Mycobacterium tuberculosis subverts negative regulatory pathways in human macrophages to drive immunopathology

PLoS Pathogens

Volumn 13, Issue 6, 2017, Pages

  Brace, Patience T ^a   Tezera, Liku B ^a   Bielecka, Magdalena K ^a   Mellows, Toby ^a   Garay, Diana ^a   Tian, Shuye ^b   Rand, Lucinda ^c   Green, Justin ^c   Jogai, Sanjay ^a   Steele, Andrew J ^a   Millar, Timothy M ^a   Sanchez Elsner, Tilman ^a   Friedland, Jon S ^c   Proud, Christopher G ^b   Elkington, Paul T ^a,d  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b UNIVERSITY OF ADELAIDE   (Australia)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

^d UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CD68 ANTIGEN; CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INITIATION FACTOR 4E; INTERSTITIAL COLLAGENASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROSTAGLANDIN SYNTHASE; PROTEIN KINASE B; SYNAPTOTAGMIN I; TOLL LIKE RECEPTOR 2; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MULTIPROTEIN COMPLEX; TARGET OF RAPAMYCIN KINASE;

ARTICLE; BACTERIUM CULTURE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOPATHOLOGY; IMMUNOREACTIVITY; MACROPHAGE; MYCOBACTERIUM TUBERCULOSIS; POLYMERASE CHAIN REACTION; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION; TH1 CELL; TH2 CELL; WESTERN BLOTTING; ANIMAL; GENETICS; IMMUNOLOGY; LUNG TUBERCULOSIS; MICROBIOLOGY; MOUSE; PATHOLOGY; PHYSIOLOGY;

ANIMALS; HUMANS; MACROPHAGES; MATRIX METALLOPROTEINASE 1; MICE; MULTIPROTEIN COMPLEXES; MYCOBACTERIUM TUBERCULOSIS; PHOSPHATIDYLINOSITOL 3-KINASES; TOR SERINE-THREONINE KINASES; TUBERCULOSIS, PULMONARY;

EID: 85021783225     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1006367     Document Type: Article

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