Airway smooth muscle NOX4 is upregulated and modulates ROS generation in COPD

Respiratory Research

Volumn 17, Issue 1, 2016, Pages

  Hollins, Fay ^a   Sutcliffe, Amanda ^a   Gomez, Edith ^a   Berair, Rachid ^a   Russell, Richard ^a   Szyndralewiez, Cédric ^b   Saunders, Ruth ^a   Brightling, Christopher ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b GENKYOTEX SA   (Switzerland)

Author keywords

Airway smooth muscle; COPD; NOX4; Oxidative stress; Reactive oxygen species

Indexed keywords

HYDROGEN PEROXIDE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; TUMOR NECROSIS FACTOR ALPHA; ENZYME INHIBITOR; NOX4 PROTEIN, HUMAN; TUMOR NECROSIS FACTOR;

AIRWAY SMOOTH MUSCLE CELL; ARTICLE; ASTHMA; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GENE FUNCTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOSTIMULATION; IN VITRO STUDY; IN VIVO STUDY; MEDICAL HISTORY; NOX4 GENE; PATHOGENESIS; SMOKING; UPREGULATION; ANTAGONISTS AND INHIBITORS; BRONCHUS; CASE CONTROL STUDY; CELL CULTURE; DRUG EFFECTS; ENZYMOLOGY; METABOLISM; PATHOPHYSIOLOGY; SMOOTH MUSCLE; SMOOTH MUSCLE CELL;

BRONCHI; CASE-CONTROL STUDIES; CELLS, CULTURED; ENZYME INHIBITORS; HUMANS; MUSCLE, SMOOTH; MYOCYTES, SMOOTH MUSCLE; NADPH OXIDASE 4; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; REACTIVE OXYGEN SPECIES; SMOKING; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 84979536670     PISSN: 14659921     EISSN: 1465993X     Source Type: Journal    
DOI: 10.1186/s12931-016-0403-y     Document Type: Article

References (14)

1. Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management and prevention of COPD, Global Initiative for Chronic Obstructive Lung Disease (GOLD), ( http://www.goldcopd.org/ ). Date last updated: December 2015. Date last Accessed: 24 Mar 2016.
2. National Institute for Health and Clinical Excellence. Chronic obstructive pulmonary disease: management of chronic obstructive pulmonary disease in adults in primary and secondary care, CG101, ( http://www.nice.org.uk/CG101 ). Date last updated: 23rd June 2010. Data last Accessed 18 Mar 2016.
3. Wilkinson TM, Patel IS, Wilks M, Donaldson GC, Wedzicha JA. Airway bacterial load and FEV1 decline in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2003;167:1090-5.
4. Fischer BM, Voynow JA, Ghio AJ. COPD: balancing oxidants and antioxidants. Int J Chron Obstruct Pulmon Dis. 2015;10:261-76.
5. Hamid Q, Cosio M, Lim S. Inflammation and remodeling in chronic obstructive pulmonary disease. J Allergy Clin Immunol. 2004;114:1479-81.
6. Pini L, Pinelli V, Modina D, Bezzi M, Tiberio L, Tantucci C. Central airways remodeling in COPD patients. Int J Chron Obstruct Pulmon Dis. 2014;9:927-32.
7. Riess A, Wiggs B, Verburgt L, Wright JL, Hogg JC, Paré PD. Morphologic determinants of airway responsiveness in chronic smokers. Am J Respir Crit Care Med. 1996;154:1444-9.
8. Sutcliffe A, Hollins F, Gomez E, Saunders R, Doe C, Cooke M, Challiss RA, Brightling CE. Increased nicotinamide adenine dinucleotide phosphate oxidase 4 expression mediates intrinsic airway smooth muscle hypercontractility in asthma. Am J Respir Crit Care Med. 2012;185:267-74.
9. Kirkham P, Rahman I. Oxidative stress in asthma and COPD: antioxidants as a therapeutic strategy. Pharmacol Ther. 2006;111:476-94.
10. Vignola AM, Chanez P, Chiappara G, Merendino A, Pace E, Rizzo A, la Rocca AM, Bellia V, Bonsignore G, Bousquet J. Transforming growth factor-beta expression in mucosal biopsies in asthma and chronic bronchitis. Am J Respir Crit Care Med. 1997;156:591-9.
11. Chiang CH, Chuang CH, Liu SL. Transforming growth factor-β1 and tumor necrosis factor-α are associated with clinical severity and airflow limitation of COPD in an additive manner. Lung. 2014;192:95-102.
12. Manea A, Tanase LI, Raicu M, Simionescu M. JAK/STAT signalling pathway regulates Nox1 and Nox4-based NADPH oxidase in human aortic smooth muscle cells. Aterioscler Thromb Vasc Biol. 2010;30:105-12.
13. Milara J, Peiró T, Serrano A, Guijarro R, Zaragozá C, Tenor H, Cortijo J. Roflumilast N-oxide inhibits bronchial epithelial to mesenchymal transition induced by cigarette smoke in smokers with COPD. Pulm Pharmacol Ther. 2014;28:138-48.
14. Sturrock A, Huecksteadt TP, Norman K, Sanders K, Murphy TM, Chitano P, Wilson K, Hoidal JR, Kennedy TP. Nox4 mediates TGF-beta1-induced retinoblastoma protein phosphorylation, proliferation, and hypertrophy in human airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2007;292:L1543-55.