메뉴 건너뛰기




Volumn 75, Issue 10, 2016, Pages 1858-1865

Nucleosome in patients with systemic sclerosis: Possible association with immunological abnormalities via abnormal activation of T and B cells

Author keywords

Autoimmunity; B cells; Cytokines; Systemic Sclerosis; T Cells

Indexed keywords

BLEOMYCIN; IMMUNOGLOBULIN G; INTERLEUKIN 17; INTERLEUKIN 4; NUCLEOSOME; TOLL LIKE RECEPTOR 9;

EID: 85021858511     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/annrheumdis-2015-207405     Document Type: Article
Times cited : (14)

References (50)
  • 1
    • 0037379343 scopus 로고    scopus 로고
    • Function blocking autoantibodies against matrix metalloproteinase-1 in patients with systemic sclerosis
    • Sato S, Hayakawa I, Hasegawa M, et al. Function blocking autoantibodies against matrix metalloproteinase-1 in patients with systemic sclerosis. J Invest Dermatol 2003; 120: 542-7.
    • (2003) J Invest Dermatol , vol.120 , pp. 542-547
    • Sato, S.1    Hayakawa, I.2    Hasegawa, M.3
  • 2
    • 0033758344 scopus 로고    scopus 로고
    • Increased interleukin-17 production in patients with systemic sclerosis
    • Kurasawa K, Hirose K, Sano H, et al. Increased interleukin-17 production in patients with systemic sclerosis. Arthritis Rheum 2000; 43: 2455-63.
    • (2000) Arthritis Rheum , vol.43 , pp. 2455-2463
    • Kurasawa, K.1    Hirose, K.2    Sano, H.3
  • 3
    • 78650658942 scopus 로고    scopus 로고
    • Elevated serum interleukin-27 levels in patients with systemic sclerosis: Association with T cell, B cell and fibroblast activation
    • Yoshizaki A, Yanaba K, Iwata Y, et al. Elevated serum interleukin-27 levels in patients with systemic sclerosis: association with T cell, B cell and fibroblast activation. Ann Rheum Dis 2011; 70: 194-200.
    • (2011) Ann Rheum Dis , vol.70 , pp. 194-200
    • Yoshizaki, A.1    Yanaba, K.2    Iwata, Y.3
  • 4
    • 33750207136 scopus 로고    scopus 로고
    • Is scleroderma an autoantibody mediated disease?
    • Arnett FC. Is scleroderma an autoantibody mediated disease? Curr Opin Rheumatol 2006; 18: 579-81.
    • (2006) Curr Opin Rheumatol , vol.18 , pp. 579-581
    • Arnett, F.C.1
  • 5
    • 54049107801 scopus 로고    scopus 로고
    • Clinical significance of serum hyaluronan levels in systemic sclerosis: Association with disease severity
    • Yoshizaki A, Iwata Y, Komura K, et al. Clinical significance of serum hyaluronan levels in systemic sclerosis: association with disease severity. J Rheumatol 2008; 35: 1825-9.
    • (2008) J Rheumatol , vol.35 , pp. 1825-1829
    • Yoshizaki, A.1    Iwata, Y.2    Komura, K.3
  • 6
    • 44849130732 scopus 로고    scopus 로고
    • CD19 regulates skin and lung fibrosis via Toll-like receptor signaling in a model of bleomycin-induced scleroderma
    • Yoshizaki A, Iwata Y, Komura K, et al. CD19 regulates skin and lung fibrosis via Toll-like receptor signaling in a model of bleomycin-induced scleroderma. Am J Pathol 2008; 172: 1650-63.
    • (2008) Am J Pathol , vol.172 , pp. 1650-1663
    • Yoshizaki, A.1    Iwata, Y.2    Komura, K.3
  • 7
    • 61849089739 scopus 로고    scopus 로고
    • Clinical significance of serum HMGB-1 and sRAGE levels in systemic sclerosis: Association with disease severity
    • Yoshizaki A, Komura K, Iwata Y, et al. Clinical significance of serum HMGB-1 and sRAGE levels in systemic sclerosis: association with disease severity. J Clin Immunol 2009; 29: 180-9.
    • (2009) J Clin Immunol , vol.29 , pp. 180-189
    • Yoshizaki, A.1    Komura, K.2    Iwata, Y.3
  • 8
    • 33750369226 scopus 로고    scopus 로고
    • Toll-like receptors in systemic autoimmune disease
    • Marshak-Rothstein A. Toll-like receptors in systemic autoimmune disease. Nat Rev Immunol 2006; 6: 823-35.
    • (2006) Nat Rev Immunol , vol.6 , pp. 823-835
    • Marshak-Rothstein, A.1
  • 9
    • 1842411320 scopus 로고    scopus 로고
    • Crystal structure of the nucleosome core particle at 2. 8 A resolution
    • Luger K, Mäder AW, Richmond RK, et al. Crystal structure of the nucleosome core particle at 2. 8 A resolution. Nature 1997; 389: 251-60.
    • (1997) Nature , vol.389 , pp. 251-260
    • Luger, K.1    Mäder, A.W.2    Richmond, R.K.3
  • 10
    • 0033529565 scopus 로고    scopus 로고
    • Twenty-five years of the nucleosome, fundamental particle of the eukaryote chromosome
    • Kornberg RD, Lorch Y. Twenty-five years of the nucleosome, fundamental particle of the eukaryote chromosome. Cell 1999; 98: 285-94.
    • (1999) Cell , vol.98 , pp. 285-294
    • Kornberg, R.D.1    Lorch, Y.2
  • 11
    • 0035916998 scopus 로고    scopus 로고
    • Nucleosomes in serum of patients with benign and malignant diseases
    • Holdenrieder S, Stieber P, Bodenmüller H, et al. Nucleosomes in serum of patients with benign and malignant diseases. Int J Cancer 2001; 95: 114-20.
    • (2001) Int J Cancer , vol.95 , pp. 114-120
    • Holdenrieder, S.1    Stieber, P.2    Bodenmüller, H.3
  • 13
    • 0037214118 scopus 로고    scopus 로고
    • Time between onset of apoptosis and release of nucleosomes from apoptotic cells: Putative implications for systemic lupus erythematosus
    • van Nieuwenhuijze AE, van Lopik T, Smeenk RJ, et al. Time between onset of apoptosis and release of nucleosomes from apoptotic cells: putative implications for systemic lupus erythematosus. Ann Rheum Dis 2003; 62: 10-14.
    • (2003) Ann Rheum Dis , vol.62 , pp. 10-14
    • Van Nieuwenhuijze, A.E.1    Van Lopik, T.2    Smeenk, R.J.3
  • 14
    • 0041849685 scopus 로고    scopus 로고
    • Elevated nucleosome levels in systemic inflammation and sepsis
    • Zeerleder S, Zwart B, Wuillemin WA, et al. Elevated nucleosome levels in systemic inflammation and sepsis. Crit Care Med 2003; 31: 1947-51.
    • (2003) Crit Care Med , vol.31 , pp. 1947-1951
    • Zeerleder, S.1    Zwart, B.2    Wuillemin, W.A.3
  • 15
    • 33749581733 scopus 로고    scopus 로고
    • Nucleosomal DNA fragments in autoimmune diseases
    • Holdenrieder S, Eichhorn P, Beuers U, et al. Nucleosomal DNA fragments in autoimmune diseases. Ann N Y Acad Sci 2006; 1075: 318-27.
    • (2006) Ann N y Acad Sci , vol.1075 , pp. 318-327
    • Holdenrieder, S.1    Eichhorn, P.2    Beuers, U.3
  • 16
    • 79958158236 scopus 로고    scopus 로고
    • The nucleosome (histone-DNA complex) is the TLR9-specific immunostimulatory component of Plasmodium falciparum that activates DCs
    • Gowda NM, Wu X, Gowda DC. The nucleosome (histone-DNA complex) is the TLR9-specific immunostimulatory component of Plasmodium falciparum that activates DCs. PLoS ONE 2011; 6: e20398.
    • (2011) PLoS ONE , vol.6 , pp. 20398
    • Gowda, N.M.1    Wu, X.2    Gowda, D.C.3
  • 17
    • 33745864016 scopus 로고    scopus 로고
    • Role of TLR9 in anti-nucleosome and anti-DNA antibody production in lpr mutation-induced murine lupus
    • Lartigue A, Courville P, Auquit I, et al. Role of TLR9 in anti-nucleosome and anti-DNA antibody production in lpr mutation-induced murine lupus. J Immunol 2006; 177: 1349-54.
    • (2006) J Immunol , vol.177 , pp. 1349-1354
    • Lartigue, A.1    Courville, P.2    Auquit, I.3
  • 18
    • 0018887574 scopus 로고
    • Preliminary criteria for the classification of systemic sclerosis (scleroderma). Subcommittee for scleroderma criteria of the American rheumatism association diagnostic and therapeutic criteria committee
    • [No authors listed]
    • [No authors listed]. Preliminary criteria for the classification of systemic sclerosis (scleroderma). Subcommittee for scleroderma criteria of the American Rheumatism Association Diagnostic and Therapeutic Criteria Committee. Arthritis Rheum 1980; 23: 581-90.
    • (1980) Arthritis Rheum , vol.23 , pp. 581-590
  • 19
    • 0023854176 scopus 로고
    • Scleroderma (systemic sclerosis): Classification, subsets and pathogenesis
    • LeRoy EC, Black C, Fleischmajer R, Jr, et al. Scleroderma (systemic sclerosis): classification, subsets and pathogenesis. J Rheumatol 1988; 15: 202-5.
    • (1988) J Rheumatol , vol.15 , pp. 202-205
    • LeRoy, E.C.1    Black, C.2    Fleischmajer, R.3
  • 20
    • 0028279886 scopus 로고
    • Antihistone antibodies in systemic sclerosis: Association with pulmonary fibrosis
    • Sato S, Ihn H, Kikuchi K, et al. Antihistone antibodies in systemic sclerosis: association with pulmonary fibrosis. Arthritis Rheum 1994; 37: 391-4.
    • (1994) Arthritis Rheum , vol.37 , pp. 391-394
    • Sato, S.1    Ihn, H.2    Kikuchi, K.3
  • 21
    • 0023839392 scopus 로고
    • Clinical correlations and prognosis based on serum autoantibodies in patients with systemic sclerosis
    • Steen VD, Powell DL, Medsger TAJ. Clinical correlations and prognosis based on serum autoantibodies in patients with systemic sclerosis. Arthritis Rheum 1988; 31: 196-203.
    • (1988) Arthritis Rheum , vol.31 , pp. 196-203
    • Steen, V.D.1    Powell, D.L.2    Medsger, T.A.J.3
  • 22
    • 1542410396 scopus 로고    scopus 로고
    • Elevated circulating CD40L concentrations in patients with systemic sclerosis
    • Komura K, Sato S, Hasegawa M, et al. Elevated circulating CD40L concentrations in patients with systemic sclerosis. J Rheumatol 2004; 31: 514-19.
    • (2004) J Rheumatol , vol.31 , pp. 514-519
    • Komura, K.1    Sato, S.2    Hasegawa, M.3
  • 23
    • 0027729083 scopus 로고
    • Skin thickness score in systemic sclerosis: An assessment of interobserver variability in 3 independent studies
    • Clements PJ, Lachenbruch PA, Seibold JR, et al. Skin thickness score in systemic sclerosis: an assessment of interobserver variability in 3 independent studies. J Rheumatol 1993; 20: 1892-6.
    • (1993) J Rheumatol , vol.20 , pp. 1892-1896
    • Clements, P.J.1    Lachenbruch, P.A.2    Seibold, J.R.3
  • 24
    • 0029094609 scopus 로고
    • Abnormal B lymphocyte development, activation and differentiation in mice that lack or overexpress the CD19 signal transduction molecule
    • Engel P, Zhou L-J, Ord DC, et al. Abnormal B lymphocyte development, activation and differentiation in mice that lack or overexpress the CD19 signal transduction molecule. Immunity 1995; 3: 39-50.
    • (1995) Immunity , vol.3 , pp. 39-50
    • Engel, P.1    Zhou, L.-J.2    Ord, D.C.3
  • 25
    • 77956899738 scopus 로고    scopus 로고
    • Cell adhesion molecules regulate fibrotic process via Th1/Th2/Th17 cell balance in a bleomycin-induced scleroderma model
    • Yoshizaki A, Yanaba K, Iwata Y, et al. Cell adhesion molecules regulate fibrotic process via Th1/Th2/Th17 cell balance in a bleomycin-induced scleroderma model. J Immunol 2010; 185: 2502-15.
    • (2010) J Immunol , vol.185 , pp. 2502-2515
    • Yoshizaki, A.1    Yanaba, K.2    Iwata, Y.3
  • 26
    • 0023914820 scopus 로고
    • Simple method of estimating severity of pulmonary fibrosis on a numerical scale
    • Ashcroft T, Simpson JM, Timbrell V. Simple method of estimating severity of pulmonary fibrosis on a numerical scale. J Clin Pathol 1988; 41: 467-70.
    • (1988) J Clin Pathol , vol.41 , pp. 467-470
    • Ashcroft, T.1    Simpson, J.M.2    Timbrell, V.3
  • 27
    • 80053495041 scopus 로고    scopus 로고
    • The specific free radical scavenger edaravone suppresses fibrosis in the bleomycin-induced and tight skin mouse models of systemic sclerosis
    • Yoshizaki A, Yanaba K, Ogawa A, et al. The specific free radical scavenger edaravone suppresses fibrosis in the bleomycin-induced and tight skin mouse models of systemic sclerosis. Arthritis Rheum 2011; 63: 3086-97.
    • (2011) Arthritis Rheum , vol.63 , pp. 3086-3097
    • Yoshizaki, A.1    Yanaba, K.2    Ogawa, A.3
  • 28
    • 0030778080 scopus 로고    scopus 로고
    • Interleukin-10 promotes activation-induced cell death of SLE lymphocytes mediated by Fas ligand
    • Georgescu L, Vakkalanka RK, Elkon KB, et al. Interleukin-10 promotes activation-induced cell death of SLE lymphocytes mediated by Fas ligand. J Clin Invest 1997; 100: 2622-33.
    • (1997) J Clin Invest , vol.100 , pp. 2622-2633
    • Georgescu, L.1    Vakkalanka, R.K.2    Elkon, K.B.3
  • 29
    • 0032862392 scopus 로고    scopus 로고
    • Lymphocyte apoptosis in systemic lupus erythematosus: Relationships with Fas expression, serum soluble Fas and disease activity
    • Courtney PA, Crockard AD, Williamson K, et al. Lymphocyte apoptosis in systemic lupus erythematosus: relationships with Fas expression, serum soluble Fas and disease activity. Lupus 1999; 8: 508-13.
    • (1999) Lupus , vol.8 , pp. 508-513
    • Courtney, P.A.1    Crockard, A.D.2    Williamson, K.3
  • 30
    • 80155206307 scopus 로고    scopus 로고
    • Immunization with DNA topoisomerase i and Freund's complete adjuvant induces skin and lung fibrosis and autoimmunity via interleukin-6 signaling
    • Yoshizaki A, Yanaba K, Ogawa A, et al. Immunization with DNA topoisomerase I and Freund's complete adjuvant induces skin and lung fibrosis and autoimmunity via interleukin-6 signaling. Arthritis Rheum 2011; 63: 3575-85.
    • (2011) Arthritis Rheum , vol.63 , pp. 3575-3585
    • Yoshizaki, A.1    Yanaba, K.2    Ogawa, A.3
  • 31
    • 21844438276 scopus 로고    scopus 로고
    • A Toll for lupus
    • Anders HJ. A Toll for lupus. Lupus 2005; 14: 417-22.
    • (2005) Lupus , vol.14 , pp. 417-422
    • Anders, H.J.1
  • 32
    • 33144467291 scopus 로고    scopus 로고
    • Targeting Toll-like receptor signaling in plasmacytoid dendritic cells and autoreactive B cells as a therapy for lupus
    • Lenert PS. Targeting Toll-like receptor signaling in plasmacytoid dendritic cells and autoreactive B cells as a therapy for lupus. Arthritis Res Ther 2006; 8: 203.
    • (2006) Arthritis Res Ther , vol.8 , pp. 203
    • Lenert, P.S.1
  • 33
    • 67649235672 scopus 로고    scopus 로고
    • The development and function of regulatory B cells expressing IL-10 (B10 cells) requires antigen receptor diversity and TLR signals
    • Yanaba K, Bouaziz JD, Matsushita T, et al. The development and function of regulatory B cells expressing IL-10 (B10 cells) requires antigen receptor diversity and TLR signals. J Immunol 2009; 182: 7459-72.
    • (2009) J Immunol , vol.182 , pp. 7459-7472
    • Yanaba, K.1    Bouaziz, J.D.2    Matsushita, T.3
  • 34
    • 78751469622 scopus 로고    scopus 로고
    • Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells
    • Iwata Y, Matsushita T, Horikawa M, et al. Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells. Blood 2011; 117: 530-41.
    • (2011) Blood , vol.117 , pp. 530-541
    • Iwata, Y.1    Matsushita, T.2    Horikawa, M.3
  • 35
    • 84959871907 scopus 로고    scopus 로고
    • Endogenous toll-like receptor 9 regulates aki by promoting regulatory t cell recruitment
    • [epub ahead of print 2015]
    • Alikhan MA, Summers SA, Gan PY, et al. Endogenous Toll-Like Receptor 9 Regulates AKI by Promoting Regulatory T Cell Recruitment. J Am Soc Nephrol 2015. [epub ahead of print 2015].
    • (2015) J Am Soc Nephrol
    • Alikhan, M.A.1    Summers, S.A.2    Gan, P.Y.3
  • 36
    • 84860338292 scopus 로고    scopus 로고
    • Coordination between TLR9 signaling in macrophages and CD3 signaling in T cells induces robust expression of IL-30
    • Dibra D, Cutrera JJ, Li S. Coordination between TLR9 signaling in macrophages and CD3 signaling in T cells induces robust expression of IL-30. J Immunol 2012; 188: 3709-15.
    • (2012) J Immunol , vol.188 , pp. 3709-3715
    • Dibra, D.1    Cutrera, J.J.2    Li, S.3
  • 37
    • 41949127055 scopus 로고    scopus 로고
    • TLR9 engagement on CD4 T lymphocytes represses gamma-radiation-induced apoptosis through activation of checkpoint kinase response elements
    • Zheng L, Asprodites N, Keene AH, et al. TLR9 engagement on CD4 T lymphocytes represses gamma-radiation-induced apoptosis through activation of checkpoint kinase response elements. Blood 2008; 111: 2704-13.
    • (2008) Blood , vol.111 , pp. 2704-2713
    • Zheng, L.1    Asprodites, N.2    Keene, A.H.3
  • 38
    • 16544364829 scopus 로고    scopus 로고
    • The CD19-CD21 signal transduction complex of B lymphocytes regulates the balance between health and autoimmune disease: Systemic sclerosis as a model system
    • Tedder TF, Poe JC, Fujimoto M, et al. The CD19-CD21 signal transduction complex of B lymphocytes regulates the balance between health and autoimmune disease: systemic sclerosis as a model system. Curr Dir Autoimmun 2005; 8: 55-90.
    • (2005) Curr Dir Autoimmun , vol.8 , pp. 55-90
    • Tedder, T.F.1    Poe, J.C.2    Fujimoto, M.3
  • 39
    • 0030588569 scopus 로고    scopus 로고
    • CD19 regulates B lymphocyte signaling thresholds critical for the development of B-1 lineage cells and autoimmunity
    • Sato S, Ono N, Steeber DA, et al. CD19 regulates B lymphocyte signaling thresholds critical for the development of B-1 lineage cells and autoimmunity. J Immunol 1996; 157: 4371-8.
    • (1996) J Immunol , vol.157 , pp. 4371-4378
    • Sato, S.1    Ono, N.2    Steeber, D.A.3
  • 40
    • 0030784484 scopus 로고    scopus 로고
    • CD19-regulated signaling thresholds control peripheral tolerance and autoantibody production in B lymphocytes
    • Inaoki M, Sato S, Weintraub BC, et al. CD19-regulated signaling thresholds control peripheral tolerance and autoantibody production in B lymphocytes. J Exp Med 1997; 186: 1923-31.
    • (1997) J Exp Med , vol.186 , pp. 1923-1931
    • Inaoki, M.1    Sato, S.2    Weintraub, B.C.3
  • 41
    • 0034544489 scopus 로고    scopus 로고
    • Quantitative genetic variation in CD19 expression correlates with autoimmunity
    • Sato S, Hasegawa M, Fujimoto M, et al. Quantitative genetic variation in CD19 expression correlates with autoimmunity. J Immunol 2000; 165: 6635-43.
    • (2000) J Immunol , vol.165 , pp. 6635-6643
    • Sato, S.1    Hasegawa, M.2    Fujimoto, M.3
  • 42
    • 5144223503 scopus 로고    scopus 로고
    • Altered B lymphocyte function induces systemic autoimmunity in systemic sclerosis
    • Sato S, Fujimoto M, Hasegawa M, et al. Altered B lymphocyte function induces systemic autoimmunity in systemic sclerosis. Mol Immunol 2004; 41: 1123-33.
    • (2004) Mol Immunol , vol.41 , pp. 1123-1133
    • Sato, S.1    Fujimoto, M.2    Hasegawa, M.3
  • 43
    • 0032917731 scopus 로고    scopus 로고
    • Autoantigens as substrates for apoptotic proteases: Implications for the pathogenesis of systemic autoimmune disease
    • Rosen A, Casciola-Rosen L. Autoantigens as substrates for apoptotic proteases: implications for the pathogenesis of systemic autoimmune disease. Cell Death Differ 1999; 6: 6-12.
    • (1999) Cell Death Differ , vol.6 , pp. 6-12
    • Rosen, A.1    Casciola-Rosen, L.2
  • 44
    • 0029999963 scopus 로고    scopus 로고
    • Endothelial cell apoptosis is a primary pathogenic event underlying skin lesions in avian and human scleroderma
    • Sgonc R, Gruschwitz MS, Dietrich H, et al. Endothelial cell apoptosis is a primary pathogenic event underlying skin lesions in avian and human scleroderma. J Clin Invest 1996; 98: 785-92.
    • (1996) J Clin Invest , vol.98 , pp. 785-792
    • Sgonc, R.1    Gruschwitz, M.S.2    Dietrich, H.3
  • 45
    • 33745620189 scopus 로고    scopus 로고
    • Serum levels of 8-isoprostane, a marker of oxidative stress, are elevated in patients with systemic sclerosis
    • Ogawa F, Shimizu K, Muroi E, et al. Serum levels of 8-isoprostane, a marker of oxidative stress, are elevated in patients with systemic sclerosis. Rheumatology (Oxford) 2006; 45: 815-18.
    • (2006) Rheumatology (Oxford) , vol.45 , pp. 815-818
    • Ogawa, F.1    Shimizu, K.2    Muroi, E.3
  • 46
    • 35349019900 scopus 로고    scopus 로고
    • How does endothelial cell injury start? The role of endothelin in systemic sclerosis
    • Abraham D, Distler O. How does endothelial cell injury start? The role of endothelin in systemic sclerosis. Arthritis Res Ther 2007; 9(Suppl 2): S2.
    • (2007) Arthritis Res Ther , vol.9 , pp. S2
    • Abraham, D.1    Distler, O.2
  • 47
    • 2442707797 scopus 로고    scopus 로고
    • Nucleosomes are exposed at the cell surface in apoptosis
    • Radic M, Marion T, Monestier M. Nucleosomes are exposed at the cell surface in apoptosis. J Immunol 2004; 172: 6692-700.
    • (2004) J Immunol , vol.172 , pp. 6692-6700
    • Radic, M.1    Marion, T.2    Monestier, M.3
  • 48
    • 0028330345 scopus 로고
    • Accelerated in vitro apoptosis of lymphocytes from patients with systemic lupus erythematosus
    • Emlen W, Niebur J, Kadera R. Accelerated in vitro apoptosis of lymphocytes from patients with systemic lupus erythematosus. J Immunol 1994; 152: 3685-92.
    • (1994) J Immunol , vol.152 , pp. 3685-3692
    • Emlen, W.1    Niebur, J.2    Kadera, R.3
  • 49
    • 1642575264 scopus 로고    scopus 로고
    • Possible role of apoptosis in the pathogenesis of bleomycin-induced scleroderma
    • Yamamoto T, Nishioka K. Possible role of apoptosis in the pathogenesis of bleomycin-induced scleroderma. J Invest Dermatol 2004; 122: 44-50.
    • (2004) J Invest Dermatol , vol.122 , pp. 44-50
    • Yamamoto, T.1    Nishioka, K.2
  • 50
    • 77953275701 scopus 로고    scopus 로고
    • Differential cytokine production and bystander activation of autoreactive B cells in response to CpG-A and CpG-B oligonucleotides
    • Avalos AM, Latz E, Mousseau B, et al. Differential cytokine production and bystander activation of autoreactive B cells in response to CpG-A and CpG-B oligonucleotides. J Immunol 2009; 183: 6262-8.
    • (2009) J Immunol , vol.183 , pp. 6262-6268
    • Avalos, A.M.1    Latz, E.2    Mousseau, B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.