메뉴 건너뛰기




Volumn 2015, Issue 3, 2015, Pages

Pentoxifylline for treatment of sepsis and necrotizing enterocolitis in neonates

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; IMMUNOGLOBULIN; IMMUNOGLOBULIN M; PENTOXIFYLLINE; ANTIINFECTIVE AGENT; ANTIINFLAMMATORY AGENT; PHOSPHODIESTERASE INHIBITOR;

EID: 84941952746     PISSN: None     EISSN: 1469493X     Source Type: Journal    
DOI: 10.1002/14651858.CD004205.pub3     Document Type: Review
Times cited : (60)

References (44)
  • 1
    • 77952125009 scopus 로고    scopus 로고
    • Effects of pentoxifylline on coagulation profile and disseminated intravascular coagulation incidence in Egyptian septic neonates
    • PUBMED: 20831528]
    • Adel M, Awad HA, Abdel-Naim AB, Al-Aziz MM. Effects of pentoxifylline on coagulation profile and disseminated intravascular coagulation incidence in Egyptian septic neonates. Journal of Clinical Pharmacy and Therapeutics 2010;35(3):257-65. [PUBMED: 20831528]
    • (2010) Journal of Clinical Pharmacy and Therapeutics , vol.35 , Issue.3 , pp. 257-265
    • Adel, M.1    Awad, H.A.2    Abdel-Naim, A.B.3    Al-Aziz, M.M.4
  • 2
    • 84929941677 scopus 로고    scopus 로고
    • Role of pentoxifylline and/or IgM-enriched intravenous immunoglobulin in the management of neonatal sepsis
    • PUBMED: 24515621]
    • Akdag A, Dilmen U, Haque K, Dilli D, Erdeve O, Goekmen T. Role of pentoxifylline and/or IgM-enriched intravenous immunoglobulin in the management of neonatal sepsis. American Journal of Perinatology 2014;31:905-12. [PUBMED: 24515621]
    • (2014) American Journal of Perinatology , vol.31 , pp. 905-912
    • Akdag, A.1    Dilmen, U.2    Haque, K.3    Dilli, D.4    Erdeve, O.5    Goekmen, T.6
  • 4
    • 9244247665 scopus 로고    scopus 로고
    • Pentoxifylline reduces plasma tumour necrosis factor-alpha concentration in premature infants with sepsis
    • [PUBMED: 8741040]
    • Lauterbach R, Zembala M. Pentoxifylline reduces plasma tumour necrosis factor-alpha concentration in premature infants with sepsis. European Journal of Pediatrics 1996;155(5):404-9. [PUBMED: 8741040]
    • (1996) European Journal of Pediatrics , vol.155 , Issue.5 , pp. 404-409
    • Lauterbach, R.1    Zembala, M.2
  • 5
    • 0032916980 scopus 로고    scopus 로고
    • Effect of immunomodulating agent, pentoxifylline, in the treatment of sepsis in prematurely delivered infants: a placebo controlled, double-blind trial
    • Lauterbach R, Pawlik D, Danuta K, Wieslaw K, Ewah K, Marek Z. Effect of immunomodulating agent, pentoxifylline, in the treatment of sepsis in prematurely delivered infants: a placebo controlled, double-blind trial. Critical Care Medicine 1999;27:807-14.
    • (1999) Critical Care Medicine , vol.27 , pp. 807-814
    • Lauterbach, R.1    Pawlik, D.2    Danuta, K.3    Wieslaw, K.4    Ewah, K.5    Marek, Z.6
  • 7
    • 0028087695 scopus 로고
    • Pentoxifylline treatment of sepsis of premature infants: preliminary clinical observations
    • PUBMED: 7957428]
    • Lauterbach R, Pawlik D, Tomaszcyk B, Cholewa B. Pentoxifylline treatment of sepsis of premature infants: preliminary clinical observations. European Journal of Pediatrics 1994;153(9):672-4. [PUBMED: 7957428]
    • (1994) European Journal of Pediatrics , vol.153 , Issue.9 , pp. 672-674
    • Lauterbach, R.1    Pawlik, D.2    Tomaszcyk, B.3    Cholewa, B.4
  • 8
    • 18444379362 scopus 로고    scopus 로고
    • Effect of pentoxifylline on tumor necrosis factor-alpha and interleukin-6 levels in neonatal sepsis
    • PUBMED: 15727386]
    • Selim K, Hüseyin C, Ibrahim KH, Hasan BU, Kazim U, Hüseyin K. Effect of pentoxifylline on tumor necrosis factor-alpha and interleukin-6 levels in neonatal sepsis. The Medical Journal of Malaysia 2004;59(3):391-4. [PUBMED: 15727386]
    • (2004) The Medical Journal of Malaysia , vol.59 , Issue.3 , pp. 391-394
    • Selim, K.1    Hüseyin, C.2    Ibrahim, K.H.3    Hasan, B.U.4    Kazim, U.5    Hüseyin, K.6
  • 9
    • 85041950195 scopus 로고    scopus 로고
    • Safety and efficacy of pentoxifylline as a treatment for preventing the progression of necrotising enterocolitis in preterm neonates - a randomised, placebo controlled pilot trial
    • (accessed 15 May 2014)
    • ACTRN12606000257561. Safety and efficacy of pentoxifylline as a treatment for preventing the progression of necrotising enterocolitis in preterm neonates - a randomised, placebo controlled pilot trial. http://apps.who.int/trialsearch/trial.aspx?trialid=ACTRN12606000257561 (accessed 15 May 2014).
  • 10
    • 33646678434 scopus 로고    scopus 로고
    • Neonatal infection and long-term neurodevelopmental outcome in the preterm infant
    • [PUBMED: 16645492]
    • Adams-Chapman I, Stoll BJ. Neonatal infection and long-term neurodevelopmental outcome in the preterm infant. Current Opinion in Infectious Diseases 2006;19(3):290-7. [PUBMED: 16645492]
    • (2006) Current Opinion in Infectious Diseases , vol.19 , Issue.3 , pp. 290-297
    • Adams-Chapman, I.1    Stoll, B.J.2
  • 11
    • 0030997420 scopus 로고    scopus 로고
    • Effects of pentoxifylline on haemodynamics and oxygenation in septic and non-septic patients
    • PUBMED: 9187598]
    • Bacher A, Mayer N, Klimscha W, Oismüller C, Steltzer H, Hammerle A. Effects of pentoxifylline on haemodynamics and oxygenation in septic and non-septic patients. Critical Care Medicine 1997;25(5):795-800. [PUBMED: 9187598]
    • (1997) Critical Care Medicine , vol.25 , Issue.5 , pp. 795-800
    • Bacher, A.1    Mayer, N.2    Klimscha, W.3    Oismüller, C.4    Steltzer, H.5    Hammerle, A.6
  • 12
    • 0017917048 scopus 로고
    • Neonatal necrotising enterocolitis. Therapeutic decisions based upon clinical staging
    • PUBMED: 413500]
    • Bell MJ, Ternberg JL, Feigin RD, Keating JP, Marshall R, Barton L, et al. Neonatal necrotising enterocolitis. Therapeutic decisions based upon clinical staging. Annals of Surgery 1978;187(1):1-7. [PUBMED: 413500]
    • (1978) Annals of Surgery , vol.187 , Issue.1 , pp. 1-7
    • Bell, M.J.1    Ternberg, J.L.2    Feigin, R.D.3    Keating, J.P.4    Marshall, R.5    Barton, L.6
  • 13
    • 0029551572 scopus 로고
    • Production of pro-inflammatory cytokines and cytokines involved in the TH1/TH2 balance is modulated by pentoxifylline
    • PUBMED: 8699868]
    • Bienvenu J, Doche C, Gutowski MC, Lenoble M, Lepape A, Perdrix JP. Production of pro-inflammatory cytokines and cytokines involved in the TH1/TH2 balance is modulated by pentoxifylline. Journal of Cardiovascular Pharmacology 1995;25 Suppl 2:S80-4. [PUBMED: 8699868]
    • (1995) Journal of Cardiovascular Pharmacology , vol.25 , pp. S80-S84
    • Bienvenu, J.1    Doche, C.2    Gutowski, M.C.3    Lenoble, M.4    Lepape, A.5    Perdrix, J.P.6
  • 14
    • 0030006971 scopus 로고    scopus 로고
    • Influence of long term continuous intravenous administration of pentoxifylline on endothelial related coagulation in critically ill patients
    • PUBMED: 8681595]
    • Boldt J, Müller M, Heyn S, Welters I, Hempelmann G. Influence of long term continuous intravenous administration of pentoxifylline on endothelial related coagulation in critically ill patients. Critical Care Medicine 1996;24(6):940-6. [PUBMED: 8681595]
    • (1996) Critical Care Medicine , vol.24 , Issue.6 , pp. 940-946
    • Boldt, J.1    Müller, M.2    Heyn, S.3    Welters, I.4    Hempelmann, G.5
  • 15
    • 0025333028 scopus 로고
    • Necrotizing enterocolitis: role of platelet activating factor, endotoxin, and tumor necrosis factor
    • [PUBMED: 2194011]
    • Caplan MS, Hsueh W. Necrotizing enterocolitis: role of platelet activating factor, endotoxin, and tumor necrosis factor. Journal of Pediatrics 1990;117(1 Pt 2):S47-51. [PUBMED: 2194011]
    • (1990) Journal of Pediatrics , vol.117 , Issue.1 , pp. S47-S51
    • Caplan, M.S.1    Hsueh, W.2
  • 16
    • 0025296725 scopus 로고
    • Role of platelet activating factor and tumor necrosis factor-alpha in neonatal necrotizing enterocolitis
    • PUBMED: 2348301]
    • Caplan MS, Sun XM, Hseuh W, Hageman JR. Role of platelet activating factor and tumor necrosis factor-alpha in neonatal necrotizing enterocolitis. Journal of Pediatrics 1990;116(6):960-4. [PUBMED: 2348301]
    • (1990) Journal of Pediatrics , vol.116 , Issue.6 , pp. 960-964
    • Caplan, M.S.1    Sun, X.M.2    Hseuh, W.3    Hageman, J.R.4
  • 17
    • 0033029932 scopus 로고    scopus 로고
    • Circulating pro- and counterinflammatory cytokine levels and severity in necrotizing enterocolitis
    • PUBMED: 10103300]
    • Edelson MB, Bagwell CE, Rozycki HJ. Circulating pro- and counterinflammatory cytokine levels and severity in necrotizing enterocolitis. Pediatrics 1999;103(4 Pt 1):766-71. [PUBMED: 10103300]
    • (1999) Pediatrics , vol.103 , Issue.4 , pp. 766-771
    • Edelson, M.B.1    Bagwell, C.E.2    Rozycki, H.J.3
  • 19
    • 26844465142 scopus 로고    scopus 로고
    • Cytokine elaboration in critically ill infants with bacterial sepsis, necrotizing enterocolitis, or sepsis syndrome: correlation with clinical parameters of inflammation and mortality
    • PUBMED: 16227031]
    • Harris MC, D'Angio CT, Gallagher PR, Kaufman D, Evans J, Kilpatrick L. Cytokine elaboration in critically ill infants with bacterial sepsis, necrotizing enterocolitis, or sepsis syndrome: correlation with clinical parameters of inflammation and mortality. Journal of Pediatrics 2005;147(4):462-8. [PUBMED: 16227031]
    • (2005) Journal of Pediatrics , vol.147 , Issue.4 , pp. 462-468
    • Harris, M.C.1    D'Angio, C.T.2    Gallagher, P.R.3    Kaufman, D.4    Evans, J.5    Kilpatrick, L.6
  • 20
    • 77956303510 scopus 로고    scopus 로고
    • Pentoxifylline in preterm neonates
    • PUBMED: 20799759]
    • Harris E, Schulzke SM, Patole SK. Pentoxifylline in preterm neonates. Pediatric Drugs 2010;12(5):301-11. [PUBMED: 20799759]
    • (2010) Pediatric Drugs , vol.12 , Issue.5 , pp. 301-311
    • Harris, E.1    Schulzke, S.M.2    Patole, S.K.3
  • 21
    • 84887346660 scopus 로고    scopus 로고
    • Cochrane Handbook for Systematic Reviews of Interventions
    • Version 5.1.0 [updated March 2011]. The Cochrane Collaboration
    • Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions. Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. www.cochrane-handbook.org.
    • (2011)
    • Higgins, J.P.T.1    Green, S.2
  • 22
    • 0021243811 scopus 로고
    • An international classification of retinopathy of prematurity
    • [PUBMED: 6547831]
    • The Committee for the Classification of Retinopathy of Prematurity. An international classification of retinopathy of prematurity. Archives of Ophthalmology 1984;102(8):1130-4. [PUBMED: 6547831]
    • (1984) Archives of Ophthalmology , vol.102 , Issue.8 , pp. 1130-1134
  • 23
    • 3242763823 scopus 로고    scopus 로고
    • Clinical microbiology of bacterial and fungal sepsis in very-low-birth-weight infants
    • [PUBMED: 15258097]
    • Kaufman D, Fairchild KD. Clinical microbiology of bacterial and fungal sepsis in very-low-birth-weight infants. Clinical Microbiology Reviews 2004;17(3):638-80. [PUBMED: 15258097]
    • (2004) Clinical Microbiology Reviews , vol.17 , Issue.3 , pp. 638-680
    • Kaufman, D.1    Fairchild, K.D.2
  • 24
    • 0029806882 scopus 로고    scopus 로고
    • Free radical scavenging by lazaroids improves renal blood flow during sepsis
    • PUBMED: 8862374]
    • Krysztopik RJ, Bentley FR, Spain DA, Wilson MA, Garrison RN. Free radical scavenging by lazaroids improves renal blood flow during sepsis. Surgery 1996;120(4):657-62. [PUBMED: 8862374]
    • (1996) Surgery , vol.120 , Issue.4 , pp. 657-662
    • Krysztopik, R.J.1    Bentley, F.R.2    Spain, D.A.3    Wilson, M.A.4    Garrison, R.N.5
  • 25
  • 26
    • 0032486989 scopus 로고    scopus 로고
    • Antimicrobial resistance: Bacteria on the defence. Resistance stems from misguided efforts to try to sterilize our environment
    • [PUBMED: 9727983]
    • Levy SB. Antimicrobial resistance: Bacteria on the defence. Resistance stems from misguided efforts to try to sterilize our environment. BMJ 1998;317(7159):612-3. [PUBMED: 9727983]
    • (1998) BMJ , vol.317 , Issue.7159 , pp. 612-613
    • Levy, S.B.1
  • 27
    • 33749256460 scopus 로고    scopus 로고
    • Necrotizing enterocolitis
    • [PUBMED: 17027734]
    • Lin PW, Stoll BJ. Necrotizing enterocolitis. Lancet 2006;368(9543):1271-83. [PUBMED: 17027734]
    • (2006) Lancet , vol.368 , Issue.9543 , pp. 1271-1283
    • Lin, P.W.1    Stoll, B.J.2
  • 29
    • 0037542501 scopus 로고    scopus 로고
    • Proinflammatory and anti-inflammatory cytokine responses in preterm infants with systemic infections
    • PUBMED: 12719394]
    • Ng PC, Li K, Wong RP, Chui K, Wong E, Li G, et al. Proinflammatory and anti-inflammatory cytokine responses in preterm infants with systemic infections. Archives of Disease in Childhood. Fetal Neonatal Ed 2003;88(3):F209-13. [PUBMED: 12719394]
    • (2003) Archives of Disease in Childhood. Fetal Neonatal Ed , vol.88 , Issue.3 , pp. F209-F213
    • Ng, P.C.1    Li, K.2    Wong, R.P.3    Chui, K.4    Wong, E.5    Li, G.6
  • 30
    • 84964921069 scopus 로고    scopus 로고
    • Review Manager (RevMan). Version 5.3.
    • Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration
    • The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). Version 5.3. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2014.
    • (2014)
  • 31
    • 0032745094 scopus 로고    scopus 로고
    • Inflammatory mechanisms in neonatal chronic lung disease
    • [PUBMED: 10592094]
    • Speer CP. Inflammatory mechanisms in neonatal chronic lung disease. European Journal of Pediatrics 1999;158 Suppl 1:S18-22. [PUBMED: 10592094]
    • (1999) European Journal of Pediatrics , vol.158 , pp. S18-S22
    • Speer, C.P.1
  • 32
    • 18444388276 scopus 로고    scopus 로고
    • Late-onset sepsis in very low birth weight neonates: the experience of the NICHD Neonatal Research Network
    • PUBMED: 12165580]
    • Stoll BJ, Hansen N, Fanaroff AA, Wright LL, Carlo WA, Ehrenkranz RA, et al. Late-onset sepsis in very low birth weight neonates: the experience of the NICHD Neonatal Research Network. Pediatrics 2002;110(2 Pt 1):285-91. [PUBMED: 12165580]
    • (2002) Pediatrics , vol.110 , Issue.2 , pp. 285-291
    • Stoll, B.J.1    Hansen, N.2    Fanaroff, A.A.3    Wright, L.L.4    Carlo, W.A.5    Ehrenkranz, R.A.6
  • 33
    • 17744362226 scopus 로고    scopus 로고
    • Infections of the neonatal infant
    • In: Behrman RE, Kliegman RM, Jenson HB editor(s). 17th Edition. Philadelphia: Saunders
    • Stoll BJ. Infections of the neonatal infant. In: Behrman RE, Kliegman RM, Jenson HB editor(s). Nelson Textbook of Pediatrics. 17th Edition. Philadelphia: Saunders, 2004:623-40.
    • (2004) Nelson Textbook of Pediatrics , pp. 623-640
    • Stoll, B.J.1
  • 34
    • 8544252449 scopus 로고    scopus 로고
    • Neurodevelopmental and growth impairment among extremely low-birth-weight infants with neonatal infection
    • PUBMED: 15547163]
    • Stoll BJ, Hansen NI, Adams-Chapman I, Fanaroff AA, Hintz SR, Vohr B, et al. Neurodevelopmental and growth impairment among extremely low-birth-weight infants with neonatal infection. JAMA 2004;292(19):2357-65. [PUBMED: 15547163]
    • (2004) JAMA , vol.292 , Issue.19 , pp. 2357-2365
    • Stoll, B.J.1    Hansen, N.I.2    Adams-Chapman, I.3    Fanaroff, A.A.4    Hintz, S.R.5    Vohr, B.6
  • 35
    • 22244462944 scopus 로고    scopus 로고
    • Very low birth weight preterm infants with early onset neonatal sepsis: the predominance of gram-negative infections continues in the National Institute of Child Health and Human Development Neonatal Research Network, 2002-2003
    • PUBMED: 15999007]
    • Stoll BJ, Hansen NI, Higgins RD, Fanaroff AA, Duara S, Goldberg R, et al. Very low birth weight preterm infants with early onset neonatal sepsis: the predominance of gram-negative infections continues in the National Institute of Child Health and Human Development Neonatal Research Network, 2002-2003. Pediatric Infectious Disease Journal 2005;24(7):635-9. [PUBMED: 15999007]
    • (2005) Pediatric Infectious Disease Journal , vol.24 , Issue.7 , pp. 635-639
    • Stoll, B.J.1    Hansen, N.I.2    Higgins, R.D.3    Fanaroff, A.A.4    Duara, S.5    Goldberg, R.6
  • 36
    • 33748053348 scopus 로고    scopus 로고
    • Pentoxifylline reduces the incidence and severity of necrotizing enterocolitis in a neonatal rat model
    • PUBMED: 16864701]
    • Travadi J, Patole S, Charles A, Dvorak B, Doherty D, Simmer K. Pentoxifylline reduces the incidence and severity of necrotizing enterocolitis in a neonatal rat model. Pediatric Research 2006;60(2):185-9. [PUBMED: 16864701]
    • (2006) Pediatric Research , vol.60 , Issue.2 , pp. 185-189
    • Travadi, J.1    Patole, S.2    Charles, A.3    Dvorak, B.4    Doherty, D.5    Simmer, K.6
  • 37
    • 0025779160 scopus 로고
    • Tumor necrosis factor. New insights into the molecular mechanisms of its multiple actions
    • [PUBMED: 1850405]
    • Vilcek J, Lee TH. Tumor necrosis factor. New insights into the molecular mechanisms of its multiple actions. Journal of Biological Chemistry 1991;266(12):7313-6. [PUBMED: 1850405]
    • (1991) Journal of Biological Chemistry , vol.266 , Issue.12 , pp. 7313-7316
    • Vilcek, J.1    Lee, T.H.2
  • 38
    • 0004263777 scopus 로고
    • 3rd Edition. Philadelphia, London: WB Saunders
    • Volpe JJ. Neurology of the Newborn. 3rd Edition. Philadelphia, London: WB Saunders, 1995.
    • (1995) Neurology of the Newborn
    • Volpe, J.J.1
  • 39
    • 0022648941 scopus 로고
    • Necrotizing enterocolitis: Treatment based on staging criteria
    • [PUBMED: 3081865]
    • Walsh MC, Kliegman RM. Necrotizing enterocolitis: Treatment based on staging criteria. Pediatric Clinics of North America 1986;33(1):179-201. [PUBMED: 3081865]
    • (1986) Pediatric Clinics of North America , vol.33 , Issue.1 , pp. 179-201
    • Walsh, M.C.1    Kliegman, R.M.2
  • 40
    • 0029822874 scopus 로고    scopus 로고
    • Pentoxifylline maintains vascular endothelial cell function during hyperdynamic sepsis
    • PUBMED: 8751606]
    • Wang P, Wood TJ, Ba ZF, Chaudry IH. Pentoxifylline maintains vascular endothelial cell function during hyperdynamic sepsis. Surgery 1996;120(2):367-73. [PUBMED: 8751606]
    • (1996) Surgery , vol.120 , Issue.2 , pp. 367-373
    • Wang, P.1    Wood, T.J.2    Ba, Z.F.3    Chaudry, I.H.4
  • 41
    • 0032888183 scopus 로고    scopus 로고
    • Pentoxifylline prevents the transition from hyperdynamic to hypodynamic response during sepsis
    • PUBMED: 10484426]
    • Yang S, Zhou M, Koo DJ, Chaudry IH, Wang P. Pentoxifylline prevents the transition from hyperdynamic to hypodynamic response during sepsis. American Journal of Physiology 1999;277(3 Pt 2):H1036-44. [PUBMED: 10484426]
    • (1999) American Journal of Physiology , vol.277 , Issue.3 , pp. H1036-H1044
    • Yang, S.1    Zhou, M.2    Koo, D.J.3    Chaudry, I.H.4    Wang, P.5
  • 42
    • 15744389852 scopus 로고    scopus 로고
    • Hospital-acquired neonatal infections in developing countries
    • PUBMED: 15794973]
    • Zaidi AK, Huskins WC, Thaver D, Bhutta ZA, Abbas Z, Goldman DA. Hospital-acquired neonatal infections in developing countries. Lancet 2005;365(9465):1175-88. [PUBMED: 15794973]
    • (2005) Lancet , vol.365 , Issue.9465 , pp. 1175-1188
    • Zaidi, A.K.1    Huskins, W.C.2    Thaver, D.3    Bhutta, Z.A.4    Abbas, Z.5    Goldman, D.A.6
  • 43
    • 9044224023 scopus 로고    scopus 로고
    • Effects of pentoxifylline on circulating cytokine concentrations and haemodynamics in patients with septic shock: results from a double blind, randomized, placebo controlled study
    • PUBMED: 8605790]
    • Zeni F, Pain P, Vindimian M, Gay JP, Gery P, Bertrand M, et al. Effects of pentoxifylline on circulating cytokine concentrations and haemodynamics in patients with septic shock: results from a double blind, randomized, placebo controlled study. Critical Care Medicine 1996;24(2):207-14. [PUBMED: 8605790]
    • (1996) Critical Care Medicine , vol.24 , Issue.2 , pp. 207-214
    • Zeni, F.1    Pain, P.2    Vindimian, M.3    Gay, J.P.4    Gery, P.5    Bertrand, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.