Lymphocyte apoptosis in systemic lupus erythematosus: Relationships with Fas expression, serum soluble Fas and disease activity

Lupus

Volumn 8, Issue 7, 1999, Pages 508-513

  Courtney, P A ^a,c   Crockard, A D ^a,b   Williamson, K ^b   McConnell, J ^a   Kennedy, R J ^b   Bell, A L ^a,b  

^a ROYAL VICTORIA HOSPITAL   (United Kingdom)

^b MUSGRAVE PARK HOSPITAL   (United Kingdom)

^c Musgrove Park Hospital   (Ireland)

Author keywords

Apoptosis; Fas; Lymphocyte; SLE; Soluble Fas

Indexed keywords

AUTOANTIGEN; DNA ANTIBODY; DOUBLE STRANDED DNA; FAS ANTIGEN; LIPOCORTIN 5;

ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ACTIVITY; ENTERITIS; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LYMPHOCYTE; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SYSTEMIC LUPUS ERYTHEMATOSUS;

ADRENAL CORTEX HORMONES; ANNEXIN A5; ANTIGENS, CD95; APOPTOSIS; ARTHRITIS, RHEUMATOID; AUTOANTIGENS; FEMALE; FLOW CYTOMETRY; HUMANS; INFLAMMATORY BOWEL DISEASES; LUPUS ERYTHEMATOSUS, SYSTEMIC; LYMPHOCYTES; MALE; SEVERITY OF ILLNESS INDEX; SOLUBILITY;

EID: 0032862392     PISSN: 09612033     EISSN: None     Source Type: Journal    
DOI: 10.1191/096120399678840765     Document Type: Article

References (32)

1. Casciola-Rosen LA, Anhalt G, Rosen A. Autoantigens targeted in SLE are clustered in two populations surface structures on apoptotic keratinocytes. J Exp Med 1994; 179: 1317-1330.
2. Utz PJ, Anderson P. Posttranslational protein modifications, apoptosis, and the bypass of tolerance to autoantigens. Arthritis Rheum 1998; 41: 1152-1160
3. Herrmann M, Zoller OM, Hagenhoffer M et al. What triggers anti-dsDNA antibodies? Mol Bio Rep 1996; 23: 265-267.
4. Perniok A, Wedekind F, Herrmann M et al. High levels of circulating early apoptotic peripheral blood mononuclear cells in SLE. Lupus 1998; 7: 113-118.
5. Lorenz HM, Grunke M, Hieronymus T et al. In vitro apoptosis and expression of apoptosis related molecules in lymphocytes from patients with SLE and other autoimmune diseases. Arthritis Rheum 1997; 40: 306-317.
6. Emlen W, Niebur JA, Adera R. Accelerated in vitro apoptosis of lymphocytes from patients with systemic lupus erythematosus. J Immunol 1994; 152: 3685-3692.
7. Kerr JFR, Wyllie AH, Currie AR. Apoptosis; a basic biological phenomenon with wide ranging implications in tissue kinetics. Brit J Cancer 1972; 26: 239-257.
8. Koopman G, Reutlingsberger CPM, Kuitjen GAM et al. Annexin V for flow cytometric detectionof phosphatidylserine expression on B cells undergoing apoptosis. Blood 1994; 84: 1415-1420.
9. Fadok VA, Voelker DR, Campbell PA et al. Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages. J Immunol 1992; 148: 2207-2216.
10. Martin S.I, Finucane DM, Amarante-Mendes GP et al. Phosphatidylserine externalization during CD95-induced apoptosis of cells and cytoplasts requires ICE/CED-3 protease activity. J Biol Chem 1996; 271: 28753-28756.
11. Watanabe Fukunaga R, Brannan CL, Copeland NG et al. Lymphoproliferation disorder in mice explained by defects in fas antigen that mediates apoptosis. Nature 1992; 356: 314-317.
12. Mysler E, Bina P, Drippa J et al. The APO-1/fas potein in human systemic lupus erythematosus. J Clin Invest 1994; 93: 1029-1034.
13. Drappa J, Vaishnaw AK, Sullivan KE et al. Fas gene mutations in the Canale-Smith syndrome, an inherited lymphoproliferative disorder associated with autoimmunity. N Engl J Med 1996; 335: 1643-1649.
14. Cheng J, Zhou T, Liu C et al. Protection from fas mediated apoptosis by a soluble form of the fas molecule. Science 1994; 263: 1759-1762.
15. Knipping E, Debatin-K M, Stricker H et al. Identification of soluble APO-1 in supernatants of human -B and T-cell lines and increased serum levels in B- and T- cell leukaemias. Blood 1995; 85: 1562-1569.
16. Jodo S, Kobayashi S, Kayagaki N et al. Serum levels of soluble Fas/APO-1 and its molecular structure in patients with systemic lupus erythematosus (SLE) and other autoimmune diseases. Clin Exp Immunol 1997; 107: 89-95.
17. Nozawa K, Kayagaki N, Tokano Y et al Soluble Fas (APO-1/CD95) and soluble Fas ligand in rheumatic diseases. Arthritis Rheum 1997; 40: 1126-1129.
18. Goel N, Ulrich DT, St Clair EW et al. Lack of correlation between serum soluble Fas/APO-1 levels and autoimmune disease. Arthritis Rheum 1995; 38: 1738-1743.
19. Cohen JJ, Duke R. Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death. J Immunol 1984; 132: 38-42.
20. Tan EM, Cohen AS, Fries JF et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1982; 25: 1271-1277.
21. Liang MH, Socher A, Larson MG, Schur PH. Reliability and validity of six systems for the clinical assessment of disease activity in SLE. Arthritis Rheum 1989; 32: 1107-1118.
22. English D, Anderson BR. Single step separation of red blood cells, granulocytes and mononuclear cells on discontinuous density gradient of ficoll-hypaque. J Immunol Meths 1974; 5: 249-252.
23. Courtney PA, Crockard AD, Williamson K et al. Increased apoptotic peripheral blood neutrophils in SLE: relations with disease activity, antibodies to double stranded DNA and neutropenia. Ann Rheum Dis 1999; 58: 309-314.
24. Courtney PA, Crockard AD, Williamson K, Bell AL. Apoptotic lymphocytes in SLE. Lupus 1998; 7: 498 (letter).
25. Richardson B, Yung RL, Johnson KJ et al. Monocyte apoptosis in patients with active lupus. Arthritis Rheum 1996; 39: 1432-1434.
26. Herrmann M, Voll RE, Zoller OM et al. Impaired phagocytosis of apoptotic cell material by monocyte-derived macrophages from patients with systemic lupus erythematosus. Arthritis Rheum 1998; 41: 1241-1250.
27. Suzuki N, Ichino M, Mihara S et al. Inhibition of fas/fas ligand-mediated apoptotic cell death of lymphocytes in vitro by circulating anti fas-ligand autoantibodies in patients with systemic lupus erythematosus. Arthritis Rheum 1998; 41: 344-353.
28. Yonehara S, Ishii A, Yonehara M. A cell killing monoclonal anti-body (anti-fas) to a cell surface antigen co-downregulated with the receptor of tumour necrosis factor. J Exp Med 1989; 169: 1747-1752.
29. Seki M, Ushiyama C, Seta M et al. Apoptosis of lymphocytes induced by glucocorticoids and relationship to therapeutic efficacy in patients with systemic lupus erythematosus. Arthritis Rheum 1998; 41: 823-830.
30. Cox G. Glucocorticoid treatment inhibits apoptosis in human neutrophils. J Immunol 1995; 154: 4719-4725.
31. Ohsako S and Elkon KB. Increased Caspace-3 like activity in freshly isolated lymphocytes from SLE patients. Arthritis Rheum 1998; 41: 70 (abstract 223).
32. Manfredi AA, Rovere P, Galati G et al. Apoptotic cell clearance in systemic lupus erythematosus. Arthritis Rheum 1998; 41: 205-214.