MAP17 Is a necessary activator of renal Na+/glucose cotransporter SGLT2

Journal of the American Society of Nephrology

Volumn 28, Issue 1, 2017, Pages 85-93

  Coady, Michael J ^a   El Tarazi, Abdulah ^b   Santer, René ^c   Bissonnette, Pierre ^b   Sasseville, Louis J ^a   Calado, Joaquim ^d   Lussier, Yoann ^b   Dumayne, Christopher ^b   Bichet, Daniel G ^a,b   Lapointe, Jean Yves ^a  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b Integrative Physiology and Groupe D'étude des Protéines Membranaires   (Canada)

^c UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^d NOVA MEDICAL SCHOOL   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

17 KDA MEMBRANE ASSOCIATED PROTEIN; MEMBRANE PROTEIN; PDZK1 PROTEIN; PDZK1IP1 PROTEIN; SCAFFOLD PROTEIN; SODIUM GLUCOSE COTRANSPORTER 2; UNCLASSIFIED DRUG; PDZK1IP1 PROTEIN, HUMAN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; APICAL MEMBRANE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL SURFACE; CONTROLLED STUDY; EXON; FEMALE; FOLLOW UP; GENE EXPRESSION; GENE MUTATION; GENETIC CODE; GENETIC HETEROGENEITY; GENETIC TRANSFECTION; HOMOZYGOSITY; HUMAN; IMMUNOFLUORESCENCE; INTRACELLULAR MEMBRANE; KIDNEY CELL; KIDNEY PROXIMAL TUBULE; MEMBRANE VESICLE; MOLECULAR CLONING; NONHUMAN; OOCYTE; OPOSSUM; PLASMID; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RENAL DIABETES; SIGNAL TRANSDUCTION; TRANSIENT TRANSFECTION; WESTERN BLOTTING; XENOPUS; ANIMAL; CELL CULTURE; CYTOLOGY; GENETICS; KIDNEY; METABOLISM; MUTATION; PHYSIOLOGY;

ANIMALS; CELLS, CULTURED; GLYCOSURIA, RENAL; HUMANS; KIDNEY; KIDNEY TUBULES, PROXIMAL; MEMBRANE PROTEINS; MUTATION; OPOSSUMS; SODIUM-GLUCOSE TRANSPORTER 2;

EID: 85021851549     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2015111282     Document Type: Article

References (49)

1. Sabolic I, Vrhovac I, Eror DB, Gerasimova M, Rose M, Breljak D, LjubojevicM, Brzica H, Sebastiani A, Thal SC, Sauvant C, Kipp H, Vallon V, Koepsell H: Expression of Na+-D-glucose cotransporter SGLT2 in rodents is kidney-specific and exhibits sex and species differences. Am J Physiol Cell Physiol 302: C1174-C1188, 2012
2. Wells RG, Pajor AM, Kanai Y, Turk E, Wright EM, Hediger MA: Cloning of a human kidney cDNA with similarity to the sodium-glucose cotransporter. Am J Physiol 263: F459-F465, 1992
3. Santer R, KinnerM, SchneppenheimR, Hillebrand G, KemperM, Ehrich J, Swift P, Skovby F, Schaub J: The molecular basis of renal glucosuria: mutations in the gene for a renal glucose transporter (SGLT2). J Inherit Metab Dis 23[Suppl 1]: 178, 2000
4. Santer R, Kinner M, Lassen CL, Schneppenheim R, Eggert P, Bald M, Brodehl J, Daschner M, Ehrich JH, Kemper M, Li Volti S, Neuhaus T, Skovby F, Swift PG, Schaub J, Klaerke D: Molecular analysis of the SGLT2 gene in patients with renal glucosuria. J Am Soc Nephrol 14: 2873-2882, 2003
5. Ullman CG, Frigotto L, Cooley RN: In vitro methods for peptide display and their applications. Brief Funct Genomics 10: 125-134, 2011
6. Hummel CS, Lu C, Loo DD, Hirayama BA, Voss AA, Wright EM: Glucose transport by human renal Na+/D-glucose cotransporters SGLT1 and SGLT2. Am J Physiol Cell Physiol 300: C14-C21, 2011
7. Wright EM: Renal Na(+)-glucose cotransporters. Am J Physiol Renal Physiol 280: F10-F18, 2001
8. Ikari A, Suketa Y: Expression of GFP-tagged low affinity Na+-dependent glucose transporter in Xenopus oocytes and CHO cells. Jpn J Physiol 52: 395-398, 2002
9. Kocher O, Cheresh P, Lee SW: Identification and partial characterization of a novel membrane-associated protein (MAP17) up-regulated in human carcinomas and modulating cell replication and tumor growth. Am J Pathol 149: 493-500, 1996
10. Hediger MA, Coady MJ, Ikeda TS, Wright EM: Expression cloning and cDNA sequencing of the Na+/glucose co-transporter. Nature 330: 379-381, 1987
11. Blasco T, Aramayona JJ, Alcalde AI, Catalán J, SarasaM, Sorribas V: Rat kidney MAP17 induces cotransport of Na-mannose and Na-glucose in Xenopus laevis oocytes. Am J Physiol Renal Physiol 285: F799-F810, 2003
12. Gisler SM, Kittanakom S, Fuster D, Wong V, BerticM, Radanovic T, Hall RA, Murer H, Biber J, Markovich D, Moe OW, Stagljar I: Monitoring protein-protein interactions between the mammalian integral membrane transporters and PDZ-interacting partners using a modified splitubiquitin membrane yeast two-hybrid system. Mol Cell Proteomics 7: 1362-1377, 2008
13. SanterR, CaladoJ: Familial renal glucosuria and SGLT2: fromamendelian trait to a therapeutic target. Clin J Am Soc Nephrol 5: 133-141, 2010
14. Finch NA, Linser PJ, Ochrietor JD: Hydrophobic interactions stabilize the basigin-MCT1 complex. Protein J 28: 362-368, 2009
15. Fernández E, Jiménez-VidalM, CalvoM, Zorzano A, Tebar F, Palacín M, Chillarón J: The structural and functional units of heteromeric amino acid transporters. The heavy subunit rBAT dictates oligomerization of the heteromeric amino acid transporters. J Biol Chem 281: 26552-26561, 2006
16. Verrey F, Singer D, Ramadan T, Vuille-dit-Bille RN, Mariotta L, Camargo SM: Kidney amino acid transport. Pflugers Arch 458: 53-60, 2009
17. Lee YJ, Kim MO, Ryu JM, Han HJ: Regulation of SGLT expression and localization through Epac/PKA-dependent caveolin-1 and F-actin activation in renal proximal tubule cells. BiochimBiophys Acta 1823: 971- 982, 2012
18. Pribanic S, Gisler SM, Bacic D, Madjdpour C, Hernando N, Sorribas V, Gantenbein A, Biber J, Murer H: Interactions of MAP17 with the NaPi- IIa/PDZK1 protein complex in renal proximal tubular cells. Am J Physiol Renal Physiol 285: F784-F791, 2003
19. Lanaspa MA, Giral H, Breusegem SY, Halaihel N, Baile G, Catalán J, Carrodeguas JA, Barry NP, Levi M, Sorribas V: Interaction of MAP17 with NHERF3/4 induces translocation of the renal Na/Pi IIa transporter to the trans-Golgi. Am J Physiol Renal Physiol 292: F230-F242, 2007
20. KocherO, Cheresh P, Brown LF, Lee SW: Identification of a novel gene, selectively up-regulated in human carcinomas, using the differential display technique. Clin Cancer Res 1: 1209-1215, 1995
21. Guijarro MV, Castro ME, Romero L, Moneo V, Carnero A: Large scale genetic screen identifies MAP17 as protein bypassing TNF-induced growth arrest. J Cell Biochem 101: 112-121, 2007
22. Guijarro MV, Link W, Rosado A, Leal JF, Carnero A: MAP17 inhibits Myc-induced apoptosis through PI3K/AKT pathway activation. Carcinogenesis 28: 2443-2450, 2007
23. Kocher O, Comella N, Tognazzi K, Brown LF: Identification and partial characterization of PDZK1: a novel protein containing PDZ interaction domains. Lab Invest 78: 117-125, 1998
24. Lamprecht G, Seidler U: The emerging role of PDZ adapter proteins for regulation of intestinal ion transport. Am J Physiol Gastrointest Liver Physiol 291: G766-G777, 2006
25. Gisler SM, Stagljar I, Traebert M, Bacic D, Biber J, Murer H: Interaction of the type IIa Na/Pi cotransporter with PDZ proteins. J Biol Chem276: 9206-9213, 2001
26. Donowitz M, Mohan S, Zhu CX, Chen TE, Lin R, Cha B, Zachos NC, Murtazina R, Sarker R, Li X:NHE3 regulatory complexes. J Exp Biol 212: 1638-1646, 2009
27. Gisler SM, Pribanic S, Bacic D, Forrer P, Gantenbein A, Sabourin LA, Tsuji A, Zhao ZS, Manser E, Biber J, Murer H: PDZK1: I. a major scaffolder in brush borders of proximal tubular cells. Kidney Int 64: 1733-1745, 2003
28. Seidler U, Singh AK, Cinar A, Chen M, Hillesheim J, Hogema B, Riederer B: The role of the NHERF family of PDZ scaffolding proteins in the regulation of salt and water transport. Ann N Y Acad Sci 1165: 249-260, 2009
29. Cinar A, Chen M, Riederer B, Bachmann O, Wiemann M, Manns M, KocherO, Seidler U:NHE3 inhibition by cAMP and Ca2+ is abolished in PDZ-domain protein PDZK1-deficient murine enterocytes. J Physiol 581: 1235-1246, 2007
30. Zachos NC, Tse M, Donowitz M: Molecular physiology of intestinal Na +/H+ exchange. Annu Rev Physiol 67: 411-443, 2005
31. Gisler SM, Madjdpour C, Bacic D, Pribanic S, Taylor SS, Biber J, Murer H: PDZK1: II. an anchoring site for the PKA-binding protein D-AKAP2 in renal proximal tubular cells. Kidney Int 64: 1746-1754, 2003
32. Kim H, Abd Elmageed ZY, Davis C, El-Bahrawy AH, Naura AS, Ekaidi I, Abdel-Mageed AB, Boulares AH: Correlation between PDZK1, Cdc37, Akt and breast cancer malignancy: the role of PDZK1 in cell growth through Akt stabilization by increasing and interacting with Cdc37. Mol Med 20: 270-279, 2014
33. Sarma GN, Moody IS, Ilouz R, Phan RH, Sankaran B, Hall RA, Taylor SS: D-AKAP2:PKA RII:PDZK1 ternary complex structure: Insights from the nucleation of a polyvalent scaffold. Protein Sci 24: 105-116, 2015
34. Silver DL, Wang N, Vogel S: Identification of small PDZK1-associated protein, DD96/MAP17, as a regulator of PDZK1 and plasma high density lipoprotein levels. J Biol Chem278: 28528-28532, 2003
35. Carnero A: MAP17, a ROS-dependent oncogene. Front Oncol 2: 112, 2012
36. Carnero A: MAP17 and the double-edged sword of ROS. Biochim Biophys Acta 1826: 44-52, 2012
37. GuijarroMV, Leal JF, Blanco-Aparicio C, Alonso S, Fominaya J, Lleonart M, Castellvi J, Ramon y Cajal S, Carnero A: MAP17 enhances the malignant behavior of tumor cells through ROS increase. Carcinogenesis 28: 2096-2104, 2007
38. Perez M, Praena-Fernandez JM, Felipe-Abrio B, Lopez-Garcia MA, Lucena-Cacace A, Garcia A, Lleonart M, Roncador G, Marin JJ, Carnero A: MAP17 and SGLT1 protein expression levels as prognostic markers for cervical tumor patient survival. PLoS One 8: e56169, 2013
39. Ishikawa N, Oguri T, Isobe T, Fujitaka K, Kohno N: SGLT gene expression in primary lung cancers and their metastatic lesions. Jpn J Cancer Res 92: 874-879, 2001
40. Scafoglio C, Hirayama BA, Kepe V, Liu J, Ghezzi C, Satyamurthy N, Moatamed NA, Huang J, Koepsell H, Barrio JR, Wright EM: Functional expression of sodium-glucose transporters in cancer. Proc Natl Acad Sci U S A 112: E4111-E4119, 2015
41. Hu S, Song E, Tian R, Ma S, Yang T, Mu Y, Li Y, Shao C, Gao S, Gao Y: Systematic analysis of a simple adaptor protein PDZK1: ligand identification, interaction and functional prediction of complex. Cell Physiol Biochem 24: 231-242, 2009
42. Pessoa TD, Campos LC, Carraro-Lacroix L, Girardi AC, Malnic G: Functional role of glucose metabolism, osmotic stress, and sodiumglucose cotransporter isoform-mediated transport on Na+/H+ exchanger isoform 3 activity in the renal proximal tubule. J Am Soc Nephrol 25: 2028-2039, 2014
43. Claperon A, Mergey M, Fouassier L: Roles of the scaffolding proteins NHERF in liver biology. Clin Res Hepatol Gastroenterol 35: 176-181, 2011
44. Sugiura T, Shimizu T, Kijima A, Minakata S, Kato Y: PDZ adaptors: their regulation of epithelial transporters and involvement in human diseases. J Pharm Sci 100: 3620-3635, 2011
45. Lin R, Murtazina R, Cha B, Chakraborty M, Sarker R, Chen TE, Lin Z, Hogema BM, de Jonge HR, Seidler U, Turner JR, Li X, Kovbasnjuk O, Donowitz M: D-glucose acts via sodium/glucose cotransporter 1 to increase NHE3 in mouse jejunal brush border by a Na+/H+ exchange regulatory factor 2-dependent process. Gastroenterology 140: 560-571, 2011
46. Coady MJ, Wallendorff B, Gagnon DG, Lapointe JY: Identification of a novelNa+/myo-inositol cotransporter. J Biol Chem277: 35219-35224, 2002
47. Johnson, KY, Liu, L, Vincent, TS: Minimal FLAG sequence useful in the functional epitope tagging of H-Ras. Biotechniques 32: 1270-1280, 2002.
48. Bissonnette P, Gagné H, Coady MJ, Benabdallah K, Lapointe JY, Berteloot A: Kinetic separation and characterization of three sugar transport modes in Caco-2 cells. Am J Physiol 270: G833-G843, 1996
49. Bissonnette P, Noël J, CoadyMJ, Lapointe JY: Functional expression of tagged human Na+-glucose cotransporter in Xenopus laevis oocytes. J Physiol 520: 359-371, 1999