Graphical review: The redox dark side of e-cigarettes; exposure to oxidants and public health concerns

Redox Biology

Volumn 13, Issue , 2017, Pages 402-406

  Cai, Hua ^a,b   Wang, Chen ^a  

^a CHINA JAPAN FRIENDSHIP HOSPITAL   (China)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

OXIDIZING AGENT;

CHEMICAL COMPOSITION; DEGENERATIVE DISEASE; ELECTRONIC CIGARETTE; EXPOSURE; GOVERNMENT REGULATION; HEALTH CARE POLICY; HEALTH HAZARD; HEART DISEASE; HUMAN; LUNG DISEASE; PACKAGING; PRIORITY JOURNAL; PUBLIC HEALTH PROBLEM; REVIEW; SMOKING CESSATION; VAPORIZATION; ANIMAL; CARDIOVASCULAR DISEASE; NEOPLASM; OXIDATIVE STRESS; PUBLIC HEALTH; STATISTICS AND NUMERICAL DATA; VAPING;

ANIMALS; CARDIOVASCULAR DISEASES; ELECTRONIC NICOTINE DELIVERY SYSTEMS; HUMANS; LUNG DISEASES; NEOPLASMS; NEURODEGENERATIVE DISEASES; OXIDATIVE STRESS; PUBLIC HEALTH; VAPING;

EID: 85021443301     PISSN: 22132317     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.redox.2017.05.013     Document Type: Review

References (38)

1. Xu, X., Wang, X., Zhang, X., Liu, Y., He, H., Mackay, J., The debate on regulation of e-cigarettes in China. Lancet Respir. Med 4 (2016), 856–858, 10.1016/S2213-2600(16)30313-7 (Epub2016 Oct 12).
2. House of Parliament Postnote Number 533 on Electronic Cigarettes, Parlimentary Office of Science and Technology.
3. Sussan, T.E., Gajghate, S., Thimmulappa, R.K., Ma, J., Kim, J.H., Sudini, K., Consolini, N., Cormier, S.A., Lomnicki, S., Hasan, F., Pekosz, A., Biswal, S., Exposure to electronic cigarettes impairs pulmonary anti-bacterial and anti-viral defenses in a mouse model. PLoS One, 10, 2015, e0116861, 10.1371/journal.pone.0116861 (eCollection2015).
4. Schoenborn, C.A., Gindi, R.M., Electronic Cigarette Use Among Adults: United States, 2014. NCHS Data Brief., 2015, 1–8.
5. Kalkhoran, S., Glantz, S.A., E-cigarettes and smoking cessation in real-world and clinical settings: a systematic review and meta-analysis. Lancet Respir. Med. 4 (2016), 116–128, 10.1016/S2213-2600(15)00521-4 (Epub 2016 Jan 14).
6. R.A. Arrazola, T. Singh, C.G. Corey, C.G. Husten, L.J. Neff, B.J., Apelberg, R.E. Bunnell, C.J. Choiniere, B.A. King, S. Cox, T. McAfee, R.S. Caraballo, Tobacco use among middle and high school students – United States, MMWR Morb Mortal Wkly Rep. 2015, 64, 2011–2014, pp. 381–5.
7. Coleman, B.N., Apelberg, B.J., Ambrose, B.K., Green, K.M., Choiniere, C.J., Bunnell, R., King, B.A., Association between electronic cigarette use and openness to cigarette smoking among US young adults. Nicotine Tob. Res. 17 (2015), 212–218, 10.1093/ntr/ntu211 (Epub 2014 Nov 4).
8. Leone, F.T., Ferkol, T.W., Such are the impositions of quackery: e-cigarettes. Ann. Am. Thorac. Soc. 12 (2015), 787–788, 10.1513/AnnalsATS.201504-252ED.
9. Schraufnagel, D.E., Blasi, F., Drummond, M.B., Lam, D.C., Latif, E., Rosen, M.J., Sansores, R., Van Zyl-Smit, R., Electronic cigarettes. A position statement of the forum of international respiratory societies. Am. J. Respir. Crit. Care Med. 190 (2014), 611–618, 10.1164/rccm.201407-1198PP.
10. Bhatnagar, A., Whitsel, L.P., Ribisl, K.M., Bullen, C., Chaloupka, F., Piano, M.R., Robertson, R.M., McAuley, T., Goff, D., Benowitz, N., Electronic cigarettes: a policy statement from the American Heart Association. Circulation 130 (2014), 1418–1436, 10.1161/CIR.0000000000000107 (Epub2014 Aug 24).
11. Zhu, S.H., Sun, J.Y., Bonnevie, E., Cummins, S.E., Gamst, A., Yin, L., Lee, M., Four hundred and sixty brands of e-cigarettes and counting: implications for product regulation. Tob. Control., 2014, 23, 10.1136/tobaccocontrol-2014-051670.
12. Durazzo, T.C., Mattsson, N., Weiner, M.W., Smoking and increased Alzheimer's disease risk: a review of potential mechanisms. Alzheimers Dement. 10 (2014), S122–S145, 10.1016/j.jalz.2014.04.009.
13. D'Ruiz, C.D., Graff, D.W., Yan, X.S., Nicotine delivery, tolerability and reduction of smoking urge in smokers following short-term use of one brand of electronic cigarettes. BMC Public Health, 15, 2015, 991, 10.1186/s12889-015-2349-2.
14. Moretto, N., Volpi, G., Pastore, F., Facchinetti, F., Acrolein effects in pulmonary cells: relevance to chronic obstructive pulmonary disease. Ann. N. Y. Acad. Sci. 1259 (2012), 39–46, 10.1111/j.1749-6632.2012.06531.x.
15. Hess, C.A., Olmedo, P., Navas-Acien, A., Goessler, W., Cohen, J.E., Rule, A.M., E-cigarettes as a source of toxic and potentially carcinogenic metals. Environ. Res. 152 (2017), 221–225, 10.1016/j.envres.2016.09.026 (Epub 2016 Oct 28).
16. Yu, V., Rahimy, M., Korrapati, A., Xuan, Y., Zou, A.E., Krishnan, A.R., Tsui, T., Aguilera, J.A., Advani, S., Crotty Alexander, L.E., Brumund, K.T., Wang-Rodriguez, J., Ongkeko, W.M., Electronic cigarettes induce DNA strand breaks and cell death independently of nicotine in cell lines. Oral Oncol. 52 (2016), 58–65, 10.1016/j.oraloncology.2015.10.018 (Epub 2015 Nov 4).
17. Khlystov, A., Samburova, V., Flavoring compounds dominate toxic aldehyde production during E-cigarette vaping. Environ. Sci. Technol. 50 (2016), 13080–13085 (Epub2016 Nov 8).
18. William P.L. Jr., S.M. Roberts, eds. Principles of Toxicology: Environmental and Industrial Applications, John Wiley & Sons, 346.
19. Hutzler, C., Paschke, M., Kruschinski, S., Henkler, F., Hahn, J., Luch, A., Chemical hazards present in liquids and vapors of electronic cigarettes. Arch. Toxicol. 88 (2014), 1295–1308, 10.1007/s00204-014-1294-7 (Epub2014 Jun 11).
20. Bahl, V., Lin, S., Xu, N., Davis, B., Wang, Y.H., Talbot, P., Comparison of electronic cigarette refill fluid cytotoxicity using embryonic and adult models. Reprod. Toxicol. 34 (2012), 529–537, 10.1016/j.reprotox.2012.08.001 (Epub2012 Aug 20).
21. Tierney, P.A., Karpinski, C.D., Brown, J.E., Luo, W., Pankow, J.F., Flavour chemicals in electronic cigarette fluids. Tob. Control 25 (2016), e10–e15, 10.1136/tobaccocontrol-2014-052175 (Epub 2015 Apr 15).
22. Scheffler, S., Dieken, H., Krischenowski, O., Forster, C., Branscheid, D., Aufderheide, M., Evaluation of E-cigarette liquid vapor and mainstream cigarette smoke after direct exposure of primary human bronchial epithelial cells. Int J. Environ. Res. Public Health 12 (2015), 3915–3925, 10.3390/ijerph120403915.
23. Lerner, C.A., Sundar, I.K., Yao, H., Gerloff, J., Ossip, D.J., McIntosh, S., Robinson, R., Rahman, I., Vapors produced by electronic cigarettes and e-juices with flavorings induce toxicity, oxidative stress, and inflammatory response in lung epithelial cells and in mouse lung. PLoS One, 10, 2015, e0116732, 10.1371/journal.pone.0116732 (eCollection2015).
24. Schweitzer, K.S., Chen, S.X., Law, S., Van Demark, M., Poirier, C., Justice, M.J., Hubbard, W.C., Kim, E.S., Lai, X., Wang, M., Kranz, W.D., Carroll, C.J., Ray, B.D., Bittman, R., Goodpaster, J., Petrache, I., Endothelial disruptive proinflammatory effects of nicotine and e-cigarette vapor exposures. Am. J. Physiol. Lung Cell Mol. Physiol. 309 (2015), L175–87, 10.1152/ajplung.00411.2014 (Epub2015 May 15).
25. Putzhammer, R., Doppler, C., Jakschitz, T., Heinz, K., Forste, J., Danzl, K., Messner, B., Bernhard, D., Vapours of US and EU market leader electronic cigarette brands and liquids are cytotoxic for human vascular endothelial cells. PLoS One, 11, 2016, e0157337, 10.1371/journal.pone.0157337 (eCollection2016).
26. Rubenstein, D.A., Hom, S., Ghebrehiwet, B., Yin, W., Tobacco and e-cigarette products initiate Kupffer cell inflammatory responses. Mol. Immunol. 67 (2015), 652–660, 10.1016/j.molimm.2015.05.020 (Epub2015 Jun 11).
27. Bodas, M., Van Westphal, C., Carpenter-Thompson, R., KM, D., Vij, N., Nicotine exposure induces bronchial epithelial cell apoptosis and senescence via ROS mediated autophagy-impairment. Free Radic. Biol. Med. 97 (2016), 441–453, 10.1016/j.freeradbiomed.2016.06.017 (Epub2016 Jul 6).
28. Lerner, C.A., Rutagarama, P., Ahmad, T., Sundar, I.K., Elder, A., Rahman, I., Electronic cigarette aerosols and copper nanoparticles induce mitochondrial stress and promote DNA fragmentation in lung fibroblasts. Biochem. Biophys. Res. Commun. 477 (2016), 620–625, 10.1016/j.bbrc.2016.06.109 (Epub2016 Jun 23).
29. Carnevale, R., Sciarretta, S., Violi, F., Nocella, C., Loffredo, L., Perri, L., Peruzzi, M., Marullo, A.G., De Falco, E., Chimenti, I., Valenti, V., Biondi-Zoccai, G., Frati, G., Acute impact of tobacco vs electronic cigarette smoking on oxidative stress and vascular function. Chest 150 (2016), 606–612, 10.1016/j.chest.2016.04.012 (Epub2016 Apr 22).
30. Moheimani, R.S., Bhetraratana, M., Yin, F., Peters, K.M., Gornbein, J., Araujo, J.A., Middlekauff, H.R., Increased cardiac sympathetic activity and oxidative stress in habitual electronic cigarette users: implications for cardiovascular risk. JAMA Cardiol. 2 (2017), 278–284, 10.1001/jamacardio.2016.5303.
31. Youn, J.Y., Gao, L., Cai, H., The p47phox- and NADPH oxidase organiser 1 (NOXO1)-dependent activation of NADPH oxidase 1 (NOX1) mediates endothelial nitric oxide synthase (eNOS) uncoupling and endothelial dysfunction in a streptozotocin-induced murine model of diabetes. Diabetologia 55 (2012), 2069–2079 (Epub2012 May 2).
32. Siu, K.L., Lotz, C., Ping, P., Cai, H., Netrin-1 abrogates ischemia/reperfusion-induced cardiac mitochondrial dysfunction via nitric oxide-dependent attenuation of NOX4 activation and recoupling of NOS. J. Mol. Cell Cardiol. 78 (2014), 174–185.
33. Cai, H., Hydrogen peroxide regulation of endothelial function: mechanisms, consequences and origins. Cardiovasc. Res. 68 (2005), 26–36.
34. Cai, H., NAD(P)H oxidase-dependent self-propagation of hydrogen peroxide and vascular disease. Circ. Res. 96 (2005), 818–822.
35. Cai, H., Harrison, D.G., Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circ. Res. 87 (2000), 840–844.
36. Tollefson, A.K., Oberley-Deegan, R.E., Butterfield, K.T., Nicks, M.E., Weaver, M.R., Remigio, L.K., Decsesznak, J., Chu, H.W., Bratton, D.L., Riches, D.W., Bowler, R.P., Endogenous enzymes (NOX and ECSOD) regulate smoke-induced oxidative stress. Free Radic. Biol. Med. 49 (2010), 1937–1946, 10.1016/j.freeradbiomed.2010.09.022 (Epub2010 Sep 29).
37. Hollins, F., Sutcliffe, A., Gomez, E., Berair, R., Russell, R., Szyndralewiez, C., Saunders, R., Brightling, C., Airway smooth muscle NOX4 is upregulated and modulates ROS generation in COPD. Respir. Res., 17, 2016, 84, 10.1186/s12931-016-0403-y.
38. Fagan, P., Pokhrel, P., Herzog, T.A., Guy, M.C., Sakuma, K.K., Trinidad, D.R., Cassel, K., Jorgensen, D., Lynch, T., Felicitas-Perkins, J.Q., Palafox, S., Hamamura, F., Maloney, S., Degree, K., Sterling, K., Moolchan, E., Clanton, M.S., Eissenberg, T., Warning statements and safety practices among manufacturers and distributors of electronic cigarette liquids in the United States. Nicotine Tob. Res., 2017, 18.