, D.M., and BOSMA, M.J. (1988). Evidence of functional lymphocytes in some (leaky) scid mice. J. Exp. Med. 167, 1016-1033.
21. SHULTZ, L.D., SCHWEITZER, P.A., CHRISTIANSON, S.W., GOTT, B., SCHWEITZER, I.B., TENNENT, B., McKENNA, S., MOBROATEN, I., RAJAN, T.V., GREINER, D.L., and LEITER, E.H. (1995). Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice. J. Immunol. 154, 180-191.
22. DI SANTO, J.P., MÜLLER, W., GUY-GRAND, D., FISCHER, A., and RAJEWSKY, K. (1995). Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor γ chain. Proc. Natl. Acad. Sci. USA 92, 377-381.
23. CAO, X., SHORES, E.W., HU-LI, J., ANVER, M.R., KELSALL, B.L., DRAGO, J., NOGUCHI, M., GRINBERG, A., BLOOM, E., et al. (1995). Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chain. Immunity 2, 223-238.
24. MALISSEN, M., PEREIRA, P., GERBER, D.J., MALISSEN, B., and DI SANTO, J.P. (1997). The common cytokine receptor gamma chain controls survival of gamma/delta T cells. J. Exp. Med. 186, 1277-1285.
25. LANTZ, O., SHARARA, L.I., TILLOY, F., ANDERSSON, A., and DI SANTO, J.P. (1997). Lineage relationships and differentiation of natural killer (NK) T cells: intrathymic selection and interleukin (IL)-4 production in the absence of NKR-P1 and Ly49 molecules. J. Exp. Med. 185, 1395-1401.
26. SHARARA, L.I., ANDERSSON, A., GUY-GRAND, D., FISCHER, A., and DI SANTO, J.P. (1997). Deregulated TCR αβT cell population provokes extramedullary hematopoiesis in mice deficient in the common γ chain. Eur. J. Immunol. 27, 990-998.
27. SHINKAI, Y., RATHBURN, G., LAM, K.P., OLTZ, E.M., STEWARD, V., MENDELSOHN, M., SHARRON, J., DATTA, M., YOUNG, F., STALL, A.M., and ALT, F.W. (1992). RAG2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell 68, 855-867.
28. GOLDMAN, J., BLUNDELL, M.P., LOPES, L., KINNON, C., DI SANTO, J.P., and THRASHER, A.J. (1998). Enhanced human cell engraftment in mice deficient in RAG2 and the common cytokine receptor gamma chain. Br. J. Haematol. 103, 335-342.
29. GEORGE, T., YU, Y.Y., LIU, J., DAVENPORT, C., LEMIEUX, S., STONEMAN, E., MATHEW, P.A., KUMAR, V., and BENNETT, M. (1997). Allorecognition by murine natural killer cells: lysis of T-lymphoblasts and rejection of bone marrow grafts. Immunol. Rev. 155, 29-40.
30. ANDERSSON, A., DAI, W.J., DI SANTO, J.P., and BROMBACHER, F. (1998). Early IFN-γ production and innate immunity during Listeria monocytogenes infection in the absence of NK cells. J. Immunol. 161, 5600-5606.
31. COLUCCI, F., SOUDAIS, C., ROSMARAKI, E., VANES, L., TYBULEWICZ, V.L.J., and DI SANTO, J.P. (1999). Dissecting NK cell development using a novel alymphoid mouse model: investigating the role of the c-abl proto-oncogene in murine NK cell differentiation. J. Immunol 162, 2761-2765.
32. TRINCHIERI, G. (1989). Biology of natural killer cells. Adv. Immunol. 47, 187-376.
33. CASHMAN, J.D., LAPIDOT, T., WANG, J.C.Y., DOEDENS, M., SHULTZ, L.D., LANSDORP, P., DICK, J.E., and EAVES, C.J. (1997). Kinetic evidence of the regeneration of multilineage hematopoiesis from primitive cells in normal human bone marrow transplanted into immunodeficient mice. Blood 89, 4307-4316.