Microbial-derived 1,4-Dihydroxy-2-naphthoic acid and related compounds as aryl hydrocarbon receptor agonists/antagonists: Structure-activity relationships and receptor modeling

Toxicological Sciences

Volumn 155, Issue 2, 2017, Pages 458-473

  Cheng, Yating ^a   Jin, Un Ho ^a   Davidson, Laurie A ^b   Chapkin, Robert S ^b   Jayaraman, Arul ^c   Tamamis, Phanourios ^c   Orr, Asuka ^c   Allred, Clint ^b   Denison, Michael S ^d   Soshilov, Anatoly ^d   Weaver, Evelyn ^b   Safe, Stephen ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

^b TEXAS A AND M UNIVERSITY   (United States)

^c Department of Electrical and Computer Engineering   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

1,4 DHNA; Agonists; Ah receptor; Antagonists; Structure activity

Indexed keywords

1,4 DIHYDROXY 2 NAPHTHOIC ACID; 2 NAPHTHOIC ACID DERIVATIVE; 2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; CYTOCHROME P450 1A1; CYTOCHROME P450 1B1; NAPHTHALENE DERIVATIVE; PROTEIN INHIBITOR; UNCLASSIFIED DRUG; 1,4-DIHYDROXY-2-NAPHTHOIC ACID; AROMATIC HYDROCARBON RECEPTOR; CYP1B1 PROTEIN, HUMAN; NAPHTHOL DERIVATIVE; POLYCHLORINATED DIBENZODIOXIN;

ADULT; ANIMAL CELL; ARTICLE; CACO-2 CELL LINE; CELL VIABILITY; CONTROLLED STUDY; CYTOSOL; DNA BINDING; DOWN REGULATION; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION; GUINEA PIG; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; SPECIES DIFFERENCE; STRUCTURE ACTIVITY RELATION; TRANSACTIVATION ASSAY; WESTERN BLOTTING; YOUNG ADULT; AGONISTS; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; METABOLISM; THEORETICAL MODEL;

ANIMALS; CACO-2 CELLS; CELL LINE; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP1B1; GUINEA PIGS; HUMANS; MICE; MODELS, THEORETICAL; NAPHTHALENES; NAPHTHOLS; POLYCHLORINATED DIBENZODIOXINS; RECEPTORS, ARYL HYDROCARBON; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 85021722510     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfw230     Document Type: Article

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