Geraniol, a natural monoterpene, ameliorates hyperglycemia by attenuating the key enzymes of carbohydrate metabolism in streptozotocin-induced diabetic rats

Pharmaceutical Biology

Volumn 55, Issue 1, 2017, Pages 1442-1449

  Babukumar, Sukumar ^a   Vinothkumar, Veerasamy ^a   Sankaranarayanan, Chandrasekaran ^a   Srinivasan, Subramani ^a  

^a ANNAMALAI UNIVERSITY   (India)

Author keywords

6 bisphoshpatase; Diabetes mellitus; Fructose 1; Glucose 6 phosphatase; Hexokinase

Indexed keywords

GERANIOL; GLICLAZIDE; GLUCOSE; GLYCOGEN; HEMOGLOBIN; HEMOGLOBIN A1C; INSULIN; LIVER ENZYME; ANTIDIABETIC AGENT; BIOLOGICAL MARKER; FRUCTOSE BISPHOSPHATASE; GLUCOSE 6 PHOSPHATASE; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; GLUCOSE BLOOD LEVEL; GLYCOSYLATED HEMOGLOBIN; HEXOKINASE; STREPTOZOCIN; TERPENE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; ARTICLE; BODY WEIGHT; CARBOHYDRATE METABOLISM; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; FLUID INTAKE; FOOD INTAKE; GLUCOSE BLOOD LEVEL; HEMOGLOBIN BLOOD LEVEL; HISTOPATHOLOGY; HYPERGLYCEMIA; INSULIN BLOOD LEVEL; LD50; LIVER CELL; MALE; NONHUMAN; PANCREAS ISLET BETA CELL; RAT; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; ANIMAL; BLOOD; CHEMICALLY INDUCED; DIABETES MELLITUS, EXPERIMENTAL; DRUG EFFECTS; ENZYMOLOGY; GLUCOSE TOLERANCE TEST; KIDNEY; LIVER; METABOLISM; PANCREAS; PATHOLOGY; TIME FACTOR; WISTAR RAT;

ANIMALS; BIOMARKERS; BLOOD GLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FRUCTOSE-BISPHOSPHATASE; GLUCOSE TOLERANCE TEST; GLUCOSE-6-PHOSPHATASE; GLUCOSEPHOSPHATE DEHYDROGENASE; HEMOGLOBIN A, GLYCOSYLATED; HEXOKINASE; HYPOGLYCEMIC AGENTS; INSULIN; KIDNEY; LETHAL DOSE 50; LIVER; MALE; PANCREAS; RATS, WISTAR; STREPTOZOCIN; TERPENES; TIME FACTORS;

EID: 85021857522     PISSN: 13880209     EISSN: 17445116     Source Type: Journal    
DOI: 10.1080/13880209.2017.1301494     Document Type: Article

References (51)

1. Baltrusch S, Schmitt H, Brix A, Langer S, Lenzen S. 2012. Additive activation of glucokinase by the bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase and the chemical activator LY2121260. Biochem Pharmacol. 83: 1300-1306.
2. Berg AH, Combs TP, Du X, Brownlee M, Scherer PE. 2001. The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat Med. 7: 947-953.
3. Bisse E, Abraham EC. 1985. New less temperature-sensitive microchromatographic method for the separation and quantitation of glycosylated hemoglobins using a non-cyanide buffer system. J Chromatogr. 344: 81-91.
4. Brandstrup N, Kirk JE, Bruni C. 1957. The hexokinase and phosphoglucoisomerase activities of aortic and pulmonary artery tissue in individuals of various ages. J Gerontol. 12: 166-171.
5. Bunn HF, Gabbay KH, Gallop PM. 1978. The glycosylation of hemoglobin: relevance to diabetes mellitus. Science. 200: 21-27.
6. Ceriello AI. 2005. Postprandial hyperglycemia and diabetes complications: is it time to treat? Diabet. 54: 1-7.
7. Cernea S, Dobreanu M. 2013. Diabetes and beta cell function: from mechanisms to evaluation and clinical implications. Biochem Med (Zagreb). 23: 266-280.
8. Chen W, Viljoen AM. 2010. Geraniol-A review of a commercially important fragrance material. S Afr J Bot. 76: 643-651.
9. Choi HS, Song HS, Ukeda H, Sawamura M. 2000. Radical-scavenging activities of citrus essential oils and their components: detection using 1,1-diphenyl-2-picrylhydrazyl. J Agric Food Chem. 48: 4156-4161.
10. Colosia AD, Palencia R, Khan S. 2013. Prevalence of hypertension and obesity in patients with type 2 diabetes mellitus in observational studies: a systematic literature review. Diabet Metab Syndr Obes. 6: 327-338.
11. Deepa B, Anuradha CV. 2011. Linalool, a plant derived monoterpene alcohol, rescues kidney from diabetic-induced, nephropathic changes via blood glucose reduction. Diabetol Croat. 3: 40-44.
12. Duncan RE, Lau D, Sohemy A, Archer MC. 2004. Geraniol and beta-ionone inhibit proliferation, cell cycle progression, and cyclin-dependent kinase 2 activity in MCF-7 breast cancer cells independent of effects on HMG-CoA reductase activity. Biochem Pharmacol. 68: 1739-1747.
13. Ellis HA, Kirkman HN. 1961. A colorimetric method for assay of erythrocytic glucose 6-phosphate dehydrogenase. Proc Soc Exp Biol Med. 106: 607-609.
14. Fatima SS, Rajasekhar MD, Kumar KV, Kumar MT, Babu KR, Rao CA. 2010. Antidiabetic and antihyperlipidemic activity of ethyl acetate: isopropanol (1: 1) fraction of Vernonia anthelmintica seeds in streptozotocin induced diabetic rats. Food Chem Toxicol. 48: 495-501.
15. Gancedo JM, Gancedo C. 1971. Fructose-1,6-diphosphatase, phospho-fructokinase and glucose-6-phosphate dehydrogenase from fermenting and none fermenting yeasts. Arch Micro. 76: 132-138.
16. Gandhi GR, Sasikumar P. 2012. Antidiabetic effect of Merremia emarginata Burm. F. in streptozotocin induced diabetic rats. Asian Pac J Trop Biomed. 2: 281-286.
17. Grover JK, Yadav S, Vats V. 2002. Medicinal plants of India with anti-diabetic potential. J Ethnopharmacol. 81: 81-100.
18. Jainandunsing S, Ozcan B, Rietveld T, van Miert JN, Isaacs AJ, Langendonk JG, de Rooij FW, Sijbrands EJ. 2015. Failing beta-cell adaptation in South Asian families with a high risk of type 2 diabetes. Acta Diabetol. 52: 11-19.
19. Ji P, Si M, Podnos Y, Imagawa DK. 2002. Monoterpene geraniol prevents acute allograft rejection. Transplant Proc. 34: 1418-1419.
20. Kaveeshwar SA, Cornwall J. 2014. The current state of diabetes mellitus in India. Australas Med J. 7: 45-48.
21. Koide H, Oda T. 1959. Pathological occurrence of glucose-6-phosphatase in serum in liver diseases. Clin Chim Acta. 4: 554-561.
22. Kondeti VK, Badri KR, Maddirala DR, Thur SK, Fatima SS, Kasetti RB, Rao CA. 2010. Effect of Pterocarpus santalinus bark, on blood glucose, serum lipids, plasma insulin and hepatic carbohydrate metabolic enzymes in streptozotocin-induced diabetic rats. Food Chem Toxicol. 48: 1281-1287.
23. Lakshmi BS, Sujatha S, Anand S, Sangeetha KN, Narayanan RB, Katiyar C, Kanaujia A, Duggar R, Singh Y, Srinivas K, et al. 2009. Cinnamic acid, from the bark of Cinnamomum cassia, regulates glucose transport via activation of GLUT4 on L6 myotubes in a phosphatidylinositol 3-kinase independent manner. J Diabet. 1: 99-106.
24. Lone J, Yun JW. 2016. Monoterpene limonene induces brown fat-like phenotype in 3T3-L1 white adipocytes. Life Sci. 153: 198-206.
25. Lorenzi V, Muselli A, Bernardini AF, Berti L, Pages JM, Amaral L. 2009. Geraniol restores antibiotic activities against multidrug-resistant isolates from Gram-negative species. Antimicrob Agents Chemother. 53: 2209-2211.
26. Malini P, Kanchana G, Rajadurai M. 2011. Antibiabetic efficacy of ellagic acid in streptozotocin-induced diabetes mellitus in albino Wistar rats. Asian J Pharm Clin Res. 4: 124-128.
27. Matschinsky FM. 2009. Assessing the potential of glucokinase activators in diabetes therapy. Nat Rev Drug Discov. 8: 399-416.
28. Murali R, Saravanan R. 2012. Antidiabetic effect of d-limonene, a monoterpene in streptozotocin-induced diabetic rats. Biomed Prev Nutr. 2: 269-275.
29. Nain P, Saini V, Sharma S, Nain J. 2012. Antidiabetic and antioxidant potential of Emblica officinalis Gaertn. leaves extract in streptozotocin-induced type-2 diabetes mellitus (T2DM) rats. J Ethnopharmacol. 142: 65-71.
30. Nordlie RC, Foster JD, Lange AJ. 1999. Regulation of glucose production by the liver. Annu Rev Nutr. 19: 379-406.
31. Ozougwu JC, Obimba KC, Belonwu CD, Unakalamba CB. 2013. The pathogenesis and pathophysiology of type 1 and type 2 diabetes mellitus. J Physiol Pathophysiol. 4: 46-57.
32. Pattanayak SP, Sunita P, Jha S. 2009. In vivo antitussive activity of Coccinia grandis against irritant aerosol and sulfur dioxide-induced cough model in rodents. J Pharmacol. 1: 157-161.
33. Prasath GS, Subramanian SP. 2014. Antihyperlipidemic effect of fisetin, a bioflavonoid of strawberries, studied in streptozotocin-induced diabetic rats. J Biochem Mol Toxicol. 28: 442-449.
34. Prathapan A, Nampoothiri SV, Mini S, Raghu KG. 2012. Antioxidant, antiglycation and inhibitory potential of Saraca ashoka flowers against the enzymes linked to type 2 diabetes and LDL oxidation. Eur Rev Med Pharmacol Sci. 16: 557-652.
35. Rakieten N, Rakieten ML, Nadkarni MV. 1963. Studies on the diabetogenic action of streptozotocin (NSC-37917). Cancer Chemother Rep. 29: 91-98.
36. Ramachandran V, Saravanan R. 2013. Efficacy of Asiatic acid, a pentacyclic triterpene on attenuating the key enzyme activities of carbohydrate metabolism in streptozotocin-induced diabetic rats. Phytomedicine. 20: 230-236.
37. Rathinam A, Pari L, Chandramohan R, Sheikh BA. 2014. Histopathological findings of the pancreas, liver, and carbohydrate metabolizing enzymes in STZ-induced diabetic rats improved by administration of myrtenal. J Physiol Biochem. 70: 935-946.
38. Selvaraja W, William Ndyeabura A. 2011. Antidiabetic activity of crude stem extracts of coscinium fenestratum on streptozotocin-induced type-2 diabetic rats. A J Pharma Clin Res. 4: 47-51.
39. Soumya D, Srilatha B. 2011. Late stage complications of diabetes and insulin resistance. J Diabetes Metab. 2: 167.
40. Srinivasan K, Ramarao P. 2007. Animal models in type 2 diabetes research: an overview. Indian J Med Res. 125: 451-472.
41. Stanton RC. 2012. Glucose-6-phosphate dehydrogenase, NADPH, and cell survival. IUBMB Life. 64: 362-369.
42. Sundaram R, Naresh R, Shanthi P, Sachdanandam P. 2013. Modulatory effect of green tea extract on hepatic key enzymes of glucose metabolism in streptozotocin and high fat diet induced diabetic rats. Phytomedicine. 20: 577-584.
43. Sundaram R, Shanthi P, Sachdanandam P. 2014. Effect of tangeretin, a polymethoxylated flavone on glucose metabolism in streptozotocin-induced diabetic rats. Phytomedicine. 21: 793-799.
44. Thiebaud D, Jacot E, DeFronzo RA, Maeder E, Jequier E, Felber JP. 1982. The effect of graded doses of insulin on total glucose uptake, glucose oxidation and glucose storage in man. Diabetes. 3: 957-963.
45. Tiwari M, Kakkar P. 2009. Plant derived antioxidants-geraniol and camphene protect rat alveolar macrophages against t-BHP induced oxidative stress. Toxicol in Vitro. 23: 295-301.
46. Trinder P. 1969. Determination of glucose in blood using glucose oxidase with analternative oxygen acceptor. J Clin Pathol. 6: 24-27.
47. Turk Z. 2010. Glycotoxines, carbonyl stress and relevance to diabetes and its complications. Physiol Res. 59: 147-156.
48. Vanitha P, Uma C, Suganya N, Bhakkiyalakshmi E, Suriyanarayanan S, Gunasekaran P, Sivasubramanian S, Ramkumar KM. 2014. Modulatory effects of morin on hyperglycemia by attenuating the hepatic key enzymes of carbohydrate metabolism and β-cell function in streptozotocin-induced diabetic rats. Environ Toxicol Pharmacol. 37: 326-335.
49. Vinothkumar V, Manoharan S. 2011. Chemopreventive efficacy of geraniol against 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis. Redox Rep. 16: 91-100.
50. Wilding JP. 2014. The role of the kidneys in glucose homeostasis in type 2 diabetes: clinical implications and therapeutic significance through sodium glucose co-transporter 2 inhibitors. Met Clin Exp. 63: 1228-1237.
51. Young PW, Cawthorne MA, Coyle PJ, Holder JC, Holman GD, Kozka IJ, Kirkham DM, Lister CA, Smith SA. 1995. Repeat treatment of obese mice with BRL 49653, a new and potent insulin sensitizer, enhances insulin action in white adipocytes. Association with increased insulin binding and cell-surface GLUT 4 as measured by photoaffinity labeling. Diabetes. 44: 1087-1092.