Staphylococcus epidermidis bacteremia induces brain injury in neonatal mice via toll-like receptor 2-dependent and -independent pathways

Journal of Infectious Diseases

Volumn 212, Issue 9, 2015, Pages 1480-1490

  Bi, Dan ^a,b   Qiao, Lili ^a,c   Bergelson, Ilana ^d,e   Ek, C Joakim ^a   Duan, Luqi ^a,b   Zhang, Xiaoli ^a,b   Albertsson, Anna Maj ^a   Pettengill, Matthew ^d,e   Kronforst, Kenny ^f   Ninkovic, Jana ^g   Goldmann, Donald ^d,e   Janzon, Anders ^a   Hagberg, Henrik ^a,h   Wang, Xiaoyang ^a,b,i   Mallard, Carina ^a,h   Levy, Ofer ^d,e  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b ZHENGZHOU UNIVERSITY   (China)

^c Department of Radiology Center Hospital of Song Jiang   (China)

^d BOSTON CHILDREN S HOSPITAL   (United States)

^e HARVARD MEDICAL SCHOOL   (United States)

^f NORTHWESTERN UNIVERSITY   (United States)

^g 3M COMPANY   (United States)

^h KING'S COLLEGE LONDON   (United Kingdom)

ⁱ UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

brain injury; preterm; Staphylococcus epidermidis; Toll like receptor

Indexed keywords

CASPASE 3; CXCL1 CHEMOKINE; CYCLOOXYGENASE 2; INTERFERON REGULATORY FACTOR 1; INTERLEUKIN 12P40; INTERLEUKIN 6; MICROTUBULE ASSOCIATED PROTEIN 2; MONOCYTE CHEMOTACTIC PROTEIN 1; TOLL LIKE RECEPTOR 2; TRANSCRIPTOME; CASP3 PROTEIN, MOUSE; CCL2 PROTEIN, MOUSE; CXCL1 PROTEIN, MOUSE; TLR2 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTEREMIA; BACTERIAL CLEARANCE; BRAIN DEVELOPMENT; BRAIN INJURY; BRAIN LEVEL; BRAIN SIZE; CEREBROSPINAL FLUID; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; GENE; GRAY MATTER; IRF 1 GENE; LEUKOCYTE COUNT; MOUSE; NEWBORN; NFKBIB GENE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN FUNCTION; PTGS2 GENE; STAPHYLOCOCCUS EPIDERMIDIS; SURVIVAL; TLR2 GENE; UPREGULATION; WHITE MATTER; ANIMAL; BACTERIAL COUNT; BLOOD; C57BL MOUSE; DISEASE MODEL; GENETICS; ISOLATION AND PURIFICATION; KNOCKOUT MOUSE; LIVER; METABOLISM; MICROBIOLOGY; PATHOLOGY; SPLEEN;

ANIMALS; ANIMALS, NEWBORN; BACTEREMIA; BRAIN INJURIES; CASPASE 3; CHEMOKINE CCL2; CHEMOKINE CXCL1; COLONY COUNT, MICROBIAL; DISEASE MODELS, ANIMAL; INTERLEUKIN-12 SUBUNIT P40; INTERLEUKIN-6; LIVER; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; SPLEEN; STAPHYLOCOCCUS EPIDERMIDIS; TOLL-LIKE RECEPTOR 2; UP-REGULATION;

EID: 84946142754     PISSN: 00221899     EISSN: 15376613     Source Type: Journal    
DOI: 10.1093/infdis/jiv231     Document Type: Article

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