Development of the gut microbiota and mucosal IgA responses in twins and gnotobiotic mice

Nature

Volumn 534, Issue 7606, 2016, Pages 263-266

  Planer, Joseph D ^a   Peng, Yangqing ^a   Kau, Andrew L ^a   Blanton, Laura V ^a   Ndao, I Malick ^a   Tarr, Phillip I ^a   Warner, Barbara B ^a   Gordon, Jeffrey I ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN A;

ANTIBODY; DIGESTIVE SYSTEM; FECAL COLIFORM; HISTOPATHOLOGY; IMMUNE RESPONSE; MICROBIAL ACTIVITY; PROTEIN; RODENT;

AGE; ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ARTICLE; ARTIFICIAL MILK; BACTERIAL COLONIZATION; BACTERIAL GENETICS; BACTERIAL GROWTH; BIFIDOBACTERIUM BIFIDUM; BREAST MILK; CHILD; CLOSTRIDIUM; CLOSTRIDIUM BOLTEAE; CLOSTRIDIUM CLOSTRIDIOFORME; CLOSTRIDIUM NEXILE; CONTROLLED STUDY; DIZYGOTIC TWINS; ESCHERICHIA COLI; FECES MICROFLORA; GENE SEQUENCE; GNOTOBIOTICS; HUMAN; INDICATOR ORGANISM; INFANT; INTESTINE EPITHELIUM; INTESTINE FLORA; MALE; MICROBIAL COMMUNITY; MONOZYGOTIC TWINS; MOUSE; MUCOSAL IMMUNITY; NONHUMAN; PRIORITY JOURNAL; PUERPERIUM; RUMINOCOCCUS; RUMINOCOCCUS GNAVUS; TWINS; ZYGOSITY; AGING; ANIMAL; ANIMAL MODEL; BREAST FEEDING; C57BL MOUSE; DIET; FECAL MICROBIOTA TRANSPLANTATION; FEMALE; GERMFREE ANIMAL; IMMUNOLOGY; INTESTINE; MICROBIOLOGY; NORMAL HUMAN; PRESCHOOL CHILD; WEANING;

UNITED STATES;

BACTERIA (MICROORGANISMS); MUS;

AGING; ANIMALS; BREAST FEEDING; CHILD, PRESCHOOL; DIET; FECAL MICROBIOTA TRANSPLANTATION; FEMALE; GASTROINTESTINAL MICROBIOME; GERM-FREE LIFE; HEALTHY VOLUNTEERS; HUMANS; IMMUNITY, MUCOSAL; IMMUNOGLOBULIN A; INFANT; INTESTINES; MALE; MICE; MICE, INBRED C57BL; MODELS, ANIMAL; TWINS; WEANING;

EID: 84973125318     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature17940     Document Type: Article

References (30)

1. Suzuki, K. et al. Aberrant expansion of segmented filamentous bacteria in IgA-deficient gut. Proc. Natl Acad. Sci. USA 101, 1981-1986 (2004).
2. Johansen, F. E. et al. Absence of epithelial immunoglobulin A transport, with increased mucosal leakiness, in polymeric immunoglobulin receptor/secretory component-deficient mice. J. Exp. Med. 190, 915-922 (1999).
3. Peterson, D. A., McNulty, N. P., Guruge, J. L. & Gordon, J. I. IgA response to symbiotic bacteria as a mediator of gut homeostasis. Cell Host Microbe 2, 328-339 (2007).
4. Bunker, J. J. et al. Innate and adaptive humoral responses coat distinct commensal bacteria with immunoglobulin A. Immunity 43, 541-553 (2015).
5. Macpherson, A. J. et al. A primitive T cell-independent mechanism of intestinal mucosal IgA responses to commensal bacteria. Science 288, 2222-2226 (2000).
6. Mathias, A. & Corthésy, B. N-Glycans on secretory component: mediators of the interaction between secretory IgA and Gram-positive commensals sustaining intestinal homeostasis. Gut Microbes 2, 287-293 (2011).
7. Palm, N. W. et al. Immunoglobulin A coating identifies colitogenic bacteria in inflammatory bowel disease. Cell 158, 1000-1010 (2014).
8. Kau, A.L. et al. Functional characterization of IgA-targeted bacterial taxa from undernourished Malawian children that produce diet-dependent enteropathy. Sci. Transl. Med. 7, 276r24 (2015).
9. Brandtzaeg, P. The mucosal immune system and its integration with the mammary glands. J. Pediatr. 156 (Suppl.), S8-S15 (2010).
10. Gustafson, C. E. et al. Limited expression of APRIL and its receptors prior to intestinal IgA plasma cell development during human infancy. Mucosal Immunol. 7, 467-477 (2014).
11. Rogosch, T. et al. IgA response in preterm neonates shows little evidence of antigen-driven selection. J. Immunol. 189, 5449-5456 (2012).
12. Subramanian, S. et al. Persistent gut microbiota immaturity in malnourished Bangladeshi children. Nature 510, 417-421 (2014).
13. Blanton, L. V. et al. Gut bacteria that prevent growth impairments transmitted by microbiota from malnourished children. Science 351, aad3311 (2016).
14. Goodrich, J. K. et al. Human genetics shape the gut microbiome. Cell 159, 789-799 (2014).
15. Hansen, E. E. et al. Pan-genome of the dominant human gut-associated archaeon, Methanobrevibacter smithii, studied in twins. Proc. Natl Acad. Sci. USA 108 (Suppl. 1), 4599-4606 (2011).
16. Dominguez-Bello, M. G. et al. Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns. Proc. Natl Acad. Sci. USA 107, 11971-11975 (2010).
17. Sela, D. A. & Mills, D. A. The marriage of nutrigenomics with the microbiome: the case of infant-associated bifidobacteria and milk. Am. J. Clin. Nutr. 99, 697S-703S (2014).
18. Dufrêne, M. & Legendre, P. Species assemblages and indicator species: the need for a flexible asymmetrical approach. Ecol. Monogr. 67, 345-366 (1999).
19. Siega-Riz, A. M. et al. Food consumption patterns of infants and toddlers: where are we now? J. Am. Diet. Assoc. 110 (Suppl.), S38-S51 (2010).
20. Rogier, E. W., Frantz, A. L., Bruno, M. E. & Kaetzel, C. S. Secretory IgA is concentrated in the outer layer of the colonic mucus along with gut bacteria. Pathogens 3, 390-403 (2014).
21. Lyte, M., Vulchanova, L. & Brown, D. R. Stress at the intestinal surface: catecholamines and mucosa-bacteria interactions. Cell Tissue Res. 343, 23-32 (2011).
22. Arrieta, M. C. et al. Early infancy microbial and metabolic alterations affect risk of childhood asthma. Sci. Transl. Med. 7, 307ra152 (2015).
23. Gilmartin, A. A. & Petri, W. A., Jr. Exploring the role of environmental enteropathy in malnutrition, infant development and oral vaccine response. Phil. Trans. R. Soc. B 370, 20140143 (2015).
24. Faith, J. J., Ahern, P. P., Ridaura, V. K., Cheng, J. & Gordon, J. I. Identifying gut microbe-host phenotype relationships using combinatorial communities in gnotobiotic mice. Sci. Transl. Med. 6, 220ra11 (2014).
25. Rideout, J. R. et al. Subsampled open-reference clustering creates consistent, comprehensive OTU definitions and scales to billions of sequences. Peer J 2, e545 (2014).
26. Caporaso, J. G. et al. Global patterns of 16S rRNA diversity at a depth of millions of sequences per sample. Proc. Natl Acad. Sci. USA 108 (Suppl. 1), 4516-4522 (2011).
27. Liaw, A. & Weiner, M. Classification and regression by random Forest. R News 2 (3), 18-22 (2002).
28. De Caceres, M. & Legendre, P. Associations between species and groups of sites: indices and statistical inference. Ecology 90, 3566-3574 (2009).
29. Oksanen, J. et al. vegan: Community Ecology Package. http://CRAN.R-project.org/package= vegan (2014).
30. Kuznetsova, A., Brockhoff, P. B. & Christensen, R. H. B. lmerTest: tests for random and fixed effects for linear mixed effect models (lmer objects of lme4 package). https://cran.r-project.org/package= lmerTest (2013).