Emulsion stability modulates gastric secretion and its mixing with emulsified fat in healthy adults in a randomized magnetic resonance imaging study

Journal of Nutrition

Volumn 146, Issue 10, 2016, Pages 2158-2164

  Liu, Dian ^a   Parker, Helen L ^b   Curcic, Jelena ^a,b   Kozerke, Sebastian ^a   Steingoetter, Andreas ^a,b  

^a ETH ZURICH   (Switzerland)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

Fat quantification; Gastric physiology; Gastric secretion; Gastrointestinal function; Healthy adults; Magnetic resonance imaging; Oil in water emulsions

Indexed keywords

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; EMULSION; HUMAN; HUMAN EXPERIMENT; INGESTION; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PARALLEL DESIGN; PHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; STOMACH SECRETION; YOUNG ADULT; ADMINISTRATION AND DOSAGE; BODY MASS; DIAGNOSTIC IMAGING; DIGESTION; FAT INTAKE; FEMALE; METABOLISM; PHARMACOKINETICS; STOMACH; STOMACH EMPTYING; STOMACH JUICE;

EMULSION; FAT INTAKE;

ADULT; BODY MASS INDEX; DIETARY FATS; DIGESTION; EMULSIONS; FEMALE; GASTRIC EMPTYING; GASTROINTESTINAL CONTENTS; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; SINGLE-BLIND METHOD; STOMACH; YOUNG ADULT;

EID: 85021849934     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.116.234955     Document Type: Article

References (35)

1. Blundell JE, Lawton CL, Cotton JR, Macdiarmid JI. Control of human appetite: implications for the intake of dietary fat. Annu Rev Nutr 1996;16:285-319
2. McClements DJ, Li Y. Structured emulsion-based delivery systems: controlling the digestion and release of lipophilic food components. Adv Colloid Interface Sci 2010;159:213-28
3. Mu H, Holm R, Mullertz A. Lipid-based formulations for oral administration of poorly water-soluble drugs. Int J Pharm 2013;453: 215-24
4. Hur SJ, Lim BO, Decker EA, McClements DJ. In vitro human digestion models for food applications. Food Chem 2011;125:1-12
5. McClements DJ, Li Y. Review of in vitro digestion models for rapid screening of emulsion-based systems. Food Funct 2010;1:32-59
6. Scheuble N, Geue T, Windhab EJ, Fischer P. Tailored interfacial rheology for gastric stable adsorption layers. Biomacromolecules 2014; 15:3139-45
7. Golding M, Wooster TJ, Day L, Xu M, Lundin L, Keogh J, Clifton P. Impact of gastric structuring on the lipolysis of emulsified lipids. Soft Matter 2011;7:3513-23
8. Wooster TJ, Day L, Xu M, Golding M, Oiseth S, Keogh J, Clifton P. Impact of different biopolymer networks on the digestion of gastric structured emulsions. Food Hydrocoll 2014;36:102-14
9. Khurana I. Medical physiology for undergraduate students. New Delhi (India):Elsevier Health Sciences APAC; 2014
10. Marciani L, Wickham MSJ, Bush D, Faulks R, Wright J, Fillery-Travis AJ, Spiller RC, Gowland PA. Magnetic resonance imaging of the behaviour of oil-in-water emulsions in the gastric lumen of man. Br J Nutr 2006;95:331-9
11. Steingoetter A, Radovic T, Buetikofer S, Curcic J, Menne D, Fried M, Schwizer W, Wooster TJ. Imaging gastric structuring of lipid emulsions and its effect on gastrointestinal function: a randomized trial in healthy subjects. Am J Clin Nutr 2015;101:714-24
12. Murray K, Placidi E, Schuring EA, Hoad CL, Koppenol W, Arnaudov LN, BlomWA, Pritchard SE, Stoyanov SD, Gowland PA, et al. Aerated drinks increase gastric volume and reduce appetite as assessed by MRI: a randomized, balanced, crossover trial. Am J Clin Nutr 2015;101: 270-8
13. Goetze O, Treier R, Fox M, Steingoetter A, Fried M, Boesiger P, Schwizer W. The effect of gastric secretion on gastric physiology and emptying in the fasted and fed state assessed by magnetic resonance imaging. Neurogastroenterol Motil 2009;21:725-e42
14. Fruehauf H, Menne D, Kwiatek MA, Forras-Kaufman Z, Kaufman E, Goetze O, Fried M, Schwizer W, Fox M. Inter-observer reproducibility and analysis of gastric volume measurements and gastric emptying assessed with magnetic resonance imaging. Neurogastroenterol Motil 2011;23:854-61
15. Heinrich H, Goetze O, Menne D, Iten PX, Fruehauf H, Vavricka SR, Schwizer W, Fried M, Fox M. Effect on gastric function and symptoms of drinking wine, black tea, or schnapps with a Swiss cheese fondue: randomised controlled crossover trial. BMJ 2010;341:c6731
16. Kunz P, Feinle-Bisset C, Faas H, Boesiger P, Fried M, Steingotter A, Schwizer W. Effect of ingestion order of the fat component of a solid meal on intragastric fat distribution and gastric emptying assessed by MRI. J Magn Reson Imaging 2005;21:383-90
17. Hussein MO, Hoad CL, Wright J, Singh G, Stephenson MC, Cox EF, Placidi E, Pritchard SE, Costigan C, Ribeiro H, et al. Fat emulsion intragastric stability and droplet size modulate gastrointestinal responses and subsequent food intake in young adults. J Nutr 2015;145: 1170-7
18. Liu D, Parker HL, Curcic J, Schwizer W, Fried M, Kozerke S, Steingoetter A. The visualisation and quantification of human gastrointestinal fat distribution with MRI: a randomised study in healthy subjects. Br J Nutr 2016;115:903-12
19. Treier R, Steingoetter A, Goetze O, Fox M, Fried M, Schwizer W, Boesiger P. Fast and optimized T1 mapping technique for the noninvasive quantification of gastric secretion. J Magn Reson Imaging 2008;28:96-102
20. Hoad CL, Parker H, Hudders N, Costigan C, Cox EF, Perkins AC, Blackshaw PE, Marciani L, Spiller RC, Fox MR, et al. Measurement of gastric meal and secretion volumes using magnetic resonance imaging. Phys Med Biol 2015;60:1367-83
21. Sauter M, Curcic J, Menne D, Goetze O, Fried M, Schwizer W, Steingoetter A. Measuring the interaction of meal and gastric secretion: a combined quantitative magnetic resonance imaging and pharmacokinetic modeling approach. Neurogastroenterol Motil 2012;24:632-8, e272-3
22. Steingoetter A, Sauter M, Curcic J, Liu D, Menne D, Fried M, Fox M, SchwizerW. Volume, distribution and acidity of gastric secretion on and off proton pump inhibitor treatment: a randomized double-blind controlled study in patients with gastro-esophageal reflux disease (GERD) and healthy subjects. BMC Gastroenterol 2015;15:111
23. Keogh JB, Wooster TJ, Golding M, Day L, Otto B, Clifton PM. Slowly and rapidly digested fat emulsions are equally satiating but their triglycerides are differentially absorbed and metabolized in humans. J Nutr 2011;141:809-15
24. Steingoetter A, Fox M, Treier R, Weishaupt D, Marincek B, Boesiger P, Fried M, Schwizer W. Effects of posture on the physiology of gastric emptying: a magnetic resonance imaging study. Scand J Gastroenterol 2006;41:1155-64
25. Tsao J, Jiang Y. Hierarchical IDEAL: fast, robust, and multiresolution separation of multiple chemical species from multiple echo times. Magn Reson Med 2013;70:155-9
26. Hu HH, Bornert P, Hernando D, Kellman P, Ma J, Reeder S, Sirlin C. ISMRM workshop on fat-water separation: insights, applications and progress in MRI. Magn Reson Med 2012;68:378-88
27. Liu CY, McKenzie CA, Yu H, Brittain JH, Reeder SB. Fat quantification with IDEAL gradient echo imaging: correction of bias from T(1) and noise. Magn Reson Med 2007;58:354-64
28. Treier R, Steingoetter A, Fried M, Schwizer W, Boesiger P. Optimized and combined T1 and B1 mapping technique for fast and accurate T1 quantification in contrast-enhanced abdominal MRI. Magn Reson Med 2007;57:568-76
29. Nehrke K, Bornert P. DREAM-a novel approach for robust, ultrafast, multislice B(1) mapping. Magn Reson Med 2012;68:1517-26
30. Banerjee S, Dixit S, Fox M, Pal A. Validation of a rapid, semiautomatic image analysis tool for measurement of gastric accommodation and emptying by magnetic resonance imaging. Am J Physiol Gastrointest Liver Physiol 2015;308:G652-63
31. R Development Core Team. R: a language and environment for statistical computing. Vienna (Austria): R Foundation for Statistical Computing, 2015
32. Sorensen T, Hohenstein S, Vasishth S. Bayesian linear mixed models using Stan: a tutorial for psychologists, linguists, and cognitive scientists. arXiv:1506.06201; 2015. [cited 2016 Feb 11] Available from: http:// arxiv.org/pdf/1506.06201v1.pdf
33. Koopmans LH, Owen DB, Rosenblatt JI. Confidence intervals for the coefficient of variation for the normal and log normal distributions. Biometrika 1964;51:25-32
34. Marciani L, Wickham M, Singh G, Bush D, Pick B, Cox E, Fillery-Travis A, Faulks R, Marsden C, Gowland PA, et al. Enhancement of intragastric acid stability of a fat emulsion meal delays gastric emptying and increases cholecystokinin release and gallbladder contraction. Am J Physiol Gastrointest Liver Physiol 2007;292:G1607-13
35. Seimon RV, Wooster T, Otto B, Golding M, Day L, Little TJ, Horowitz M, Clifton PM, Feinle-Bisset C. The droplet size of intraduodenal fat emulsions influences antropyloroduodenal motility, hormone release, and appetite in healthy males. Am J Clin Nutr 2009;89:1729-36