Human Secretory IgM Emerges from Plasma Cells Clonally Related to Gut Memory B Cells and Targets Highly Diverse Commensals

Immunity

Volumn 47, Issue 1, 2017, Pages 118-134.e8

  Magri, Giuliana ^a   Comerma, Laura ^a   Pybus, Marc ^a   Sintes, Jordi ^a   Lligé, David ^a   Segura Garzón, Daniel ^a   Bascones, Sabrina ^a   Yeste, Ada ^a   Grasset, Emilie K ^b,c   Gutzeit, Cindy ^b   Uzzan, Mathieu ^b   Ramanujam, Meera ^d   van Zelm, Menno C ^e   Albero González, Raquel ^a   Vazquez, Ivonne ^a   Iglesias, Mar ^a,f   Serrano, Sergi ^a,f   Márquez, Lucía ^a   Mercade, Elena ^g   Mehandru, Saurabh ^b   Cerutti, Andrea ^a,b,h   more..

^a HOSPITAL DEL MAR   (Spain)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^d BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

^e MONASH UNIVERSITY   (Australia)

^f UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^g UNIVERSITY OF BARCELONA   (Spain)

^h INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS ICREA   (Spain)

Author keywords

gut; human; IgA; IgM; memory B cells; microbiota; mucosa; plasma cells; repertoire

Indexed keywords

APRIL PROTEIN; B CELL ACTIVATING FACTOR; CHEMOKINE RECEPTOR CCR7; CHEMOKINE RECEPTOR CXCR4; GLYCOPROTEIN P 15095; HUMAN IMMUNOGLOBULIN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN M; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 6; L SELECTIN; LEUKOSIALIN; RNA 16S; SECRETORY IMMUNOGLOBULIN; TRANSCRIPTOME;

ARTICLE; ASCENDING COLON; CELL DIFFERENTIATION; COMMENSAL; CONTROLLED STUDY; DOWN REGULATION; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE TEST; MEMORY CELL; NOTCH SIGNALING; PLASMA CELL; PLASMABLAST; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; TERMINAL ILEUM; UPREGULATION; ADULT; AGED; ANGIODYSPLASIA; ANIMAL; B LYMPHOCYTE; C57BL MOUSE; CELL CLONE; COLON POLYP; COLON TUMOR; FEMALE; GENE REARRANGEMENT; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; INTESTINE; INTESTINE FLORA; MALE; METABOLISM; MICROBIOLOGY; MIDDLE AGED; MOUSE; MUCOSAL IMMUNITY; SYMBIOSIS; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; ANGIODYSPLASIA; ANIMALS; B-LYMPHOCYTES; CLONE CELLS; COLONIC NEOPLASMS; COLONIC POLYPS; FEMALE; GASTROINTESTINAL MICROBIOME; HUMANS; IMMUNITY, MUCOSAL; IMMUNOGLOBULIN A; IMMUNOGLOBULIN CLASS SWITCHING; IMMUNOGLOBULIN M; IMMUNOLOGIC MEMORY; INTESTINES; MALE; MICE; MICE, INBRED C57BL; MIDDLE AGED; PLASMA CELLS; SYMBIOSIS;

EID: 85021941611     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2017.06.013     Document Type: Article

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