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Volumn 16, Issue 12, 2016, Pages 767-774

Do antibodies select a healthy microbiota?

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN A; ANTIBODY; IMMUNOGLOBULIN RECEPTOR;

EID: 84994152097     PISSN: 14741733     EISSN: 14741741     Source Type: Journal    
DOI: 10.1038/nri.2016.114     Document Type: Review
Times cited : (106)

References (55)
  • 1
    • 84856872027 scopus 로고    scopus 로고
    • Age, microbiota, and T cells shape diverse individual IgA repertoires in the intestine
    • Lindner, C. et al. Age, microbiota, and T cells shape diverse individual IgA repertoires in the intestine. J. Exp. Med. 209, 365-377 (2012).
    • (2012) J. Exp. Med. , vol.209 , pp. 365-377
    • Lindner, C.1
  • 2
    • 84866461477 scopus 로고    scopus 로고
    • Familial transmission rather than defective innate immunity shapes the distinct intestinal microbiota of TLR-deficient mice
    • Ubeda, C. et al. Familial transmission rather than defective innate immunity shapes the distinct intestinal microbiota of TLR-deficient mice. J. Exp. Med. 209, 1445-1456 (2012).
    • (2012) J. Exp. Med. , vol.209 , pp. 1445-1456
    • Ubeda, C.1
  • 3
    • 2942516894 scopus 로고    scopus 로고
    • Human neonatal Fc receptor mediates transport of IgG into luminal secretions for delivery of antigens to mucosal dendritic cells
    • Yoshida, M. et al. Human neonatal Fc receptor mediates transport of IgG into luminal secretions for delivery of antigens to mucosal dendritic cells. Immunity 20, 769-783 (2004).
    • (2004) Immunity , vol.20 , pp. 769-783
    • Yoshida, M.1
  • 4
    • 34249284197 scopus 로고    scopus 로고
    • Use of axenic animals in studying the adaptation of mammals to their commensal intestinal microbiota
    • Smith, K., McCoy, K. D. & Macpherson, A. J. Use of axenic animals in studying the adaptation of mammals to their commensal intestinal microbiota. Semin. Immunol. 19, 59-69 (2007).
    • (2007) Semin. Immunol. , vol.19 , pp. 59-69
    • Smith, K.1    McCoy, K.D.2    Macpherson, A.J.3
  • 5
    • 0034705397 scopus 로고    scopus 로고
    • A primitive T cell-independent mechanism of intestinal mucosal IgA responses to commensal bacteria
    • Macpherson, A. J. et al. A primitive T cell-independent mechanism of intestinal mucosal IgA responses to commensal bacteria. Science 288, 2222-2226 (2000).
    • (2000) Science , vol.288 , pp. 2222-2226
    • Macpherson, A.J.1
  • 6
    • 0015177024 scopus 로고
    • Immunoglobulins in intact, immunized, and contaminated axenic mice: Study of serum IgA
    • Benveniste, J., Lespinats, G., Adam, C. & Salomon, J. C. Immunoglobulins in intact, immunized, and contaminated axenic mice: study of serum IgA. J. Immunol. 107, 1647-1655 (1971).
    • (1971) J. Immunol. , vol.107 , pp. 1647-1655
    • Benveniste, J.1    Lespinats, G.2    Adam, C.3    Salomon, J.C.4
  • 7
    • 0029155360 scopus 로고
    • Commensal enteric bacteria engender a self-limiting humoral mucosal immune response while permanently colonizing the gut
    • Shroff, K. E., Meslin, K. & Cebra, J. J. Commensal enteric bacteria engender a self-limiting humoral mucosal immune response while permanently colonizing the gut. Infect. Immun. 63, 3904-3913 (1995).
    • (1995) Infect. Immun. , vol.63 , pp. 3904-3913
    • Shroff, K.E.1    Meslin, K.2    Cebra, J.J.3
  • 9
    • 84860123211 scopus 로고    scopus 로고
    • The inhibitory receptor PD-1 regulates IgA selection and bacterial composition in the gut
    • Kawamoto, S. et al. The inhibitory receptor PD-1 regulates IgA selection and bacterial composition in the gut. Science 336, 485-489 (2012).
    • (2012) Science , vol.336 , pp. 485-489
    • Kawamoto, S.1
  • 10
    • 84922937083 scopus 로고    scopus 로고
    • MyD88 signaling in T cells directs IgA-mediated control of the microbiota to promote health
    • Kubinak, J. L. et al. MyD88 signaling in T cells directs IgA-mediated control of the microbiota to promote health. Cell Host Microbe 17, 153-163 (2015).
    • (2015) Cell Host Microbe , vol.17 , pp. 153-163
    • Kubinak, J.L.1
  • 11
    • 84945286826 scopus 로고    scopus 로고
    • MHC variation sculpts individualized microbial communities that control susceptibility to enteric infection
    • Kubinak, J. L. et al. MHC variation sculpts individualized microbial communities that control susceptibility to enteric infection. Nat. Commun. 6, 8642 (2015).
    • (2015) Nat. Commun. , vol.6 , pp. 8642
    • Kubinak, J.L.1
  • 12
    • 84941659588 scopus 로고    scopus 로고
    • Innate and adaptive humoral responses coat distinct commensal bacteria with immunoglobulin A
    • Bunker, J. J. et al. Innate and adaptive humoral responses coat distinct commensal bacteria with immunoglobulin A. Immunity 43, 541-553 (2015).
    • (2015) Immunity , vol.43 , pp. 541-553
    • Bunker, J.J.1
  • 13
    • 84973125318 scopus 로고    scopus 로고
    • Development of the gut microbiota and mucosal IgA responses in twins and gnotobiotic mice
    • Planer, J. D. et al. Development of the gut microbiota and mucosal IgA responses in twins and gnotobiotic mice. Nature 534, 263-266 (2016).
    • (2016) Nature , vol.534 , pp. 263-266
    • Planer, J.D.1
  • 14
    • 84907300008 scopus 로고    scopus 로고
    • Immunoglobulin A coating identifies colitogenic bacteria in inflammatory bowel disease
    • Palm, N. W. et al. Immunoglobulin A coating identifies colitogenic bacteria in inflammatory bowel disease. Cell 158, 1000-1010 (2014).
    • (2014) Cell , vol.158 , pp. 1000-1010
    • Palm, N.W.1
  • 15
    • 84991929179 scopus 로고    scopus 로고
    • Functional characterization of IgA-targeted bacterial taxa from undernourished Malawian children that produce diet-dependent enteropathy
    • Kau, A. L. et al. Functional characterization of IgA-targeted bacterial taxa from undernourished Malawian children that produce diet-dependent enteropathy. Sci. Transl Med. 7, 276ra24 (2015).
    • (2015) Sci. Transl Med. , vol.7 , pp. 276ra24
    • Kau, A.L.1
  • 16
    • 84887886701 scopus 로고    scopus 로고
    • Innate and adaptive immunity interact to quench microbiome flagellar motility in the gut
    • Cullender, T. C. et al. Innate and adaptive immunity interact to quench microbiome flagellar motility in the gut. Cell Host Microbe 14, 571-581 (2013).
    • (2013) Cell Host Microbe , vol.14 , pp. 571-581
    • Cullender, T.C.1
  • 17
    • 84914094986 scopus 로고    scopus 로고
    • Secretory IgA is concentrated in the outer layer of colonic mucus along with gut bacteria
    • Rogier, E. W., Frantz, A. L., Bruno, M. E. & Kaetzel, C. S. Secretory IgA is concentrated in the outer layer of colonic mucus along with gut bacteria. Pathogens 3, 390-403 (2014).
    • (2014) Pathogens , vol.3 , pp. 390-403
    • Rogier, E.W.1    Frantz, A.L.2    Bruno, M.E.3    Kaetzel, C.S.4
  • 18
    • 84892638554 scopus 로고    scopus 로고
    • Mucus properties and goblet cell quantification in mouse, rat and human ileal Peyer's patches
    • Ermund, A., Gustafsson, J. K., Hansson, G. C. & Keita, A. V. Mucus properties and goblet cell quantification in mouse, rat and human ileal Peyer's patches. PLoS ONE 8, e83688 (2013).
    • (2013) PLoS ONE , vol.8 , pp. e83688
    • Ermund, A.1    Gustafsson, J.K.2    Hansson, G.C.3    Keita, A.V.4
  • 19
    • 0036337774 scopus 로고    scopus 로고
    • Secretory component: A new role in secretory IgA-mediated immune exclusion in vivo
    • Phalipon, A. et al. Secretory component: a new role in secretory IgA-mediated immune exclusion in vivo. Immunity 17, 107-115 (2002).
    • (2002) Immunity , vol.17 , pp. 107-115
    • Phalipon, A.1
  • 20
    • 32944462309 scopus 로고    scopus 로고
    • Anti-immunology: Evasion of the host immune system by bacterial and viral pathogens
    • Finlay, B. B. & McFadden, G. Anti-immunology: evasion of the host immune system by bacterial and viral pathogens. Cell 124, 767-782 (2006).
    • (2006) Cell , vol.124 , pp. 767-782
    • Finlay, B.B.1    McFadden, G.2
  • 21
    • 84874691463 scopus 로고    scopus 로고
    • Temporal stability of the mouse gut microbiota in relation to innate and adaptive immunity
    • Dimitriu, P. A. et al. Temporal stability of the mouse gut microbiota in relation to innate and adaptive immunity. Environ. Microbiol. Rep. 5, 200-210 (2013).
    • (2013) Environ. Microbiol. Rep. , vol.5 , pp. 200-210
    • Dimitriu, P.A.1
  • 23
    • 84904384753 scopus 로고    scopus 로고
    • + T cells regulate immunoglobulin a selection and facilitate diversification of bacterial species responsible for immune homeostasis
    • + T cells regulate immunoglobulin a selection and facilitate diversification of bacterial species responsible for immune homeostasis. Immunity 41, 152-165 (2014).
    • (2014) Immunity , vol.41 , pp. 152-165
    • Kawamoto, S.1
  • 24
    • 0035846113 scopus 로고    scopus 로고
    • In situ class switching and differentiation to IgA-producing cells in the gut lamina propria
    • Fagarasan, S., Kinoshita, K., Muramatsu, M., Ikuta, K. & Honjo, T. In situ class switching and differentiation to IgA-producing cells in the gut lamina propria. Nature 413, 639-643 (2001).
    • (2001) Nature , vol.413 , pp. 639-643
    • Fagarasan, S.1    Kinoshita, K.2    Muramatsu, M.3    Ikuta, K.4    Honjo, T.5
  • 25
    • 0037112050 scopus 로고    scopus 로고
    • Critical roles of activation-induced cytidine deaminase in the homeostasis of gut flora
    • Fagarasan, S. et al. Critical roles of activation-induced cytidine deaminase in the homeostasis of gut flora. Science 298, 1424-1427 (2002).
    • (2002) Science , vol.298 , pp. 1424-1427
    • Fagarasan, S.1
  • 26
    • 1242296822 scopus 로고    scopus 로고
    • Aberrant expansion of segmented filamentous bacteria in IgA-deficient gut
    • Suzuki, K. et al. Aberrant expansion of segmented filamentous bacteria in IgA-deficient gut. Proc. Natl Acad. Sci. USA 101, 1981-1986 (2004).
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 1981-1986
    • Suzuki, K.1
  • 27
    • 79951602552 scopus 로고    scopus 로고
    • Mice carrying a knock-in mutation of Aicda resulting in a defect in somatic hypermutation have impaired gut homeostasis and compromised mucosal defense
    • Wei, M. et al. Mice carrying a knock-in mutation of Aicda resulting in a defect in somatic hypermutation have impaired gut homeostasis and compromised mucosal defense. Nat. Immunol. 12, 264-270 (2011).
    • (2011) Nat. Immunol. , vol.12 , pp. 264-270
    • Wei, M.1
  • 28
    • 84900549422 scopus 로고    scopus 로고
    • Proteobacteria-specific IgA regulates maturation of the intestinal microbiota
    • Mirpuri, J. et al. Proteobacteria-specific IgA regulates maturation of the intestinal microbiota. Gut Microbes 5, 28-39 (2014).
    • (2014) Gut Microbes , vol.5 , pp. 28-39
    • Mirpuri, J.1
  • 29
    • 84868101602 scopus 로고    scopus 로고
    • Epithelial-microbial crosstalk in polymeric Ig receptor deficient mice
    • Reikvam, D. H. et al. Epithelial-microbial crosstalk in polymeric Ig receptor deficient mice. Eur. J. Immunol. 42, 2959-2970 (2012).
    • (2012) Eur. J. Immunol. , vol.42 , pp. 2959-2970
    • Reikvam, D.H.1
  • 30
    • 0024468421 scopus 로고
    • Many of the IgA producing plasma cells in murine gut are derived from self-replenishing precursors in the peritoneal cavity
    • Kroese, F. G. et al. Many of the IgA producing plasma cells in murine gut are derived from self-replenishing precursors in the peritoneal cavity. Int. Immunol. 1, 75-84 (1989).
    • (1989) Int. Immunol. , vol.1 , pp. 75-84
    • Kroese, F.G.1
  • 31
    • 34249298559 scopus 로고    scopus 로고
    • Intestinal IgA synthesis: A primitive form of adaptive immunity that regulates microbial communities in the gut
    • Suzuki, K., Ha, S. A., Tsuji, M. & Fagarasan, S. Intestinal IgA synthesis: a primitive form of adaptive immunity that regulates microbial communities in the gut. Semin. Immunol. 19, 127-135 (2007).
    • (2007) Semin. Immunol. , vol.19 , pp. 127-135
    • Suzuki, K.1    Ha, S.A.2    Tsuji, M.3    Fagarasan, S.4
  • 32
    • 77952311371 scopus 로고    scopus 로고
    • Adaptive immune regulation in the gut: T cell-dependent and T cell-independent IgA synthesis
    • Fagarasan, S., Kawamoto, S., Kanagawa, O. & Suzuki, K. Adaptive immune regulation in the gut: T cell-dependent and T cell-independent IgA synthesis. Annu. Rev. Immunol. 28, 243-273 (2010).
    • (2010) Annu. Rev. Immunol. , vol.28 , pp. 243-273
    • Fagarasan, S.1    Kawamoto, S.2    Kanagawa, O.3    Suzuki, K.4
  • 33
    • 0037270866 scopus 로고    scopus 로고
    • Intestinal IgA synthesis: Regulation of front-line body defences
    • Fagarasan, S. & Honjo, T. Intestinal IgA synthesis: regulation of front-line body defences. Nat. Rev. Immunol. 3, 63-72 (2003).
    • (2003) Nat. Rev. Immunol. , vol.3 , pp. 63-72
    • Fagarasan, S.1    Honjo, T.2
  • 34
    • 77958505148 scopus 로고    scopus 로고
    • GALT: Organization and dynamics leading to IgA synthesis
    • Suzuki, K., Kawamoto, S., Maruya, M. & Fagarasan, S. GALT: organization and dynamics leading to IgA synthesis. Adv. Immunol. 107, 153-185 (2010).
    • (2010) Adv. Immunol. , vol.107 , pp. 153-185
    • Suzuki, K.1    Kawamoto, S.2    Maruya, M.3    Fagarasan, S.4
  • 36
    • 84856083002 scopus 로고    scopus 로고
    • Crosstalk between B lymphocytes, microbiota and the intestinal epithelium governs immunity versus metabolism in the gut
    • Shulzhenko, N. et al. Crosstalk between B lymphocytes, microbiota and the intestinal epithelium governs immunity versus metabolism in the gut. Nat. Med. 17, 1585-1593 (2011).
    • (2011) Nat. Med. , vol.17 , pp. 1585-1593
    • Shulzhenko, N.1
  • 37
    • 58749117434 scopus 로고    scopus 로고
    • An indispensable role for the chemokine receptor CCR10 in IgA antibody-secreting cell accumulation
    • Morteau, O. et al. An indispensable role for the chemokine receptor CCR10 in IgA antibody-secreting cell accumulation. J. Immunol. 181, 6309-6315 (2008).
    • (2008) J. Immunol , vol.181 , pp. 6309-6315
    • Morteau, O.1
  • 38
    • 84937814800 scopus 로고    scopus 로고
    • Diversification of memory B cells drives the continuous adaptation of secretory antibodies to gut microbiota
    • Lindner, C. et al. Diversification of memory B cells drives the continuous adaptation of secretory antibodies to gut microbiota. Nat. Immunol. 16, 880-888 (2015).
    • (2015) Nat. Immunol. , vol.16 , pp. 880-888
    • Lindner, C.1
  • 39
    • 84896884079 scopus 로고    scopus 로고
    • Secretory antibodies in breast milk promote long-term intestinal homeostasis by regulating the gut microbiota and host gene expression
    • Rogier, E. W. et al. Secretory antibodies in breast milk promote long-term intestinal homeostasis by regulating the gut microbiota and host gene expression. Proc. Natl Acad. Sci. USA 111, 3074-3079 (2014).
    • (2014) Proc. Natl Acad. Sci. USA , vol.111 , pp. 3074-3079
    • Rogier, E.W.1
  • 40
    • 84965176609 scopus 로고    scopus 로고
    • Maternal IgG and IgA antibodies dampen mucosal T helper cell responses in early life
    • Koch, M. A. et al. Maternal IgG and IgA antibodies dampen mucosal T helper cell responses in early life. Cell 165, 827-841 (2016).
    • (2016) Cell , vol.165 , pp. 827-841
    • Koch, M.A.1
  • 41
    • 59249106391 scopus 로고    scopus 로고
    • Breastfeeding and genetic factors in the etiology of inflammatory bowel disease in children
    • Mikhailov, T. A. & Furner, S. E. Breastfeeding and genetic factors in the etiology of inflammatory bowel disease in children. World J. Gastroenterol. 15, 270-279 (2009).
    • (2009) World J. Gastroenterol. , vol.15 , pp. 270-279
    • Mikhailov, T.A.1    Furner, S.E.2
  • 42
    • 0015453265 scopus 로고
    • Breast milk and defence against infection in the newborn
    • Hanson, L. A. & Winberg, J. Breast milk and defence against infection in the newborn. Arch. Dis. Child. 47, 845-848 (1972).
    • (1972) Arch. Dis. Child. , vol.47 , pp. 845-848
    • Hanson, L.A.1    Winberg, J.2
  • 43
    • 3242664636 scopus 로고    scopus 로고
    • Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis
    • Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S. & Medzhitov, R. Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell 11 8, 229-241 (2004).
    • (2004) Cell , vol.118 , pp. 229-241
    • Rakoff-Nahoum, S.1    Paglino, J.2    Eslami-Varzaneh, F.3    Edberg, S.4    Medzhitov, R.5
  • 44
    • 33750507279 scopus 로고    scopus 로고
    • Regulation of B1 cell migration by signals through Toll-like receptors
    • Ha, S. A. et al. Regulation of B1 cell migration by signals through Toll-like receptors. J. Exp. Med. 203, 2541-2550 (2006).
    • (2006) J. Exp. Med. , vol.203 , pp. 2541-2550
    • Ha, S.A.1
  • 45
    • 84857444508 scopus 로고    scopus 로고
    • B cell-intrinsic MyD88 signaling prevents the lethal dissemination of commensal bacteria during colonic damage
    • Kirkland, D. et al. B cell-intrinsic MyD88 signaling prevents the lethal dissemination of commensal bacteria during colonic damage. Immunity 36, 228-238 (2012).
    • (2012) Immunity , vol.36 , pp. 228-238
    • Kirkland, D.1
  • 46
    • 77955921430 scopus 로고    scopus 로고
    • The transmembrane activator TACI triggers immunoglobulin class switching by activating B cells through the adaptor MyD88
    • He, B. et al. The transmembrane activator TACI triggers immunoglobulin class switching by activating B cells through the adaptor MyD88. Nat. Immunol. 11, 836-845 (2010).
    • (2010) Nat. Immunol. , vol.11 , pp. 836-845
    • He, B.1
  • 47
    • 77950250064 scopus 로고    scopus 로고
    • Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5
    • Vijay-Kumar, M. et al. Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5. Science 328, 228-231 (2010).
    • (2010) Science , vol.328 , pp. 228-231
    • Vijay-Kumar, M.1
  • 48
    • 35848931007 scopus 로고    scopus 로고
    • IgA response to symbiotic bacteria as a mediator of gut homeostasis
    • Peterson, D. A., McNulty, N. P., Guruge, J. L. & Gordon, J. I. IgA response to symbiotic bacteria as a mediator of gut homeostasis. Cell Host Microbe 2, 328-339 (2007).
    • (2007) Cell Host Microbe , vol.2 , pp. 328-339
    • Peterson, D.A.1    McNulty, N.P.2    Guruge, J.L.3    Gordon, J.I.4
  • 49
    • 0033523608 scopus 로고    scopus 로고
    • Absence of epithelial immunoglobulin A transport, with increased mucosal leakiness, in polymeric immunoglobulin receptor/ secretory component-deficient mice
    • Johansen, F. E. et al. Absence of epithelial immunoglobulin A transport, with increased mucosal leakiness, in polymeric immunoglobulin receptor/ secretory component-deficient mice. J. Exp. Med. 190, 915-922 (1999).
    • (1999) J. Exp. Med. , vol.190 , pp. 915-922
    • Johansen, F.E.1
  • 50
    • 84960388607 scopus 로고    scopus 로고
    • Gut microbiota-induced immunoglobulin G controls systemic infection by symbiotic bacteria and pathogens
    • Zeng, M. Y. et al. Gut microbiota-induced immunoglobulin G controls systemic infection by symbiotic bacteria and pathogens. Immunity 44, 647-658 (2016).
    • (2016) Immunity , vol.44 , pp. 647-658
    • Zeng, M.Y.1
  • 51
    • 0033566004 scopus 로고    scopus 로고
    • Lack of J chain inhibits the transport of gut IgA and abrogates the development of intestinal antitoxic protection
    • Lycke, N., Erlandsson, L., Ekman, L., Schon, K. & Leanderson, T. Lack of J chain inhibits the transport of gut IgA and abrogates the development of intestinal antitoxic protection. J. Immunol. 163, 913-919 (1999).
    • (1999) J. Immunol. , vol.163 , pp. 913-919
    • Lycke, N.1    Erlandsson, L.2    Ekman, L.3    Schon, K.4    Leanderson, T.5
  • 52
    • 51949090627 scopus 로고    scopus 로고
    • Inhibition of Salmonella enterica serovar typhimurium motility and entry into epithelial cells by a protective antilipopolysaccharide monoclonal immunoglobulin A antibody
    • Forbes, S. J., Eschmann, M. & Mantis, N. J. Inhibition of Salmonella enterica serovar typhimurium motility and entry into epithelial cells by a protective antilipopolysaccharide monoclonal immunoglobulin A antibody. Infect. Immun. 76, 4137-4144 (2008).
    • (2008) Infect. Immun. , vol.76 , pp. 4137-4144
    • Forbes, S.J.1    Eschmann, M.2    Mantis, N.J.3
  • 53
    • 77952149753 scopus 로고    scopus 로고
    • Secretory IgA: Arresting microbial pathogens at epithelial borders
    • Mantis, N. J. & Forbes, S. J. Secretory IgA: arresting microbial pathogens at epithelial borders. Immunol. Invest. 39, 383-406 (2010).
    • (2010) Immunol. Invest. , vol.39 , pp. 383-406
    • Mantis, N.J.1    Forbes, S.J.2
  • 54
    • 84929356648 scopus 로고    scopus 로고
    • Humoral immunity in the gut selectively targets phenotypically virulent attaching-and-effacing bacteria for intraluminal elimination
    • Kamada, N. et al. Humoral immunity in the gut selectively targets phenotypically virulent attaching-and-effacing bacteria for intraluminal elimination. Cell Host Microbe 17, 617-627 (2015).
    • (2015) Cell Host Microbe , vol.17 , pp. 617-627
    • Kamada, N.1
  • 55
    • 0031682282 scopus 로고    scopus 로고
    • Diagnostic accuracy of serological assays in pediatric inflammatory bowel disease
    • Ruemmele, F. M. et al. Diagnostic accuracy of serological assays in pediatric inflammatory bowel disease. Gastroenterology 11 5, 822-829 (1998).
    • (1998) Gastroenterology , vol.115 , pp. 822-829
    • Ruemmele, F.M.1


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