Pentoxifylline inhibits TLR- A nd inflammasome-mediated in vitro inflammatory cytokine production in human blood with greater efficacy and potency in newborns

Pediatric Research

Volumn 81, Issue 5, 2017, Pages 806-816

  Speer, Esther M ^a   Dowling, David J ^b,c   Ozog, Lukasz S ^a   Xu, Jianjin ^d   Yang, Jie ^a   Kennady, Geetika ^a   Levy, Ofer ^b,c  

^a STONY BROOK UNIVERSITY   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d STONY BROOK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; I KAPPA B KINASE ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INFLAMMASOME; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; PENTOXIFYLLINE; RESIQUIMOD; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RECEPTOR; ADENOSINE TRIPHOSPHATE; ANTIINFLAMMATORY AGENT; AUTACOID; BIOLOGICAL MARKER; IL10 PROTEIN, HUMAN; IL1B PROTEIN, HUMAN; IL6 PROTEIN, HUMAN; IMIDAZOLE DERIVATIVE; LIPOPOLYSACCHARIDE;

ADULT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BLOOD SAMPLING; CELL LEVEL; COMPARATIVE STUDY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DRUG EFFICACY; DRUG POTENCY; ENZYME DEGRADATION; ENZYME PHOSPHORYLATION; FLOW CYTOMETRY; GENE EXPRESSION; GENE EXPRESSION ASSAY; HUMAN; HUMAN CELL; IMMUNOMODULATION; IMMUNOSTIMULATION; IN VITRO STUDY; INFLAMMATION; NEWBORN; NORMAL HUMAN; PLASMA FACTOR; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UMBILICAL CORD BLOOD; AGE; BLOOD; DOSE RESPONSE; DRUG EFFECTS; FETUS BLOOD; GENETICS; METABOLISM; TIME FACTOR;

ADENOSINE TRIPHOSPHATE; ADULT; AGE FACTORS; ANTI-INFLAMMATORY AGENTS; BIOMARKERS; DOSE-RESPONSE RELATIONSHIP, DRUG; FETAL BLOOD; HUMANS; IMIDAZOLES; INFANT, NEWBORN; INFLAMMASOMES; INFLAMMATION MEDIATORS; INTERLEUKIN-10; INTERLEUKIN-1BETA; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; PENTOXIFYLLINE; RNA, MESSENGER; TIME FACTORS; TOLL-LIKE RECEPTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 85021756827     PISSN: 00313998     EISSN: 15300447     Source Type: Journal    
DOI: 10.1038/pr.2017.6     Document Type: Article

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